Regulation of apelin and its receptor expression in adipose tissues of obesity rats with hypertension and cultured 3T3-L1 adipocytes

Experimental Animals

Volumn 63, Issue 2, 2014, Pages 257-267

  Wu, Hongxian ^a,b   Cheng, Xian Wu ^b   Hao, Changning ^b   Zhang, Zhi ^a   Yao, Huali ^a   Murohara, Toyoaki ^b   Dai, Qiuyan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

3T3 L1 adipocytes; Angiotensin II; Apelin; Hypertension; Obesity

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; APELIN; APELIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HYPERTENSION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

3T3 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HYPERTENSION; IMIDAZOLES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OBESITY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SIGNAL TRANSDUCTION; TETRAZOLES;

EID: 84899450967     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.63.257     Document Type: Article

References (40)

1. Bełtowski, J. 2006. Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity? Med. Sci. Monit. 12: RA112-RA119. [Medline]
2. Bogaert, Y.E. and Linas, S. 2009. The role of obesity in the pathogenesis of hypertension. Nat. Clin. Pract. Nephrol. 5:101-111. [Medline] [CrossRef]
3. Boucher, J., Masri, B., Daviaud, D., Gesta, S., Guigné, C., Mazzucotelli, A., Castan-Laurell, I., Tack, I., Knibiehler, B., Carpéné, C., Audigier, Y., Saulnier-Blache, J.S., and Valet, P. 2005. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146: 1764-1771. [Medline] [CrossRef]
4. Boustany, C.M., Bharadwaj, K., Daugherty, A., Brown, D.R., Randall, D.C., and Cassis, L.A. 2004. Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287: R943-R949. [Medline] [CrossRef]
5. Castan-Laurell, I., Vítkova, M., Daviaud, D., Dray, C., Kováciková, M., Kovacova, Z., Hejnova, J., Stich, V., and Valet, P. 2008. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur. J. Endocrinol. 158: 905-910. [Medline] [CrossRef]
6. Cheng, X.W., Kuzuya, M., Sasaki, T., Inoue, A., Hu, L., Song, H., Huang, Z., Li, P., Takeshita, K., Hirashiki, A., Sato, K., Shi, G.P., Okumura, K., and Murohara, T. 2011. Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. J. Hypertens. 29: 542-552. [Medline] [CrossRef]
7. Daviaud, D., Boucher, J., Gesta, S., Dray, C., Guigne, C., Quilliot, D., Ayav, A., Ziegler, O., Carpene, C., Saulnier-Blache, J.S., Valet, P., and Castan-Laurell, I. 2006. TNF alpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J. 20: 1528-1530. [Medline] [CrossRef]
8. Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., and Lambert, E. 2006. Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 48: 787-796. [Medline] [CrossRef]
9. Fernández-Galilea, M., Pérez-Matute, P., Prieto-Hontoria, P., Martínez, J.A., and Moreno-Aliaga, M.J. 2011. Effects of lipoic acid on apelin in 3T3-L1 adipocytes and in high-fat fed rats. J. Physiol. Biochem. 67: 479-486. [Medline] [CrossRef]
10. Frederich, R.C. Jr., Kahn, B.B., Peach, M.J., and Flier, J.S. 1992. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension 19: 339-344. [Medline] [CrossRef]
11. Garrison, R.J., Kannel, W.B., Stokes, J. 3rd., and Castelli, W.P. 1987. Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev. Med. 16: 235-251. [Medline] [CrossRef]
