-
1
-
-
84871313410
-
Association of clopidogrel pretreatment with mortality, cardiovascular events, and major bleeding among patients undergoing percutaneous coronary intervention: A systematic review and meta-analysis
-
A. Bellemain-Appaix, S. A. O'Connor, J. Silvain, M. Cucherat, F. Beygui, O. Barthelemy, J. P. Collet, L. Jacq, F. Bernasconi, G. Montalescot,. Association of clopidogrel pretreatment with mortality, cardiovascular events, and major bleeding among patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis. J. Am. Med. Assn. 2012, 308, 2507.
-
(2012)
J. Am. Med. Assn.
, vol.308
, pp. 2507
-
-
Bellemain-Appaix, A.1
O'Connor, S.A.2
Silvain, J.3
Cucherat, M.4
Beygui, F.5
Barthelemy, O.6
Collet, J.P.7
Jacq, L.8
Bernasconi, F.9
Montalescot, G.10
-
2
-
-
18644372477
-
Structure and stereochemistry of the active metabolite of clopidogrel
-
J. M. Pereillo, M. Maftouh, A. Andrieu, M. F. Uzabiaga, O. Fedeli, P. Savi, M. Pascal, J. M. Herbert, J. P. Maffrand, C. Picard,. Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab. Dispos. 2002, 30, 1288.
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 1288
-
-
Pereillo, J.M.1
Maftouh, M.2
Andrieu, A.3
Uzabiaga, M.F.4
Fedeli, O.5
Savi, P.6
Pascal, M.7
Herbert, J.M.8
Maffrand, J.P.9
Picard, C.10
-
3
-
-
84859747728
-
Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer
-
P. M. Dansette, J. Rosi, G. Bertho, D. Mansuy,. Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer. Chem. Res. Toxicol. 2012, 25, 348.
-
(2012)
Chem. Res. Toxicol.
, vol.25
, pp. 348
-
-
Dansette, P.M.1
Rosi, J.2
Bertho, G.3
Mansuy, D.4
-
4
-
-
84874423935
-
Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation
-
H. J. Zhu, X. Wang, B. E. Gawronski, B. J. Brinda, D. J. Angiolillo, J. S. Markowitz,. Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation. J. Pharmacol. Exp. Ther. 2013, 344, 665.
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.344
, pp. 665
-
-
Zhu, H.J.1
Wang, X.2
Gawronski, B.E.3
Brinda, B.J.4
Angiolillo, D.J.5
Markowitz, J.S.6
-
5
-
-
84875463958
-
The role of human carboxylesterases in drug metabolism: Have we overlooked their importance?
-
S. C. Laizure, V. L. Herring, Z. Hu, K. Witbrodt, R. B. Parker,. The role of human carboxylesterases in drug metabolism: Have we overlooked their importance? Pharmacotherapy 2013, 33, 210.
-
(2013)
Pharmacotherapy
, vol.33
, pp. 210
-
-
Laizure, S.C.1
Herring, V.L.2
Hu, Z.3
Witbrodt, K.4
Parker, R.B.5
-
6
-
-
73149119363
-
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
-
M. Kazui, Y. Nishiya, T. Ishizuka, K. Hagihara, N. A. Farid, O. Okazaki, T. Ikeda, A. Kurihara,. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab. Dispos. 2010, 38, 92.
-
(2010)
Drug Metab. Dispos.
, vol.38
, pp. 92
-
-
Kazui, M.1
Nishiya, Y.2
Ishizuka, T.3
Hagihara, K.4
Farid, N.A.5
Okazaki, O.6
Ikeda, T.7
Kurihara, A.8
-
7
-
-
78650317150
-
Genetic variability in response to clopidogrel therapy: Clinical implications
-
K. Huber,. Genetic variability in response to clopidogrel therapy: clinical implications. Eur. Heart J. 2010, 31, 2974.
-
(2010)
Eur. Heart J.
, vol.31
, pp. 2974
-
-
Huber, K.1
-
8
-
-
79955086040
-
An improved method for specific and quantitative determination of the clopidogrel active metabolite isomers in human plasma
-
G. Tuffal, S. Roy, M. Lavisse, D. Brasseur, J. Schofield, N. Delesque Touchard, P. Savi, N. Bremond, M. C. Rouchon, F. Hurbin, E. Sultan,. An improved method for specific and quantitative determination of the clopidogrel active metabolite isomers in human plasma. Thromb. Haemost. 2011, 105, 696.
