-
1
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
2
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007)
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
-
3
-
-
67650095196
-
Elite and stochastic models for induced pluripotent stem cell generation
-
Yamanaka, S. Elite and stochastic models for induced pluripotent stem cell generation. Nature 460, 49-52 (2009
-
(2009)
Nature
, vol.460
, pp. 49-52
-
-
Yamanaka, S.1
-
4
-
-
84866780162
-
Molecular roadblocks for cellular reprogramming
-
Vierbuchen, T. & Wernig, M. Molecular roadblocks for cellular reprogramming. Mol. Cell 47, 827-838 (2012
-
(2012)
Mol. Cell
, vol.47
, pp. 827-838
-
-
Vierbuchen, T.1
Wernig, M.2
-
5
-
-
84871586080
-
A molecular roadmap of reprogramming somatic cells into iPS cells
-
Polo, J. M. et al. A molecular roadmap of reprogramming somatic cells into iPS cells. Cell 151, 1617-1632 (2012
-
(2012)
Cell
, vol.151
, pp. 1617-1632
-
-
Polo, J.M.1
-
6
-
-
84879879314
-
High-resolution analysis with novel cell-surface markers identifies routes to iPS cells
-
O?Malley, J. et al. High-resolution analysis with novel cell-surface markers identifies routes to iPS cells. Nature 499, 88-91 (2013
-
(2013)
Nature
, vol.499
, pp. 88-91
-
-
Omalley, J.1
-
7
-
-
84866369892
-
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase
-
Buganim, Y. et al. Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 150, 1209-1222 (2012
-
(2012)
Cell
, vol.150
, pp. 1209-1222
-
-
Buganim, Y.1
-
8
-
-
0021745096
-
Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells
-
Andrews, P. W., Banting, G., Damjanov, I., Arnaud, D. & Avner, P. Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells. Hybridoma 3, 347-361 (1984
-
(1984)
Hybridoma
, vol.3
, pp. 347-361
-
-
Andrews, P.W.1
Banting, G.2
Damjanov, I.3
Arnaud, D.4
Avner, P.5
-
9
-
-
70449344685
-
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells
-
Chan, E. M. et al. Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat. Biotechnol. 27, 1033-1037 (2009
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 1033-1037
-
-
Chan, E.M.1
-
10
-
-
84880651864
-
Not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts
-
Tanabe, K., Nakamura, M., Narita, M., Takahashi, K. & Yamanaka, S. Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts. Proc. Natl Acad. Sci. USA 110, 12172-12179 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 12172-12179
-
-
Tanabe, K.1
Nakamura, M.2
Narita, M.3
Takahashi, K.4
Maturation, Y.S.5
-
11
-
-
28644448149
-
Efficient differentiation of human embryonic stem cells to definitive endoderm
-
D?Amour, K. A. et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat. Biotechnol. 23, 1534-1541 (2005
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1534-1541
-
-
Damour, K.A.1
-
12
-
-
79952161362
-
FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation
-
Yu, P., Pan, G., Yu, J. & Thomson, J. A. FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation. Cell Stem Cell 8, 326-334 (2011
-
(2011)
Cell Stem Cell
, vol.8
, pp. 326-334
-
-
Yu, P.1
Pan, G.2
Yu, J.3
Thomson, J.A.4
-
13
-
-
78149322604
-
Directed differentiation of human embryonic stem cells toward chondrocytes
-
Oldershaw, R. A. et al. Directed differentiation of human embryonic stem cells toward chondrocytes. Nat. Biotechnol. 28, 1187-1194 (2010
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 1187-1194
-
-
Oldershaw, R.A.1
-
14
-
-
39349097787
-
Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors
-
Davis, R. P. et al. Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. Blood 111, 1876-1884 (2008
-
(2008)
Blood
, vol.111
, pp. 1876-1884
-
-
Davis, R.P.1
-
15
-
-
84855490988
-
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming
-
Panopoulos, A. D. et al. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res. 22, 168-177 (2012
-
(2012)
Cell Res.
, vol.22
, pp. 168-177
-
-
Panopoulos, A.D.1
-
16
-
-
71449109765
-
Direct cell reprogramming is a stochastic process amenable to acceleration
-
Hanna, J. et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 462, 595-601 (2009
-
(2009)
Nature
, vol.462
, pp. 595-601
-
-
Hanna, J.1
-
17
-
-
69349100179
-
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
-
Hong, H. et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460, 1132-1135 (2009
-
(2009)
Nature
, vol.460
, pp. 1132-1135
-
-
Hong, H.1
-
18
-
-
69349094006
-
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
-
Marion, R. M. et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460, 1149-1153 (2009
-
(2009)
Nature
, vol.460
, pp. 1149-1153
-
-
Marion, R.M.1
-
19
-
-
69349103956
-
The Ink4/Arf locus is a barrier for iPS cell reprogramming
-
Li, H. et al. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460, 1136-1139 (2009
-
(2009)
Nature
, vol.460
, pp. 1136-1139
-
-
Li, H.1
-
20
-
-
69349098273
-
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
-
Utikal, J. et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460, 1145-1148 (2009
-
(2009)
Nature
, vol.460
, pp. 1145-1148
-
-
Utikal, J.1
-
21
-
-
69349100455
-
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
-
Kawamura, T. et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460, 1140-1144 (2009
-
(2009)
Nature
, vol.460
, pp. 1140-1144
-
-
Kawamura, T.1
-
22
-
-
77956320116
-
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
-
Samavarchi-Tehrani, P. et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 7, 64-77 (2010
-
(2010)
Cell Stem Cell
, vol.7
, pp. 64-77
-
-
Samavarchi-Tehrani, P.1
-
23
-
-
77957551870
-
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
-
Li, R. et al. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 7, 51-63 (2010
-
(2010)
Cell Stem Cell
, vol.7
, pp. 51-63
-
-
Li, R.1
-
24
-
-
0035872927
-
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
-
Yamamoto, M. et al. The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15, 1242-1256 (2001
-
(2001)
Genes Dev.