12. Gurzu, B., Petrescu, B.C., Costuleanu, M., and Petrescu, G. 2006. Interactions between apelin and angiotensin II on rat portal vein. J. Renin Angiotensin Aldosterone Syst. 7: 212-216. [Medline] [CrossRef]
13. Heinonen, M.V., Purhonen, A.K., Miettinen, P., Pääkkönen, M., Pirinen, E., Alhava, E., Akerman, K., and Herzig, K.H. 2005. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul. Pept. 130: 7-13. [Medline] [CrossRef]
14. Ishida, J., Hashimoto, T., Hashimoto, Y., Nishiwaki, S., Iguchi, T., Harada, S., Sugaya, T., Matsuzaki, H., Yamamoto, R., Shiota, N., Okunishi, H., Kihara, M., Umemura, S., Sugiyama, F., Yagami, K., Kasuya, Y., Mochizuki, N., and Fukamizu, A. 2004. Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J. Biol. Chem. 279: 26274-26279. [Medline] [CrossRef]
15. Iwanaga, Y., Kihara, Y., Takenaka, H., and Kita, T. 2006. Down-regulation of cardiac apelin system in hypertrophied and failing hearts: Possible role of angiotensin II-angiotensin type 1 receptor system. J. Mol. Cell. Cardiol. 41: 798-806. [Medline] [CrossRef]
16. Japp, A.G., Cruden, N.L., Amer, D.A., Li, V.K., Goudie, E.B., Johnston, N.R., Sharma, S., Neilson, I., Webb, D.J., Megson, I.L., Flapan, A.D., and Newby, D.E. 2008. Vascular effects of apelin in vivo in man. J. Am. Coll. Cardiol. 52: 908-913. [Medline] [CrossRef]
17. Japp, A.G., Cruden, N.L., Barnes, G., van Gemeren, N., Mathews, J., Adamson, J., Johnston, N.R., Denvir, M.A., Megson, I.L., Flapan, A.D., and Newby, D.E. 2010. Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure. Circulation 121:(16): 1818-1827. [Medline] [CrossRef]
18. Kanai, H., Matsuzawa, Y., Kotani, K., Keno, Y., Kobatake, T., Nagai, Y., Fujioka, S., Tokunaga, K., and Tarui, S. 1990. Close correlation of intra-abdominal fat accumulation to hypertension in obese women. Hypertension 16: 484-490. [Medline] [CrossRef]
19. Kelly, R.B. 1985. Pathways of protein secretion in eukaryotes. Science 230: 25-32. [Medline] [CrossRef]
20. Lee, D.K., George, S.R., and O'Dowd, B.F. 2006. Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity. Trends Pharmacol. Sci. 27: 190-194. [Medline] [CrossRef]
21. Lorente-Cebrián, S., Bustos, M., Marti, A., Martinez, J.A., and Moreno-Aliaga, M.J. 2010. Eicosapentaenoic acid upregulates apelin secretion and gene expression in 3T3-L1 adipocytes. Mol. Nutr. Food Res. 54:(Suppl 1): S104-S111. [Medline] [CrossRef]
22. Mathai, M.L., Naik, S., Sinclair, A.J., Weisinger, H.S., and Weisinger, R.S. 2008. Selective reduction in body fat mass and plasma leptin induced by angiotensin-converting enzyme inhibition in rats. Int. J. Obes. 32: 1576-1584. [Medline] [CrossRef]
23. O'Dowd, B.F., Heiber, M., Chan, A., Heng, H.H., Tsui, L.C., Kennedy, J.L., Shi, X., Petronis, A., George, S.R., and Nguyen, T. 1993. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 136: 355-360. [Medline] [CrossRef]
24. Przewlocka-Kosmala, M., Kotwica, T., Mysiak, A., and Kosmala, W. 2011. Reduced circulating apelin in essential hypertension and its association with cardiac dysfunction. J Hypertens. 29: 971-979. [Medline] [CrossRef]
25. Rahmouni, K., Correia, M.L., Haynes, W.G., and Mark, A.L. 2005. Obesity-associated hypertension: new insights into mechanisms. Hypertension 45: 9-14. [Medline] [CrossRef]
