Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders

Molecular Autism

Volumn 5, Issue 1, 2014, Pages

  Correia, Catarina T ^a,b,c   Conceição, Inês C ^a,b,c   Oliveira, Bárbara ^a,b,c   Coelho, Joana ^a,b,c   Sousa, Inês ^a,b,c   Sequeira, Ana F ^a,b,c   Almeida, Joana ^d   Café, Cátia ^d   Duque, Frederico ^d   Mouga, Susana ^d,e   Roberts, Wendy ^f   Gao, Kun ^g   Lowe, Jennifer K ^g   Thiruvahindrapuram, Bhooma ^h   Walker, Susan ^h   Marshall, Christian R ^h   Pinto, Dalila ⁱ   Nurnberger, John I ^j   Scherer, Stephen W ^h,k   Geschwind, Daniel H ^g   Oliveira, Guiomar ^d,e   Vicente, Astrid M ^a,b,c   more..

^a NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

^c INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^d CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^e UNIVERSITY OF COIMBRA   (Portugal)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h HOSPITAL FOR SICK CHILDREN   (Canada)

ⁱ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^j INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF TORONTO   (Canada)

more..

Author keywords

ANXA1; Autism; Brain homeostasis; Copy number variants; Duplication; Glucocorticoids

Indexed keywords

LIPOCORTIN 1; SPACER DNA;

3' UNTRANSLATED REGION; AMPLICON; ARTICLE; AUTISM; CHILD; CONTROLLED STUDY; COPY NUMBER VARIATION; EXON; FEMALE; FOLLOW UP; GENE DUPLICATION; GENE SEGREGATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC SCREENING; GENOME; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84899476399     PISSN: None     EISSN: 20402392     Source Type: Journal    
DOI: 10.1186/2040-2392-5-28     Document Type: Article

References (81)

