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Volumn 151, Issue , 2014, Pages 77-83

Environmental concentrations of the selective serotonin reuptake inhibitor fluoxetine impact specific behaviors involved in reproduction, feeding and predator avoidance in the fish Pimephales promelas (fathead minnow)

Author keywords

Fecundity; Mating; Neuroendocrine; Pharmaceuticals; Prozac; SSRI

Indexed keywords

ESTROGEN; FLUOXETINE; SURFACE WATER; TESTOSTERONE;

EID: 84899473002     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2013.10.012     Document Type: Article
Times cited : (224)

References (54)
  • 1
    • 36049018439 scopus 로고    scopus 로고
    • Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC)
    • Airhart M.J., Lee D.H., Wilson T.D., Miller B.E., Miller M.N., Skalko R.G. Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC). Neurotoxicol. Teratol. 2007, 29:652-664.
    • (2007) Neurotoxicol. Teratol. , vol.29 , pp. 652-664
    • Airhart, M.J.1    Lee, D.H.2    Wilson, T.D.3    Miller, B.E.4    Miller, M.N.5    Skalko, R.G.6
  • 2
    • 81055131791 scopus 로고    scopus 로고
    • Behavioral characterization of the alarm reaction and anxiolytic-like effect of acute treatment with fluoxetine in piauçu fish
    • Barbosa Júnior A., Alves F.L., Pereira Ade S., Ide L.M., Hoffmann A. Behavioral characterization of the alarm reaction and anxiolytic-like effect of acute treatment with fluoxetine in piauçu fish. Physiol. Behav. 2012, 105:784-790.
    • (2012) Physiol. Behav. , vol.105 , pp. 784-790
    • Barbosa Júnior, A.1    Alves, F.L.2    Pereira Ade, S.3    Ide, L.M.4    Hoffmann, A.5
  • 3
    • 84878349788 scopus 로고    scopus 로고
    • Effects of fluoxetine on the swimming and behavioral responses of the Arabian killifish
    • Barry M.J. Effects of fluoxetine on the swimming and behavioral responses of the Arabian killifish. Ecotoxicology 2013, 22:425-432.
    • (2013) Ecotoxicology , vol.22 , pp. 425-432
    • Barry, M.J.1
  • 4
    • 43449094636 scopus 로고    scopus 로고
    • Fish on Prozac: effect of serotonin reuptake inhibitors on cognition in goldfish
    • Beulig A., Fowler J. Fish on Prozac: effect of serotonin reuptake inhibitors on cognition in goldfish. Behav. Neurosci. 2008, 122(April (2)):426-432.
    • (2008) Behav. Neurosci. , vol.122 , Issue.APRIL 2 , pp. 426-432
    • Beulig, A.1    Fowler, J.2
  • 5
    • 84886427276 scopus 로고    scopus 로고
    • Pharmaceutical and personal care products found in the great lakes above concentrations of environmental concern
    • Blair B.D., Crago J.P., Hedman C.J., Klaper R. Pharmaceutical and personal care products found in the great lakes above concentrations of environmental concern. Chemosphere 2013, 93:2116-2123.
    • (2013) Chemosphere , vol.93 , pp. 2116-2123
    • Blair, B.D.1    Crago, J.P.2    Hedman, C.J.3    Klaper, R.4
  • 7
    • 0038122783 scopus 로고    scopus 로고
    • Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA and Ontario, Canada
    • Boyd G.R., Reemtsma H., Grimm D.A., Mitra S. Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA and Ontario, Canada. Sci. Total Environ. 2003, 311:135-149.
    • (2003) Sci. Total Environ. , vol.311 , pp. 135-149
    • Boyd, G.R.1    Reemtsma, H.2    Grimm, D.A.3    Mitra, S.4
  • 8
    • 84899484585 scopus 로고    scopus 로고
    • Introduction and background for alternative nontraditional end points in aquatic toxicology
    • Brooks B.W., Brain R.A. Introduction and background for alternative nontraditional end points in aquatic toxicology. Chem. Res. Toxicol. 2010, 23. 271-271.