-
(2011)
Thromb. Haemost.
, vol.105
, pp. 696
-
-
Tuffal, G.1
Roy, S.2
Lavisse, M.3
Brasseur, D.4
Schofield, J.5
Delesque Touchard, N.6
Savi, P.7
Bremond, N.8
Rouchon, M.C.9
Hurbin, F.10
Sultan, E.11
-
9
-
-
0033678468
-
Identification and biological activity of the active metabolite of clopidogrel
-
P. Savi, J. M. Pereillo, M. F. Uzabiaga, J. Combalbert, C. Picard, J. P. Maffrand, M. Pascal, J. M. Herbert,. Identification and biological activity of the active metabolite of clopidogrel. Thromb. Haemost. 2000, 84, 891.
-
(2000)
Thromb. Haemost.
, vol.84
, pp. 891
-
-
Savi, P.1
Pereillo, J.M.2
Uzabiaga, M.F.3
Combalbert, J.4
Picard, C.5
Maffrand, J.P.6
Pascal, M.7
Herbert, J.M.8
-
10
-
-
79960603688
-
Genetic polymorphisms and the impact of a higher clopidogrel dose regimen on active metabolite exposure and antiplatelet response in healthy subjects
-
T. Simon, D. L. Bhatt, L. Bergougnan, C. Farenc, K. Pearson, L. Perrin, E. Vicaut, F. Lacreta, F. Hurbin, M. Dubar,. Genetic polymorphisms and the impact of a higher clopidogrel dose regimen on active metabolite exposure and antiplatelet response in healthy subjects. Clin. Pharmacol. Ther. 2011, 90, 287.
-
(2011)
Clin. Pharmacol. Ther.
, vol.90
, pp. 287
-
-
Simon, T.1
Bhatt, D.L.2
Bergougnan, L.3
Farenc, C.4
Pearson, K.5
Perrin, L.6
Vicaut, E.7
Lacreta, F.8
Hurbin, F.9
Dubar, M.10
-
11
-
-
33847639764
-
Influence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics
-
K. S. Patrick, A. B. Straughn, R. R. Minhinnett, S. D. Yeatts, A. E. Herrin, C. L. DeVane, R. Malcolm, G. C. Janis, J. S. Markowitz,. Influence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics. Clin. Pharmacol. Ther. 2007, 81, 346.
-
(2007)
Clin. Pharmacol. Ther.
, vol.81
, pp. 346
-
-
Patrick, K.S.1
Straughn, A.B.2
Minhinnett, R.R.3
Yeatts, S.D.4
Herrin, A.E.5
Devane, C.L.6
Malcolm, R.7
Janis, G.C.8
Markowitz, J.S.9
-
12
-
-
76149144764
-
The effect of ethanol on oral cocaine pharmacokinetics reveals an unrecognized class of ethanol-mediated drug interactions
-
R. B. Parker, S. C. Laizure,. The effect of ethanol on oral cocaine pharmacokinetics reveals an unrecognized class of ethanol-mediated drug interactions. Drug Metab. Dispos. 2010, 38, 317.
-
(2010)
Drug Metab. Dispos.
, vol.38
, pp. 317
-
-
Parker, R.B.1
Laizure, S.C.2
-
13
-
-
0027469977
-
Concurrent cocaine-ethanol ingestion in humans: Pharmacology, physiology, behavior, and the role of cocaethylene
-
E. F. McCance-Katz, L. H. Price, C. J. McDougle, T. R. Kosten, J. E. Black, P. I. Jatlow,. Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene. Psychopharmacology (Berl.) 1993, 111, 39.
-
(1993)
Psychopharmacology (Berl.)
, vol.111
, pp. 39
-
-
McCance-Katz, E.F.1
Price, L.H.2
McDougle, C.J.3
Kosten, T.R.4
Black, J.E.5
Jatlow, P.I.6
-
14
-
-
0038347311
-
Cocaethylene metabolism and interaction with cocaine and ethanol: Role of carboxylesterases
-
S. C. Laizure, T. Mandrell, N. M. Gades, R. B. Parker,. Cocaethylene metabolism and interaction with cocaine and ethanol: role of carboxylesterases. Drug Metab. Dispos. 2003, 31, 16.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 16
-
-
Laizure, S.C.1
Mandrell, T.2
Gades, N.M.3
Parker, R.B.4
-
15
-
-
33751171573
-
Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol
-
M. Tang, M. Mukundan, J. Yang, N. Charpentier, E. L. LeCluyse, C. Black, D. Yang, D. Shi, B. Yan,. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. J Pharmacol. Exp. Ther. 2006, 319, 1467.