1. Advances in autism genetics: on the threshold of a new neurobiology. Abrahams BS, Geschwind DH, Nat Rev Genet 2008 9 341 355 10.1038/nrg2346 18414403
2. Genetics of autistic disorders: review and clinical implications. Freitag CM, Staal W, Klauck SM, Duketis E, Waltes R, Eur Child Adolesc Psychiatry 2010 19 169 178 10.1007/s00787-009-0076-x 19941018
3. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Glessner JT, Wang K, Cai G, Korvatska O, Kim CE, Wood S, Zhang H, Estes A, Brune CW, Bradfield JP, Imielinski M, Frackelton EC, Reichert J, Crawford EL, Munson J, Sleiman PM, Chiavacci R, Annaiah K, Thomas K, Hou C, Glaberson W, Flory J, Otieno F, Garris M, Soorya L, Klei L, Piven J, Meyer KJ, Anagnostou E, Sakurai T, et al. Nature 2009 459 569 573 10.1038/nature07953 19404257
4. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Autism Genome Project C, Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu XQ, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, Wright HH, Abramson RK, Betancur C, Bourgeron T, Gillberg C, Leboyer M, et al. Nat Genet 2007 39 319 328 10.1038/ng1985 17322880
5. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS, Salyakina D, Imielinski M, Bradfield JP, Sleiman PM, Kim CE, Hou C, Frackelton E, Chiavacci R, Takahashi N, Sakurai T, Rappaport E, Lajonchere CM, Munson J, Estes A, Korvatska O, Piven J, Sonnenblick LI, Alvarez Retuerto AI, Herman EI, Dong H, Hutman T, Sigman M, Ozonoff S, Klin A, et al. Nature 2009 459 528 533 10.1038/nature07999 19404256
6. A genome-wide linkage and association scan reveals novel loci for autism. Weiss LA, Arking DE, Daly MJ, Chakravarti A, Gene Discovery Project of Johns Hopkins & the Autism Consortium, Nature 2009 461 802 808 10.1038/nature08490 19812673
7. Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting. Betancur C, Brain Res 2011 1380 42 77 21129364
8. Multiple rare variants in the etiology of autism spectrum disorders. Buxbaum JD, Dialogues Clin Neurosci 2009 11 35 43 19432386
9. Detection and characterization of copy number variation in autism spectrum disorder. Marshall CR, Scherer SW, Methods Mol Biol 2012 838 115 135 10.1007/978-1-61779-507-7-5 22228009
10. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Neale BM, Kou Y, Liu L, Ma'ayan A, Samocha KE, Sabo A, Lin CF, Stevens C, Wang LS, Makarov V, Polak P, Yoon S, Maguire J, Crawford EL, Campbell NG, Geller ET, Valladares O, Schafer C, Liu H, Zhao T, Cai G, Lihm J, Dannenfelser R, Jabado O, Peralta Z, Nagaswamy U, Muzny D, Reid JG, Newsham I, Wu Y, et al. Nature 2012 485 242 245 10.1038/nature11011 22495311
11. Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations. O'Roak BJ, Deriziotis P, Lee C, Vives L, Schwartz JJ, Girirajan S, Karakoc E, Mackenzie AP, Ng SB, Baker C, Rieder MJ, Nickerson DA, Bernier R, Fisher SE, Shendure J, Eichler EE, Nat Genet 2011 43 585 589 10.1038/ng.835 21572417
12. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. O'Roak BJ, Vives L, Girirajan S, Karakoc E, Krumm N, Coe BP, Levy R, Ko A, Lee C, Smith JD, Turner EH, Stanaway IB, Vernot B, Malig M, Baker C, Reilly B, Akey JM, Borenstein E, Rieder MJ, Nickerson DA, Bernier R, Shendure J, Eichler EE, Nature 2012 485 246 250 10.1038/nature10989 22495309
13. Functional impact of global rare copy number variation in autism spectrum disorders. Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, et al. Nature 2010 466 368 372 10.1038/nature09146 20531469
14. Strong association of de novo copy number mutations with autism. Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, Spence SJ, Lee AT, Puura K, Lehtimäki T, Ledbetter D, Gregersen PK, Bregman J, Sutcliffe JS, Jobanputra V, Chung W, Warburton D, King MC, Skuse D, Geschwind DH, Gilliam TC, et al. Science 2007 316 445 449 10.1126/science.1138659 17363630
