Ubiquitin C-terminal hydrolase L1 is expressed in mouse pituitary gonadotropes In vivo and gonadotrope cell lines In vitro

Experimental Animals

Volumn 63, Issue 2, 2014, Pages 247-256

  Xu, Yang ^a   Hideshima, Makoto ^a   Ishii, Yoshiyuki ^a   Yoshikawa, Yasuhiro ^a   Kyuwa, Shigeru ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Gad mice; L T 2 cells; Pituitary gland; UCH L1; T3 1 cells

Indexed keywords

BETA ACTIN; CYCLIN DEPENDENT KINASE; FOLLITROPIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LUTEINIZING HORMONE; PENICILLIN DERIVATIVE; STREPTOMYCIN; UBIQUITIN THIOLESTERASE;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELLULAR DISTRIBUTION; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONTROLLED STUDY; GAMETOGENESIS; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIMARY IMMUNE RESPONSE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; CELL LINE; GONADOTROPHS; GONADS; HYPOTHALAMUS; MALE; MICE; MICE, INBRED ICR; PITUITARY GLAND; PITUITARY GLAND, ANTERIOR; REPRODUCTION; UBIQUITIN THIOLESTERASE;

EID: 84899456209     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.63.247     Document Type: Article

References (39)

1. Alarid, E.T., Windle, J.J., Whyte, D.B., and Mellon, P.L. 1996. Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development 122: 3319-3329. [Medline]
2. Baker, B.L. and Gross, D.S. 1978. Cytology and distribution of secretory cell types in the mouse hypophysis as demonstrated with immunocytochemistry. Am. J. Anat. 153: 193-215. [Medline] [CrossRef]
3. Campbell, L.K., Thomas, J.R., Lamps, L.W., Smoller, B.R., and Folpe, A.L. 2003. Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms. Mod. Pathol. 16: 963-969. [Medline] [CrossRef]
4. Doran, J.F., Jackson, P., Kynoch, P.A.M., and Thompson, R.J. 1983. Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis. J. Neurochem. 40: 1542-1547. [Medline] [CrossRef]
5. Graham, K.E., Nusser, K.D., and Low, M.J. 1999. LβT2 gonadotroph cells secrete follicle stimulating hormone (FSH) in response to activin A. J. Endocrinol. 162: R1-R5. [Medline] [CrossRef]
6. Hershko, A., and Ciechanover, A. 1998. The ubiquitin system. Annu. Rev. Biochem. 67: 425-479. [Medline] [Cross-Ref]5
7. Hochstrasser, M. 1995. Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol. 7: 215-223. [Medline] [CrossRef]
8. Horvath, E. and Kovacs, K. 1988. Fine structural cytology of the adenohypophysis in rat and man. J. Electron. Microsc. Tech. 8: 401-432. [Medline] [CrossRef]
9. Horvath, E. and Kovacs, K. 2002. Folliculo-stellate cells of the human pituitary: a type of adult stem cell? Ultrastruct. Pathol. 26: 219-228. [Medline] [CrossRef]
10. Inoue, K., Couch, E.F., Takano, K., and Ogawa, S. 1999. The structure and function of folliculo-stellate cells in the anterior pituitary gland. Arch. Histol. Cytol. 62: 205-218. [Medline] [CrossRef]
11. Kabuta, T., Mitsui, T., Takahashi, M., Fujiwara, Y., Kabuta, C., Konya, C., Tsuchiya, Y., Hatanaka, Y., Uchida, K., Hohjoh, H., and Wada, K. 2013. Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity. J. Biol. Chem. 288: 12615-12626. [Medline] [CrossRef]
