Diagnosis of endocrine disease: Thyroid ultrasound (US) and US-assisted procedures: From the shadows into an array of applications

European Journal of Endocrinology

Volumn 170, Issue 4, 2014, Pages

  Papini, Enrico ^a   Pacella, Claudio M ^a   Hegedus, Laszlo ^b  

^a REGINA APOSTOLORUM HOSPITAL   (Italy)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; MOLECULAR MARKER;

ABLATION THERAPY; CYTOLOGY; DISEASE CLASSIFICATION; DISEASE MARKER; FOLLOW UP; HISTOCHEMISTRY; HISTOPATHOLOGY; HUMAN; LOW LEVEL LASER THERAPY; MEDICAL EDUCATION; MINIMALLY INVASIVE PROCEDURE; OUTPATIENT; POSTOPERATIVE COMPLICATION; PREDICTIVE VALUE; PRIORITY JOURNAL; RADIOFREQUENCY; RELIABILITY; REVIEW; SAMPLING; SYMPTOM; THERMAL ABLATION; THYROID CANCER; THYROID FUNCTION; THYROID GLAND EXAMINATION; THYROID NODULE; THYROID SURGERY; TUMOR BIOPSY; TUMOR GROWTH; TUMOR LOCALIZATION; ULTRASOUND;

ABLATION TECHNIQUES; BIOPSY, FINE-NEEDLE; HUMANS; IMAGE-GUIDED BIOPSY; THERAPY, COMPUTER-ASSISTED; THYROID GLAND; THYROID NEOPLASMS; THYROID NODULE;

EID: 84899476458     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-13-0917     Document Type: Review

References (123)

1. Gharib H & Papini E. Thyroid nodules: clinical importance, assessment, and treatment. Endocrinology and Metabolism Clinics of North America 2007 36 707-735 vi. (doi:10.1016/j.ecl.2007.04.009)
2. Hegedus L, Bonnema SJ & Bennedbaek FN. Management of simple nodular goiter: current status and future perspectives. Endocrine Reviews 2003 24 102-132. (doi:10.1210/er.2002-0016)
3. Gharib H, Papini E, Paschke R, Duick DS, Valcavi R, Hegedus L & Vitti P. American Association of Clinical Endocrinologist, Associazione Medici Endocrinologi, and European Thyroid Association Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules. Endocrine Practice 2010 16 (Suppl 1) 1-43. (doi:10.4158/10024. GL)
4. Gharib H, Hegedus L, Pacella CM, Baek JH & Papini E. Nonsurgical, image-guided, minimally invasive therapy for thyroid nodules. Journal of Clinical Endocrinology and Metabolism 2013 98 3949-3957. (doi:10.1210/jc.2013- 1806)
5. Yamakawa M & Naito S. In Diagnostic Ultrasound, vol 966, pp 27-41. Eds CH Grossman, JH Holmes, CL Joyner & EW Purnell. Plenum Press and Plenum Publishing Corporation, New York Proceeding of the First International Congress, University of Pittsburgh.
6. Fugimoto Y, Oka A, Omoto R & Hirose M. Ultrasound scanning of the thyroid gland as a new diagnostic approach. Ultrasonics 1967 5 177-180. (doi:10.1016/S0041-624X (67) 80065-9)
7. Damascelli B, Cascinelli N, Livraghi T & Veronesi U. Preoperative approach to thyroid tumours by a two-dimensional pulsed echo technique. Ultrasonics 1968 6 242-243. (doi:10.1016/0041-624X (68) 90135-2)
8. Rasmussen SN, Christiansen NJ, Jorgensen JS & Holm HH. Differentiation between cystic and solid thyroid nodules by ultrasonic examination. An estimation of the value of ultrasonic examination as a supplement to isotope scanning. A preliminary communication. Acta Chirurgica Scandinavica 1971 137 331-333.
9. Thijs LG. Diagnostic ultrasound in clinical thyroid investigation. Journal of Clinical Endocrinology and Metabolism 1971 32 709-716. (doi:10.1210/jcem-32-6-709)
10. Blum M, Weiss B & Hernberg J. Evaluation of thyroid nodules by A-mode echography. Radiology 1971 101 651-656.
11. Miskin M, Rosen IB & Walfish PG. B-mode ultrasonography in assessment of thyroid gland lesions. Annals of Internal Medicine 1973 79 505-510. (doi:10.7326/0003-4819-79-4-505)
12. Rosen IB, Walfish PG & Miskin M. The ultrasound of thyroid masses. Surgical Clinics of North America 1979 59 19-33.
13. Crocker EF, McLaughlin AF, Kossoff G & Jellins J. The gray scale echographic appearance of thyroid malignancy. Journal of Clinical Ultrasound 1974 2 305-306. (doi:10.1002/jcu.1870020411)
14. Scheible W, Leopold GR, Woo VL & Gosink BB. High-resolution real-time ultrasonography of thyroid nodules. Radiology 1979 133 413-417.
