SDA, a DNA aptamer inhibiting E- And P-Selectin mediated adhesion of cancer and leukemia cells, the first and pivotal step in transendothelial migration during metastasis formation

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Faryammanesh, Rassa ^a   Lange, Tobias ^b   Magbanua, Eileen ^a   Haas, Sina ^a   Meyer, Cindy ^a,c   Wicklein, Daniel ^b   Schumacher, Udo ^b   Hahn, Ulrich ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMETASTATIC AGENT; APTAMER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; PADGEM PROTEIN; SELECTIN DNA APTAMER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER CELL; CELL ADHESION; CELL MIGRATION; COLORECTAL CANCER; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; LAMINAR FLOW; LEUKEMIA CELL; LIGAND BINDING; LUNG BLOOD VESSEL; METASTASIS; METASTASIS INHIBITION; MICROVASCULAR ENDOTHELIAL CELL; PHYSIOLOGICAL STRESS; SHEAR STRESS; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; COLORECTAL NEOPLASMS; COMBINATORIAL CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETICS; LEUKEMIA; LUNG; METABOLISM; PATHOLOGY; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; VASCULAR ENDOTHELIUM; VASCULARIZATION;

APTAMERS, NUCLEOTIDE; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; COLORECTAL NEOPLASMS; E-SELECTIN; ENDOTHELIUM, VASCULAR; HUMANS; LEUKEMIA; LUNG; P-SELECTIN; SELEX APTAMER TECHNIQUE; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

EID: 84899462242     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093173     Document Type: Article

References (34)

