-
1
-
-
0030840464
-
STATs and gene regulation
-
Darnell, J.E., Jr. STATs and gene regulation. Science 1997, 277, 1630-1635.
-
(1997)
Science
, vol.277
, pp. 1630-1635
-
-
Darnell Jr., J.E.1
-
2
-
-
0035313701
-
The Stat family in cytokine signaling
-
Ihle, J.N. The Stat family in cytokine signaling. Curr. Opin. Cell Biol. 2001, 13, 211-217.
-
(2001)
Curr. Opin. Cell Biol
, vol.13
, pp. 211-217
-
-
Ihle, J.N.1
-
3
-
-
70350500225
-
STATs in cancer inflammation and immunity: A leading role for STAT3
-
Yu, H.; Pardoll, D.; Jove, R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat. Rev. Cancer 2009, 9, 798-809.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
4
-
-
67649988989
-
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation
-
Gough, D.J.; Corlett, A.; Schlessinger, K.; Wegrzyn, J.; Larner, A.C.; Levy, D.E. Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 2009, 324, 1713-1716.
-
(2009)
Science
, vol.324
, pp. 1713-1716
-
-
Gough, D.J.1
Corlett, A.2
Schlessinger, K.3
Wegrzyn, J.4
Larner, A.C.5
Levy, D.E.6
-
5
-
-
84886678359
-
Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727
-
Zhang, Q.; Raje, V.; Yakovlev, V.A.; Yacoub, A.; Szczepanek, K.; Meier, J.; Derecka, M.; Chen, Q.; Hu, Y.; Sisler, J. Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727. J. Biol. Chem. 2013, 288, 31280-31288.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 31280-31288
-
-
Zhang, Q.1
Raje, V.2
Yakovlev, V.A.3
Yacoub, A.4
Szczepanek, K.5
Meier, J.6
Derecka, M.7
Chen, Q.8
Hu, Y.9
Sisler, J.10
-
6
-
-
0038673854
-
STAT signaling in cancer: Insights into pathogenesis and treatment strategies
-
Frank, D.A. STAT signaling in cancer: Insights into pathogenesis and treatment strategies. Cancer Treat. Res. 2003, 115, 267-291.
-
(2003)
Cancer Treat. Res
, vol.115
, pp. 267-291
-
-
Frank, D.A.1
-
7
-
-
84871862427
-
STAT3 negatively regulates thyroid tumorigenesis
-
Couto, J.P.; Daly, L.; Almeida, A.; Knauf, J.A.; Fagin, J.A.; Sobrinho-Simões, M.; Lima, J.; Máximo, V.; Soares, P.; Lyden, D. STAT3 negatively regulates thyroid tumorigenesis. Proc. Natl. Acad. Sci. USA 2012, 109, E2361-E2370.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
-
-
Couto, J.P.1
Daly, L.2
Almeida, A.3
Knauf, J.A.4
Fagin, J.A.5
Sobrinho-Simões, M.6
Lima, J.7
Máximo, V.8
Soares, P.9
Lyden, D.10
-
8
-
-
39449093328
-
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
-
De la Iglesia, N.; Konopka, G.; Puram, S.V.; Chan, J.A.; Bachoo, R.M.; You, M.J.; Levy, D.E.; Depinho, R.A.; Bonni, A. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 2008, 22, 449-462.
-
(2008)
Genes Dev
, vol.22
, pp. 449-462
-
-
De la Iglesia, N.1
Konopka, G.2
Puram, S.V.3
Chan, J.A.4
Bachoo, R.M.5
You, M.J.6
Levy, D.E.7
Depinho, R.A.8
Bonni, A.9
-
9
-
-
84860760469
-
Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis
-
Sonnenblick, A.; Shriki, A.; Galun, E.; Axelrod, J.H.; Daum, H.; Rottenberg, Y.; Hamburger, T.; Mali, B.; Peretz, T. Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis. Clin. Transl. Oncol. 2012, 14, 232-236.
-
(2012)
Clin. Transl. Oncol
, vol.14
, pp. 232-236
-
-
Sonnenblick, A.1
Shriki, A.2
Galun, E.3
Axelrod, J.H.4
Daum, H.5
Rottenberg, Y.6
Hamburger, T.7
Mali, B.8
Peretz, T.9
-
10
-
-
84880271158
-
Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma
-
Gordziel, C.; Bratsch, J.; Moriggl, R.; Knösel, T.; Friedrich, K. Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma. Br. J. Cancer 2013, 109, 138-146.
