Selectin binding is essential for peritoneal carcinomatosis in a xenograft model of human pancreatic adenocarcinoma in pfp-/rag2-mice

Gut

Volumn 62, Issue 5, 2013, Pages 741-750

  Gebauer, Florian ^a   Wicklein, Daniel ^a   Stübke, Katrin ^a   Nehmann, Nina ^a   Schmidt, Anna ^a   Salamon, Johannes ^a   Peldschus, Kersten ^a   Nentwich, Michael Fabian ^a   Adam, Gerhard ^a   Tolstonog, Genrich ^b   Bockhorn, Maximilian ^a   Izbicki, Jakob R ^a   Wagener, Christoph ^a   Schumacher, Udo ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; PADGEM PROTEIN; PERFORIN; RAG2 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER GROWTH; CARCINOMATOUS PERITONITIS; CELL ADHESION; CELL ISOLATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIGAND BINDING; MESOTHELIUM CELL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS ADENOCARCINOMA; PERFORIN GENE; PERITONEUM CELL; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAG2 GENE; TUMOR XENOGRAFT; WILD TYPE;

ADENOCARCINOMA; ANIMALS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; E-SELECTIN; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; P-SELECTIN; PANCREATIC NEOPLASMS; PERITONEAL NEOPLASMS; SELECTINS; TRANSPLANTATION, HETEROLOGOUS; TUMOR MARKERS, BIOLOGICAL;

EID: 84875819124     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-300629     Document Type: Article

References (46)