, vol.15
, pp. 1242-1256
-
-
Yamamoto, M.1
-
25
-
-
0035873224
-
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
-
Hoodless, P. A. et al. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 15, 1257-1271 (2001
-
(2001)
Genes Dev.
, vol.15
, pp. 1257-1271
-
-
Hoodless, P.A.1
-
26
-
-
79958292714
-
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
-
Maekawa, M. et al. Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature 474, 225-229 (2011
-
(2011)
Nature
, vol.474
, pp. 225-229
-
-
Maekawa, M.1
-
27
-
-
38049028459
-
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
-
Nakagawa, M. et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 26, 101-106 (2008
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 101-106
-
-
Nakagawa, M.1
-
28
-
-
34249880066
-
Generation of germ-line competent induced pluripotent stem cells
-
Okita, K., Ichisaka, T. & Yamanaka, S. Generation of germ-line competent induced pluripotent stem cells. Nature 448, 313-317 (2007
-
(2007)
Nature
, vol.448
, pp. 313-317
-
-
Okita, K.1
Ichisaka, T.2
Yamanaka, S.3
-
29
-
-
84863615190
-
Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells
-
Tomoda, K. et al. Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. Cell Stem Cell 11, 91-99 (2012
-
(2012)
Cell Stem Cell
, vol.11
, pp. 91-99
-
-
Tomoda, K.1
-
30
-
-
0034046944
-
Plat-E an efficient and stable system for transient packaging of retroviruses
-
Morita, S., Kojima, T. & Kitamura, T. Plat-E: An efficient and stable system for transient packaging of retroviruses. Gene. Ther. 7, 1063-1066 (2000
-
(2000)
Gene. Ther.
, vol.7
, pp. 1063-1066
-
-
Morita, S.1
Kojima, T.2
Kitamura, T.3
-
31
-
-
0032491416
-
Embryonic stem cell lines derived from human blastocysts
-
Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998
-
(1998)
Science
, vol.282
, pp. 1145-1147
-
-
Thomson, J.A.1
-
32
-
-
33646851050
-
Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage
-
Suemori, H. et al. Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage. Biochem. Biophys. Res. Commun. 345, 926-932 (2006
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.345
, pp. 926-932
-
-
Suemori, H.1
-
33
-
-
0025188130
-
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
-
McMahon, A. P. & Bradley, A. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085 (1990
-
(1990)
Cell
, vol.62
, pp. 1073-1085
-
-
McMahon, A.P.1
Bradley, A.2
-
34
-
-
79955634826
-
A more efficient method to generate integration-free human iPS cells
-
Okita, K. et al. A more efficient method to generate integration-free human iPS cells. Nat. Methods 8, 409-412 (2011
-
(2011)
Nat. Methods
, vol.8
, pp. 409-412
-
-
Okita, K.1
-
35
-
-
77956278519
-
Promotion of direct reprogramming by transformation-deficient Myc
-
Nakagawa, M., Takizawa, N., Narita, M., Ichisaka, T. & Yamanaka, S. Promotion of direct reprogramming by transformation-deficient Myc. Proc. Natl Acad. Sci. USA 107, 14152-14157 (2010
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 14152-14157
-
-
Nakagawa, M.1
Takizawa, N.2
Narita, M.3
Ichisaka, T.4
Yamanaka, S.5
-
36
-
-
84864508175
-
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
-
Kajiwara, M. et al. Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells. Proc. Natl Acad. Sci. USA 109, 12538-12543 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 12538-12543
-
-
Kajiwara, M.1
-
37
-
-
84875386413
-
Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells
-
Mae, S. et al. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat. Commun. 4, 1367 (2013
-
(2013)
Nat. Commun.
, vol.4
, pp. 1367
-
-
Mae, S.1
-
38
-
-
62149125434
-
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
-
Chambers, S. M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27, 275-280 (2009
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 275-280
-
-
Chambers, S.M.1
-
39
-
-
78650197228
-
Small molecule inhibitors of BMP and activin/Nodal signals promote highly efficient neural induction from human pluripotent stem cell efficient neural induct stem cell
-
Morizane, A., Doi, D., Kikuchi, T., Nishimura, K. & Takahashi, J. Small molecule inhibitors of BMP and activin/Nodal signals promote highly efficient neural induction from human pluripotent stem cell efficient neural induct stem cell. J. Neurosci. Res. 89, 117-126 (2010
-
(2010)
J. Neurosci. Res.
, vol.89
, pp. 117-126
-
-
Morizane, A.1
Doi, D.2
Kikuchi, T.3
Nishimura, K.4
Takahashi, J.5
-
40
-
-
0043199578
-
Telomerase maintains telomere structure in normal human cells
-
Masutomi, K. et al. Telomerase maintains telomere structure in normal human cells. Cell 114, 241-253 (2003
-
(2003)
Cell
, vol.114
, pp. 241-253
-
-
Masutomi, K.1
-
41
-
-
34250206996
-
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
-
Watanabe, K. et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25, 681-686 (2007).
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 681-686
-
-
Watanabe, K.1
|