-
(2013)
Br. J. Cancer
, vol.109
, pp. 138-146
-
-
Gordziel, C.1
Bratsch, J.2
Moriggl, R.3
Knösel, T.4
Friedrich, K.5
-
11
-
-
20444446371
-
Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors
-
Alvarez, J.V.; Febbo, P.G.; Ramaswamy, S.; Loda, M.; Richardson, A.; Frank, D.A. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res. 2005, 65, 5054-5062.
-
(2005)
Cancer Res
, vol.65
, pp. 5054-5062
-
-
Alvarez, J.V.1
Febbo, P.G.2
Ramaswamy, S.3
Loda, M.4
Richardson, A.5
Frank, D.A.6
-
12
-
-
84893395880
-
STAT signaling in the pathogenesis and treatment of myeloid malignancies
-
Bar-Natan, M.; Nelson, E.A.; Xiang, M.; Frank, D.A. STAT signaling in the pathogenesis and treatment of myeloid malignancies. JAKSTAT 2012, 1, 55-64.
-
(2012)
JAKSTAT
, vol.1
, pp. 55-64
-
-
Bar-Natan, M.1
Nelson, E.A.2
Xiang, M.3
Frank, D.A.4
-
13
-
-
34247600538
-
STAT3 as a central mediator of neoplastic cellular transformation
-
Frank, D.A. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett. 2007, 251, 199-210.
-
(2007)
Cancer Lett
, vol.251
, pp. 199-210
-
-
Frank, D.A.1
-
14
-
-
0027993605
-
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
-
Gouilleux, F.; Wakao, H.; Mundt, M.; Groner, B. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J. 1994, 13, 4361-4369.
-
(1994)
EMBO J
, vol.13
, pp. 4361-4369
-
-
Gouilleux, F.1
Wakao, H.2
Mundt, M.3
Groner, B.4
-
15
-
-
0028217452
-
Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
-
Wakao, H.; Gouilleux, F.; Groner, B. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 1994, 13, 2182-2191.
-
(1994)
EMBO J
, vol.13
, pp. 2182-2191
-
-
Wakao, H.1
Gouilleux, F.2
Groner, B.3
-
16
-
-
0029115640
-
Cloning and expression of stat5 and an additional homologue (stat5b) involved in prolactin signal transduction in mouse mammary tissue
-
Liu, X.; Robinson, G.W.; Gouilleux, F.; Groner, B.; Hennighausen, L. Cloning and expression of stat5 and an additional homologue (stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci. USA 1995, 92, 8831-8835.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8831-8835
-
-
Liu, X.1
Robinson, G.W.2
Gouilleux, F.3
Groner, B.4
Hennighausen, L.5
-
17
-
-
0034469415
-
Linear and cooperative signaling: Roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium
-
Groner, B.; Hennighausen, L. Linear and cooperative signaling: Roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium. Breast Cancer Res. 2000, 2, 149-153.
-
(2000)
Breast Cancer Res
, vol.2
, pp. 149-153
-
-
Groner, B.1
Hennighausen, L.2
-
18
-
-
33748158716
-
The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition
-
Desrivieres, S.; Kunz, C.; Barash, I.; Vafaizadeh, V.; Borghouts, C.; Groner, B. The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition. J. Mammary Gland Biol. Neoplasia 2006, 11, 75-87.
-
(2006)
J. Mammary Gland Biol. Neoplasia
, vol.11
, pp. 75-87
-
-
Desrivieres, S.1
Kunz, C.2
Barash, I.3
Vafaizadeh, V.4
Borghouts, C.5
Groner, B.6
-
19
-
-
67649619334
-
Reciprocal effects of STAT5 and STAT3 in breast cancer
-
Walker, S.R.; Nelson, E.A.; Zou, L.; Chaudhury, M.; Signoretti, S.; Richardson, A.; Frank, D.A. Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol. Cancer Res. 2009, 7, 966-976.
-
(2009)
Mol. Cancer Res
, vol.7
, pp. 966-976
-
-
Walker, S.R.1
Nelson, E.A.2
Zou, L.3
Chaudhury, M.4
Signoretti, S.5
Richardson, A.6
Frank, D.A.7
-
20
-
-
4644279718
-
Plasma prolactin concentrations and risk of postmenopausal breast cancer
-
Tworoger, S.S.; Eliassen, A.H.; Rosner, B.; Sluss, P.; Hankinson, S.E. Plasma prolactin concentrations and risk of postmenopausal breast cancer. Cancer Res. 2004, 64, 6814-6819.