1. Siegel R, Naishadham D, Jemal A (2013) Cancer statistics, 2013. CA Cancer J Clin 63: 11-30.
2. Valastyan S, Weinberg RA (2011) Tumor Metastasis: Molecular Insights and Evolving Paradigms. Cell 147: 275-292.
3. Fidler IJ (1978) Tumor Heterogeneity and Biology of Cancer Invasion and Metastasis. Cancer Res 38: 2651-2660.
4. Kohler S, Ullrich S, Richter U, Schumacher U (2010) E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung. Br J Cancer 102: 602-609.
5. Bevilacqua MP, Pober JS, Mendrick DL, Cotran RS, Gimbrone MA (1987) Identification of an Inducible Endothelial Leukocyte Adhesion Molecule. Proc Natl Acad Sci U S A 84: 9238-9242.
6. Lasky LA (1991) Lectin Cell-Adhesion Molecules (Lec-Cams) - a New Family of Cell-Adhesion Proteins Involved with Inflammation. Journal of Cellular Biochemistry 45: 139-146.
7. Gebauer F, Wicklein D, Stubke K, Nehmann N, Schmidt A, et al. (2013) Selectin binding is essential for peritoneal carcinomatosis in a xenograft model of human pancreatic adenocarcinoma in pfp(-)/rag2(-) mice. Gut 62: 741-750.
8. Wicklein D, Schmidt A, Labitzky V, Ullrich S, Valent P, et al. (2013) E- and P-Selectins Are Essential for Repopulation of Chronic Myelogenous and Chronic Eosinophilic Leukemias in a Scid Mouse Xenograft Model. Plos One 8.
9. Ernst B, Magnani JL (2009) From carbohydrate leads to glycomimetic drugs. Nature Reviews Drug Discovery 8: 661-677.
10. Pendergrast PS, Marsh HN, Grate D, Healy JM, Stanton M (2005) Nucleic acid aptamers for target validation and therapeutic applications. J Biomol Tech 16: 224-234.
11. Keefe AD, Schaub RG (2008) Aptamers as candidate therapeutics for cardiovascular indications. Current Opinion in Pharmacology 8: 147-152.
12. Keefe AD, Pai S, Ellington A (2010) Aptamers as therapeutics (vol 9, pg 537, 2010). Nature Reviews Drug Discovery 9.
13. Tuerk C, Gold L (1990) Systematic Evolution of Ligands by Exponential Enrichment - Rna Ligands to Bacteriophage-T4 DNA-Polymerase. Science 249: 505-510.
14. Ellington AD, Szostak JW (1990) Invitro Selection of RNA Molecules That Bind Specific Ligands. Nature 346: 818-822.
15. Robertson DL, Joyce GF (1990) Selection Invitro of an Rna Enzyme That Specifically Cleaves Single-Stranded-DNA. Nature 344: 467-468.
16. Mayer G, Hover T (2009) In vitro selection of ssDNA aptamers using biotinylated target proteins. Methods Mol Biol 535: 19-32.
17. Rong-liang H, Ting G, WYing W, Ye-Wei L, Cheng.Iong S (2011) Construction of a pUC19-T vector Based on Xcm I. Agricultural Science & Technology 12: 363-365.
18. Marchuk D, Drumm M, Saulino A, Collins FS (1991) Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res 19: 1154.
19. Sheikh S, Rainger GE, Gale Z, Rahman M, Nash GB (2003) Exposure to fluid shear stress modulates the ability of endothelial cells to recruit neutrophils in response to tumor necrosis factor-alpha: a basis for local variations in vascular sensitivity to inflammation. Blood 102: 2828-2834. (Pubitemid 37248853)
20. Richter U, Schroder C, Wicklein D, Lange T, Geleff S, et al. (2011) Adhesion of small cell lung cancer cells to E- and P-selectin under physiological flow conditions: implications for metastasis formation. Histochem Cell Biol 135: 499-512.
21. Richter U, Wicklein D, Geleff S, Schumacher U (2012) The interaction between CD44 on tumour cells and hyaluronan under physiologic flow conditions: implications for metastasis formation. Histochem Cell Biol 137: 687-695.
22. Larsen GR, Sako D, Ahern TJ, Shaffer M, Erban J, et al. (1992) P-Selectin and E-Selectin - Distinct but Overlapping Leukocyte Ligand Specificities. Journal of Biological Chemistry 267: 11104-11110.
23. Revelle BM, Scott D, Kogan TP, Zheng JH, Beck PJ (1996) Structure-function analysis of P-selectin-sialyl Lewis(x) binding interactions - Mutagenic alteration of ligand binding specificity. Journal of Biological Chemistry 271: 4289-4297.
24. Erbe DV, Watson SR, Presta LG, Wolitzky BA, Foxall C, et al. (1993) P-Selectin and E-Selectin Use Common Sites for Carbohydrate Ligand Recognition and Cell-Adhesion. Journal of Cell Biology 120: 1227-1235.
25. Zuker M (2003) Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 31: 3406-3415.
26. Zuker M (1989) On finding all suboptimal foldings of an RNA molecule. Science 244: 48-52.
27. Strell C, Entschladen F (2008) Extravasation of leukocytes in comparison to tumor cells. Cell Commun Signal 6: 10.
28. Reymond N, d'Agua BB, Ridley AJ (2013) Crossing the endothelial barrier during metastasis. Nature Reviews Cancer 13: 858-870.
29. Somers WS, Tang J, Shaw GD, Camphausen RT (2000) Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of Pand E-selectin bound to SLe(X) and PSGL-1. Cell 103: 467-479.
30. Gutsaeva DR, Parkerson JB, Yerigenahally SD, Kurz JC, Schaub RG, et al. (2011) Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease. Blood 117: 727-735.
31. Brandley BK, Swiedler SJ, Robbins PW (1990) Carbohydrate Ligands of the Lec Cell-Adhesion Molecules. Cell 63: 861-863.
32. Mann AP, Somasunderam A, Nieves-Alicea R, Li X, Hu A, et al. (2010) Identification of Thioaptamer Ligand against E-Selectin: Potential Application for Inflamed Vasculature Targeting. Plos One 5.
33. Burnette AD, Nimjee SM, Batchvarova M, Zennadi R, Telen MJ, et al. (2011) RNA Aptamer Therapy for Vaso-Occlusion in Sickle Cell Disease. Nucleic Acid Therapeutics 21: 275-283.
34. Jenison RD, Jennings SD, Walker DW, Bargatze RF, Parma D (1998) Oligonucleotide inhibitors of P-selectin-dependent neutrophil-platelet adhesion. Antisense & Nucleic Acid Drug Development 8: 265-279. (Pubitemid 28446114)