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 271-271
    • Brooks, B.W.1    Brain, R.A.2
  • 11
    • 33751053331 scopus 로고    scopus 로고
    • Pharmaceutically active compounds in Atlantic Canadian sewage treatment plant effluents and receiving waters, and potential for environmental effects as measured by acute and chronic aquatic toxicity
    • Brun G.L., Bernier M., Losier R., Doe K., Jackman P., Lee H.B. Pharmaceutically active compounds in Atlantic Canadian sewage treatment plant effluents and receiving waters, and potential for environmental effects as measured by acute and chronic aquatic toxicity. Environ. Toxicol. Chem. 2006, 25:2163-2176.
    • (2006) Environ. Toxicol. Chem. , vol.25 , pp. 2163-2176
    • Brun, G.L.1    Bernier, M.2    Losier, R.3    Doe, K.4    Jackman, P.5    Lee, H.B.6
  • 13
    • 70249102046 scopus 로고    scopus 로고
    • Probabilistic environmental risk characterization of pharmaceuticals in sewage treatment plant discharges
    • Christensen A.M., Markussen B., Baun A., Halling-Sørensen B. Probabilistic environmental risk characterization of pharmaceuticals in sewage treatment plant discharges. Chemosphere 2009, 77:351-358.
    • (2009) Chemosphere , vol.77 , pp. 351-358
    • Christensen, A.M.1    Markussen, B.2    Baun, A.3    Halling-Sørensen, B.4
  • 14
    • 34547849597 scopus 로고    scopus 로고
    • Analysis of paroxetine, fluoxetine and norfluoxetine in fish tissues using pressurized liquid extraction, mixed mode solid phase extraction cleanup and liquid chromatography-tandem mass spectrometry
    • Chu S., Metcalfe C.D. Analysis of paroxetine, fluoxetine and norfluoxetine in fish tissues using pressurized liquid extraction, mixed mode solid phase extraction cleanup and liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2007, 1163:112-118.
    • (2007) J. Chromatogr. A , vol.1163 , pp. 112-118
    • Chu, S.1    Metcalfe, C.D.2
  • 16
    • 0030988141 scopus 로고    scopus 로고
    • The kinematics and performance of fish fast-start swimming
    • Domenici P., Blake R. The kinematics and performance of fish fast-start swimming. J. Exp. Biol. 1997, 200:1165-1178.
    • (1997) J. Exp. Biol. , vol.200 , pp. 1165-1178
    • Domenici, P.1    Blake, R.2
  • 17
    • 84863109299 scopus 로고    scopus 로고
    • Fluoxetine alters behavioral consistency of aggression and courtship in male Siamese fighting fish Betta splendens
    • Dzieweczynski T.L., Herbert O.L. Fluoxetine alters behavioral consistency of aggression and courtship in male Siamese fighting fish Betta splendens. Physiol. Behav. 2012, 107:92-97.
    • (2012) Physiol. Behav. , vol.107 , pp. 92-97
    • Dzieweczynski, T.L.1    Herbert, O.L.2
  • 18
    • 0001868484 scopus 로고
    • The role of the Mauthner cell in fast-starts involving escape in teleost fishes
    • Eaton R.C., Hackett J.T. The role of the Mauthner cell in fast-starts involving escape in teleost fishes. Neural Mechanisms of Startle Behavior 1984, 213-266.
    • (1984) Neural Mechanisms of Startle Behavior , pp. 213-266
    • Eaton, R.C.1    Hackett, J.T.2
  • 19
    • 0035058463 scopus 로고    scopus 로고
    • The Mauthner cell and other identified neurons of the brainstem escape network of fish
    • Eaton R.C., Lee R.K.K., Foreman M.B. The Mauthner cell and other identified neurons of the brainstem escape network of fish. Prog. Neurobiol. 2001, 63:467-485.