12. Kent, C. and Rowe, H.L. 1992. The immunolocalisation of ubiquitin carboxyl-terminal hydrolase (PGP9.5) in developing paraneurons in the rat. Brain Res. Dev. Brain Res. 68: 241-246. [Medline] [CrossRef]
13. Kon, Y., Endoh, D., and Iwanaga, T. 1999. Expression of protein gene product 9.5, a neuronal ubiquitin C-terminal hydrolase, and its developing change in Sertoli cells of mouse testis. Mol. Reprod. Dev. 54: 333-341. [Medline] [CrossRef]
14. Koyanagi, S., Hamasaki, H., Sekiguchi, S., Hara, K., Ishii, Y., Kyuwa, S., and Yoshikawa, Y. 2012. Effects of ubiquitin C-terminal hydrolase L1 deficiency on mouse ova. Reproduction 143: 271-279. [Medline] [CrossRef]
15. Kurihara, L.J., Kikuchi, T., Wada, K., and Tilghman, S.M. 2001. Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Hum. Mol. Genet. 10: 1963-1970. [Medline] [CrossRef]
16. Kwon, J., Wang, Y.L., Setsuie, R., Sekiguchi, S., Sakurai, M., Sato, Y., Lee, W.W., Ishii, Y., Kyuwa, S., Noda, M., Wada, K., and Yoshikawa, Y. 2004a. Developmental regulation of ubiquitin C-terminal hydrolase isozyme expression during spermatogenesis in mice. Biol. Reprod. 71: 515-521. [Medline] [CrossRef]
17. Kwon, J., Wang, Y.L., Setsuie, R., Sekiguchi, S., Sato, Y., Sakurai, M., Noda, M., Aoki, S., Yoshikawa, Y., and Wada, K. 2004b. Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis. Am. J. Pathol. 165: 1367-1374. [Medline] [CrossRef]
18. Kwon, J., Mochida, K., Wang, Y.L., Sekiguchi, S., Sankai, T., Aoki, S., Ogura, A., Yoshikawa, Y., and Wada, K. 2005. Ubiquitin C-terminal hydrolase L-1 is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis. Biol. Reprod. 73: 29-35. [Medline] [CrossRef]
19. Larsen, C.N., Krantz, B.A., and Wilkinson, K.D. 1998. Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Biochemistry 37: 3358-3368. [Medline] [CrossRef]
20. Lim, S., Luo, M., Koh, M., Yang, M., bin Abdul Kadir, M.N., Tan, J.H., Ye, Z., Wang, W., and Melamed, P. 2007. Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone. Mol. Cell Biol. 27: 4105-4120. [Medline] [CrossRef]
21. Lowe, J., McDermott, H., Landon, M., Mayer, R.J., and Wilkinson, K.D. 1990. Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases. J. Pathol. 161: 153-160. [Medline] [CrossRef]
22. Osaka, H., Wang, Y.L., Takada, K., Takizawa, S., Setsuie, R., Li, H., Sato, Y., Nishikawa, K., Sun, Y.J., Sakurai, M., Harada, T., Hara, Y., Kimura, I., Chiba, S., Namikawa, K., Kiyama, H., Noda, M., Aoki, S., and Wada, K. 2003. Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum. Mol. Genet. 12: 1945-1958. [Medline] [CrossRef]
23. Osawa, Y., Wang, Y.L., Osaka, H., Aoki, S., and Wada, K. 2001. Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3. Biochem. Biophys. Res. Commun. 283: 627-633. [Medline] [CrossRef]
24. Pernasetti, F., Vasilyev, V.V., Rosenberg, S.B., Bailey, J.S., Huang, H.J., Miller, W.L., and Mellon, P.L. 2001. Cellspecific transcriptional regulation of follicle-stimulating hormone-β by activin and gonadotropin-releasing hormone in the LβT2 pituitary gonadotrope cell model. Endocrinology 142: 2284-2295. [Medline]
