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Volumn 38, Issue 5, 2014, Pages 631-638

A novel estrogen receptor GPER mediates proliferation induced by 17b-estradiol and selective GPER agonist G-1 in estrogen receptor α (ERα)-negative ovarian cancer cells

Author keywords

Estrogen; GPER; Ovarian cancer; Proliferation

Indexed keywords

1 [4 (6 BROMOBENZO[1,3] DIOXOL 5 YL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLIN 8 YL]ETHANONE; AGENTS AFFECTING CELL DIVISION; CYCLIN D1; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; G PROTEIN COUPLED RECEPTOR 30; PERTUSSIS TOXIN; PROTEIN C FOS; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 1-(4-(6-BROMOBENZO(1,3)DIOXOL-5-YL)-3A,4,5,9B-TETRAHYDRO-3H-CYCLOPENTA(C)QUINOLIN-8-YL)ETHANONE; CYCLOPENTANE DERIVATIVE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA, HUMAN; G PROTEIN COUPLED RECEPTOR; GPER PROTEIN, HUMAN; QUINOLINE DERIVATIVE;

EID: 84899108648     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10243     Document Type: Article
Times cited : (41)

References (32)
  • 1
    • 33847755409 scopus 로고    scopus 로고
    • G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells
    • Albanito L, Madeo A, Lappano R, Vivacqua A, Rago V, Carpino A, Oprea TI, Prossnitz ER, Musti AM, Andò S, Maggiolini M (2007) G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res 67(4): 1859-66.
    • (2007) Cancer Res , vol.67 , Issue.4 , pp. 1859-1866
    • Albanito, L.1    Madeo, A.2    Lappano, R.3    Vivacqua, A.4    Rago, V.5    Carpino, A.6    Oprea, T.I.7    Prossnitz, E.R.8    Musti, A.M.9    Andò, S.10    Maggiolini, M.11
  • 4
    • 77955711650 scopus 로고    scopus 로고
    • Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, cjun/ c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest
    • Chan QK, Lam HM, Ng CF, Lee AY, Chan ES, Ng HK, Ho SM, Lau KM (2010) Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, cjun/ c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest. Cell Death Differ 17(9): 1511-23.
    • (2010) Cell Death Differ , vol.17 , Issue.9 , pp. 1511-1523
    • Chan, Q.K.1    Lam, H.M.2    Ng, C.F.3    Lee, A.Y.4    Chan, E.S.5    Ng, H.K.6    Ho, S.M.7    Lau, K.M.8
  • 5
    • 0035009393 scopus 로고    scopus 로고
    • Estradiol up-regulates antiapoptotic Bcl-2 messenger ribonucleic acid and protein in tumorigenic ovarian surface epithelium cells
    • Choi KC, Kang SK, Tai CJ, Auersperg N, Leung PC (2001) Estradiol up-regulates antiapoptotic Bcl-2 messenger ribonucleic acid and protein in tumorigenic ovarian surface epithelium cells. Endocrinology 142(6): 2351-60.
    • (2001) Endocrinology , vol.142 , Issue.6 , pp. 2351-2360
    • Choi, K.C.1    Kang, S.K.2    Tai, C.J.3    Auersperg, N.4    Leung, P.C.5
  • 6
    • 0023798751 scopus 로고
    • Fos and Jun: the AP-1 connection
    • Curran T, Franza BR (1988) Fos and Jun: the AP-1 connection. Cell 55(3): 395-7.
    • (1988) Cell , vol.55 , Issue.3 , pp. 395-397
    • Curran, T.1    Franza, B.R.2
  • 7
    • 33751272253 scopus 로고    scopus 로고
    • Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression
    • Filardo EJ, Graeber CT, Quinn JA, Resnick MB, Giri D, DeLellis RA, Steinhoff MM, Sabo E (2006) Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression. Clin Cancer Res 12(21): 6359-66.
    • (2006) Clin Cancer Res , vol.12 , Issue.21 , pp. 6359-6366
    • Filardo, E.J.1    Graeber, C.T.2    Quinn, J.A.3    Resnick, M.B.4    Giri, D.5    DeLellis, R.A.6    Steinhoff, M.M.7    Sabo, E.8
  • 8
    • 0036140032 scopus 로고    scopus 로고
    • Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    • Filardo EJ, Quinn JA, Frackelton AR, Bland KI (2002) Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol 16(1): 70-84.
