A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma

Blood

Volumn 123, Issue 8, 2014, Pages 1187-1198

  Salaverria, Itziar ^a,b   Martin Guerrero, Idoia ^a,c   Wagener, Rabea ^a   Kreuz, Markus ^d   Kohler, Christian W ^e   Richter, Julia ^a   Pienkowska Grela, Barbara ^f   Adam, Patrick ^g   Burkhardt, Birgit ^h   Claviez, Alexander ^a   Damm Welk, Christine ⁱ   Drexler, Hans G ^j   Hummel, Michael ^k   Jaffe, Elaine S ^l   Kup̈pers, Ralf ^m   Lefebvre, Christine ⁿ   Lisfeld, Jasmin ⁱ   Lof̈fler, Markus ^d   Macleod, Roderick A F ^j   Nagel, Inga ^a   Oschlies, Ilske ^a   Rosolowski, Maciej ^d   Russell, Robert B ^o   Rymkiewicz, Grzegorz ^f   Schindler, Detlev ^p   Schlesner, Matthias ^q   Scholtysik, René ^m   Schwaenen, Carsten ^r   Spang, Rainer ^e   Szczepanowski, Monika ^a   Trum̈per, Lorenz ^s   Vater, Inga ^a   Wessendorf, Swen ^r   Klapper, Wolfram ^a   Siebert, Reiner ^a   more..

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e UNIVERSITY OF REGENSBURG   (Germany)

^f INSTITUTE OF ONCOLOGY   (Poland)

^g UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^h UNIVERSITY HOSPITAL MÜNSTER   (Germany)

ⁱ JUSTUS LIEBIG UNIVERSITY   (Germany)

^j LEIBNIZ INSTITUTE DSMZ GERMAN COLLECTION OF MICROORGANISMS AND CELL CULTURES   (Germany)

^k CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^l NATIONAL CANCER INSTITUTE   (United States)

^m UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

ⁿ Biology and Pathology Institute   (France)

^o UNIVERSITY OF HEIDELBERG   (Germany)

^p UNIVERSITY OF WÜRZBURG   (Germany)

^q GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^r KLINIKUM ESSLINGEN   (Germany)

^s UNIVERSITY OF GÖTTINGEN   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; B CELL LYMPHOMA; BURKITT LYMPHOMA; CHILD; CHROMOSOME 11Q; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CLINICAL FEATURE; DISEASE ASSOCIATION; FEMALE; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TELOMERE; YOUNG ADULT; B LYMPHOCYTE; CANCER GRADING; CELL LINE; CHROMOSOME 11; CHROMOSOME 14; CHROMOSOME 8; CLASSIFICATION; GENE EXPRESSION REGULATION; GENETICS; ONCOGENE MYC; PATHOLOGY; PHYSIOLOGY; RECURRENT DISEASE;

ADOLESCENT; ADULT; AGED; B-LYMPHOCYTES; BURKITT LYMPHOMA; CELL LINE; CHILD; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 8; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HUMANS; MALE; NEOPLASM GRADING; RECURRENCE; TRANSLOCATION, GENETIC; YOUNG ADULT;

EID: 84899137727     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-06-507996     Document Type: Article

References (46)

