-
1
-
-
43449118968
-
Dynamic binding orientations direct activity of HIV reverse transcriptase
-
Abbondanzieri EA, Bokinsky G, Rausch JW, Zhang JX, Le Grice SF, Zhuang X (2008) Dynamic binding orientations direct activity of HIV reverse transcriptase. Nature 453(7192):184-189
-
(2008)
Nature
, vol.453
, Issue.7192
, pp. 184-189
-
-
Abbondanzieri, E.A.1
Bokinsky, G.2
Rausch, J.W.3
Zhang, J.X.4
Le Grice, S.F.5
Zhuang, X.6
-
2
-
-
33144463548
-
The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine
-
Ambrose Z, Julias JG, Boyer PL, Kewalramani VN, Hughes SH (2006) The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine. J Virol 80(5):2578-2581
-
(2006)
J Virol
, vol.80
, Issue.5
, pp. 2578-2581
-
-
Ambrose, Z.1
Julias, J.G.2
Boyer, P.L.3
Kewalramani, V.N.4
Hughes, S.H.5
-
3
-
-
79955535358
-
Replicative fitness costs of nonnucleoside reverse transcriptase inhibitor drug resistance mutations on HIV subtype C
-
Armstrong KL, Lee TH, Essex M (2011) Replicative fitness costs of nonnucleoside reverse transcriptase inhibitor drug resistance mutations on HIV subtype C. Antimicrob Agents Chemother 55(5):2146-2153
-
(2011)
Antimicrob Agents Chemother
, vol.55
, Issue.5
, pp. 2146-2153
-
-
Armstrong, K.L.1
Lee, T.H.2
Essex, M.3
-
4
-
-
0029977510
-
Targeting HIV reverse transcriptase for anti-AIDS drug design: Structural and biological considerations for chemotherapeutic strategies
-
Arnold E, Das K, Ding J, Yadav PNS, Hsiou Y, Boyer PL, Hughes SH (1996) Targeting HIV reverse transcriptase for anti-AIDS drug design: Structural and biological considerations for chemotherapeutic strategies. Drug Design and Discovery 13(3-4):29-47
-
(1996)
Drug Design and Discovery
, vol.13
, Issue.3-4
, pp. 29-47
-
-
Arnold, E.1
Das, K.2
Ding, J.3
Yadav, P.N.S.4
Hsiou, Y.5
Boyer, P.L.6
Hughes, S.H.7
-
5
-
-
0025084615
-
HIV-1 reverse transcriptase: Structure predictions for the polymerase domain
-
Barber AM, Hizi A, Maizel JV Jr, Hughes SH (1990) HIV-1 reverse transcriptase: structure predictions for the polymerase domain. AIDS Res Hum Retroviruses 6(9):1061-1072
-
(1990)
AIDS Res Hum Retroviruses
, vol.6
, Issue.9
, pp. 1061-1072
-
-
Barber, A.M.1
Hizi, A.2
Maizel, J.V.3
Hughes, S.H.4
-
6
-
-
0028024028
-
Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase
-
Boyer PL, Ding J, Arnold E, Hughes SH (1994) Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 38(9):1909-1914
-
(1994)
Antimicrob Agents Chemother
, vol.38
, Issue.9
, pp. 1909-1914
-
-
Boyer, P.L.1
Ding, J.2
Arnold, E.3
Hughes, S.H.4
-
7
-
-
79960358849
-
Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): A phase 3, randomised, non-inferiority trial
-
Cohen CJ, Andrade-Villanueva J, Clotet B, Fourie J, Johnson MA, Ruxrungtham K et al (2011) Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial. Lancet 378(9787):229-237
-
(2011)
Lancet
, vol.378
, Issue.9787
, pp. 229-237
-
-
Cohen, C.J.1
Andrade-Villanueva, J.2
Clotet, B.3
Fourie, J.4
Johnson, M.A.5
Ruxrungtham, K.6
-
8
-
-
0030596068
-
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant
-
Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L et al (1996) Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J Mol Biol 264(5):1085-1100
-
(1996)
J Mol Biol
, vol.264
, Issue.5
, pp. 1085-1100
-
-
Das, K.1
Ding, J.2
Hsiou, Y.3
Clark, A.D.4
Moereels, H.5
Koymans, L.6
-
9
-
-
2342620790
-
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants
-