15. Origins and functional impact of copy number variation in the human genome. Conrad DF, Pinto D, Redon R, Feuk L, Gokcumen O, Zhang Y, Aerts J, Andrews TD, Barnes C, Campbell P, Fitzgerald T, Hu M, Ihm CH, Kristiansson K, Macarthur DG, Macdonald JR, Onyiah I, Pang AW, Robson S, Stirrups K, Valsesia A, Walter K, Wei J, Wellcome Trust Case Control C, Tyler-Smith C, Carter NP, Lee C, Scherer SW, Hurles ME, Nature 2010 464 704 712 10.1038/nature08516 19812545
16. CNVs: harbingers of a rare variant revolution in psychiatric genetics. Malhotra D, Sebat J, Cell 2012 148 1223 1241 10.1016/j.cell.2012.02.039 22424231
17. Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation. Flower RJ, Blackwell GJ, Nature 1979 278 456 459 10.1038/278456a0 450050
18. Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE, Solito E, J Immunol 2010 185 6317 6328 10.4049/jimmunol.1001095 20962261
19. Annexin 1, glucocorticoids, and the neuroendocrine-immune interface. Buckingham JC, John CD, Solito E, Tierney T, Flower RJ, Christian H, Morris J, Ann N Y Acad Sci 2006 1088 396 409 10.1196/annals.1366.002 17192583
20. A genome-wide scan for common alleles affecting risk for autism. Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Carson AR, Casallo G, Casey J, Chu SH, Cochrane L, Corsello C, Crawford EL, Crossett A, et al. Hum Mol Genet 2010 19 4072 4082 10.1093/hmg/ddq307 20663923
21. Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study. Stewart AF, Dandona S, Chen L, Assogba O, Belanger M, Ewart G, LaRose R, Doelle H, Williams K, Wells GA, McPherson R, Roberts R, J Am Coll Cardiol 2009 53 1471 1472 10.1016/j.jacc.2008.12.051 19371834
22. PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships. Krawczak M, Nikolaus S, von Eberstein H, Croucher PJ, El Mokhtari NE, Schreiber S, Community Genet 2006 9 55 61 10.1159/000090694 16490960
23. A genome-wide association study of alcohol dependence. Bierut LJ, Agrawal A, Bucholz KK, Doheny KF, Laurie C, Pugh E, Fisher S, Fox L, Howells W, Bertelsen S, Hinrichs AL, Almasy L, Breslau N, Culverhouse RC, Dick DM, Edenberg HJ, Foroud T, Grucza RA, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Krueger RF, Kuperman S, Lynskey M, Mann K, Neuman RJ, Nöthen MM, Nurnberger JI Jr, Porjesz B, et al. Proc Natl Acad Sci U S A 2010 107 5082 5087 10.1073/pnas.0911109107 20202923
24. High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications. Shaikh TH, Gai X, Perin JC, Glessner JT, Xie H, Murphy K, O'Hara R, Casalunovo T, Conlin LK, D'Arcy M, Frackelton EC, Geiger EA, Haldeman-Englert C, Imielinski M, Kim CE, Medne L, Annaiah K, Bradfield JP, Dabaghyan E, Eckert A, Onyiah CC, Ostapenko S, Otieno FG, Santa E, Shaner JL, Skraban R, Smith RM, Elia J, Goldmuntz E, Spinner NB, et al. Genome Res 2009 19 1682 1690 10.1101/gr.083501.108 19592680
25. Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Casey J, Conroy J, Correia C, Corsello C, Crawford EL, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Gilbert J, Gillberg C, Glessner JT, Green A, et al. Hum Mol Genet 2012 21 4781 4792 10.1093/hmg/dds301 22843504
26. QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data. Colella S, Yau C, Taylor JM, Mirza G, Butler H, Clouston P, Bassett AS, Seller A, Holmes CC, Ragoussis J, Nucleic Acids Res 2007 35 2013 2025 10.1093/nar/gkm076 17341461
27. Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions. Oliveira G, Ataíde A, Marques C, Miguel TS, Coutinho AM, Mota-Vieira L, Gonçalves E, Lopes NM, Rodrigues V, Carmona Da Mota H, Vicente AM, Dev Med Child Neurol 2007 49 726 733 10.1111/j.1469-8749.2007.00726.x 17880640
28. Intergenerational transmission of subthreshold autistic traits in the general population. Constantino JN, Todd RD, Biol Psychiatry 2005 57 655 660 10.1016/j.biopsych.2004.12.014 15780853