1. Swerdlow S, Campo E, Harris N, et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. IARC Lyon; 2008.
2. Boxer LM, Dang CV. Translocations involving c-myc and c-myc function. Oncogene. 2001;20(40):5595-5610. (Pubitemid 32928100)
3. Hecht JL, Aster JC. Molecular biology of Burkitt's lymphoma. J Clin Oncol. 2000;18(21):3707-3721.
4. Salaverria I, Siebert R. The gray zone between Burkitt's lymphoma and diffuse large B-cell lymphoma from a genetics perspective. J Clin Oncol. 2011;29(14):1835-1843.
5. Leucci E, Cocco M, Onnis A, et al. MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation. J Pathol. 2008;216(4):440-450.
6. Aukema SM, Siebert R, Schuuring E, et al. Double-hit B-cell lymphomas. Blood. 2011;117(8):2319-2331.
7. Hummel M, Bentink S, Berger H, et al; Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med. 2006;354(23):2419-2430. (Pubitemid 43855045)
8. Pienkowska-Grela B, Rymkiewicz G, Grygalewicz B, et al. Partial trisomy 11, dup(11)(q23q13), as a defect characterizing lymphomas with Burkitt pathomorphology without MYC gene rearrangement. Med Oncol. 2011;28(4):1589-1595.
9. Rymkiewicz G, Walewski J, Blachnio K, et al. MYC negative BL with a partial trisomy 11, dup (11)(q23.3q13.1). Can inverted duplication of CCND1, ATM and MLL genes be a substitute for MYC translocations? Unpublished. 2013.
10. Einerson RR, Law ME, Blair HE, et al. Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2. Leukemia. 2006;20(10):1790- 1799. (Pubitemid 44574990)
11. Poirel HA, Cairo MS, Heerema NA, et al; FAB/LMB 96 International Study Committee. Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB/LMB 96 international study. Leukemia. 2009;23(2):323-331.
12. Bentink S, Wessendorf S, Schwaenen C, et al; Molecular Mechanisms in Malignant Lymphomas Network Project of the. Pathway activation patterns in diffuse large B-cell lymphomas. Leukemia. 2008;22(9):1746-1754.
13. Martin-Guerrero I, Salaverria I, Burkhardt B, et al. Recurrent loss of heterozygosity in 1p36 associated with TNFRSF14 mutations in IRF4 translocation negative pediatric follicular lymphomas. Haematologica. 2013;98(8):1237-1241.
14. Oschlies I, Salaverria I, Mahn F, et al. Pediatric follicular lymphoma - a clinico-pathological study of a population-based series of patients treated within the Non-Hodgkin's Lymphoma - Berlin-Frankfurt-Munster (NHL-BFM) multicenter trials. Haematologica. 2010;95(2):253-259.
15. Harder L, Gesk S, Martin-Subero JI, et al. Cytogenetic and molecular characterization of simultaneous chronic and acute myelocytic leukemia. Cancer Genet Cytogenet. 2003;142(1):80-82. (Pubitemid 36349270)
16. Oschlies I, Klapper W, Zimmermann M, et al. Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Munster) Multicenter Trial. Blood. 2006;107(10):4047-4052. (Pubitemid 43726813)
17. Ventura RA, Martin-Subero JI, Jones M, et al. FISH analysis for the detection of lymphoma-associated chromosomal abnormalities in routine paraffin-embedded tissue. J Mol Diagn. 2006;8(2):141-151. (Pubitemid 43811236)
18. Korn JM, Kuruvilla FG, McCarroll SA, et al. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet. 2008;40(10):1253-1260.
19. Baumer A, Bernthaler U, Wolz W, Hoehn H, Schindler D. New mutations in the ataxia telangiectasia gene. Hum Genet. 1996;98(2):246-249. (Pubitemid 26237516)
20. Sandoval N, Platzer M, Rosenthal A, et al. Characterization of ATM gene mutations in 66 ataxia telangiectasia families. Hum Mol Genet. 1999;8(1):69-79. (Pubitemid 29039050)
21. Richter J, Schlesner M, Hoffmann S, et al; ICGC MMML-Seq Project. Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet. 2012;44(12):1316-1320.
22. Wang X, Terfve C, Rose JC, Markowetz F. HTSanalyzeR: an R/Bioconductor package for integrated network analysis of high-throughput screens. Bioinformatics. 2011;27(6):879-880.
23. Love C, Sun Z, Jima D, et al. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012;44(12):1321-1325.
24. Schmitz R, Young RM, Ceribelli M, et al. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012;490(7418):116-120.
25. Zhang XK, Moussa O, LaRue A, et al. The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. 2008;181(3):1644-1654.
26. Morin RD, Mendez-Lago M, Mungall AJ, et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011;476(7360):298-303.
27. Mandelbaum J, Bhagat G, Tang H, et al. BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. Cancer Cell. 2010;18(6):568-579.
28. Oricchio E, Nanjangud G, Wolfe AL, et al. The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma. Cell. 2011;147(3):554-564.
29. Dave SS, Fu K, Wright GW, et al; Lymphoma/Leukemia Molecular Profiling Project. Molecular diagnosis of Burkitt's lymphoma. N Engl J Med. 2006;354(23):2431-2442. (Pubitemid 43855046)
30. Haralambieva E, Schuuring E, Rosati S, et al. Interphase fluorescence in situ hybridization for detection of 8q24/MYC breakpoints on routine histologic sections: validation in Burkitt lymphomas from three geographic regions. Genes Chromosomes Cancer. 2004;40(1):10-18. (Pubitemid 38524614)
31. Klapper W, Szczepanowski M, Burkhardt B, et al; Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trials. Blood. 2008;112(4):1374-1381.
32. Salaverria I, Zettl A, Beà S, et al; Leukemia and Lymphoma Molecular Profiling Project (LLMPP). Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma. Haematologica. 2008;93(9):1327-1334.
33. Bea S. Amplifications and target genes in diffuse large B-cell lymphoma: real targets or consequences of structural features of the genome? Leuk Lymphoma. 2010;51(5):743-744.
34. Bonetti P, Testoni M, Scandurra M, et al. Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma. Blood. 2013;122(13):2233-2241.
35. Salaverria I, Martin-Guerrero I, Burkhardt B, et al. High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas. Genes Chromosomes Cancer. 2013;52(2):150-155.
36. Pasqualucci L, Trifonov V, Fabbri G, et al. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet. 2011;43(9):830-837.
37. Lecointe N, Meerabux J, Ebihara M, Hill A, Young BD. Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma. Oncogene. 1999;18(18):2852-2859. (Pubitemid 29250875)
38. Stelzl U, Worm U, Lalowski M, et al. A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005;122(6):957-968. (Pubitemid 41345212)
39. Pospisilova H, Baens M, Michaux L, et al. Interstitial del(14)(q) involving IGH: a novel recurrent aberration in B-NHL. Leukemia. 2007;21(9):2079-2083. (Pubitemid 47299996)
40. Nagel I, Bug S, Tönnies H, et al. Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del(14)(q24.1q32.33). Leukemia. 2009;23(11):2153-2155.
41. Morin RD, Mungall K, Pleasance E, et al. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013;122(7):1256-1265.
42. Green MR, Monti S, Rodig SJ, et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010;116(17):3268-3277.
43. Rui L, Emre NC, Kruhlak MJ, et al. Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell. 2010;18(6):590-605.
44. Watson DK, McWilliams-Smith MJ, Nunn MF, Duesberg PH, O'Brien SJ, Papas TS. The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active. Proc Natl Acad Sci USA. 1985;82(21):7294-7298. (Pubitemid 16193728)
45. Sander S, Calado DP, Srinivasan L, et al. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell. 2012;22(2):167-179.
46. Lenze D, Leoncini L, Hummel M, et al. The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma. Leukemia. 2011;25(12):1869-1876.