Das K, Clark AD Jr, Lewi PJ, Heeres J, De Jonge MR, Koymans LM et al (2004) Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. J Med Chem 47(10): 2550-2560
-
(2004)
J Med Chem
, vol.47
, Issue.10
, pp. 2550-2560
-
-
Das, K.1
Clark, A.D.2
Lewi, P.J.3
Heeres, J.4
De Jonge, M.R.5
Koymans, L.M.6
-
10
-
-
9744258219
-
Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of nonnucleoside HIV-1 reverse transcriptase inhibitors
-
Das K, Lewi PJ, Hughes SH, Arnold E (2005) Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of nonnucleoside HIV-1 reverse transcriptase inhibitors. Prog Biophys Mol Biol 88(2):209-231
-
(2005)
Prog Biophys Mol Biol
, vol.88
, Issue.2
, pp. 209-231
-
-
Das, K.1
Lewi, P.J.2
Hughes, S.H.3
Arnold, E.4
-
11
-
-
40349091258
-
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
-
Das K, Bauman JD, Clark AD Jr, Frenkel YV, Lewi PJ, Shatkin AJ et al (2008) High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Proc Natl Acad Sci USA 105(5):1466-1471
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.5
, pp. 1466-1471
-
-
Das, K.1
Bauman, J.D.2
Clark, A.D.3
Frenkel, Y.V.4
Lewi, P.J.5
Shatkin, A.J.6
-
12
-
-
79955434216
-
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket
-
Das K, Bauman JD, Rim AS, Dharia C, Clark AD Jr, Camarasa MJ et al (2011) Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. J Med Chem 54(8):2727-2737
-
(2011)
J Med Chem
, vol.54
, Issue.8
, pp. 2727-2737
-
-
Das, K.1
Bauman, J.D.2
Rim, A.S.3
Dharia, C.4
Clark, A.D.5
Camarasa, M.J.6
-
13
-
-
84856711380
-
HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism
-
Das K, Martinez SE, Bauman JD, Arnold E (2012) HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat Struct Mol Biol 19(2):253-259
-
(2012)
Nat Struct Mol Biol
, vol.19
, Issue.2
, pp. 253-259
-
-
Das, K.1
Martinez, S.E.2
Bauman, J.D.3
Arnold, E.4
-
14
-
-
0035281213
-
International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance
-
Deeks SG (2001) International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance. J Acquir Immune Defic Syndr 26(Suppl 1):S25-S33
-
(2001)
J Acquir Immune Defic Syndr
, vol.26
, pp. S25-S33
-
-
Deeks, S.G.1
-
15
-
-
0029075207
-
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
-
Ding J, Das K, Moereels H, Koymans L, Andries K, Janssen PA et al (1995) Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Nat Struct Biol 2(5):407-415
-
(1995)
Nat Struct Biol
, vol.2
, Issue.5
, pp. 407-415
-
-
Ding, J.1
Das, K.2
Moereels, H.3
Koymans, L.4
Andries, K.5
Janssen, P.A.6
-
16
-
-
77954966735
-
Addition of 7 days of zidovudine plus lamivudine to peripartum single-dose nevirapine effectively reduces nevirapine resistance postpartum in HIV-infected mothers in Malawi
-
Farr SL, Nelson JA, Ng'ombe TJ, Kourtis AP, Chasela C, Johnson JA et al (2010) Addition of 7 days of zidovudine plus lamivudine to peripartum single-dose nevirapine effectively reduces nevirapine resistance postpartum in HIV-infected mothers in Malawi. J Acquir Immune Defic Syndr 54(5):515-523
-
(2010)
J Acquir Immune Defic Syndr
, vol.54
, Issue.5
, pp. 515-523
-
-
Farr, S.L.1
Nelson, J.A.2
Ng'ombe, T.J.3
Kourtis, A.P.4
Chasela, C.5
Johnson, J.A.6
-
17
-
-
80855123632
-
Safety of efavirenz in the first trimester of pregnancy: An updated systematic review and meta-analysis
-
Ford N, Calmy A, Mofenson L (2011) Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis. AIDS 25(18):2301-2304
-
(2011)
AIDS
, vol.25
, Issue.18
, pp. 2301-2304
-
-
Ford, N.1
Calmy, A.2
Mofenson, L.3
-
18
-
-
80855130709
-