15. Hegedus L, Perrild H, Poulsen LR, Andersen JR, Holm B, Schnohr P, Jensen G & Hansen JM. The determination of thyroid volume by ultrasound and its relationship to body weight, age, and sex in normal subjects. Journal of Clinical Endocrinology and Metabolism 1983 56 260-263. (doi:10.1210/jcem-56-2- 260)
16. Rails PW, Mayekawa DS, Lee KP, Colletti PM, Radin DR, Boswell WD & Halls JM. Color-flow Doppler sonography in Graves' disease: "thyroid inferno". AJNR. American Journal of Neuroradiology 1988 150 781-784.
17. Burns PN. The physical principles of Doppler and spectral analysis. Journal of Clinical Ultrasound 1987 15 567-590. (doi:10.1002/jcu. 1870150903)
18. Rubin JM, Bude RO, Carson PL, Bree RL & Adler RS. Power Doppler US: a potentially useful alternative to mean frequency-based color Doppler US. Radiology 1994 190 853-856.
19. Bude RO & Rubin JM. Power Doppler sonography. Radiology 1996 200 21-23.
20. Grant EG. Sonographic contrast agents in vascular imaging. Seminars in Ultrasound, CT, and MR 2001 22 25-41. (doi:10.1016/S0887-2171 (01) 90016-2)
21. Lyshchik A, Higashi T, Asato R, Tanaka S, Ito J, Mai JJ, Pellot-Barakat C, Insana MF, Brill AB, Saga T et al. Thyroid gland tumor diagnosis at US elastography. Radiology 2005 237 202-211. (doi:10.1148/radiol. 2363041248)
22. Trimboli P, Guglielmi R, Monti S, Misischi I, Graziano F, Nasrollah N, Amendola S, Morgante SN, Deiana MG, Valabrega S et al. Ultrasound sensitivity for thyroid malignancy is increased by real-time elastography: a prospective multicenter study. Journal of Clinical Endocrinology and Metabolism 2012 97 4524-4530. (doi:10.1210/jc. 2012-2951)
23. Papini E, Bizzarri G, Bianchini A, Guglielmi R, Graziano F, Lonero F, Pacella S & Pacella CM. Contrast-enhanced ultrasound in the management of thyroid nodules. In Thyroid Ultrasound and Ultrasound-Guided FNA, pp 151-171. Eds HJ Baskin, DS Duick & RA Levine. New York, NY: Springer, 2008.
24. Papini E, Guglielmi R, Bianchini A, Crescenzi A, Taccogna S, Nardi F, Panunzi C, Rinaldi R, Toscano V & Pacella CM. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. Journal of Clinical Endocrinology and Metabolism 2002 87 1941-1946. (doi:10.1210/jcem.87.5.8504)
25. Kim EK, Park CS, Chung WY, Oh KK, Kim DI, Lee JT & Yoo HS. New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. AJR. American Journal of Roentgenology 2002 178 687-691. (doi:10.2214/ajr.178.3.1780687)
26. Khoo ML, Asa SL, Witterick IJ & Freeman JL. Thyroid calcification and its association with thyroid carcinoma. Head & Neck 2002 24 651-655. (doi:10.1002/hed.10115)
27. Nam-Goong IS, Kim HY, Gong G, Lee HK, Hong SJ, Kim WB & Shong YK. Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings. Clinical Endocrinology 2004 60 21-28. (doi:10.1046/j.1365-2265.2003.01912.x)
28. Peccin S, De Castsro JA, Furlanetto TW, Furtado AP, Brasil BA & Czepielewski MA. Ultrasonography: is it useful in the diagnosis of cancer in thyroid nodules? Journal of Endocrinological Investigation 2002 25 39-43.
29. Alexander EK, Marqusee E, Orcutt J, Benson CB, Frates MC, Doubilet PM, Cibas ES & Atri A. Thyroid nodule shape and prediction of malignancy. Thyroid 2004 14 953-958. (doi:10.1089/thy.2004. 14.953)
30. Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR et al. Management of thyroid nodules detected at US: society of radiologists in ultrasound consensus conference statement. Radiology 2005 237 794-800. (doi:10.1148/radiol. 2373050220)
31. Wienke JR, Chong WK, Fielding JR, Zou KH & Mittelstaedt CA. Sonographic features of benign thyroid nodules: interobserver reliability and overlap with malignancy. Journal of Ultrasound in Medicine 2003 22 1027-1031.
