Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability

Oncogene

Volumn 33, Issue 15, 2014, Pages 2004-2010

  Kim, H ^a   Claps, G ^a   Moller A ^b   Bowtell, D ^b,c   Lu, X ^d   Ronai, Z A ^a  

^a BURNHAM INSTITUTE   (United States)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

ASPP2; epithelial polarity; hypoxia; Siah2; tight junction

Indexed keywords

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL HYPOXIA; CELL POLARITY; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROBLASTS; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MICE; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIGHT JUNCTIONS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 84899436854     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.149     Document Type: Article

References (31)

1. House CM, Moller A, Bowtell DD. Siah proteins: Novel drug targets in the Ras and hypoxia pathways. Cancer Res 2009; 69: 8835-8838
2. Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, et al. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 2004; 117: 941-952
3. Calzado MA, De la Vega L, Munoz E, Schmitz ML. Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation. Biol Chem 2009; 390: 1079-1083
4. Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, et al. Fine-Tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell 2011; 44: 532-544
5. Li S, Li Y, Carthew RW, Lai ZC. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Cell 1997; 90: 469-478
6. Schmidt RL, Park CH, Ahmed AU, Gundelach JH, Reed NR, Cheng S, et al. Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. Cancer Res 2007; 67: 11798-11810
7. Ahmed AU, Schmidt RL, Park CH, Reed NR, Hesse SE, Thomas CF, et al. Effect of disrupting seven-in-Absentia homolog 2 function on lung cancer cell growth. J Natl Cancer Inst 2008; 100: 1606-1629
8. Qi J, Nakayama K, Gaitonde S, Goydos JS, Krajewski S, Eroshkin A, et al. The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and-independent pathways. Proc Natl Acad Sci USA 2008; 105: 16713-16718
9. Qi J, Nakayama K, Cardiff RD, Borowsky AD, Kaul K, Williams R, et al. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell 2010; 18: 23-38
10. Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK, Zhong S, et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 2001; 8: 781-794
11. Vives V, Su J, Zhong S, Ratnayaka I, Slee E, Goldin R, et al. ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev 2006; 20: 1262-1267
12. Kampa KM, Acoba JD, Chen D, Gay J, Lee H, Beemer K, et al. Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci USA 2009; 106: 4390-4395
13. Langton PF, Colombani J, Chan EH, Wepf A, Gstaiger M, Tapon N. The dASPPdRASSF8 complex regulates cell-cell adhesion during Drosophila retinal morphogenesis. Curr Biol 2009; 19: 1969-1978
14. Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K, Hirano H, et al. ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol 2010; 20: 1408-1414
15. Sottocornola R, Royer C, Vives V, Tordella L, Zhong S, Wang Y, et al. ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. Dev Cell 2010; 19: 126-137
16. Chen D, Padiernos E, Ding F, Lossos IS, Lopez CD. Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene. Cell Death Differ 2005; 12: 358-368
17. Fogal V, Kartasheva NN, Trigiante G, Llanos S, Yap D, Vousden KH, et al. ASPP1 and ASPP2 are new transcriptional targets of E2F. Cell Death Differ 2005; 12: 369-376
18. Liu ZJ, Lu X, Zhang Y, Zhong S, Gu SZ, Zhang XB, et al. Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-Type p53. FEBS Lett 2005; 579: 1587-1590
19. Zhu Z, Ramos J, Kampa K, Adimoolam S, Sirisawad M, Yu Z, et al. Control of ASPP2/ (53BP2L) protein levels by proteasomal degradation modulates p53 apoptotic function. J Biol Chem 2005; 280: 34473-34480
20. Habelhah H, Laine A, Erdjument-Bromage H, Tempst P, Gershwin ME, Bowtell DD, et al. Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah. J Biol Chem 2004; 279: 53782-53788
21. Szczepanowski M, Adam-Klages S, Kruse ML, Pollmann M, Klapper W, Parwaresch R, et al. Regulation of repp86 stability by human Siah2. Biochem Biophys Res Commun 2007; 362: 485-490
22. Sen N, Hara MR, Kornberg MD, Cascio MB, Bae BI, Shahani N, et al. Nitric oxideinduced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol 2008; 10: 866-873
23. House CM, Frew IJ, Huang HL, Wiche G, Traficante N, Nice E, et al. A binding motif for Siah ubiquitin ligase. Proc Natl Acad Sci USA 2003; 100: 3101-3106
24. Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet 2003; 33: 162-167
25. Moller A, House CM, Wong CS, Scanlon DB, Liu MC, Ronai Z, et al. Inhibition of Siah ubiquitin ligase function. Oncogene 2009; 28: 289-296
26. Feigin ME, Muthuswamy SK. Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol 2009; 21: 694-700
27. Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 2005; 307: 1603-1609
28. Bryant DM, Datta A, Rodriguez-Fraticelli AE, Peranen J, Martin-Belmonte F, Mostov KE. A molecular network for De novo generation of the apical surface and lumen. Nat Cell Biol 2010; 12: 1035-1045
29. Viloria-Petit AM, David L, Jia JY, Erdemir T, Bane AL, Pinnaduwage D, et al. A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci USA 2009; 106: 14028-14033
30. Chen M, Gutierrez GJ, Ronai ZA. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. Proc Natl Acad Sci USA 2011; 108: 9119-9124
31. Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003; 30: 256-268