29. The broad autism phenotype questionnaire. Hurley RS, Losh M, Parlier M, Reznick JS, Piven J, J Autism Dev Disord 2007 37 1679 1690 10.1007/s10803-006- 0299-3 17146701
30. Primer3 on the WWW for general users and for biologist programmers. Rozen S, Skaletsky H, Methods Mol Biol 2000 132 365 386 10547847
31. PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Wang K, Li M, Hadley D, Liu R, Glessner J, Grant SF, Hakonarson H, Bucan M, Genome Res 2007 17 1665 1674 10.1101/gr.6861907 17921354
32. A new DNA sequence assembly program. Bonfield JK, Smith K, Staden R, Nucleic Acids Res 1995 23 4992 4999 10.1093/nar/23.24.4992 8559656
33. Human Splicing Finder: an online bioinformatics tool to predict splicing signals. Desmet FO, Hamroun D, Lalande M, Collod-Béroud G, Claustres M, Béroud C, Nucleic Acids Res 2009 37 67 10.1093/nar/gkp215 19339519
34. ESEfinder: A web resource to identify exonic splicing enhancers. Cartegni L, Wang J, Zhu Z, Zhang MQ, Krainer AR, Nucleic Acids Res 2003 31 3568 3571 10.1093/nar/gkg616 12824367
35. TRANSFAC: transcriptional regulation, from patterns to profiles. Matys V, Fricke E, Geffers R, Gössling E, Haubrock M, Hehl R, Hornischer K, Karas D, Kel AE, Kel-Margoulis OV, Kloos DU, Land S, Lewicki-Potapov B, Michael H, Münch R, Reuter I, Rotert S, Saxel H, Scheer M, Thiele S, Wingender E, Nucleic Acids Res 2003 31 374 378 10.1093/nar/gkg108 12520026
36. Human MicroRNA targets. John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS, PLoS Biol 2004 2 363 10.1371/journal.pbio.0020363 15502875
37. Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, Rosenbloom K, Clawson H, Spieth J, Hillier LW, Richards S, Weinstock GM, Wilson RK, Gibbs RA, Kent WJ, Miller W, Haussler D, Genome Res 2005 15 1034 1050 10.1101/gr.3715005 16024819
38. The human genome browser at UCSC. Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D, Genome Res 2002 12 996 1006 10.1101/gr.229102. Article published online before print in May 2002 12045153
39. Autism genetics: searching for specificity and convergence. Berg JM, Geschwind DH, Genome Biol 2012 13 247 10.1186/gb-2012-13-7-247 22849751
40. Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases. Yan J, Feng J, Craddock N, Jones IR, Cook EH, Goldman D, Heston LL, Chen J, Burkhart P, Li W, Shibayama A, Sommer SS, Neurosci Lett 2005 380 37 41 10.1016/j.neulet.2005.01.018 15854747
41. 2p15-p16.1 microdeletion syndrome: molecular characterization and association of the OTX1 and XPO1 genes with autism spectrum disorders. Liu X, Malenfant P, Reesor C, Lee A, Hudson ML, Harvard C, Qiao Y, Persico AM, Cohen IL, Chudley AE, Forster-Gibson C, Rajcan-Separovic E, Lewis ME, Holden JJ, Eur J Hum Genet 2011 19 1264 1270 10.1038/ejhg.2011.112 21750575
42. Estimate of the mutation rate per nucleotide in humans. Nachman MW, Crowell SL, Genetics 2000 156 297 304 10978293
43. SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms. Chelala C, Khan A, Lemoine NR, Bioinformatics 2009 25 655 661 10.1093/bioinformatics/btn653 19098027
44. Copy-number variations associated with neuropsychiatric conditions. Cook EH, Scherer SW, Nature 2008 455 919 923 10.1038/nature07458 18923514
45. Recurrent 16p11.2 microdeletions in autism. Kumar RA, KaraMohamed S, Sudi J, Conrad DF, Brune C, Badner JA, Gilliam TC, Nowak NJ, Cook EH, Dobyns WB, Christian SL, Hum Mol Genet 2008 17 628 638 18156158
46. Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. Noor A, Whibley A, Marshall CR, Gianakopoulos PJ, Piton A, Carson AR, Orlic-Milacic M, Lionel AC, Sato D, Pinto D, Drmic I, Noakes C, Senman L, Zhang X, Mo R, Gauthier J, Crosbie J, Pagnamenta AT, Munson J, Estes AM, Fiebig A, Franke A, Schreiber S, Stewart AF, Roberts R, McPherson R, Guter SJ, Cook EH Jr, Dawson G, Schellenberg GD, et al. Sci Transl Med 2010 2 49ra68 20844286
47. Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. Virkud YV, Todd RD, Abbacchi AM, Zhang Y, Constantino JN, Am J Med Genet B Neuropsychiatr Genet 2009 150B 328 334 10.1002/ajmg.b.30810 18618672
48. Penetrance for copy number variants associated with schizophrenia. Vassos E, Collier DA, Holden S, Patch C, Rujescu D, St Clair D, Lewis CM, Hum Mol Genet 2010 19 3477 3481 10.1093/hmg/ddq259 20587603
49. Variable expression of the autism broader phenotype: findings from extended pedigrees. Pickles A, Starr E, Kazak S, Bolton P, Papanikolaou K, Bailey A, Goodman R, Rutter M, J Child Psychol Psychiatry 2000 41 491 502 10.1111/1469-7610.00634 10836679
50. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Cross-Disorder Group of the Psychiatric Genomics Consortium, et al. Nat Genet 2013 45 984 994 10.1038/ng.2711 23933821
51. Consortium GROoPG, Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Consortium C-DGPG, Lancet 2013 381 1371 1379 23453885
52. Prospective diagnostic analysis of copy number variants using SNP microarrays in individuals with autism spectrum disorders. Nava C, Keren B, Mignot C, Rastetter A, Chantot-Bastaraud S, Faudet A, Fonteneau E, Amiet C, Laurent C, Jacquette A, Whalen S, Afenjar A, Périsse D, Doummar D, Dorison N, Leboyer M, Siffroi JP, Cohen D, Brice A, Héron D, Depienne C, Eur J Hum Genet 2014 22 71 78 10.1038/ejhg.2013.88 23632794
53. A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay. Girirajan S, Rosenfeld JA, Cooper GM, Antonacci F, Siswara P, Itsara A, Vives L, Walsh T, McCarthy SE, Baker C, Mefford HC, Kidd JM, Browning SR, Browning BL, Dickel DE, Levy DL, Ballif BC, Platky K, Farber DM, Gowans GC, Wetherbee JJ, Asamoah A, Weaver DD, Mark PR, Dickerson J, Garg BP, Ellingwood SA, Smith R, Banks VC, Smith W, et al. Nat Genet 2010 42 203 209 10.1038/ng.534 20154674
54. Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders. Leblond CS, Heinrich J, Delorme R, Proepper C, Betancur C, Huguet G, Konyukh M, Chaste P, Ey E, Rastam M, Anckarsäter H, Nygren G, Gillberg IC, Melke J, Toro R, Regnault B, Fauchereau F, Mercati O, Lemière N, Skuse D, Poot M, Holt R, Monaco AP, Järvelä I, Kantojärvi K, Vanhala R, Curran S, Collier DA, Bolton P, Chiocchetti A, et al. PLoS Genet 2012 8 1002521 10.1371/journal.pgen.1002521 22346768
55. Mutation spectrum revealed by breakpoint sequencing of human germline CNVs. Conrad DF, Bird C, Blackburne B, Lindsay S, Mamanova L, Lee C, Turner DJ, Hurles ME, Nat Genet 2010 42 385 391 10.1038/ng.564 20364136
56. Analysis of copy number variants and segmental duplications in the human genome: Evidence for a change in the process of formation in recent evolutionary history. Kim PM, Lam HY, Urban AE, Korbel JO, Affourtit J, Grubert F, Chen X, Weissman S, Snyder M, Gerstein MB, Genome Res 2008 18 1865 1874 10.1101/gr.081422.108 18842824
57. Annexin-1 is abnormally expressed in fragile X syndrome: two-dimensional electrophoresis study in lymphocytes. Sun HT, Cohen S, Kaufmann WE, Am J Med Genet 2001 103 81 90 10.1002/1096-8628(20010915)103:1<81::AID-AJMG1505>3. 0.CO;2-T 11562939
58. An integrated encyclopedia of DNA elements in the human genome. Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M, ENCODE Project Consortium, Nature 2012 489 57 74 10.1038/nature11247 22955616
59. Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Perretti M, D'Acquisto F, Nat Rev Immunol 2009 9 62 70 10.1038/nri2470 19104500
60. Annexin 1: an endogenous anti-inflammatory protein. Perretti M, Gavins FN, News Physiol Sci 2003 18 60 64 12644621
61. Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications. Tyburczy ME, Kotulska K, Pokarowski P, Mieczkowski J, Kucharska J, Grajkowska W, Roszkowski M, Jozwiak S, Kaminska B, Am J Pathol 2010 176 1878 1890 10.2353/ajpath.2010.090950 20133820
