Reduction in urinary organophosphate pesticide metabolites in adults after a week-long organic diet

Environmental Research

Volumn 132, Issue , 2014, Pages 105-111

  Oates, Liza ^a   Cohen, Marc ^a   Braun, Lesley ^b   Schembri, Adrian ^c   Taskova, Rilka ^d  

^a RMIT UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c Scientific Division   (Australia)

^d Waiwhetu   (New Zealand)

Author keywords

Biomonitoring; Dialkylphosphate metabolites; Organic diets; Organic food; Organophosphate pesticides

Indexed keywords

DIALKYLPHOSPHATE; ORGANOPHOSPHATE PESTICIDE; UNCLASSIFIED DRUG;

ADULT; BIOMONITORING; CHILD HEALTH; DIET; FOOD CONSUMPTION; HEALTH IMPACT; HEALTH RISK; METABOLITE; ORGANOPHOSPHATE; POLLUTION EXPOSURE;

ADULT; ARTICLE; BIOLOGICAL MONITORING; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIETARY INTAKE; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD INDUSTRY; FOOD INTAKE; GAS CHROMATOGRAPHY; HUMAN; LIMIT OF DETECTION; MALE; METABOLITE; MIDDLE AGED; ORGANIC FOOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TANDEM MASS SPECTROMETRY; URINALYSIS;

BIOMONITORING; DIALKYLPHOSPHATE METABOLITES; ORGANIC DIETS; ORGANIC FOOD; ORGANOPHOSPHATE PESTICIDES;

ADULT; CROSS-OVER STUDIES; DIET; FEMALE; FOOD, ORGANIC; HUMANS; MALE; MIDDLE AGED; ORGANOPHOSPHATES; PESTICIDES; PROSPECTIVE STUDIES;

EID: 84899135307     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2014.03.021     Document Type: Article

References (41)