    • (2001) Prog. Neurobiol. , vol.63 , pp. 467-485
    • Eaton, R.C.1    Lee, R.K.K.2    Foreman, M.B.3
  • 20
    • 84872115501 scopus 로고    scopus 로고
    • Evolutionary shift from fighting to foraging in blind cavefish through changes in the serotonin network
    • Elipot Y., Hinaux H., Callebert J., Rétaux S. Evolutionary shift from fighting to foraging in blind cavefish through changes in the serotonin network. Curr. Biol. 2013, 23:1-10.
    • (2013) Curr. Biol. , vol.23 , pp. 1-10
    • Elipot, Y.1    Hinaux, H.2    Callebert, J.3    Rétaux, S.4
  • 21
    • 80053132283 scopus 로고    scopus 로고
    • Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study
    • Fernandes D., Schnell S., Porte C. Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study. Mar. Pollut. Bull. 2011, 62:2250-2253.
    • (2011) Mar. Pollut. Bull. , vol.62 , pp. 2250-2253
    • Fernandes, D.1    Schnell, S.2    Porte, C.3
  • 22
    • 0030200069 scopus 로고    scopus 로고
    • Serotonin modulation of lymphocyte proliferation via 5-HT1A receptors in rainbow trout (Oncorhynchus mykiss)
    • Ferriere F., Khan N.A., Troutaud D., Deschaux P. Serotonin modulation of lymphocyte proliferation via 5-HT1A receptors in rainbow trout (Oncorhynchus mykiss). Dev. Comp. Immunol. 1996, 20:273-283.
    • (1996) Dev. Comp. Immunol. , vol.20 , pp. 273-283
    • Ferriere, F.1    Khan, N.A.2    Troutaud, D.3    Deschaux, P.4
  • 23
    • 0002786625 scopus 로고    scopus 로고
    • Antidepressants in aquatic organisms: a wide range of effects
    • American Chemical Society, Washington, DC, C.G. Daughton, T.L. Jones-Lepp (Eds.)
    • Fong P. Antidepressants in aquatic organisms: a wide range of effects. Pharmaceuticals and Personal Care Products in the Environment: Scientific and Regulatory Issues 2001, 396. American Chemical Society, Washington, DC. C.G. Daughton, T.L. Jones-Lepp (Eds.).
    • (2001) Pharmaceuticals and Personal Care Products in the Environment: Scientific and Regulatory Issues , pp. 396
    • Fong, P.1
  • 24
    • 1942530812 scopus 로고    scopus 로고
    • Reproductive assessment of Japanese medaka (Oryzias latipes) following a four-week fluoxetine (SSRI) exposure
    • Foran C.M., Weston J., Slattery M., Brooks B.W., Huggett D.B. Reproductive assessment of Japanese medaka (Oryzias latipes) following a four-week fluoxetine (SSRI) exposure. Arch. Environ. Contam. Toxicol. 2004, 46:511-517.
    • (2004) Arch. Environ. Contam. Toxicol. , vol.46 , pp. 511-517
    • Foran, C.M.1    Weston, J.2    Slattery, M.3    Brooks, B.W.4    Huggett, D.B.5
  • 25
    • 46249115914 scopus 로고    scopus 로고
    • Behavioral and biochemical responses of hybrid striped bass during and after fluoxetine exposure
    • Gaworecki K.M., Klaine S.J. Behavioral and biochemical responses of hybrid striped bass during and after fluoxetine exposure. Aquat. Toxicol. 2008, 88:207-213.
    • (2008) Aquat. Toxicol. , vol.88 , pp. 207-213
    • Gaworecki, K.M.1    Klaine, S.J.2
  • 26
    • 0033539661 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes
    • Griffin L.D., Mellon S.H. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:13512-13517.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 13512-13517
    • Griffin, L.D.1    Mellon, S.H.2
  • 27
    • 0037052865 scopus 로고    scopus 로고
    • Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data
    • Heberer T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 2002, 131:5-17.
