Amplifications and target genes in diffuse large B-cell lymphoma: Real targets or consequences of structural features of the genome?

Leukemia and Lymphoma

Volumn 51, Issue 5, 2010, Pages 743-744

  Bea, Silvia ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; DNA; PHOSPHOTRANSFERASE; PROTEIN P53; PROTEIN SIK2; UNCLASSIFIED DRUG;

CANCER SURVIVAL; CHROMOSOME 11Q; CHROMOSOME DELETION; CHROMOSOME REARRANGEMENT; CHROMOSOME STRUCTURE; DNA REPAIR; ENZYME REGULATION; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC SUSCEPTIBILITY; GENOME; GENOMIC INSTABILITY; GLUCOSE METABOLISM; HOMOZYGOSITY; HUMAN; LARGE CELL LYMPHOMA; NOTE; PRIORITY JOURNAL; PROMOTER REGION;

CHROMOSOMES, HUMAN, PAIR 11; GENE AMPLIFICATION; HUMANS; LYMPHOMA, LARGE B-CELL, DIFFUSE; PROTEIN-SERINE-THREONINE KINASES;

EID: 77951776445     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428191003699894     Document Type: Note

References (9)

1. Werner CA, Dohner H, Joos S, et al. High-level DNA amplifications are common genetic aberrations in B-cell neoplasms. Am J Pathol 1997;151:335-342.
2. Nagel S, Leich E, Quentmeier H, et al. Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma. Leuk Lymphoma 2010;51:881-891.
3. Bea S, Salaverria I, Armengol L, et al. Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling. Blood 2009;113:3059-3069.
4. Mestre-Escorihuela C, Rubio-Moscardo F, Richter JA, et al. Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood 2007;109:271-280.
5. Dyer MJ, Fischer P, Nacheva E, Labastide W, Karpas A. A new human B-cell non-Hodgkin's lymphoma cell line (Karpas 422) exhibiting both t (14;18) and t (4;11) chromosomal translocations. Blood 1990;75:709-714.
6. Kobayashi H, Espinosa R III, Thirman MJ, et al. Variability of 11q23 rearrangements in hematopoietic cell lines identified with fluorescence in situ hybridization. Blood 1993;81:3027-3033.
7. Coquelle A, Pipiras E, Toledo F, Buttin G, Debatisse M. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell 1997;89:215-225.
8. Cox C, Bignell G, Greenman C, et al. A survey of homozygous deletions in human cancer genomes. Proc Natl Acad Sci USA 2005;102:4542-4547.
9. Fechter A, Buettel I, Kuehnel E, Savelyeva L, Schwab M. Common fragile site FRA11G and rare fragile site FRA11B at 11q23.3 encompass distinct genomic regions. Genes Chromosomes Cancer 2007;46:98-106.