32. Moon WJ, Jung SL, Lee JH, Na DG, Baek JH, Lee YH, Kim J, Kim HS, Byun JS & Lee DH. Benign and malignant thyroid nodules: US differentiation - multicenter retrospective study. Radiology 2008 247 762-770. (doi:10.1148/radiol.2473070944)
33. Lee YH, Kim DW, In HS, Park JS, Kim SH, Eom JW, Kim B, Lee EJ & Rho MH. Differentiation between benign and malignant solid thyroid nodules using an US classification system. Korean Journal of Radiology 2011 12 559-567. (doi:10.3348/kjr.2011.12.5.559)
34. Leenhardt L, Hejblum G, Franc B, Fediaevsky LD, Delbot T, Le Guillouzic D, Menegaux F, Guillausseau C, Hoang C, Turpin G et al. Indications and limits of ultrasound-guided cytology in the management of nonpalpable thyroid nodules. Journal of Clinical Endocrinology and Metabolism 1999 84 24-28. (doi:10.1210/jcem.84.1.5418)
35. Russ G, Royer B, Bigorgne C, Rouxel A, Bienvenu-Perrard M & Leenhardt L. Prospective evaluation of thyroid imaging reporting and data system on 4550 nodules with and without elastography. European Journal of Endocrinology 2013 168 649-655. (doi:10.1530/EJE-12-0936)
36. Walfish PG, Hazani E, Strawbridge HT, Miskin M & Rosen IB. A prospective study of combined ultrasonography and needle aspiration biopsy in the assessment of the hypofunctioning thyroid nodule. Surgery 1977 82 474-482.
37. Hegedus L. Therapy: a new nonsurgical therapy option for benign thyroid nodules? Nature Reviews. Endocrinology 2009 5 476-478. (doi:10.1038/nrendo.2009. 152)
38. Can AS. Cost-effectiveness comparison between palpation- and ultrasound-guided thyroid fine-needle aspiration biopsies. BMC Endocrine Disorders 2009 9 14. (doi:10.1186/1472-6823-9-14)
39. Gharib H, Papini E, Paschke R, Duick DS, Valcavi R, Hegedus L & Vitti P. Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. Journal of Clinical Investigation 2010 33 51-56.
40. Samir AE, Vij A, Seale MK, Desai G, Halpern E, Faquin WC, Parangi S, Hahn PF & Daniels GH. Ultrasound-guided percutaneous thyroid nodule core biopsy: clinical utility in patients with prior nondiagnostic fine-needle aspirate. Thyroid 2012 22 461-467. (doi:10.1089/thy.2011.0061)
41. Nasrollah N, Trimboli P, Guidobaldi L, Cicciarella Modica DD, Ventura C, Ramacciato G, Taccogna S, Romanelli F, Valabrega S & Crescenzi A. Thin core biopsy should help to discriminate thyroid nodules cytologically classified as indeterminate. A new sampling technique. Endocrine 2013 43 659-665. (doi:10.1007/s12020-012-9811-z)
42. Faquin WC. Can a gene-expression classifier with high negative predictive value solve the indeterminate thyroid fine-needle aspiration dilemma? Cancer Cytopathology 2013 121 116-119. (doi:10.1002/cncy.21277)
43. Bergenfelz A, Jansson S, Kristoffersson A, Martensson H, Reihner E, Wallin G & Lausen I. Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3, 660 patients. Langenbeck's Archives of Surgery 2008 393 667-673. (doi:10.1007/s00423-008-0366-7)
44. Watt T, Groenvold M, Rasmussen AK, Bonnema SJ, Hegedus L, Bjorner JB & Feldt-Rasmussen U. Quality of life inpatients with benign thyroid disorders. A review. European Journal of Endocrinology 2006 154 501-510. (doi:10.1530/eje.1.02124)
45. Chandrasekhar SS, Randolph GW, Seidman MD, Rosenfeld RM, Angelos P, Barkmeier-Kraemer J, Benninger MS, Blumin JH, Dennis G, Hanks J et al. Clinical practice guideline: improving voice outcomes after thyroid surgery. Otolaryngology - Head and Neck Surgery 2013 148 S1-S37. (doi:10.1177/ 0194599813487301)
46. Sugiura N, Takara K, Ohto M, Okuda K & Hirooka N. Percutaneous intratumoral injection of ethanol under ultrasound imaging for treatment of small heptocellular carcinoma. Acta Hepatologica 1983 24 1920.
47. Livraghi T, Festi D, Monti F, Salmi A & Vettori C. US-guided percutaneous alcohol injection of small hepatic and abdominal tumors. Radiology 1986 161 309-312.