62. A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S, Perretti M, FASEB J 2003 17 1544 1546 12824302
63. Annexins: from structure to function. Gerke V, Moss SE, Physiol Rev 2002 82 331 371 11917092
64. Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids. Blackwell GJ, Carnuccio R, Di Rosa M, Flower RJ, Parente L, Persico P, Nature 1980 287 147 149 10.1038/287147a0 6893620
65. The immune system's role in the biology of autism. Goines P, Van de Water J, Curr Opin Neurol 2010 23 111 117 10.1097/WCO.0b013e3283373514 20160651
66. Immunity, neuroglia and neuroinflammation in autism. Pardo CA, Vargas DL, Zimmerman AW, Int Rev Psychiatry 2005 17 485 495 10.1080/02646830500381930 16401547
67. Autism: where genetics meets the immune system. Persico AM, Van de Water J, Pardo CA, Autism Res Treat 2012 2012 486359 22988503
68. Autoantibody repertoires to brain tissue in autism nuclear families. Silva SC, Correia C, Fesel C, Barreto M, Coutinho AM, Marques C, Miguel TS, Ataide A, Bento C, Borges L, Oliveira G, Vicente AM, J Neuroimmunol 2004 152 176 182 10.1016/j.jneuroim.2004.03.015 15223250
69. Annexin 1 and the regulation of endocrine function. John CD, Christian HC, Morris JF, Flower RJ, Solito E, Buckingham JC, Trends Endocrinol Metab 2004 15 103 109 10.1016/j.tem.2004.02.001 15046738
70. MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Aylward EH, Minshew NJ, Goldstein G, Honeycutt NA, Augustine AM, Yates KO, Barta PE, Pearlson GD, Neurology 1999 53 2145 2150 10.1212/WNL.53.9.2145 10599796
71. Neurosteroids, brain damage, and mental illness. Herbert J, Exp Gerontol 1998 33 713 727 10.1016/S0531-5565(98)00039-4 9951618
72. Subtypes of autism by cluster analysis based on structural MRI data. Hrdlicka M, Dudova I, Beranova I, Lisy J, Belsan T, Neuwirth J, Komarek V, Faladova L, Havlovicova M, Sedlacek Z, Blatny M, Urbanek T, Eur Child Adolesc Psychiatry 2005 14 138 144 10.1007/s00787-005-0453-z 15959659
73. Neuropathological findings in autism. Palmen SJ, van Engeland H, Hof PR, Schmitz C, Brain 2004 127 2572 2583 10.1093/brain/awh287 15329353
74. Hippocampus and amygdala volumes in parents of children with autistic disorder. Rojas DC, Smith JA, Benkers TL, Camou SL, Reite ML, Rogers SJ, Am J Psychiatry 2004 161 2038 2044 10.1176/appi.ajp.161.11.2038 15514404
75. Neurofunctional mechanisms in autism. Waterhouse L, Fein D, Modahl C, Psychol Rev 1996 103 457 489 8759044
76. Cortisol circadian rhythms and response to stress in children with autism. Corbett BA, Mendoza S, Abdullah M, Wegelin JA, Levine S, Psychoneuroendocrinology 2006 31 59 68 10.1016/j.psyneuen.2005.05.011 16005570
77. Comparing cortisol, stress, and sensory sensitivity in children with autism. Corbett BA, Schupp CW, Levine S, Mendoza S, Autism Res 2009 2 39 49 10.1002/aur.64 19358306
78. Lower cortisol and higher ACTH levels in individuals with autism. Curin JM, Terzić J, Petković ZB, Zekan L, Terzić IM, Susnjara IM, J Autism Dev Disord 2003 33 443 448 10.1023/A:1025019030121 12959423
79. Investigation of the serum levels of anterior pituitary hormones in male children with autism. Iwata K, Matsuzaki H, Miyachi T, Shimmura C, Suda S, Tsuchiya KJ, Matsumoto K, Suzuki K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Sato K, Mori N, Mol Autism 2011 2 16 10.1186/2040-2392-2-16 22011527
80. Urinary cortisol circadian rhythm in a group of high-functioning children with autism. Richdale AL, Prior MR, J Autism Dev Disord 1992 22 433 447 10.1007/BF01048245 1400105
81. Lack of annexin 1 results in an increase in corticotroph number in male but not female mice. Morris JF, Omer S, Davies E, Wang E, John C, Afzal T, Wain S, Buckingham JC, Flower RJ, Christian HC, J Neuroendocrinol 2006 18 835 846 10.1111/j.1365-2826.2006.01481.x 17026533