-
(2004)
Cancer Res
, vol.64
, pp. 6814-6819
-
-
Tworoger, S.S.1
Eliassen, A.H.2
Rosner, B.3
Sluss, P.4
Hankinson, S.E.5
-
21
-
-
84888302680
-
Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer
-
Walker, S.R.; Xiang, M.; Frank, D.A. Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer. Mol. Cell. Endocrinol. 2014, 382, 616-621.
-
(2014)
Mol. Cell. Endocrinol
, vol.382
, pp. 616-621
-
-
Walker, S.R.1
Xiang, M.2
Frank, D.A.3
-
22
-
-
84880677334
-
STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6
-
Walker, S.R.; Nelson, E.A.; Yeh, J.E.; Pinello, L.; Yuan, G.-C.; Frank, D.A. STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6. Mol. Cell. Biol. 2013, 33, 2879-2890.
-
(2013)
Mol. Cell. Biol
, vol.33
, pp. 2879-2890
-
-
Walker, S.R.1
Nelson, E.A.2
Yeh, J.E.3
Pinello, L.4
Yuan, G.-C.5
Frank, D.A.6
-
23
-
-
85027912667
-
The transcriptional modulator BCL6 as a molecular target for breast cancer therapy
-
in press
-
Walker, S.R.; Liu, S.; Xiang, M.; Nicolais, M.; Hatzi, K.; Giannopoulou, E.; Elemento, O.; Cerchietti, L.; Melnick, A.; Frank, D.A. The transcriptional modulator BCL6 as a molecular target for breast cancer therapy. Oncogene 2014, in press.
-
(2014)
Oncogene
-
-
Walker, S.R.1
Liu, S.2
Xiang, M.3
Nicolais, M.4
Hatzi, K.5
Giannopoulou, E.6
Elemento, O.7
Cerchietti, L.8
Melnick, A.9
Frank, D.A.10
-
24
-
-
0035042611
-
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
-
Yoshikawa, H.; Matsubara, K.; Qian, G.S.; Jackson, P.; Groopman, J.D.; Manning, J.E.; Harris, C.C.; Herman, J.G. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat. Genet. 2001, 28, 29-35.
-
(2001)
Nat. Genet
, vol.28
, pp. 29-35
-
-
Yoshikawa, H.1
Matsubara, K.2
Qian, G.S.3
Jackson, P.4
Groopman, J.D.5
Manning, J.E.6
Harris, C.C.7
Herman, J.G.8
-
25
-
-
33644867711
-
Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas
-
Lee, T.L.; Yeh, J.; van Waes, C.; Chen, Z. Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas. Mol. Cancer Ther. 2006, 5, 8-19.
-
(2006)
Mol. Cancer Ther
, vol.5
, pp. 8-19
-
-
Lee, T.L.1
Yeh, J.2
van Waes, C.3
Chen, Z.4
-
26
-
-
0038784365
-
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
-
Galm, O.; Yoshikawa, H.; Esteller, M.; Osieka, R.; Herman, J.G. SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood 2003, 101, 2784-2788.
-
(2003)
Blood
, vol.101
, pp. 2784-2788
-
-
Galm, O.1
Yoshikawa, H.2
Esteller, M.3
Osieka, R.4
Herman, J.G.5
-
27
-
-
2942584857
-
SOCS1 and SHP1 hypermethylation in multiple myeloma: Implications for epigenetic activation of the Jak/STAT pathway
-
Chim, C.S.; Fung, T.K.; Cheung, W.C.; Liang, R.; Kwong, Y.L. SOCS1 and SHP1 hypermethylation in multiple myeloma: Implications for epigenetic activation of the Jak/STAT pathway. Blood 2004, 103, 4630-4635.
-
(2004)
Blood
, vol.103
, pp. 4630-4635
-
-
Chim, C.S.1
Fung, T.K.2
Cheung, W.C.3
Liang, R.4
Kwong, Y.L.5
-
28
-
-
0037043125
-
Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer
-
Gilmore, T.; Gapuzan, M.E.; Kalaitzidis, D.; Starczynowski, D. Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer. Cancer Lett. 2002, 181, 1-9.