    • (2002) Toxicol. Lett. , vol.131 , pp. 5-17
    • Heberer, T.1
  • 28
    • 0026282679 scopus 로고
    • Characterizing individual population and community effects of sublethal levels of aquatic toxicants - an experimental case-study using Daphnia
    • Jones M., Folt C., Guarda S. Characterizing individual population and community effects of sublethal levels of aquatic toxicants - an experimental case-study using Daphnia. Freshw. Biol. 1991, 26:35-44.
    • (1991) Freshw. Biol. , vol.26 , pp. 35-44
    • Jones, M.1    Folt, C.2    Guarda, S.3
  • 29
    • 0027081509 scopus 로고
    • Stimulatory effects of serotonin on maturational gonadotropin release in the Atlantic croaker Micropogonias undulatus
    • Khan I.A., Thomas P. Stimulatory effects of serotonin on maturational gonadotropin release in the Atlantic croaker Micropogonias undulatus. Gen. Comp. Endocrinol. 1992, 88:388-396.
    • (1992) Gen. Comp. Endocrinol. , vol.88 , pp. 388-396
    • Khan, I.A.1    Thomas, P.2
  • 30
    • 84861136572 scopus 로고    scopus 로고
    • Decreased aggressive and locomotor behaviors in Betta splendens after exposure to fluoxetine
    • Kohlert J.G., Mangan B.P., Kodra C., Drako L., Long E., Simpson H. Decreased aggressive and locomotor behaviors in Betta splendens after exposure to fluoxetine. Psychol. Rep. 2012, 110:51-62.
    • (2012) Psychol. Rep. , vol.110 , pp. 51-62
    • Kohlert, J.G.1    Mangan, B.P.2    Kodra, C.3    Drako, L.4    Long, E.5    Simpson, H.6
  • 32
    • 36049043771 scopus 로고    scopus 로고
    • Risks to aquatic organisms posed by human pharmaceutical use
    • Kostich M.S., Lazorchak J.M. Risks to aquatic organisms posed by human pharmaceutical use. Sci. Total Environ. 2008, 389:329-339.
    • (2008) Sci. Total Environ. , vol.389 , pp. 329-339
    • Kostich, M.S.1    Lazorchak, J.M.2
  • 33
    • 71549149009 scopus 로고    scopus 로고
    • Inhibition of egg production in zebrafish by fluoxetine and municipal effluents: a mechanistic evaluation
    • Lister A., Regan C., Van Zwol J., Van Der Kraak G. Inhibition of egg production in zebrafish by fluoxetine and municipal effluents: a mechanistic evaluation. Aquat. Toxicol. 2009, 95:320-329.
    • (2009) Aquat. Toxicol. , vol.95 , pp. 320-329
    • Lister, A.1    Regan, C.2    Van Zwol, J.3    Van Der Kraak, G.4
  • 34
    • 34250792161 scopus 로고    scopus 로고
    • Behavioral and physiological changes in Daphnia magna when exposed to nanoparticle suspensions (titanium dioxide, nano-C60, and C60HxC70Hx)
    • Lovern S.B., Strickler J.R., Klaper R. Behavioral and physiological changes in Daphnia magna when exposed to nanoparticle suspensions (titanium dioxide, nano-C60, and C60HxC70Hx). Environ. Sci. Technol. 2007, 41:4465-4470.
    • (2007) Environ. Sci. Technol. , vol.41 , pp. 4465-4470
    • Lovern, S.B.1    Strickler, J.R.2    Klaper, R.3
  • 35
    • 37149022540 scopus 로고    scopus 로고
    • Fish on Prozac: a simple, noninvasive physiology laboratory investigating the mechanisms of aggressive behavior in Betta splendens
    • Lynn S.E., Egar J.M., Walker B.G., Sperry T.S., Ramenofsky M. Fish on Prozac: a simple, noninvasive physiology laboratory investigating the mechanisms of aggressive behavior in Betta splendens. Adv. Physiol. Educ. 2007, 31:358-363.
