Human beta-defensin-1 suppresses tumor migration and invasion and is an independent predictor for survival of oral squamous cell carcinoma patients

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Han, Qi ^a   Wang, Ruinan ^a   Sun, Chongkui ^a   Jin, Xin ^a   Liu, Dongjuan ^a   Zhao, Xin ^a   Wang, Lili ^a   Ji, Ning ^a   Li, Jing ^a   Zhou, Yu ^a   Ye, Ling ^a   Liang, Xinhua ^a   Jiang, Lu ^a   Liao, Ga ^a   Dan, Hongxia ^a   Zeng, Xin ^a   Chen, Qianming ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 1; GELATINASE A; GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOC PROTEIN; UNCLASSIFIED DRUG; BETA DEFENSIN; DEFB1 PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HSC 3; CELL STRAIN SCC 25; CELL STRAIN SCC 9; CELL STRAIN UM1; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MIGRATION INHIBITION; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SURVIVAL TIME; TISSUE MICROARRAY; TUMOR INVASION; CELL MOTION; FORECASTING; GENETICS; METABOLISM; MOUTH TUMOR; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; SQUAMOUS CELL CARCINOMA; SURVIVAL;

BETA-DEFENSINS; CARCINOMA, SQUAMOUS CELL; CELL MOVEMENT; FORECASTING; HUMANS; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; PROGNOSIS; SURVIVAL ANALYSIS;

EID: 84899123348     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091867     Document Type: Article