48. Sheu JC, Huang GT, Chen DS, Sung JL, Yang PM, Wei TC, Lai MY, Su CT, Tsang YM, Hsu HC et al. Small hepatocellular carcinoma: intratumor ethanol treatment using new needle and guidance systems. Radiology 1987 163 43-48.
49. Bown SG. Phototherapy in tumors. World Journal of Surgery 1983 7 700-709. (doi:10.1007/BF01655209)
50. Rossi S, Di Stasi M, Buscarini E, Cavanna L, Quaretti P, Squassante E, Garbagnati F & Buscarini L. Percutaneous radiofrequency interstitial thermal ablation in the treatment of small hepatocellular carcinoma. Cancer Journal from Scientific American 1995 1 73-81.
51. McGahan JP, Browning PD, Brock JM & Tesluk H. Hepatic ablation using radiofrequency electrocautery. Investigative Radiology 1990 25 267-270. (doi:10.1097/00004424-199003000-00011)
52. Seki T, Wakabayashi M, Nakagawa T, Imamura M, Tamai T, Nishimura A, Yamashiki N, Okamura A & Inoue K. Percutaneous microwave coagulation therapy for patients with small hepatocellular carcinoma: comparison with percutaneous ethanol injection therapy. Cancer 1999 85 1694-1702. (doi:10.1002/(SICI) 1097-0142 (19990415) 85:8<1694::AID-CNCR8>3.0. CO;2-3)
53. Seifert JK, Cozzi PJ & Morris DL. Cryotherapy for neuroendocrine liver metastases. Seminars in Surgical Oncology 1998 14 175-183. (doi:10. 1002/(SICI) 1098-2388 (199803) 14:2<175::AID-SSU10>3.0. CO;2-2)
54. Livraghi T, Paracchi A, Ferrari C, Bergonzi M, Garavaglia G, Raineri P & Vettori C. Treatment of autonomous thyroid nodules with percutaneous ethanol injection: preliminary results. Work in progress. Radiology 1990 175 827-829.
55. Pacella CM, Bizzarri G, Guglielmi R, Anelli V, Bianchini A, Crescenzi A, Pacella S & Papini E. Thyroid tissue: US-guided percutaneous interstitial laser ablation - a feasibility study. Radiology 2000 217 673-677. (doi:10.1148/radiology.217.3.r00dc09673)
56. Kim YS, Rhim H, Tae K, Park DW & Kim ST. Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience. Thyroid 2006 16 361-367. (doi:10.1089/thy.2006.16.361)
57. Esnault O, Rouxel A, Le Nestour E, Gheron G & Leenhardt L. Minimally invasive ablation of a toxic thyroid nodule by highintensity focused ultrasound. AJNR. American Journal of Neuroradiology 2010 31 1967-1968. (doi:10.3174/ajnr. A1979)
58. Feng B, Liang P, Cheng Z, Yu X, Yu J, Han Z & Liu F. Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules: experimental and clinical studies. European Journal of Endocrinology 2012 166 1031-1037. (doi:10.1530/EJE-11-0966)
59. Crescenzi A, Papini E, Pacella CM, Rinaldi R, Panunzi C, Petrucci L, Fabbrini R, Bizzarri GC, Anelli V, Nardi F et al. Morphological changes in a hyperfunctioning thyroid adenoma after percutaneous ethanol injection: histological, enzymatic and sub-microscopical alterations. Journal of Endocrinological Investigation 1996 19 371-376.