    • (2007) Adv. Physiol. Educ. , vol.31 , pp. 358-363
    • Lynn, S.E.1    Egar, J.M.2    Walker, B.G.3    Sperry, T.S.4    Ramenofsky, M.5
  • 38
    • 78649703250 scopus 로고    scopus 로고
    • Higher levels of aggression are observed in socially dominant toadfish treated with the selective serotonin reuptake inhibitor, fluoxetine
    • McDonald M.D., Gonzalez A., Sloman K.A. Higher levels of aggression are observed in socially dominant toadfish treated with the selective serotonin reuptake inhibitor, fluoxetine. Comp. Biochem. Physiol. C: Toxicol. Pharmacol. 2010, 153:107-112.
    • (2010) Comp. Biochem. Physiol. C: Toxicol. Pharmacol. , vol.153 , pp. 107-112
    • McDonald, M.D.1    Gonzalez, A.2    Sloman, K.A.3
  • 40
    • 77957567376 scopus 로고    scopus 로고
    • Waterborne fluoxetine disrupts feeding and energy metabolism in the goldfish, Carassius auratus
    • Mennigen J.A., Sassine J., Trudeau V.L., Moon T.W. Waterborne fluoxetine disrupts feeding and energy metabolism in the goldfish, Carassius auratus. Aquat. Toxicol. 2010, 100:128-137.
    • (2010) Aquat. Toxicol. , vol.100 , pp. 128-137
    • Mennigen, J.A.1    Sassine, J.2    Trudeau, V.L.3    Moon, T.W.4
  • 42
    • 0345305721 scopus 로고    scopus 로고
    • Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada
    • Metcalfe C.D., Miao X.S., Koenig B.G., Struger J. Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada. Environ. Toxicol. Chem. 2003, 22:2881-2889.
    • (2003) Environ. Toxicol. Chem. , vol.22 , pp. 2881-2889
    • Metcalfe, C.D.1    Miao, X.S.2    Koenig, B.G.3    Struger, J.4
  • 43
    • 67649487963 scopus 로고    scopus 로고
    • Fluoxetine treatment affects nitrogen waste excretion and osmoregulation in a marine teleost fish
    • Morando M.B., Medeiros L.R., McDonald M.D. Fluoxetine treatment affects nitrogen waste excretion and osmoregulation in a marine teleost fish. Aquat. Toxicol. 2009, 93:253-260.
    • (2009) Aquat. Toxicol. , vol.93 , pp. 253-260
    • Morando, M.B.1    Medeiros, L.R.2    McDonald, M.D.3
  • 44
    • 59849115520 scopus 로고    scopus 로고
    • Brain region-specific effects of short-term treatment with duloxetine, venlafaxine milnacipran and sertraline on monoamine metabolism in rats
    • Muneoka K., Shirayama Y., Takigawa M., Shioda S. Brain region-specific effects of short-term treatment with duloxetine, venlafaxine milnacipran and sertraline on monoamine metabolism in rats. Neurochem. Res. 2009, 34:542-555.
    • (2009) Neurochem. Res. , vol.34 , pp. 542-555
    • Muneoka, K.1    Shirayama, Y.2    Takigawa, M.3    Shioda, S.4
  • 46
    • 0035141862 scopus 로고    scopus 로고
    • Augmentation of fluoxetine's antidepressant action by pindolol: analysis of clinical, pharmacokinetic, and methodologic factors
    • Perez V., Puiigdemont D., Gilaberte I., Alvarez E., Artigas F. Augmentation of fluoxetine's antidepressant action by pindolol: analysis of clinical, pharmacokinetic, and methodologic factors. J. Clin. Psychopharmacol. 2001, 21:36-45.
    • (2001) J. Clin. Psychopharmacol. , vol.21 , pp. 36-45
    • Perez, V.1    Puiigdemont, D.2    Gilaberte, I.3    Alvarez, E.4    Artigas, F.5
  • 47
    • 0042884141 scopus 로고    scopus 로고
    • Fluoxetine treatment decreases territorial aggression in a coral reef fish
    • Perreault H.A.N., Semsar K., Godwin J. Fluoxetine treatment decreases territorial aggression in a coral reef fish. Physiol. Behav. 2003, 79:719-724.