1. Aprea C., et al. Biological monitoring of pesticide exposure: a review of analytical methods. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2002, 769:191-219. 10.1016/S1570-0232(02)00044-2.
2. AQIS National Standard for Organic and Bio-Dynamic Produce-Edition 3.4 2009, Australian Quarantine and Inspection Service.
3. Babina K., et al. Environmental exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children: a cross sectional study. Environ. Int. 2012, 48:109-120. 10.1016/j.envint.2012.07.007.
4. Baker B.P., et al. Pesticide residues in conventional, integrated pest management (IPM)-grown and organic foods: insights from three US data sets. Food Addit. Contam. 2002, 19:427-446.
5. Barr D.B., et al. Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Environ. Health Perspect. 2004, 112:186-200. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241828/.
6. Bouchard M.F., et al. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics 2010, 125:e1270-e1277. 10.1542/peds.2009-3058.
7. Bouchard M.F., et al. Prenatal exposure to organophosphate pesticides and IQ in 7-year old children. Environ. Health Perspect. 2011, 119:1189-1195. 10.1289/ehp.1003185.
8. Bouvier G., et al. Insecticide urinary metabolites in nonoccupationally exposed populations. J. Toxicol. Environ. Health B: Crit. Rev. 2005, 8:485-512. 10.1080/10937400591007284.
9. Bravo R., et al. Measurement of dialkyl phosphate metabolites of organophosphorus pesticides in human urine using lyophilization with gas chromatography-tandem mass spectrometry and isotope dilution quantification. J. Expo. Anal. Environ. Epidemiol. 2004, 14:249-259. 10.1038/sj.jea.7500322.
10. Buratti F., Leoni C., Testai E. The human metabolism of organophosphorothionate pesticides: consequences for toxicological risk assessment. J. Consum. Prot. Food Saf. 2007, 2:37-44.
11. CDC, 2008. Laboratory Procedure Manual. Urinary Dialkylphosphate Metabolites. NHANES 2003-2004. Available from: (retrieved 18.12.13). http://www.cdc.gov/nchs/data/nhanes/nhanes_03_04/l26opd_c_met_organophosphorus_pesticides.pdf.
12. Curl C., et al. Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environ. Health Perspect. 2003, 111:377-382. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241395/.
13. Fenske R.A., et al. Strategies for assessing children[U+05F3]s organophosphorus pesticide exposures in agricultural communities. J Expo Anal Environ Epidemiol 2000, 10:662-671.
14. Field A. Discovering Statistics Using IBM SPSS Statistics 2013, SAGE Publications Ltd., London, England. fourth ed.
15. Fortin M.C., et al. Alteration of the expression of pesticide-metabolizing enzymes in pregnant mice: potential role in the increased vulnerability of the developing brain. Drug Metab. Dispos. 2012, 41:326-331. 10.1124/dmd.112.049395.
16. FSANZ, 2011. The 23rd Australian Total Diet Survey. Available from: (retrieved 18.12.13). http://www.foodstandards.gov.au/publications/pages/23rdaustraliantotald5367.aspx.
17. Health Canada. 2011. Results of the Canadian Health Measures Survey Cycle 1 (2007-2009). Report on Human Biomonitoring of Environmental Chemicals in Canada. Available from: (retrieved 26.12.13). http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/chms-ecms/index-eng.php#n5_8.
18. Heudorf U., et al. Current internal exposure to pesticides in children and adolescents in Germany: urinary levels of metabolites of pyrethroid and organophosphorus insecticides. Int. Arch. Occup. Environ. Health 2004, 77:67-72.
19. Holland N., Furlong C., Bastaki M., Richter R., Bradman A., Huen K., Beckman K., Eskenazi B. Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns. Environ. Health Perspect. 2006, 114:985-991.
20. Huen K., et al. Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms. Environ. Health Perspect. 2009, 117:1632-1638. 10.1289/ehp.0900870.
21. Kissel J.C., et al. Comparison of organophosphorus pesticide metabolite levels in single and multiple daily urine samples collected from preschool children in Washington State. J. Expo. Anal. Environ. Epidemiol. 2005, 15:164-171. 10.1038/sj.jea.7500384.
22. Landrigan P., Garg A. Children are not little adults. Children[U+05F3]s Health and the Environment: A Global Perspective - A Resource Manual for the Health Sector 2005, World Health Organization, Geneva. J. Pronzczuk de Garbino (Ed.).
23. Lu C., et al. Dietary intake and its contribution to longitudinal organophosphorus pesticide exposure in urban/suburban children. Environ. Health Perspect. 2008, 116:537-542. 10.1289/ehp.10912.
24. Lu C., et al. Organic diets significantly lower children[U+05F3]s dietary exposure to organophosphorus pesticides. Environ. Health Perspect. 2006, 114:260-263. 10.1289/ehp.8418.
25. MacIntosh D.L., et al. Longitudinal investigation of dietary exposure to selected pesticides. Environ. Health Perspect. 2001, 109:145-150. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240634/.
26. McGowan, R., 2003. Chemical Monitoring Survey of Victorian Certified Organic and Bio-dynamic Produce. Technical Report for Industry. Department of Primary Industries, Victoria. Retrieved from: http://www.dpi.vic.gov.au.
27. Monk, A., et al., 2012. Australian Organic Market Report 2012. Available from: (retrieved 10.12.13). http://austorganic.com/wp-content/uploads/2013/09/Organic-market-report-2012-web.pdf.
28. Morgan M.K., et al. Exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol in their everyday environments. J. Expo. Anal. Environ. Epidemiol. 2005, 15:297-309. 10.1038/sj.jea.7500406.
29. Oates L., et al. Characteristics and consumption patterns of Australian organic consumers. J. Sci. Food Agric. 2012, 92:2782-2787. 10.1002/jsfa.5664.
30. Oglobline A.N., et al. Negative ion chemical ionization GC/MS-MS analysis of dialkylphosphate metabolites of organophosphate pesticides in urine of non-occupationally exposed subjects. Analyst 2001, 126:1037-1041. 10.1039/b102004h.
31. Radcliffe, J.C., 2002. Pesticide Use in Australia. A Review Undertaken by the Australian Academy of Technological Sciences and Engineering, Melbourne. pp. 310.
32. Rauch S.A., et al. Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birthweight. Environ. Health Perspect. 2012, 120:1055-1060. (doi:10.1289%2Fehp.1104615).
33. Riederer A.M., et al. Diet and nondiet predictors of urinary 3-phenoxybenzoic acid in NHANES 1999-2002. Environ. Health Perspect. 2008, 116:1015-1022. 10.1289/ehp.11082.
34. Ross S.M., et al. Neurobehavioral problems following low-level exposure to organophosphate pesticides: a systematic and meta-analytic review. Crit. Rev. Toxicol. 2013, 43:21-44. 10.3109/10408444.2012.738645.
35. Sudakin D.L., Stone D.L. Dialkyl phosphates as biomarkers of organophosphates: the current divide between epidemiology and clinical toxicology. Clin. Toxicol. 2011, 49:771-781. 10.3109/15563650.2011.624101.
36. Tasiopoulou S., et al. Results of the monitoring program of pesticide residues in organic food of plant origin in Lombardy (Italy). J. Environ. Sci. Health B 2007, 42:835-841. 10.1080/03601230701555054.
37. The Expert Committee on Pesticide Residues in Food, 2013. Pesticide Residues Monitoring Programme for Quarter 1 2013. Available from: (retrieved 3 December). http://www.pesticides.gov.uk/Resources/CRD/PRiF/Documents/Results%20and%20Reports/2013/2013%20Q1%20Final.pdf.
38. United States Department of Agriculture, 2013. Pesticide Data Program: Annual Summary, Calendar Year 2011. Available from: (retrieved 03.10.13). http://www.ams.usda.gov/AMSv1.0/getfile?dDocName=stelprdc5102692.
39. USDA, 2012. 2010-2011 Pilot Study Pesticide Residue Testing of Organic Produce. Available from: (retrieved 15.12.13). http://www.ams.usda.gov/AMSv1.0/getfile?dDocName=STELPRDC5101234.
40. Willer, H., et al., 2013. The World of Organic Agriculture - Statistics and Emerging Trends 2013. Research Institute of Organic Agriculture (FiBL), Frick, and International Federation of Organic Agriculture Movements (IFOAM), Bonn.
41. Wilson N.K., et al. Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home. J. Expo. Anal. Environ. Epidemiol. 2003, 13:187-202. 10.1038/sj.jea.7500270.