1. Jemal A, Siegel R, Xu J, et al. Cancer Statistics, 2010. CA Cancer J Clin 2010;60:277-300.
2. Loos M, Kleeff J, Friess H, et al. Surgical treatment of pancreatic cancer. Ann N Y Acad Sci 2008;1138:169-80.
3. Neoptolemos JP, Stocken DD, Friess H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 2004;350:1200-10. (Pubitemid 38339364)
4. Neoptolemos JP, Stocken DD, Bassi C, et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 2011;304:1073-81.
5. Oettle H, Post S, Neuhaus P, et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 2007;297:267-77. (Pubitemid 46143304)
6. Ko AH, Tempero MA. Treatment of metastatic pancreatic cancer. J Natl Compr Canc Netw 2005;3:627-36. (Pubitemid 44265411)
7. Seelig SK, Burkert B, Chromik AM, et al. Pancreatic resections for advanced M1- pancreatic carcinoma: the value of synchronous metastasectomy. HPB Surg 2011;2010:579672.
8. Ferrone CR, Haas B, Tang L, et al. The influence of positive peritoneal cytology on survival in patients with pancreatic adenocarcinoma. J Gastrointest Surg 2006;10:1347-53. (Pubitemid 44908995)
9. Neoptolemos JP, Stocken DD, Tudur Smith C, et al. Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials. Br J Cancer 2009;100:246-50.
10. Sperti C, Pasquali C, Piccoli A, et al. Recurrence after resection for ductal adenocarcinoma of the pancreas. World J Surg 1997;21:195-200. (Pubitemid 27053441)
11. Van den Broeck A, Sergeant G, Ectors N, et al. Patterns of recurrence after curative resection of pancreatic ductal adenocarcinoma. Eur J Surg Oncol 2009;35:600-4.
12. Eggermont AM, Steller EP, Marquet RL, et al. Local regional promotion of tumor growth after abdominal surgery is dominant over immunotherapy with interleukin-2 and lymphokine activated killer cells. Cancer Detect Prev 1988;12:421-9.
13. Sugarbaker PH. Peritoneal carcinomatosis: natural history and rational therapeutic interventions using intraperitoneal chemotherapy. Cancer Treat Res 1996;81:149-68.
14. van Rossen ME, Hofland LJ, van den Tol MP, et al. Effect of inflammatory cytokines and growth factors on tumour cell adhesion to the peritoneum. J Pathol 2001;193:530-7. (Pubitemid 32266824)
15. Laferriere J, Houle F, Huot J. Adhesion of HT-29 colon carcinoma cells to endothelial cells requires sequential events involving E-selectin and integrin beta4. Clin Exp Metastasis 2004;21:257-64.
16. Kohler S, Ullrich S, Richter U, et al. E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung. Br J Cancer 2010;102:602-9.
17. Gout S, Tremblay PL, Huot J. Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis. Clin Exp Metastasis 2008;25:335-44. (Pubitemid 351752950)
18. Tremblay PL, Huot J, Auger FA. Mechanisms by which E-selectin regulates diapedesis of colon cancer cells under flow conditions. Cancer Res 2008;68:5167-76.
19. Garcia J, Callewaert N, Borsig L. P-selectin mediates metastatic progression through binding to sulfatides on tumor cells. Glycobiology 2007;17:185-96. (Pubitemid 46152535)
20. Groves RW, Allen MH, Barker JN, et al. Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation. Br J Dermatol 1991;124:117-23.
21. Kansas GS. Selectins and their ligands: current concepts and controversies. Blood 1996;88:3259-87. (Pubitemid 26365560)
22. Morigi M, Zoja C, Figliuzzi M, et al. Fluid shear stress modulates surface expression of adhesion molecules by endothelial cells. Blood 1995;85:1696-703.
23. Sperandio M, Gleissner CA, Ley K. Glycosylation in immune cell trafficking. Immunol Rev 2009;230:97-113.
24. Paschos KA, Canovas D, Bird NC. The engagement of selectins and their ligands in colorectal cancer liver metastases. J Cell Mol Med 2010;14:165-74.
25. Klein CL, Bittinger F, Kohler H, et al. Comparative studies on vascular endothelium in vitro. 3. Effects of cytokines on the expression of E-selectin, ICAM-1 and VCAM-1 by cultured human endothelial cells obtained from different passages. Pathobiology 1995;63:83-92.
26. Wu YJ, Parker LM, Binder NE, et al. The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell 1982;31:693-703. (Pubitemid 13223952)
27. Kalinina T, Gungor C, Thieltges S, et al. Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung. BMC Cancer 2010;10:295.
28. Workman P, Aboagye EO, Balkwill F, et al. Guidelines for the welfare and use of animals in cancer research. Br J Cancer 2010;102:1555-77.
29. Sugarbaker PH. Surgical responsibilities in the management of peritoneal carcinomatosis. J Surg Oncol 2010;101:713-24.
30. Klein CL, Bittinger F, Skarke CC, et al. Effects of cytokines on the expression of cell adhesion molecules by cultured human omental mesothelial cells. Pathobiology 1995;63:204-12. (Pubitemid 26044718)
31. Iwai K, Ishikura H, Kaji M, et al. Importance of E-selectin (ELAM-1) and sialyl Lewis (a) in the adhesion of pancreatic carcinoma cells to activated endothelium. Int J Cancer 1993;54:972-7. (Pubitemid 23267471)
32. Kaji M, Ishikura H, Kishimoto T, et al. E-selectin expression induced by pancreascarcinoma- derived interleukin-1 alpha results in enhanced adhesion of pancreascarcinoma cells to endothelial cells. Int J Cancer 1995;60:712-17.
33. Koprowski H, Steplewski Z, Mitchell K, et al. Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet 1979;5:957-71. (Pubitemid 10132218)
34. Ordonez NG, Freedman RS, Herlyn M. Lewis and related tumor-associated determinants on ovarian carcinoma. Gynecol Oncol 1987;26:1-10. (Pubitemid 17213010)
35. Schuessler MH, Pintado S, Welt S, et al. Blood group and blood-group-related antigens in normal pancreas and pancreas cancer: enhanced expression of precursor type 1, Tn and sialyl-Tn in pancreas cancer. Int J Cancer 1991;47:180-7.
36. Koprowski H, Herlyn M, Steplewski Z, et al. Specific antigen in serum of patients with colon carcinoma. Science 1981;212:53-5. (Pubitemid 11114676)
37. Kondo N, Murakami Y, Uemura K, et al. Prognostic impact of Perioperative serum CA 19-9 levels in patients with resectable pancreatic cancer. Ann Surg Oncol 2010;17:2321-9.
38. Barton JG, Bois JP, Sarr MG, et al. Predictive and prognostic value of CA 19-9 in resected pancreatic adenocarcinoma. J Gastrointest Surg 2009;13:2050-8.
39. Ferrone CR, Finkelstein DM, Thayer SP, et al. Perioperative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma. J Clin Oncol 2006;24:2897-902. (Pubitemid 46630592)
40. Kinsella TJ, Seo Y, Willis J, et al. The impact of resection margin status and postoperative CA19-9 levels on survival and patterns of recurrence after postoperative high-dose radiotherapy with 5-FU-based concurrent chemotherapy for resectable pancreatic cancer. Am J Clin Oncol 2008;31:446-53.
41. Hata S, Sakamoto Y, Yamamoto Y, et al. Prognostic impact of postoperative serum CA 19-9 levels in patients with resectable pancreatic cancer. Ann Surg Oncol 2012;19:636-41.
42. Strell C, Lang K, Niggemann B, et al. Surface molecules regulating rolling and adhesion to endothelium of neutrophil granulocytes and MDA-MB-468 breast carcinoma cells and their interaction. Cell Mol Life Sci 2007;64:3306-16.
43. Alkhamesi NA, Ziprin P, Pfistermuller K, et al. ICAM-1 mediated peritoneal carcinomatosis, a target for therapeutic intervention. Clin Exp Metastasis 2005;22:449-59. (Pubitemid 41750697)
44. Lessan K, Aguiar DJ, Oegema T, et al. CD44 and beta1 integrin mediate ovarian carcinoma cell adhesion to peritoneal mesothelial cells. Am J Pathol 1999;154:1525-37. (Pubitemid 29226447)
45. Stoeck A, Schlich S, Issa Y, et al. L1 on ovarian carcinoma cells is a binding partner for Neuropilin-1 on mesothelial cells. Cancer Lett 2006;239:212-26. (Pubitemid 43974866)
46. Sawada R, Sun SM, Wu X, et al. Human monoclonal antibodies to sialyl-Lewisa (CA19.9) with potent CDC, ADCC, and antitumor activity. Clin Cancer Res 2011;17:1024-32.