Phase 2 doubleblind, randomized trial of etravirine versus efavirenz in treatment-naive patients: 48-week results
-
Gazzard B, Duvivier C, Zagler C, Castagna A, Hill A, van Delft Y et al (2011) Phase 2 doubleblind, randomized trial of etravirine versus efavirenz in treatment-naive patients: 48-week results. AIDS 25(18):2249-2258
-
(2011)
AIDS
, vol.25
, Issue.18
, pp. 2249-2258
-
-
Gazzard, B.1
Duvivier, C.2
Zagler, C.3
Castagna, A.4
Hill, A.5
Van Delft, Y.6
-
19
-
-
0028023808
-
Effect of a thiobenzimidazolone derivative on DNA strand transfer catalyzed by HIV-1 reverse transcriptase
-
Gopalakrishnan V, Benkovic S (1994) Effect of a thiobenzimidazolone derivative on DNA strand transfer catalyzed by HIV-1 reverse transcriptase. J Biol Chem 269(6):4110-4115
-
(1994)
J Biol Chem
, vol.269
, Issue.6
, pp. 4110-4115
-
-
Gopalakrishnan, V.1
Benkovic, S.2
-
20
-
-
0029976422
-
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors
-
Hopkins AL, Ren J, Esnouf RM, Willcox BE, Jones EY, Ross C et al (1996) Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. J Med Chem 39(8):1589-1600
-
(1996)
J Med Chem
, vol.39
, Issue.8
, pp. 1589-1600
-
-
Hopkins, A.L.1
Ren, J.2
Esnouf, R.M.3
Willcox, B.E.4
Jones, E.Y.5
Ross, C.6
-
21
-
-
0030586090
-
Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: Implications of conformational changes for polymerization and inhibition mechanisms
-
Hsiou Y, Ding J, Das K, Clark AD Jr, Hughes SH, Arnold E (1996) Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure 4(7):853-860
-
(1996)
Structure
, vol.4
, Issue.7
, pp. 853-860
-
-
Hsiou, Y.1
Ding, J.2
Das, K.3
Clark, A.D.4
Hughes, S.H.5
Arnold, E.6
-
22
-
-
13144282707
-
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: Inhibitor flexibility is a useful design feature for reducing drug resistance
-
Hsiou Y, Das K, Ding J, Clark AD Jr, Kleim JP, Rosner M et al (1998) Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. J Mol Biol 284(2):313-323
-
(1998)
J Mol Biol
, vol.284
, Issue.2
, pp. 313-323
-
-
Hsiou, Y.1
Das, K.2
Ding, J.3
Clark, A.D.4
Kleim, J.P.5
Rosner, M.6
-
23
-
-
0035368238
-
The Lys103Asn mutation of HIV-1 RT: A novel mechanism of drug resistance
-
Hsiou Y, Ding J, Das K, Clark AD Jr, Boyer PL, Lewi P et al (2001) The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J Mol Biol 309(2):437-445
-
(2001)
J Mol Biol
, vol.309
, Issue.2
, pp. 437-445
-
-
Hsiou, Y.1
Ding, J.2
Das, K.3
Clark, A.D.4
Boyer, P.L.5
Lewi, P.6
-
24
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
Huang H, Chopra R, Verdine GL, Harrison SC (1998) Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 282(5394):1669-1675
-
(1998)
Science
, vol.282
, Issue.5394
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
25
-
-
0027318776
-
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA
-
Jacobo-Molina A, Ding J, Nanni RG, Clark AD Jr, Lu X, Tantillo C et al (1993) Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc Natl Acad Sci USA 90(13):6320-6324
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, Issue.13
, pp. 6320-6324
-
-
Jacobo-Molina, A.1
Ding, J.2
Nanni, R.G.3
Clark, A.D.4
Lu, X.5
Tantillo, C.6
-
26
-
-
20144372481
-
In search of a novel anti-HIV drug: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine)
-
Janssen PA, Lewi PJ, Arnold E, Daeyaert F, de Jonge M, Heeres J et al (2005) In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine). J Med Chem 48(6):1901-1909
-
(2005)
J Med Chem
, vol.48
, Issue.6
, pp. 1901-1909
-
-