    • (2002) Mol Endocrinol , vol.16 , Issue.1 , pp. 70-84
    • Filardo, E.J.1    Quinn, J.A.2    Frackelton, A.R.3    Bland, K.I.4
  • 9
    • 79953168739 scopus 로고    scopus 로고
    • GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERa) phosphorylation signals
    • Gao F, Ma X, Ostmann AB, Das SK (2011) GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERa) phosphorylation signals. Endocrinology 152(4): 1434-47.
    • (2011) Endocrinology , vol.152 , Issue.4 , pp. 1434-1447
    • Gao, F.1    Ma, X.2    Ostmann, A.B.3    Das, S.K.4
  • 10
    • 84863984601 scopus 로고    scopus 로고
    • Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy
    • Girgert R, Emons G, Gründker C (2012) Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy. Breast Cancer Res Treat 134(1): 199-205.
    • (2012) Breast Cancer Res Treat , vol.134 , Issue.1 , pp. 199-205
    • Girgert, R.1    Emons, G.2    Gründker, C.3
  • 11
    • 0035813112 scopus 로고    scopus 로고
    • The multifaceted mechanisms of estradiol and estrogen receptor signaling
    • Hall JM, Couse JF, Korach KS (2001) The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276(40): 36869-72.
    • (2001) J Biol Chem , vol.276 , Issue.40 , pp. 36869-36872
    • Hall, J.M.1    Couse, J.F.2    Korach, K.S.3
  • 12
    • 67649888455 scopus 로고    scopus 로고
    • Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway
    • He YY, Cai B, Yang YX, Liu XL, Wan XP (2009) Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway. Cancer Sci 100(6): 1051-61.
    • (2009) Cancer Sci , vol.100 , Issue.6 , pp. 1051-1061
    • He, Y.Y.1    Cai, B.2    Yang, Y.X.3    Liu, X.L.4    Wan, X.P.5
  • 15
    • 67649361895 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel
    • Kim SM, Lee SY, Yuk DY, Moon DC, Choi SS, Kim Y, Han SB, Oh KW, Hong JT (2009) Inhibition of NF-kappaB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel. Arch Pharm Res 32(5): 755-65.
    • (2009) Arch Pharm Res , vol.32 , Issue.5 , pp. 755-765
    • Kim, S.M.1    Lee, S.Y.2    Yuk, D.Y.3    Moon, D.C.4    Choi, S.S.5    Kim, Y.6    Han, S.B.7    Oh, K.W.8    Hong, J.T.9
  • 16
    • 84858201263 scopus 로고    scopus 로고
    • The G protein-coupled estrogen receptor 1 (GPER/GPR30) does not predict survival in patients with ovarian cancer
    • Kolkova Z, Casslén V, Henic E, Ahmadi S, Ehinger A, Jirström K, Casslén B (2012) The G protein-coupled estrogen receptor 1 (GPER/GPR30) does not predict survival in patients with ovarian cancer. J Ovarian Res 5: 9.
    • (2012) J Ovarian Res , vol.5 , pp. 9
    • Kolkova, Z.1    Casslén, V.2    Henic, E.3    Ahmadi, S.4    Ehinger, A.5    Jirström, K.6    Casslén, B.7
  • 19
    • 77955398981 scopus 로고    scopus 로고
    • Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells
    • Lucas TF, Royer C, Siu ER, Lazari MF, Porto CS (2010) Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells. Biol Reprod 83(2): 307-17.
    • (2010) Biol Reprod , vol.83 , Issue.2 , pp. 307-317
    • Lucas, T.F.1    Royer, C.2    Siu, E.R.3    Lazari, M.F.4    Porto, C.S.5
  • 23
    • 14844343093 scopus 로고    scopus 로고
    • A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    • Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER (2005) A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307(5715): 1625-30.
    • (2005) Science , vol.307 , Issue.5715 , pp. 1625-1630
    • Revankar, C.M.1    Cimino, D.F.2    Sklar, L.A.3    Arterburn, J.B.4    Prossnitz, E.R.5
  • 24
    • 0035925788 scopus 로고    scopus 로고
    • Estrogen replacement therapy and ovarian cancermortality in a large prospective study of US women