60. Monzani F, Caraccio N, Basolo F, Iacconi P, Li Volsi V & Miccoli P. Surgical and pathological changes after percutaneous ethanol injection therapy of thyroid nodules. Thyroid 2000 10 1087-1092. (doi:10.1089/thy.2000.10.1087)
61. Pomorski L & Bartos M. Histologic changes in thyroid nodules after percutaneous ethanol injection in patients subsequently operated on due to new focal thyroid lesions. APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica 2002 110 172-176. (doi:10.1034/j.1600-0463.2002.100208.x)
62. Bennedbaek FN, Karstrup S & Hegedus L. Percutaneous ethanol injection therapy in the treatment of thyroid and parathyroid diseases. European Journal of Endocrinology 1997 136 240-250. (doi:10.1530/eje.0.1360240)
63. Bennedbaek FN, Nielsen LK & Hegedus L. Effect of percutaneous ethanol injection therapy versus suppressive doses of L-thyroxine on benign solitary solid cold thyroid nodules: a randomized trial. Journal of Clinical Endocrinology and Metabolism 1998 83 830-835. (doi:10.1210/jcem.83.3.4673)
64. Bennedbaek FN & Hegedus L. Percutaneous ethanol injection therapy in benign solitary solid cold thyroid nodules: a randomized trial comparing one injection with three injections. Thyroid 1999 9 225-233. (doi:10.1089/thy.1999. 9.225)
65. Bennedbaek FN & Hegedus L. Alcohol sclerotherapy for benign solitary solid cold thyroid nodules. Lancet 1995 346 1227. (doi:10.1016/S0140-6736 (95) 92930-4)
66. Guglielmi R, Pacella CM, Bianchini A, Bizzarri G, Rinaldi R, Graziano FM, Petrucci L, Toscano V, Palma E, Poggi M et al. Percutaneous ethanol injection treatment in benign thyroid lesions: role and efficacy. Thyroid 2004 14 125-131. (doi:10.1089/105072504322880364)
67. Verde G, Papini E, Pacella CM, Gallotti C, Delpiano S, Strada S, Fabbrini R, Bizzarri G, Rinaldi R, Panunzi C et al. Ultrasound guided percutaneous ethanol injection in the treatment of cystic thyroid nodules. Clinical Endocrinology 1994 41 719-724. (doi:10.1111/j.1365-2265.1994.tb02785.x)
68. Zingrillo M, Torlontano M, Chiarella R, Ghiggi MR, Nirchio V, Bisceglia M & Trischitta V. Percutaneous ethanol injection may be a definitive treatment for symptomatic thyroid cystic nodules not treatable by surgery: five-year follow-up study. Thyroid 1999 9 763-767. (doi:10.1089/thy.1999.9.763)
69. Bennedbaek FN & Hegedus L. Treatment of recurrent thyroid cysts with ethanol: a randomized double-blind controlled trial. Journal of Clinical Endocrinology and Metabolism 2003 88 5773-5777. (doi:10.1210/jc.2003-031000)
70. Watt T, Hegedus L, Groenvold M, Bjorner JB, Rasmussen AK, Bonnema SJ & Feldt-Rasmussen U. Validity and reliability of the novel thyroid-specific quality of life questionnaire, ThyPRO. European Journal of Endocrinology 2010 162 161-167. (doi:10.1530/EJE-09-0521)
71. Paschke R, Hegedus L, Alexander E, Valcavi R, Papini E & Gharib H. Thyroid nodule guidelines: agreement, disagreement and need for future research. Nature Reviews. Endocrinology 2011 7 354-361. (doi:10.1038/nrendo.2011.1)
72. Bonnema SJ & Hegedus L. Radioiodine therapy in benign thyroid diseases: effects, side effects, and factors affecting therapeutic outcome. Endocrine Reviews 2012 33 920-980. (doi:10.1210/er.2012-1030)
73. Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Endocrine Practice 2011 17 456-520. (doi:10.4158/EP.17.3.456)
74. Nygaard B, Hegedus L, Nielsen KG, Ulriksen P & Hansen JM. Long-term effect of radioactive iodine on thyroid function and size in patients with solitary autonomously functioning toxic thyroid nodules. Clinical Endocrinology 1999 50 197-202. (doi:10.1046/j.1365-2265.1999.00635.x)
75. Lippi F, Ferrari C, Manetti L, Rago T, Santini F, Monzani F, Bellitti P, Papini E, Busnardo B, Angelini F et al. Treatment of solitary autonomous thyroid nodules by percutaneous ethanol injection: results of an Italian multicenter study. The Multicenter Study Group. Journal of Clinical Endocrinology and Metabolism 1996 81 3261-3264.
76. Monzani F, Caraccio N, Goletti O, Casolaro A, Lippolis PV, Cavina E & Miccoli P. Treatment of hyperfunctioning thyroid nodules with percutaneous ethanol injection: eight years' experience. Experimental and Clinical Endocrinology & Diabetes 1998 106 (Suppl 4) S54-S58. (doi:10.1055/s-0029- 1212058)
77. Yano Y, Sugino K, Akaishi J, Uruno T, Okuwa K, Shibuya H, Kitagawa W, Nagahama M, Ito K & Ito K. Treatment of autonomously functioning thyroid nodules at a single institution: radioiodine therapy, surgery, and ethanol injection therapy. Annals of Nuclear Medicine 2011 25 749-754. (doi:10.1007/s12149-011-0526-7)
78. Jacques SL. Laser-tissue interactions. Photochemical, photothermal, and photomechanical. Surgical Clinics of North America 1992 72 531-558.