    • (2003) Physiol. Behav. , vol.79 , pp. 719-724
    • Perreault, H.A.N.1    Semsar, K.2    Godwin, J.3
  • 48
    • 34247346615 scopus 로고    scopus 로고
    • Analysis of pharmaceuticals in fish using liquid chromatography-tandem mass spectrometry
    • Ramirez A.J., Mottaleb M.A., Brooks B.W., Chambliss C.K. Analysis of pharmaceuticals in fish using liquid chromatography-tandem mass spectrometry. Anal. Chem. 2007, 79:3155-3163.
    • (2007) Anal. Chem. , vol.79 , pp. 3155-3163
    • Ramirez, A.J.1    Mottaleb, M.A.2    Brooks, B.W.3    Chambliss, C.K.4
  • 50
    • 34547546696 scopus 로고    scopus 로고
    • Enantiospecific sublethal effects of the antidepressant fluoxetine to a model aquatic vertebrate and invertebrate
    • Stanley J.K., Ramirez A.J., Chambliss C.K., Brooks B.W. Enantiospecific sublethal effects of the antidepressant fluoxetine to a model aquatic vertebrate and invertebrate. Chemosphere 2007, 69:9-16.
    • (2007) Chemosphere , vol.69 , pp. 9-16
    • Stanley, J.K.1    Ramirez, A.J.2    Chambliss, C.K.3    Brooks, B.W.4
  • 51
    • 81855170291 scopus 로고    scopus 로고
    • Gene-class analysis of expression patterns induced by psychoactive pharmaceutical exposure in fathead minnow (Pimephales promelas) indicates induction of neuronal systems
    • Thomas M., Joshi P.P., Klaper R.D. Gene-class analysis of expression patterns induced by psychoactive pharmaceutical exposure in fathead minnow (Pimephales promelas) indicates induction of neuronal systems. Comp. Biochem. Physiol. C 2011, 155:109-120.
    • (2011) Comp. Biochem. Physiol. C , vol.155 , pp. 109-120
    • Thomas, M.1    Joshi, P.P.2    Klaper, R.D.3
  • 52
    • 32844465507 scopus 로고    scopus 로고
    • Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats
    • Uphouse L., Hensler J.G., Sarkar J., Grossie B. Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats. Brain Res. 2006, 1072:79-90.
    • (2006) Brain Res. , vol.1072 , pp. 79-90
    • Uphouse, L.1    Hensler, J.G.2    Sarkar, J.3    Grossie, B.4
  • 53
    • 0012790905 scopus 로고    scopus 로고
    • A data based perspective on the environmental risk assessment of human pharmaceuticals II - aquatic risk characterization
    • Springer, Berlin/New York, K. Kümmerer (Ed.)
    • Webb S.F. A data based perspective on the environmental risk assessment of human pharmaceuticals II - aquatic risk characterization. Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks 2001, 265. Springer, Berlin/New York. K. Kümmerer (Ed.).
    • (2001) Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks , pp. 265
    • Webb, S.F.1
  • 54
    • 63449091474 scopus 로고    scopus 로고
    • Effects of fluoxetine exposure on serotonin-related activity in the sheepshead minnow (Cyprinodon variegatus) using LC/MS/MS detection and quantitation
    • Winder V.L., Sapozhnikova Y., Pennington P.L., Wirth E.F. Effects of fluoxetine exposure on serotonin-related activity in the sheepshead minnow (Cyprinodon variegatus) using LC/MS/MS detection and quantitation. Biochem. Physiol. C: Toxicol. Pharmacol. 2009, 149:559-565.
    • (2009) Biochem. Physiol. C: Toxicol. Pharmacol. , vol.149 , pp. 559-565
    • Winder, V.L.1    Sapozhnikova, Y.2    Pennington, P.L.3    Wirth, E.F.4


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