26. Ronkainen, V.P., Ronkainen, J.J., Hänninen, S.L., Leskinen, H., Ruas, J.L., Pereira, T., Poellinger, L., Vuolteenaho, O., and Tavi, P. 2007. Hypoxia inducible factor regulates the cardiac expression and secretion of apelin. FASEB J. 21: 1821-1830. [Medline] [CrossRef]
27. Sironi, A.M., Gastaldelli, A., Mari, A., Ciociaro, D., Positano, V., Buzzigoli, E., Ghione, S., Turchi, S., Lombardi, M., and Ferrannini, E. 2004. Visceral fat in hypertension: influence on insulin resistance and beta-cell function. Hypertension 44: 127-133. [Medline] [CrossRef]
28. Smith, A.D., Brands, M.W., Wang, M.H., and Dorrance, A.M. 2006. Obesity-induced hypertension develops in young rats independently of the renin-angiotensin-aldosterone system. Exp. Biol. Med. (Maywood) 231: 282-287. [Medline]
29. Sonmez, A., Celebi, G., Erdem, G., Tapan, S., Genc, H., Tasci, I., Ercin, C.N., Dogru, T., Kilic, S., Uckaya, G., Yilmaz, M.I., Erbil, M.K., and Kutlu, M. 2010. Plasma apelin and ADMA Levels in patients with essential hypertension. Clin. Exp. Hypertens. 32: 179-183. [Medline] [CrossRef]
30. Tatemoto, K., Hosoya, M., Habata, Y., Fujii, R., Kakegawa, T., Zou, M.X., Kawamata, Y., Fukusumi, S., Hinuma, S., Kitada, C., Kurokawa, T., Onda, H., and Fujino, M. 1998. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem. Biophys. Res. Commun. 251: 471-476. [Medline] [CrossRef]
31. Tatemoto, K., Takayama, K., Zou, M.X., Kumaki, I., Zhang, W., Kumano, K., and Fujimiya, M. 2001. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul. Pept. 99: 87-92. [Medline] [CrossRef]
32. Than, A., Tee, W.T., and Chen, P. 2012. Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors. Mol. Cell Endocrinol. 351: 296-305. [Medline] [CrossRef]
33. Turban, S., Hainault, I., Truccolo, J., Andre, J., Ferre, P., Quignard-Boulange, A., and Guerre-Millo, M. 2002. Specific increase in leptin production in obese (fa/fa) rat adipose cells. Biochem. J. 362:(Pt 1): 113-118. [Medline] [Cross-Ref]10.1042/0264-6021:3620113
34. Wakabayashi, I. 2012. Stronger associations of obesity with prehypertension and hypertension in young women than in young men. J. Hypertens. 30: 1423-1429. [Medline] [Cross-Ref]
35. Wei, L., Hou, X., and Tatemoto, K. 2005. Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes. Regul. Pept. 132: 27-32. [Medline] [CrossRef]
36. Weisinger, R.S., Stanley, T.K., Begg, D.P., Weisinger, H.S., Spark, K.J., and Jois, M. 2009. Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet. Physiol. Behav. 98: 192-197. [Medline] [CrossRef]
37. Xie, L., Boyle, D., Sanford, D., Scherer, P.E., Pessin, J.E., and Mora, S. 2006. Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles. J. Biol. Chem. 281: 7253-7259. [Medline] [CrossRef]
38. Ye, F., Than, A., Zhao, Y., Goh, K.H., and Chen, P. 2010. Vesicular storage, vesicle trafficking, and secretion of leptin and resistin: the similarities, differences, and interplays. J. Endocrinol. 206: 27-36. [Medline] [CrossRef]
39. Zhang, J., Ren, C.X., Qi, Y.F., Lou, L.X., Chen, L., Zhang, L.K., Wang, X., and Tang, C. 2006. Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. Life Sci. 79: 1153-1159. [Medline] [CrossRef]
40. Zhong, J.C., Huang, D.Y., Liu, G.F., Jin, H.Y., Yang, Y.M., Li, Y.F., Song, X.H., and Du, K. 2005. Effects of all-trans retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive rats. Cardiovasc. Res. 65: 743-750. [Medline] [CrossRef]