25. Saigoh, K., Wang, Y.L., Suh, J.G., Yamanishi, T., Sakai, Y., Kiyosawa, H., Harada, T., Ichihara, N., Wakana, S., Kikuchi, T., and Wada, K. 1999. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. Nat. Genet. 23: 47-51. [Medline] [CrossRef]
26. Sakurai, M., Ayukawa, K., Setsuie, R., Nishikawa, K., Hara, Y., Ohashi, H., Nishimoto, M., Abe, T., Kudo, Y., Sekiguchi, M., Sato, Y., Aoki, S., Noda, M., and Wada, K. 2006. Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation. J. Cell Sci. 119: 162-171. [Medline] [CrossRef]
27. Sekiguchi, S., Kwon, J., Yoshida, E., Hamasaki, H., Ichinose, S., Hideshima, M., Kuraoka, M., Takahashi, A., Ishii, Y., Kyuwa, S., Wada, K., and Yoshikawa, Y. 2006. Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy. Am. J. Pathol. 169: 1722-1729. [Medline] [CrossRef]
28. Setsuie, R. and Wada, K. 2007. The functions of UCH-L1 and its relation to neurodegenerative diseases. Neurochem. Int. 51: 105-111. [Medline] [CrossRef]
29. Susor, A., Ellederova, Z., Jelinkova, L., Halada, P., Kavan, D., Kubelka, M., and Kovarova, H. 2007. Proteomic analysis of porcine oocytes during in vitro maturation reveals essential role for the ubiquitin C-terminal hydrolase-L1. Reproduction 134: 559-568. [Medline] [CrossRef]
30. Thrower, J.S., Hoffman, L., Rechsteiner, M., and Pickart, C.M. 2000. Recognition of the polyubiquitin proteolytic signal. EMBO J. 19: 94-102. [Medline] [CrossRef]
31. Wang, Y.L., Liu, W., Sun, Y.J., Kwon, J., Setsuie, R., Osaka, H., Noda, M., Aoki, S., Yoshikawa, Y., and Wada, K. 2006. Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice. Mol. Reprod. Dev. 73: 40-49. [Medline] [CrossRef]
32. Wilkinson, K.D., Lee, K.M., Deshpande, S., Duerksen-Hughes, P., Boss, J.M., and Pohl, J. 1989. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science 246: 670-673. [Medline] [CrossRef]
33. Wilkinson, K.D. 1997. Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. FASEB J. 11: 1245-1256. [Medline]
34. Wilson, P.O.G., Barber, P.C., Hamid, Q.A., Power, B.F., Dhillon, A.P., Rode, J., Day, I.N.M., Thompson, R.J., and Polak, J.M. 1988. The immunolocalization of protein gene product 9.5 using rabbit polyclonal and mouse monoclonal antibodies. Br. J. Exp. Pathol. 69: 91-104. [Medline]
35. Windle, J.J., Weiner, R.I., and Mellon, P.L. 1990. Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol. Endocrinol. 4: 597-603. [Medline] [CrossRef]
36. Yamazaki, K., Wakasugi, N., Sakakibara, A., and Tomita, T. 1988. Reduced fertility in gracile axonal dystrophy (gad) mice. Jikken Dobutsu 37: 195-199. [Medline]
37. Yamazaki, K., Wakasugi, N., Tomita, T., Kikuchi, T., Mukoyama, M., and Ando, K. 1988. Gracile axonal dystrophy (GAD), a new neurological mutant in the mouse. Proc. Soc. Exp. Biol. Med. 187: 209-215. [Medline] [CrossRef]
38. Yasuda, T., Nihira, T., Ren, Y.R., Cao, X.Q., Wada, K., Setsuie, R., Kabuta, T., Wada, K., Hattori, N., Mizuno, Y., and Mochizuki, H. 2009. Effects of UCH-L1 on α-synuclein over-expression mouse model of Parkinson's disease. J. Neurochem. 108: 932-944. [Medline] [CrossRef]
39. Yeung, C.M., Chan, C.B., Leung, P.S., and Cheng, C.H.K. 2006. Cells of the anterior pituitary. Int. J. Biochem. Cell. Biol. 38: 1441-1449. [Medline] [CrossRef]