Familial aggregation of quantitative autistic traits in multiplex versus simplex autism

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 150, Issue 3, 2009, Pages 328-334

  Virkud, Yamini V ^a   Todd, Richard D ^a   Abbacchi, Anna M ^a   Zhang, Yi ^a   Constantino, John N ^a,b  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Complex disease; Endophenotype; Family studies; Genetics; Pervasive developmental disorders; Social responsiveness scale

Indexed keywords

ARTICLE; AUTISM; CHILD; CONTROLLED STUDY; FAMILY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RELATIVE; SCHOOL CHILD; SIBLING;

AUTISTIC DISORDER; CHILD; CHILD, PRESCHOOL; FAMILY; FEMALE; HUMANS; MALE; PARENTS; PEDIGREE; PHENOTYPE; PSYCHIATRIC STATUS RATING SCALES; QUANTITATIVE TRAIT, HERITABLE; SIBLINGS; SOCIAL BEHAVIOR;

EID: 63449088785     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30810     Document Type: Article

References (25)

1. Campbell DB, Sutcliffe JS, Ebert PJ, Militerni R, Bravaccio C, Trillo S, Elia M, Schneider C, Melmed R, Sacco R, Persico AM, Levitt P. 2006. A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci USA 103:16834-16839.
2. Constantino JN, Gruber CP. 2005. The social responsiveness scale manual. Los Angeles, CA: Western Psychological Services.
3. Constantino JN, Todd RD. 2003. Autistic traits in the general population: A twin study. Arch Gen Psychiatry 60:524-530.
4. Constantino JN, Todd RD. 2005. Intergenerational transmission of sub- threshold autistic traits in the general population. Biol Psychiatry 57: 655-660.
5. Constantino JN, Pryzbeck T, Friesen D, Todd RD. 2000. Reciprocal social behavior in children with and without pervasive developmental disorders. J Dev Behav Pediatr 21:2-11.
6. Constantino JN, Davis SA, Todd RD, Schindler MK, Gross MM, BrophySL, Metzger LM, Shoushtari CS, Splinter R, Reich W. 2003. Validation ofa brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview-revised. J Autism Dev Disord 33:427-433.
7. Constantino JN, Gruber CP, Davis S, Hayes S, Passanante N, Przybeck T. 2004. The factor structure of autistic traits. J Child Psychol Psychiatry 45:719-726.
8. Constantino JN, Lajonchere C, Lutz M, Gray T, Abbacchi A, McKenna K, Singh D, Todd RD. 2006. Autistic social impairment in the siblings of children with pervasive developmental disorders. Am J Psychiatry 163:294-296.
9. Constantino JN, Lavesser PD, Zhang Y, Abbacchi AM, Gray T, Todd RD. 2007. Rapid quantitative assessment of autistic social impairment by classroom teachers. J Am Acad Child Adolesc Psychiatry 46(12): 1668 -1676.
10. Constantino JN, Abbacchi AM, LaVesser PD, Reed H, Givens L, Chiang L, Gray T, Gross M, Zhang Y, Todd RD. 2009. Developmental course of autistic social impairment in males. Dev Psychopathol 21(1).
11. Dalton KM, Nacewicz BM, Alexander AL, Davidson RJ. 2007. Gaze- fixation, brain activation, and amygdala volume in unaffected siblings of individuals with autism. Biol Psychiatry 61(4):512-520.
12. Dawson G, Webb SJ, Wijsman E, Schellenberg G, Estes A, Munson J, Faja S. 2005. Neurocognitive and electrophysiological evidence of altered face processing in parents of children with autism: Implications for a model of abnormal development of social brain circuitry in autism. Dev Psycho-pathol 17:679-697.
13. Duvall JA, Lu A, Cantor RM, Todd RD, Constantino JN, Geschwind DH. 2007. A quantitative trait locus analysis of social responsiveness in multiplex autism families. Am J Psychiatry 164:656-662.
14. Le Couteur A, Bailey A, Goode S, Pickles A, Robertson S, Gottesman I, Rutter M. 1996. A broader phenotype ofautism: The clinical spectrum in twins. J Child Psychol Psychiatry 37:785-801.
15. Losh M, Childress D, Lam K, Piven J. 2008. Defining key features of the broad autism phenotype: A comparison across parents of multiple- and single-incidence autism families. Am J Med Genet Part B 147B(4): 424-433.
16. Miles JH, Takahashi TN, Bagby S, Sahota PK, Vaslow DF, Wang CH, Hillman RE, Farmer JE. 2005. Essential versus complex autism: Definition offundamental prognostic subtypes. Am J Med Genet Part A 135A: 171 -180.
17. Murphy M, Bolton PF, Pickles A, Fombonne E, Piven J, Rutter M. 2000. Personality traits of the relatives of autistic probands. Psychol Med 30(6):1411-1424.
18. Pickles A, Bolton P, Macdonald H, Bailey A, LeCouteur A, Sim CH, Rutter M. 1995. Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: A twin and family history study of autism. Am J Hum Genet 57(3):717-726.
19. Pickles A, Starr E, Kazak S, Bolton P, Papanikolaou K, Bailey A, Goodman R, Rutter M. 2000. Variable expression of the autism broader phenotype: Findings from extended pedigrees. J Child Psychol Psychiatry 41(4): 491-502.
20. Piven J, Palmer P, Jacobi D, Childress D, Arndt S. 1997. Broader autism phenotype: Evidence from a family history study of multiple-incidence autism families. Am J Psychiatry 154:185-190.
21. Risch N, Spiker D, Lotspeich L, Nouri N, Hinds D, Hallmayer J, Kalaydjieva L, McCague P, Dimiceli S, Pitts T, Nguyen L, Yang J, Harper C, Thorpe D, Vermeer S, Young H, Herbert J, Lin A, Ferguson J, Chiotti C, Wiese-Slater S, Rogers T, Salmon B, Nicholas P, Peterson PB, Pingree C, McMahon W, Wong DL, Cavalli-Sforza LL, Kraemer HC, Myers RM. 1999. A genomic screen of autism: Evidence for a multilocus etiology. Am J Hum Genet 65:493-507.
22. Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee Y, Hicks J, Spence SJ, Lee AT, Puura K, Lehtimaki T, Ledbetter D, Gregersen PK, Bregman J, Sutcliffe JS, Jobanputra V, Chung W, Warburton D, King M, Skuse D, Geschwind DH, Gilliam TC, Ye K, Wigler M. 2007. Strong association of de novo copy number mutations with autism. Science 316:445-449.
23. Sung YJ, Dawson G, Munson J, Estes A, Schellenberg GD, Wijsman EM. 2005. Genetic investigation ofquantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment. Am J Hum Genet 76(1):68-81.
24. Szatmari P, MacLean JE, Jones MB, Bryson SE, Zwaigenbaum L, Bartolucci G, Mahoney WJ, Tuff L. 2000. The familial aggregation of the lesser variant in biological and nonbiological relatives of PDD probands: A family history study. J Child Psychol Psychiatry 41:579-586.
25. Weiss LA, Shen Y, Korn JM, Arking DE, Miller DT, Fossdal R, Saemundsen E, Stefansson H, Ferreira M, Green T, Platt OS, Ruderfer DM, Walsh CA, Altshuler D, Chakravarti A, Tanzi RE, Stefansson K, Santangelo S, Gusella JF, Sklar P, Wu B, Daly MJ. 2008. the Autism Consortium. Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med 358:667-675.