Janssen, P.A.1
Lewi, P.J.2
Arnold, E.3
Daeyaert, F.4
De Jonge, M.5
Heeres, J.6
-
27
-
-
84857955750
-
A quantitative basis for antiretroviral therapy for HIV-1 infection
-
Jilek BL, Zarr M, Sampah ME, Rabi SA, Bullen CK, Lai J et al (2012) A quantitative basis for antiretroviral therapy for HIV-1 infection. Nat Med 18(3):446-451
-
(2012)
Nat Med
, vol.18
, Issue.3
, pp. 446-451
-
-
Jilek, B.L.1
Zarr, M.2
Sampah, M.E.3
Rabi, S.A.4
Bullen, C.K.5
Lai, J.6
-
28
-
-
0347992032
-
Evolution of human immunodeficiency virus type 1 (HIV-1) resistance mutations in nonnucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1-infected patients switched to antiretroviral therapy without NNRTIs
-
Joly V, Descamps D, Peytavin G, Touati F, Mentre F, Duval X et al (2004) Evolution of human immunodeficiency virus type 1 (HIV-1) resistance mutations in nonnucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1-infected patients switched to antiretroviral therapy without NNRTIs. Antimicrob Agents Chemother 48(1):172-175
-
(2004)
Antimicrob Agents Chemother
, vol.48
, Issue.1
, pp. 172-175
-
-
Joly, V.1
Descamps, D.2
Peytavin, G.3
Touati, F.4
Mentre, F.5
Duval, X.6
-
29
-
-
0034990535
-
Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase
-
Julias JG, Ferris AL, Boyer PL, Hughes SH (2001) Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase. J Virol 75(14):6537-6546
-
(2001)
J Virol
, vol.75
, Issue.14
, pp. 6537-6546
-
-
Julias, J.G.1
Ferris, A.L.2
Boyer, P.L.3
Hughes, S.H.4
-
30
-
-
44649102135
-
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
-
Keele BF, Giorgi EE, Salazar-Gonzalez JF, Decker JM, Pham KT, Salazar MG et al (2008) Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc Natl Acad Sci USA 105(21):7552-7557
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.21
, pp. 7552-7557
-
-
Keele, B.F.1
Giorgi, E.E.2
Salazar-Gonzalez, J.F.3
Decker, J.M.4
Pham, K.T.5
Salazar, M.G.6
-
31
-
-
0026693137
-
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA (1992) Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256(5065): 1783-1790
-
(1992)
Science
, vol.256
, Issue.5065
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
32
-
-
77950019614
-
Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex
-
Lansdon EB, Samuel D, Lagpacan L, Brendza KM, White KL, Hung M et al (2010) Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex. J Mol Biol 397(4):967-978
-
(2010)
J Mol Biol
, vol.397
, Issue.4
, pp. 967-978
-
-
Lansdon, E.B.1
Samuel, D.2
Lagpacan, L.3
Brendza, K.M.4
White, K.L.5
Hung, M.6
-
33
-
-
84861543040
-
Effects of shortcourse zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine
-
Micek MA, Blanco AJ, Carlsson J, Beck IA, Dross S, Matunha L et al (2012) Effects of shortcourse zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine. J Infect Dis 205(12):1811-1815
-
(2012)
J Infect Dis
, vol.205
, Issue.12
, pp. 1811-1815
-
-
Micek, M.A.1
Blanco, A.J.2
Carlsson, J.3
Beck, I.A.4
Dross, S.5
Matunha, L.6
-
34
-
-
79960381844
-
Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): A phase 3 randomised double-blind active-controlled trial
-
Molina JM, Cahn P, Grinsztejn B, Lazzarin A, Mills A, Saag M et al (2011) Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial. Lancet 378(9787): 238-246
-
(2011)
Lancet
, vol.378
, Issue.9787
, pp. 238-246
-
-
Molina, J.M.1
Cahn, P.2
Grinsztejn, B.3
Lazzarin, A.4
Mills, A.5
Saag, M.6
-
35
-
-
0028926938
-
Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase
-
Palaniappan C, Fay PJ, Bambara RA (1995) Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase. J Biol Chem 270(9): 4861-4869
-
(1995)
J Biol Chem
, vol.270
, Issue.9
, pp. 4861-4869
-
-
Palaniappan, C.1
Fay, P.J.2
Bambara, R.A.3
-
36
-
-
33646474114
-
Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission
-
Palmer S, Boltz V, Martinson N, Maldarelli F, Gray G, McIntyre J et al (2006) Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission. Proc Natl Acad Sci USA 103(18):7094-7099
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.18
, pp. 7094-7099
-
-
Palmer, S.1
Boltz, V.2
Martinson, N.3
Maldarelli, F.4
Gray, G.5
McIntyre, J.6
-
37
-
-
84860323820
-
Short-course Combivir after single-dose nevirapine reduces but does not eliminate the emergence of nevirapine resistance in women
-
Palmer S, Boltz VF, Chow JY, Martinson NA, McIntyre JA, Gray GE et al (2012) Short-course Combivir after single-dose nevirapine reduces but does not eliminate the emergence of nevirapine resistance in women. Antivir Ther 17(2):327-336
-
(2012)
Antivir Ther
, vol.17
, Issue.2
, pp. 327-336
-
-
Palmer, S.1
Boltz, V.F.2
Chow, J.Y.3
Martinson, N.A.4
McIntyre, J.A.5
Gray, G.E.6
-
38
-
-
0034094041
-
Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors
-
Pelemans H, Esnouf R, De Clercq E, Balzarini J (2000) Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors. Mol Pharmacol 57(5):954-960
-
(2000)
Mol Pharmacol
, vol.57
, Issue.5
, pp. 954-960
-
-
Pelemans, H.1
Esnouf, R.2
De Clercq, E.3
Balzarini, J.4
-
39
-
-
0029645409
-
The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: Lessons for inhibitor design
-
Ren J, Esnouf R, Hopkins A, Ross C, Jones Y, Stammers D et al (1995) The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design. Structure 3(9):915-926
-
(1995)
Structure
, vol.3
, Issue.9
, pp. 915-926
-
-
Ren, J.1
Esnouf, R.2
Hopkins, A.3
Ross, C.4
Jones, Y.5
Stammers, D.6
-
40
-
-
0033598368
-
Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies
-
Ren J, Esnouf RM, Hopkins AL, Stuart DI, Stammers DK (1999) Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies. J Med Chem 42(19):3845-3851
-
(1999)
J Med Chem
, vol.42
, Issue.19
, pp. 3845-3851
-
-
Ren, J.1
Esnouf, R.M.2
Hopkins, A.L.3
Stuart, D.I.4
Stammers, D.K.5
-
41
-
-
0037195081
-
Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to nonnucleoside inhibitors
-
Ren J, Bird LE, Chamberlain PP, Stewart-Jones GB, Stuart DI, Stammers DK (2002) Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to nonnucleoside inhibitors. Proc Natl Acad Sci USA 99(22):14410-14415
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.22
, pp. 14410-14415
-
-
Ren, J.1
Bird, L.E.2
Chamberlain, P.P.3
Stewart-Jones, G.B.4
Stuart, D.I.5
Stammers, D.K.6
-
42
-
-
0025297454
-
Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention
-
Restle T, Muller B, Goody RS (1990) Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention. J Biol Chem 265(16): 8986-8988
-
(1990)
J Biol Chem
, vol.265
, Issue.16
, pp. 8986-8988
-
-
Restle, T.1
Muller, B.2
Goody, R.S.3
-
43
-
-
0029150042
-
Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors
-
Rittinger K, Divita G, Goody RS (1995) Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors. Proc Natl Acad Sci USA 92(17):8046-8049
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.17
, pp. 8046-8049
-
-
Rittinger, K.1
Divita, G.2
Goody, R.S.3
-
44
-
-
0035868713
-
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA
-
Sarafianos SG, Das K, Tantillo C, Clark AD Jr, Ding J, Whitcomb JM et al (2001) Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. EMBO J 20(6):1449-1461
-
(2001)
EMBO J
, vol.20
, Issue.6
, pp. 1449-1461
-
-
Sarafianos, S.G.1
Das, K.2
Tantillo, C.3
Clark, A.D.4
Ding, J.5
Whitcomb, J.M.6
-
45
-
-
18744365757
-
Structures of HIV-1 reverse transcriptase with pre-and post-translocation AZTMP-terminated DNA
-
Sarafianos SG, Clark AD Jr, Das K, Tuske S, Birktoft JJ, Ilankumaran P et al (2002) Structures of HIV-1 reverse transcriptase with pre-and post-translocation AZTMP-terminated DNA. EMBO J 21(23):6614-6624
-
(2002)
EMBO J
, vol.21
, Issue.23
, pp. 6614-6624
-
-
Sarafianos, S.G.1
Clark, A.D.2
Das, K.3
Tuske, S.4
Birktoft, J.J.5
Ilankumaran, P.6
-
46
-
-
0028925773
-
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
-
Spence RA, Kati WM, Anderson KS, Johnson KA (1995) Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Science 267(5200):988-993
-
(1995)
Science
, vol.267
, Issue.5200
, pp. 988-993
-
-
Spence, R.A.1
Kati, W.M.2
Anderson, K.S.3
Johnson, K.A.4
-
47
-
-
0141515727
-
The effect of NNRTIs on HIV reverse transcriptase dimerization
-
Tachedjian G, Goff SP (2003) The effect of NNRTIs on HIV reverse transcriptase dimerization. Curr Opin Investig Drugs 4(8):966-973
-
(2003)
Curr Opin Investig Drugs
, vol.4
, Issue.8
, pp. 966-973
-
-
Tachedjian, G.1
Goff, S.P.2
-
48
-
-
0035912717
-
Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase
-
Tachedjian G, Orlova M, Sarafianos SG, Arnold E, Goff SP (2001) Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase. Proc Natl Acad Sci USA 98(13):7188-7193
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.13
, pp. 7188-7193
-
-
Tachedjian, G.1
Orlova, M.2
Sarafianos, S.G.3
Arnold, E.4
Goff, S.P.5
-
49
-
-
11844282799
-
Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation
-
Tachedjian G, Moore KL, Goff SP, Sluis-Cremer N (2005) Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation. FEBS Lett 579(2):379-384
-
(2005)
FEBS Lett
, vol.579
, Issue.2
, pp. 379-384
-
-
Tachedjian, G.1
Moore, K.L.2
Goff, S.P.3
Sluis-Cremer, N.4
-
50
-
-
77957797787
-
Structural basis of HIV-1 resistance to AZT by excision
-
Tu X, Das K, Han Q, Bauman JD, Clark AD Jr, Hou X et al (2010) Structural basis of HIV-1 resistance to AZT by excision. Nat Struct Mol Biol 17(10):1202-1209
-
(2010)
Nat Struct Mol Biol
, vol.17
, Issue.10
, pp. 1202-1209
-
-
Tu, X.1
Das, K.2
Han, Q.3
Bauman, J.D.4
Clark, A.D.5
Hou, X.6
-
51
-
-
2342453265
-
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
-
Tuske S, Sarafianos SG, Clark AD Jr, Ding J, Naeger LK, White KL et al (2004) Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Nat Struct Mol Biol 11(5):469-474
-
(2004)
Nat Struct Mol Biol
, vol.11
, Issue.5
, pp. 469-474
-
-
Tuske, S.1
Sarafianos, S.G.2
Clark, A.D.3
Ding, J.4
Naeger, L.K.5
White, K.L.6
-
52
-
-
77956042549
-
Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions
-
Wang J, Bambara RA, Demeter LM, Dykes C (2010) Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions. J Virol 84(18):9377-9389
-
(2010)
J Virol
, vol.84
, Issue.18
, pp. 9377-9389
-
-
Wang, J.1
Bambara, R.A.2
Demeter, L.M.3
Dykes, C.4
-
53
-
-
34848869951
-
Teratogenicity risk of antiretroviral therapy in pregnancy
-
Watts DH (2007) Teratogenicity risk of antiretroviral therapy in pregnancy. Curr HIV/AIDS Rep 4(3):135-140
-
(2007)
Curr HIV/AIDS Rep
, vol.4
, Issue.3
, pp. 135-140
-
-
Watts, D.H.1
|