Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study

Marine Pollution Bulletin

Volumn 62, Issue 10, 2011, Pages 2250-2253

  Fernandes, Denise ^a   Schnell, Sabine ^a   Porte, Cinta ^a  

^a INSTITUTE OF ENVIRONMENTAL ASSESSMENT AND WATER RESEARCH   (Spain)

Author keywords

11 hydroxylase; Androgen synthesis; C17,20 lyase; Carp; Pharmaceuticals

Indexed keywords

ANTI-INFLAMMATORIES; C17,20-LYASE; CARP; CLOFIBRIC ACID; DICLOFENAC; DISRUPTIVE EFFECTS; ENZYMATIC SYSTEM; FLUOXETINE; FLUVOXAMINE; GEMFIBROZILS; HYDROXYLASES; IN-VITRO; IN-VIVO; PHARMACEUTICAL COMPOUNDS;

DRUG PRODUCTS;

ANDROGEN; CLOFIBRATE; CLOFIBRIC ACID; CYTOCHROME P450 17; DICLOFENAC; FLUOXETINE; FLUVOXAMINE; GEMFIBROZIL; HYDROXYSTEROID DEHYDROGENASE; IBUPROFEN; STEROID 11BETA MONOOXYGENASE; STEROID 17,20 LYASE;

ANDROGEN; DRUG; ENDOCRINE DISRUPTOR; ENZYME ACTIVITY; FISH; INHIBITOR; POLLUTION EFFECT; REPRODUCTIVE BEHAVIOR; TOXICITY TEST;

ANDROGEN SYNTHESIS; ANIMAL TISSUE; ARTICLE; CARP; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL MONITORING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME METABOLISM; GONAD; IC 50; IN VITRO STUDY; MALE; MOLECULAR INTERACTION; NONHUMAN; REPRODUCTIVE TOXICITY; SEXUAL BEHAVIOR; SEXUAL DEVELOPMENT; SPERMATOGENESIS; WATER POLLUTANT;

ANDROGENS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIDEPRESSIVE AGENTS; BIOLOGICAL MARKERS; CARPS; CLOFIBRATE; CLOFIBRIC ACID; DICLOFENAC; FIBRIC ACIDS; FLUOXETINE; GEMFIBROZIL; IBUPROFEN; MALE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; TESTIS; WATER POLLUTANTS, CHEMICAL;

CYPRINIDAE;

EID: 80053132283     PISSN: 0025326X     EISSN: 18793363     Source Type: Journal    
DOI: 10.1016/j.marpolbul.2011.07.011     Document Type: Article

References (25)

1. Ahmed S., Smith J.H., Nicholls P.J., Whomsley R., Cariuk P. Synthesis and biological evaluation of imidazole based compounds as cytochrome P450 inhibitors. Drug Des. Discov. 1995, 13:27-41.
2. Amacher D.E., Beck R., Schomaker S.J., Kenny C. Hepatic microsomal enzyme induction, β-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat. Toxicol. Appl. Pharmacol. 1997, 142:143-150.
3. Borg B. Androgens in teleosts fishes. Comp. Biochem. Physiol. 1994, 109C:219-245.
4. Bradford M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
5. Corcoran J., Winter M.J., Tyler C.R. Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit. Rev. Toxicol. 2010, 40:287-304.
6. Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ. Health Perspect. 1999, 107:907-938.
7. Devlin R.H., Nagahama Y. Sex determination and sex differentiation in fish: an overview of genetic, physiological and environmental influences. Aquaculture 2002, 208:191-364.
8. Fent K., Weston A.A., Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 2006, 76:122-159.
9. Fernandes D., Bebianno M.J., Porte C. Mitochondrial metabolism of 17α-hydroxyprogesterone in male sea bass (Dicentrarchus labrax): a potential target for endocrine disruptors. Aquat. Toxicol. 2007, 85:258-266.
10. Foran C.M., Weston J., Slattery M., Brooks B.W., Huggett D.B. Reproductive assessment of Japanese medaka (Oryzias latipes) following a four-week fluoxetine (SSRI) exposure. Arch. Environ. Contam. Toxicol. 2004, 46:511-517.
11. Han S., Choi K., Kim J., Ji K., Kim S., Ahn B., Yun J., Choi K., Khim J.S., Zhang X., Giesy J.P. Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzian latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa. Aquat. Toxicol. 2010, 98:256-264.
12. Hemeryck A., Belpaire F.M. Selective serotonin reuptake inhibitors and cytochrome P450 mediated drug-drug interactions: an update. Current Drug Metab. 2002, 3:13-37.
13. Kime D.E. " Classical" and " non-classical" reproductive steroids in fish. Rev. Fish Biol. Fisher. 1993, 3:160-180.
14. Laville N., Aït-Aïssa S., Gomez E., Casellas C., Porcher J.M. Effects of human pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes. Toxicology 2004, 196:41-55.
15. Lister A., Regan C., Van Zwol J., Van der Kraak G. Inhibition of egg production in zebra fish by fluoxetine and municipal effluents: a mechanistic evaluation. Aquat. Toxicol. 2009, 95:320-329.
16. Liu S., Govoroun M., D'Cotta H., Ricordel M.-J., Lareyre J.-J., McMeel O.M., Smith T., Nagahama Y., Guiguen Y. Expression of cytochrome P45011β (11β-hydroxylase) gene during gonadal sex differentiation and spermatogenesis in rainbow trout, Oncorhynchus mykiss. J. Steroid Biochem. Mol. Biol. 2000, 75:291-298.
17. Mennigen J.A., Lado W.E., Zamora J.M., Duarte-Guterman P., Langlois V.S., Metcalfe C.D., Chang J.P., Moon T.W., Trudeau V.L. Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus. Aquat. Toxicol. 2010, 100:354-364.
18. Monteiro P.R.R., Reis-Henriques M.A., Coimbra J. Polycyclic aromatic hydrocarbons inhibit in vitro ovarian steroidogenesis in the flounder (Platichthys flesus L.). Aquat. Toxicol 2000, 48:549-559.
19. Nakamura Y., Yamamoto H., Sekizawa J., Kondo T., Hirai N., Tatarazako N. The effects of pH on fluoxetine on Japanese medaka (Oryzias latipes): acute toxicity in fish larvae and bioaccumulation in juvenile fish. Chemosphere 2008, 70:865-873.
20. Paterson G., Metcalfe C.D. Uptake and depuration of the anti-depressant fluoxetine by the Japanese medaka (Oryzias latipes). Chemosphere 2008, 74:125-130.
21. Pelkonen O., Turpeinen M., Hakkola J., Honkakoski P., Hukkanen J., Raunio H. Inhibition and induction of human cytochrome P450 enzymes: current status. Arch. Toxicol. 2008, 82:667-715.
22. Schnell S., Martin-Skilton R., Fernandes D., Porte C. The interference of nitro- and polycyclic musks with endogenous and xenobiotic metabolizing enzymes in carp: an in vitro study. Environ. Sci. Technol. 2009, 43:9458-9464.
23. Tang W. The metabolism of diclofenac-enzymology and toxicology perspectives. Curr Drug Metab. 2003, 11:319-329.
24. Thibaut R., Schnell S., Porte C. The interference of pharmaceuticals with endogenous and xenobiotic metabolizing enzymes in carp liver: an in vitro study. Environ. Sci. Technol. 2006, 40:5154-5160.
25. Weber M.M., Will A., Adelmann B., Engelhardt D. Effect of ketoconazole on human ovarian C17, 20-desmolase and aromatase. J. Steroid. Biochem. Mol. Biol. 1991, 38:213-218.