References (40)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
2. Messadi DV (2013) Diagnostic aids for detection of oral precancerous conditions. Int J Oral Sci 5: 59-65.
3. Zhou Y, Zhu X, Lu R, Dan H, Wang F, et al. (2012) Vesicular stomatitis virus matrix protein (VSVMP) inhibits the cell growth and tumor angiogenesis in oral squamous cell carcinoma. Oral Oncol 48: 110-116.
4. Li J, Gong C, Feng X, Zhou X, Xu X, et al. (2012) Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma xenografts. PLoS One 7: e33860.
5. Ai JY, Smith B, Wong DT (2012) Bioinformatics advances in saliva diagnostics. Int J Oral Sci 4: 85-87.
6. Pazgier M, Hoover DM, Yang D, Lu W, Lubkowski J (2006) Human beta-defensins. Cell Mol Life Sci 63: 1294-1313.
7. Krisanaprakornkit S, Weinberg A, Perez CN, Dale BA (1998) Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun 66: 4222-4228. (Pubitemid 28402695)
8. Sahasrabudhe KS, Kimball JR, Morton TH, Weinberg A, Dale BA (2000) Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva. J Dent Res 79: 1669-1674. (Pubitemid 32489432)
9. Singh PK, Jia HP, Wiles K, Hesselberth J, Liu L, et al. (1998) Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A 95: 14961-14966. (Pubitemid 29003739)
10. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB, et al. (1998) Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 101: 1633-1642. (Pubitemid 28198492)
11. Ali RS, Falconer A, Ikram M, Bissett CE, Cerio R, et al. (2001) Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin. J Invest Dermatol 117: 106-111. (Pubitemid 32652446)
12. Zhao C, Wang I, Lehrer RI (1996) Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 396: 319-322. (Pubitemid 26377848)
13. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, et al. (1997) Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88: 553-560. (Pubitemid 27154420)
14. Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, et al. (1999) Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286: 525-528.
15. Donald CD, Sun CQ, Lim SD, Macoska J, Cohen C, et al. (2003) Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas. Lab Invest 83: 501-505. (Pubitemid 36457704)
16. Gambichler T, Skrygan M, Huyn J, Bechara FG, Sand M, et al. (2006) Pattern of mRNA expression of beta-defensins in basal cell carcinoma. BMC Cancer 6: 163.
17. Sun CQ, Arnold R, Fernandez-Golarz C, Parrish AB, Almekinder T, et al. (2006) Human beta-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinoma. Cancer Res 66: 8542-8549. (Pubitemid 44449167)
18. Bullard RS, Gibson W, Bose SK, Belgrave JK, Eaddy AC, et al. (2008) Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer. Mol Immunol 45: 839-848. (Pubitemid 47505263)
19. Bissell J, Joly S, Johnson GK, Organ CC, Dawson D, et al. (2004) Expression of beta-defensins in gingival health and in periodontal disease. J Oral Pathol Med 33: 278-285. (Pubitemid 38579446)
20. Dale BA, Kimball JR, Krisanaprakornkit S, Roberts F, Robinovitch M, et al. (2001) Localized antimicrobial peptide expression in human gingiva. J Periodontal Res 36: 285-294. (Pubitemid 33641093)
21. Wenghoefer M, Pantelis A, Dommisch H, Reich R, Martini M, et al. (2008) Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity. Int J Oral Maxillofac Surg 37: 660-663. (Pubitemid 351905974)
22. Abiko Y, Mitamura J, Nishimura M, Muramatsu T, Inoue T, et al. (1999) Pattern of expression of beta-defensins in oral squamous cell carcinoma. Cancer Lett 143: 37-43. (Pubitemid 29327187)
23. Joly S, Compton LM, Pujol C, Kurago ZB, Guthmiller JM (2009) Loss of human beta-defensin 1, 2, and 3 expression in oral squamous cell carcinoma. Oral Microbiol Immunol 24: 353-360.
24. Winter J, Pantelis A, Reich R, Martini M, Kraus D, et al. (2011) Human beta-defensin-1, -2, and -3 exhibit opposite effects on oral squamous cell carcinoma cell proliferation. Cancer Invest 29: 196-201.
25. Sobin LH, Compton CC (2010) TNM seventh edition: what's new, what's changed: communication from the International Union Against Cancer and the American Joint Committee on Cancer. Cancer 116: 5336-5339.
26. Nakayama S, Sasaki A, Mese H, Alcalde RE, Matsumura T (1998) Establishment of high and low metastasis cell lines derived from a human tongue squamous cell carcinoma. Invasion Metastasis 18: 219-228. (Pubitemid 30223698)
27. Nishitani J, Chen Z, Qin M, Liu F, Chen H, et al. (2002) Identification of genes required for immortalization in human papillomavirus-infected human oral keratinocytes. Cell Mol Biol (Noisy-le-grand) 48 Online Pub: OL331-341.
28. Wang Z, Jiang L, Huang C, Li Z, Chen L, et al. (2008) Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma. Mol Cell Proteomics 7: 1639-1650.
29. Wang Z, Zhang B, Jiang L, Zeng X, Chen Y, et al. (2009) RACK1, an excellent predictor for poor clinical outcome in oral squamous carcinoma, similar to Ki67. Eur J Cancer 45: 490-496.
30. Joly S, Organ CC, Johnson GK, McCray PB, Guthmiller JM (2005) Correlation between beta-defensin expression and induction profiles in gingival keratino-cytes. Mol Immunol 42: 1073-1084.
31. Sørensen OE, Thapa DR, Rosenthal A, Liu L, Roberts AA, et al. (2005) Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol 174: 4870-4879.
32. Duits LA, Ravensbergen B, Rademaker M, Hiemstra PS, Nibbering PH (2002) Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 106: 517-525. (Pubitemid 34994717)
33. Bose SK, Gibson W, Bullard RS, Donald CD (2009) PAX2 oncogene negatively regulates the expression of the host defense peptide human beta defensin-1 in prostate cancer. Mol Immunol 46: 1140-1148.
34. Nishimura M, Abiko Y, Kurashige Y, Takeshima M, Yamazaki M, et al. (2004) Effect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines. J Dermatol Sci 36: 87-95. (Pubitemid 39424131)
35. Masters JR (2002) HeLa cells 50 years on: the good, the bad and the ugly. Nat Rev Cancer 2: 315-319.
36. Hu L, Lau SH, Tzang CH, Wen JM, Wang W, et al. (2004) Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene 23: 298-302. (Pubitemid 38142264)
37. Iiizumi M, Bandyopadhyay S, Pai SK, Watabe M, Hirota S, et al. (2008) RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res 68: 7613-7620.
38. Islam M, Lin G, Brenner JC, Pan Q, Merajver SD, et al. (2009) RhoC expression and head and neck cancer metastasis. Mol Cancer Res 7: 1771-1780.
39. Struckhoff AP, Rana MK, Worthylake RA (2011) RhoA can lead the way in tumor cell invasion and metastasis. Front Biosci 16: 1915-1926.
40. Mendes O, Kim HT, Lungu G, Stoica G (2007) MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. Clin Exp Metastasis 24: 341-351. (Pubitemid 47124935)