79. Prapavat V, Roggan A, Walter J, Beuthan J, Klingbeil U & Muller G. In vitro studies and computer simulations to assess the use of a diode laser (850 nm) for laser-induced thermotherapy (LITT). Lasers in Surgery and Medicine 1996 18 22-33. (doi:10.1002/(SICI) 1096-9101 (1996) 18:1<22::AID-LSM3>3.0. CO;2-T)
80. Gambelunghe G, Bini V, Monacelli M, Avenia N, D'Ajello M, Colella R & De Feo P. The administration of anesthetic in the thyroid pericapsular region increase the possibility of side effects during percutaneous laser ablation of thyroid nodules. Lasers in Surgery and Medicine 2013 45 34-37. (doi:10.1002/lsm.22110)
81. Dossing H, Bennedbaek FN, Karstrup S & Hegedus L. Benign solitary solid cold thyroid nodules: US-guided interstitial laser photocoagulation - initial experience. Radiology 2002 225 53-57. (doi:10.1148/radiol.2251011042)
82. Pacella CM, Bizzarri G, Spiezia S, Bianchini A, Guglielmi R, Crescenzi A, Pacella S, Toscano V & Papini E. Thyroid tissue: US-guided percutaneous laser thermal ablation. Radiology 2004 232 272-280. (doi:10.1148/radiol. 2321021368)
83. Amabile G, Rotondi M, De Chiara G, Silvestri A, Di Filippo B, Bellastella A & Chiovato L. Low-energy interstitial laser photocoagulation for treatment of nonfunctioning thyroid nodules: therapeutic outcome in relation to pretreatment and treatment parameters. Thyroid 2006 16 749-755. (doi:10.1089/thy.2006.16.749)
84. Dossing H, Bennedbaek FN & Hegedus L. Ultrasound-guided interstitial laser photocoagulation of an autonomous thyroid nodule: the introduction of a novel alternative. Thyroid 2003 13 885-888. (doi:10.1089/105072503322401104)
85. Dossing H, Bennedbaek FN & Hegedus L. Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules - a randomised study. European Journal of Endocrinology 2005 152 341-345. (doi:10.1530/eje.1.01865)
86. Dossing H, Bennedbaek FN & Hegedus L. Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules: one versus three treatments. Thyroid 2006 16 763-768. (doi:10.1089/thy.2006.16.763)
87. Dossing H, Bennedbaek FN & Hegedus L. Beneficial effect of combined aspiration and interstitial laser therapy in patients with benign cystic thyroid nodules: a pilot study. British Journal of Radiology 2006 79 943-947. (doi:10.1259/bjr/40698061)
88. Dossing H, Bennedbaek FN, Bonnema SJ, Grupe P & Hegedus L. Randomized prospective study comparing a single radioiodine dose and a single laser therapy session in autonomously functioning thyroid nodules. European Journal of Endocrinology 2007 157 95-100. (doi:10.1530/EJE-07-0094)
89. Dossing H, Bennedbaek FN & Hegedus L. Long-term outcome following interstitial laser photocoagulation of benign cold thyroid nodules. European Journal of Endocrinology 2011 165 123-128. (doi:10.1530/EJE-11-0220)
90. Dossing H, Bennedbaek FN & Hegedus L. Interstitial laser photocoagulation (ILP) of benign cystic thyroid nodules - a prospective randomized trial. Journal of Clinical Endocrinology and Metabolism 2013 98 E1213-E1217. (doi:10.1210/jc.2013-1503)
91. Amabile G, Rotondi M, Pirali B, Dionisio R, Agozzino L, Lanza M, Buonanno L, Di Filippo B, Fonte R & Chiovato L. Interstitial laser photocoagulation for benign thyroid nodules: time to treat large nodules. Lasers in Surgery and Medicine 2011 43 797-803. (doi:10.1002/lsm.21114)
92. Cakir B, Topaloglu O, Gul K, Agac T, Aydin C, Dirikoc A, Gumus M, Yazicioglu K, Ersoy RU & Ugras S. Effects of percutaneous laser ablation treatment in benign solitary thyroid nodules on nodule volume, thyroglobulin and anti-thyroglobulin levels, and cytopathology of nodule in 1 yr follow-up. Journal of Endocrinological Investigation 2006 29 876-884.