    • Rodriguez C, Patel AV, Calle EE, Jacob EJ, Thun MJ (2001) Estrogen replacement therapy and ovarian cancermortality in a large prospective study of US women. JAMA 285(11): 1460-5.
    • (2001) JAMA , vol.285 , Issue.11 , pp. 1460-1465
    • Rodriguez, C.1    Patel, A.V.2    Calle, E.E.3    Jacob, E.J.4    Thun, M.J.5
  • 25
    • 0036098552 scopus 로고    scopus 로고
    • AP-1 as a regulator of cell life and death
    • Shaulian E, Karin M (2002) AP-1 as a regulator of cell life and death. Nat Cell Biol 4(5): E131-6.
    • (2002) Nat Cell Biol , vol.4 , Issue.5
    • Shaulian, E.1    Karin, M.2
  • 26
    • 0342803689 scopus 로고    scopus 로고
    • Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice
    • Singh M, Sétáló G, Guan X, Frail DE, Toran-Allerand CD (2000) Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice. J Neurosci 20(5): 1694-700.
    • (2000) J Neurosci , vol.20 , Issue.5 , pp. 1694-1700
    • Singh, M.1    Sétáló, G.2    Guan, X.3    Frail, D.E.4    Toran-Allerand, C.D.5
  • 28
    • 47949092800 scopus 로고    scopus 로고
    • The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation
    • Teng J, Wang ZY, Prossnitz ER, Bjorling DE (2008) The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation. Endocrinology 149(8): 4024-34.
    • (2008) Endocrinology , vol.149 , Issue.8 , pp. 4024-4034
    • Teng, J.1    Wang, Z.Y.2    Prossnitz, E.R.3    Bjorling, D.E.4
  • 29
    • 33748923143 scopus 로고    scopus 로고
    • 17betaestradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g proteincoupled receptor GPR30
    • Vivacqua A, Bonofiglio D, Albanito L, Madeo A, Rago V, Carpino A, Musti AM, Picard D, Andò S, MaggioliniM(2006a) 17betaestradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g proteincoupled receptor GPR30. Mol Pharmacol 70(4): 1414-23.
    • (2006) Mol Pharmacol , vol.70 , Issue.4 , pp. 1414-1423
    • Vivacqua, A.1    Bonofiglio, D.2    Albanito, L.3    Madeo, A.4    Rago, V.5    Carpino, A.6    Musti, A.M.7    Picard, D.8    Andò, S.9    Maggiolini, M.10
  • 30
    • 33344461590 scopus 로고    scopus 로고
    • The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17betaestradiol and hydroxytamoxifen in endometrial cancer cells
    • Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, Andò S, MaggioliniM (2006b) The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17betaestradiol and hydroxytamoxifen in endometrial cancer cells. Mol Endocrinol 20(3): 631-46.
    • (2006) Mol Endocrinol , vol.20 , Issue.3 , pp. 631-646
    • Vivacqua, A.1    Bonofiglio, D.2    Recchia, A.G.3    Musti, A.M.4    Picard, D.5    Andò, S.6    Maggiolini, M.7
  • 31
    • 84887456860 scopus 로고    scopus 로고
    • The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization
    • Wang C, Lv X, He C, Hua G, Tsai MY, Davis JS (2013) The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization. Cell Death Dis 4: e869.
    • (2013) Cell Death Dis , vol.4
    • Wang, C.1    Lv, X.2    He, C.3    Hua, G.4    Tsai, M.Y.5    Davis, J.S.6
  • 32
    • 84899050373 scopus 로고    scopus 로고
    • Expression of G protein-coupled receptor 30 (GPR30) in epithelial ovarian carcinoma and its correlation with proliferation associated genes c-fos and cyclinD1
    • [in Chinese]
    • Yan Y, Liu HD, Cao XF, Tan PZ, Lv CM, Li XM, Liu GY (2011) Expression of G protein-coupled receptor 30 (GPR30) in epithelial ovarian carcinoma and its correlation with proliferation associated genes c-fos and cyclinD1. Reprod Contracept 31: 236-40. [in Chinese].
    • (2011) Reprod Contracept , vol.31 , pp. 236-240
    • Yan, Y.1    Liu, H.D.2    Cao, X.F.3    Tan, P.Z.4    Lv, C.M.5    Li, X.M.6    Liu, G.Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.