-
(2002)
Cancer Lett
, vol.181
, pp. 1-9
-
-
Gilmore, T.1
Gapuzan, M.E.2
Kalaitzidis, D.3
Starczynowski, D.4
-
29
-
-
84858126071
-
MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review
-
Iorio, M.V.; Croce, C.M. MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol. Med. 2012, 4, 143-159.
-
(2012)
EMBO Mol. Med
, vol.4
, pp. 143-159
-
-
Iorio, M.V.1
Croce, C.M.2
-
30
-
-
79951516643
-
MicroRNA-21 expression in CD4+ T Cells is regulated by STAT3 and is pathologically involved in sézary syndrome
-
Van der Fits, L.; van Kester, M.S.; Qin, Y.; Out-Luiting, J.J.; Smit, F.; Zoutman, W.H.; Willemze, R.; Tensen, C.P.; Vermeer, M.H. MicroRNA-21 expression in CD4+ T Cells is regulated by STAT3 and is pathologically involved in sézary syndrome. J. Investig. Dermatol. 2010, 131, 762-768.
-
(2010)
J. Investig. Dermatol
, vol.131
, pp. 762-768
-
-
Van der Fits, L.1
van Kester, M.S.2
Qin, Y.3
Out-Luiting, J.J.4
Smit, F.5
Zoutman, W.H.6
Willemze, R.7
Tensen, C.P.8
Vermeer, M.H.9
-
31
-
-
84863526545
-
Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating Glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
-
Wang, B.; Hsu, S.H.; Frankel, W.; Ghoshal, K.; Jacob, S.T. Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating Glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. Hepatology 2012, 56, 186-197.
-
(2012)
Hepatology
, vol.56
, pp. 186-197
-
-
Wang, B.1
Hsu, S.H.2
Frankel, W.3
Ghoshal, K.4
Jacob, S.T.5
-
32
-
-
84878351462
-
Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells
-
Rozovski, U.; Calin, G.A.; Setoyama, T.; D'Abundo, L.; Harris, D.M.; Li, P.; Liu, Z.; Grgurevic, S.; Ferrajoli, A.; Faderl, S. Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells. Mol. Cancer 2013, 12, e50.
-
(2013)
Mol. Cancer
, vol.12
-
-
Rozovski, U.1
Calin, G.A.2
Setoyama, T.3
D'Abundo, L.4
Harris, D.M.5
Li, P.6
Liu, Z.7
Grgurevic, S.8
Ferrajoli, A.9
Faderl, S.10
-
33
-
-
79956105175
-
STAT3 mediates resistance to MEK inhibitor through microRNA miR-17
-
Dai, B.; Meng, J.; Peyton, M.; Girard, L.; Bornmann, W.G.; Ji, L.; Minna, J.D.; Fang, B.; Roth, J.A. STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. Cancer Res. 2011, 71, 3658-3668.
-
(2011)
Cancer Res
, vol.71
, pp. 3658-3668
-
-
Dai, B.1
Meng, J.2
Peyton, M.3
Girard, L.4
Bornmann, W.G.5
Ji, L.6
Minna, J.D.7
Fang, B.8
Roth, J.A.9
-
34
-
-
84899413852
-
STAT3-regulated MiR-146b forms a feedback circuit to counteract the NF-κB/IL-6 axis and STAT3-driven cancer phenotypes
-
in press
-
Xiang, M.; Birkbak, N.J.; Vafaizadeh, V.; Walker, S.R.; Yeh, J.E.; Liu, S.; Kroll, Y.; Boldin, M.; Taganov, K.; Groner, B.; et al. STAT3-regulated MiR-146b forms a feedback circuit to counteract the NF-κB/IL-6 axis and STAT3-driven cancer phenotypes. Sci. Signal. 2014, in press.
-
Sci. Signal
-
-
Xiang, M.1
Birkbak, N.J.2
Vafaizadeh, V.3
Walker, S.R.4
Yeh, J.E.5
Liu, S.6
Kroll, Y.7
Boldin, M.8
Taganov, K.9
Groner, B.10
-
35
-
-
33747608638
-
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
-
Taganov, K.D.; Boldin, M.P.; Chang, K.J.; Baltimore, D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA 2006, 103, 12481-12486.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 12481-12486
-
-
Taganov, K.D.1
Boldin, M.P.2
Chang, K.J.3
Baltimore, D.4
|