-
(2006)
J Pharmacol. Exp. Ther.
, vol.319
, pp. 1467
-
-
Tang, M.1
Mukundan, M.2
Yang, J.3
Charpentier, N.4
Lecluyse, E.L.5
Black, C.6
Yang, D.7
Shi, D.8
Yan, B.9
-
16
-
-
84874638172
-
Selective tumor cell targeting by the disaccharide moiety of bleomycin
-
Z. Q. Yu, R. M. Schmaltz, T. C. Bozeman, R. Paul, M. J. Rishel, K. S. Tsosie, S. M. Hecht,. Selective tumor cell targeting by the disaccharide moiety of bleomycin. J. Am. Chem. Soc. 2013, 135, 2883.
-
(2013)
J. Am. Chem. Soc
, vol.135
, pp. 2883
-
-
Yu, Z.Q.1
Schmaltz, R.M.2
Bozeman, T.C.3
Paul, R.4
Rishel, M.J.5
Tsosie, K.S.6
Hecht, S.M.7
-
17
-
-
39649112160
-
A selective fluorescence reaction for peptides and chromatographic analysis
-
T. Kabashima, Z. Q Yu, C. H. Tang, Y. Nakagawa, K. Okumura, T. Shibata, J. Z. Lu, M. Kai,. A selective fluorescence reaction for peptides and chromatographic analysis. Peptides. 2008, 29, 356.
-
(2008)
Peptides
, vol.29
, pp. 356
-
-
Kabashima, T.1
Yu, Z.Q.2
Tang, C.H.3
Nakagawa, Y.4
Okumura, K.5
Shibata, T.6
Lu, J.Z.7
Kai, M.8
-
18
-
-
84877812890
-
A validated HPLC-MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: Application to a clinical pharmacokinetic study
-
M. T. Furlong, I. Savant, M. Yuan, L. Scott, W. Mylott, T. Mariannino, P. Kadiyala, V. Roongta, M. E. Arnold,. A validated HPLC-MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: application to a clinical pharmacokinetic study. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2013, 926, 36.
-
(2013)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.926
, pp. 36
-
-
Furlong, M.T.1
Savant, I.2
Yuan, M.3
Scott, L.4
Mylott, W.5
Mariannino, T.6
Kadiyala, P.7
Roongta, V.8
Arnold, M.E.9
-
19
-
-
84870477806
-
HPLC-MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples
-
M. Karazniewicz-Lada, D. Danielak, A. Tezyk, C. Zaba, G. Tuffal, F. Glowka,. HPLC-MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2012, 911, 105.
-
(2012)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.911
, pp. 105
-
-
Karazniewicz-Lada, M.1
Danielak, D.2
Tezyk, A.3
Zaba, C.4
Tuffal, G.5
Glowka, F.6
-
20
-
-
17444395255
-
Synthesis and pharmacology of ethylphenidate enantiomers: The human transesterification metabolite of methylphenidate and ethanol
-
K. S. Patrick, R. L. Williard, A. L. VanWert, J. J. Dowd, J. E. Oatis, Jr., L. D. Middaugh,. Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol. J. Med. Chem. 2005, 48, 2876.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 2876
-
-
Patrick, K.S.1
Williard, R.L.2
Vanwert, A.L.3
Dowd, J.J.4
Oatis Jr., J.E.5
Middaugh, L.D.6
-
21
-
-
0033617182
-
Cocaethylene formation in rat, dog, and human hepatic microsomes
-
N. Song, R. B. Parker, S. C. Laizure,. Cocaethylene formation in rat, dog, and human hepatic microsomes. Life Sci. 1999, 64, 2101.
-
(1999)
Life Sci.
, vol.64
, pp. 2101
-
-
Song, N.1
Parker, R.B.2
Laizure, S.C.3
-
22
-
-
84873702919
-
Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism
-
Z. Y. Hu, R. B. Parker, V. L. Herring, S. C. Laizure,. Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal. Bioanal. Chem. 2013, 405, 1695.
-
(2013)
Anal. Bioanal. Chem.
, vol.405
, pp. 1695
-
-
Hu, Z.Y.1
Parker, R.B.2
Herring, V.L.3
Laizure, S.C.4
|