93. Cakir B, Gul K, Ugras S, Ersoy R, Topaloglu O, Agac T, Aydin C, Dirikoc A, Gumus M, Korukluoglu B et al. Percutaneous laser ablation of an autonomous thyroid nodule: effects on nodule size and histopathology of the nodule 2 years after the procedure. Thyroid 2008 18 803-805. (doi:10.1089/thy.2007.0316)
94. Cakir B, Gul K, Ersoy R, Topaloglu O & Korukluoglu B. Subcapsular hematoma complication during percutaneous laser ablation to a hypoactive benign solitary thyroid nodule. Thyroid 2008 18 917-918. (doi:10.1089/thy.2007.0338)
95. Cakir B, Ugras NS, Gul K, Ersoy R & Korukluoglu B. Initial report of the results of percutaneous laser ablation of benign cold thyroid nodules: evaluation of histopathological changes after 2 years. Endocrine Pathology 2009 20 170-176. (doi:10.1007/s12022-009-9081-3)
96. Rotondi M, Amabile G, Leporati P, Di Filippo B & Chiovato L. Repeated laser thermal ablation of a large functioning thyroid nodule restores euthyroidism and ameliorates constrictive symptoms. Journal of Clinical Endocrinology and Metabolism 2009 94 382-383. (doi:10.1210/jc.2008-1782)
97. Spiezia S, Vitale G, Di Somma C, Pio Assanti A, Ciccarelli A, Lombardi G & Colao A. Ultrasound-guided laser thermal ablation in the treatment of autonomous hyperfunctioning thyroid nodules and compressive nontoxic nodular goiter. Thyroid 2003 13 941-947. (doi:10.1089/105072503322511346)
98. Papini E, Guglielmi R, Bizzarri G & Pacella CM. Ultrasound-guided laser thermal ablation for treatment of benign thyroid nodules. Endocrine Practice 2004 10 276-283. (doi:10.4158/EP.10.3.276)
99. Gambelunghe G, Fatone C, Ranchelli A, Fanelli C, Lucidi P, Cavaliere A, Avenia N, D'Ajello M, Santeusanio F & De Feo P. A randomized controlled trial to evaluate the efficacy of ultrasoundguided laser photocoagulation for treatment of benign thyroid nodules. Journal of Endocrinological Investigation 2006 29 RC23-RC26.
100. Barbaro D, Orsini P, Lapi P, Pasquini C, Tuco A, Righini A & Lemmi P. Percutaneous laser ablation in the treatment of toxic and pretoxic nodular goiter. Endocrine Practice 2007 13 30-36. (doi:10.4158/EP.13.1.30)
101. Papini E, Guglielmi R, Bizzarri G, Graziano F, Bianchini A, Brufani C, Pacella S, Valle D & Pacella CM. Treatment of benign cold thyroid nodules: a randomized clinical trial of percutaneous laser ablation versus levothyroxine therapy or follow-up. Thyroid 2007 17 229-235. (doi:10.1089/thy.2006.0204)
102. Valcavi R, Bertani A, Pesenti M, Al Jandali Rifa'Y LR, Frasoldati A & Pacella CM. Laser and radiofrequency ablation procedures. In Thyroid Ultrasound and Ultrasound-Guided FNA, 2nd edn, pp 198-208. Eds BJ Baskin, DS Duick & RA Levine RA. New York: Springer, 2008.
103. Valcavi R, Riganti F, Bertani A, Formisano D & Pacella CM. Percutaneous laser ablation of cold benign thyroid nodules: a 3-year follow-up study in 122 patients. Thyroid 2010 20 1253-1261. (doi:10.1089/thy.2010.0189)
104. Gambelunghe G, Fede R, Bini V, Monacelli M, Avenia N, D'Ajello M, Colella R, Nasini G & De Feo P. Ultrasound-guided interstitial laser ablation for thyroid nodules is effective only at high total amounts of energy: results from a three-year pilot study. Surgical Innovation 2013 20 345-350. (doi:10.1177/1553350612459276)
105. Rago T, Papini E, Vitti P, De Feo P, Gambelunghe G, Valcavi R, Bizzarri G & Pacella CM. A multicenter randomized prospective trial of laser ablation versus follow-up for the treatment of cold thyroid nodules - twelve-month results. In 36th Annual Meeting of the European Thyroid Association (ETA), abstact No. A-485-0124-00180; 8th-12th September, Pisa, 2012.
106. Piana S, Frasoldati A, Ferrari M, Valcavi R, Froio E, Barbieri V, Pedroni C & Gardini G. Is a five-category reporting scheme for thyroid fine needle aspiration cytology accurate? Experience of over 18, 000 FNAs reported at the same institution during 1998-2007. Cytopathology 2011 22 164-173. (doi:10.1111/j.1365-2303.2010.00777.x)
107. Siperstein AE & Gitomirsky A. History and technological aspects of radiofrequency termoablation. Cancer Journal from Scientific American 2000 6 5293-5305.
108. Scudamore C. Volumetric radiofrequency ablation: technical considerations. Cancer Journal from Scientific American 2000 6 S316-S318.
109. Jeong WK, Baek JH, Rhim H, Kim YS, Kwak MS, Jeong HJ & Lee D. Radiofrequency ablation of benign thyroid nodules: safety and imaging follow-up in 236 patients. European Radiology 2008 18 1244-1250. (doi:10.1007/s00330-008- 0880-6)
110. Baek JH, Jeong HJ, Kim YS, Kwak MS & Lee D. Radiofrequency ablation for an autonomously functioning thyroid nodule. Thyroid 2008 18 675-676. (doi:10.1089/thy.2007.0274)
111. Spiezia S, Garberoglio R, Di Somma C, Deandrea M, Basso E, Limone PP, Milone F, Ramundo V, Macchia PE, Biondi B et al. Efficacy and safety of radiofrequency thermal ablation in the treatment of thyroid nodules with pressure symptoms in elderly patients. Journal of the American Geriatrics Society 2007 55 1478-1479. (doi:10.1111/j.1532-5415.2007.01306.x)
112. Baek JH, Moon WJ, Kim YS, Lee JH & Lee D. Radiofrequency ablation for the treatment of autonomously functioning thyroid nodules. World Journal of Surgery 2009 33 1971-1977. (doi:10.1007/s00268-009-0130-3)
113. Baek JH, Kim YS, Lee D, Huh JY & Lee JH. Benign predominantly solid thyroid nodules: prospective study of efficacy of sonographically guided radiofrequency ablation versus control condition. AJR. American Journal of Roentgenology 2010 194 1137-1142. (doi:10.2214/AJR.09.3372)
114. Huh JY, Baek JH, Choi H, Kim JK & Lee JH. Symptomatic benign thyroid nodules: efficacy of additional radiofrequency ablation treatment session - prospective randomized study. Radiology 2012 263 909-916. (doi:10.1148/radiol. 12111300)
115. Deandrea M, Limone P, Basso E, Mormile A, Ragazzoni F, Gamarra E, Spiezia S, Faggiano A, Colao A, Molinari F et al. US-guided percutaneous radiofrequency thermal ablation for the treatment of solid benign hyperfunctioning or compressive thyroid nodules. Ultrasound in Medicine & Biology 2008 34 784-791. (doi:10.1016/j.ultrasmedbio.2007.10.018)
116. Spiezia S, Garberoglio R, Milone F, Ramundo V, Caiazzo C, Assanti AP, Deandrea M, Limone PP, Macchia PE, Lombardi G et al. Thyroid nodules and related symptoms are stably controlled two years after radiofrequency thermal ablation. Thyroid 2009 19 219-225. (doi:10.1089/thy.2008.0202)
117. Faggiano A, Ramundo V, Assanti AP, Fonderico F, Macchia PE, Misso C, Marciello F, Marotta V, Del Prete M, Papini E et al. Thyroid nodules treated with percutaneous radiofrequency thermal ablation: a comparative study. Journal of Clinical Endocrinology and Metabolism 2012 97 4439-4445. (doi:10.1210/jc. 2012-2251)
118. Lim HK, Lee JH, Ha EJ, Sung JY, Kim JK & Baek JH. Radiofrequency ablation of benign non-functioning thyroid nodules: 4-year follow-up results for 111 patients. European Radiology 2013 23 1044-1049. (doi:10.1007/s00330-012- 2671-3)
119. Baek JH, Lee JH, Sung JY, Bae JI, Kim KT, Sim J, Baek SM, Kim YS, Shin JH, Park JS et al. Complications encountered in the treatment of benign thyroid nodules with US-guided radiofrequency ablation: a multicenter study. Radiology 2012 262 335-342. (doi:10.1148/radiol.11110416)
120. Sung JY, Kim YS, Choi H, Lee JH & Baek JH. Optimum first-line treatment technique for benign cystic thyroid nodules: ethanol ablation or radiofrequency ablation? AJR. American Journal of Roentgenology 2011 196 W210-W214. (doi:10.2214/AJR.10.5172)
121. Sung JY, Baek JH, Kim KS, Lee D, Yoo H, Kim JK & Park SH. Single-session treatment of benign cystic thyroid nodules with ethanol versus radiofrequency ablation: a prospective randomized study. Radiology 2013 269 293-300. (doi:10.1148/radiol.13122134)
122. Esnault O, Franc B, Menegaux F, Rouxel A, De Kerviler E, Bourrier P, Lacoste F, Chapelon JY & Leenhardt L. High-intensity focused ultrasound ablation of thyroid nodules: first human feasibility study. Thyroid 2011 21 965-973. (doi:10.1089/thy.2011.0141)
123. Yue W, Wang S, Wang B, Xu Q, Yu S, Yonglin Z & Wang X. Ultrasound guided percutaneous microwave ablation of benign thyroid nodules: safety and imaging follow-up in 222 patients. European Journal of Radiology 2013 82 e11-e16. (doi:10.1016/j.ejrad.2012.07.020)