Association of bone turnover markers with mortality in women referred to coronary angiography: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Osteoporosis International

Volumn 25, Issue 2, 2014, Pages 455-465

  Lerchbaum, E ^a   Schwetz, V ^a   Pilz, S ^a,b   Boehm, B O ^c   Marz W ^a,d,e  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF ULM   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e SYNLAB ACADEMY   (Germany)

Author keywords

Beta crosslaps; Bone turnover; Cardiovascular disease; Mortality; Osteocalcin

Indexed keywords

25 HYDROXYVITAMIN D; BETA CROSSLAPS; BIOLOGICAL MARKER; CREATININE; OSTEOCALCIN; PARATHYROID HORMONE; PROTEIN; UNCLASSIFIED DRUG; COLLAGEN; GLUTAMYL-LYSYL-ALANYL-HISTIDYL-ASPARTYL-GLYCYL-GLYCYL-ARGININE; PEPTIDE FRAGMENT;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD SAMPLING; BODY MASS; BONE TURNOVER; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CAUSE OF DEATH; CEREBROVASCULAR DISEASE; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; FRAIL ELDERLY; HAZARD RATIO; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MENOPAUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PARATHYROID HORMONE BLOOD LEVEL; PERIPHERAL VASCULAR DISEASE; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SURVIVAL TIME; BLOOD; BONE REMODELING; CARDIOVASCULAR DISEASE; EPIDEMIOLOGY; FOLLOW UP; GERMANY; MALE; MIDDLE AGED; MORTALITY; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIOGRAPHY;

AGED; BIOLOGICAL MARKERS; BONE REMODELING; CARDIOVASCULAR DISEASES; COLLAGEN; CORONARY ANGIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; GERMANY; HUMANS; MALE; MIDDLE AGED; OSTEOCALCIN; PEPTIDE FRAGMENTS; PROSPECTIVE STUDIES;

EID: 84899105552     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-013-2411-9     Document Type: Article

References (30)

1. Cooper C, Atkinson EJ, Jacobsen SJ, O'Fallon WM, Melton LJ 3rd (1993) Population-based study of survival after osteoporotic fractures. Am J Epidemiol 137:1001-1005 (Pubitemid 23191067)
2. Trivedi DP, Khaw KT (2001) Bone mineral density at the hip predicts mortality in elderly men. Osteoporos Int 12:259-256
3. Sambrook PN, Chen CJ, March L, Cameron ID, Cumming RG, Lord SR, Simpson JM, Seibel MJ (2006) High bone turnover is an independent predictor of mortality in the frail elderly. J Bone Miner Res 21:549-555
4. Lerchbaum E, Schwetz V, Pilz S, Grammer TB, Look M, Boehm BO, Obermayer-Pietsch B, März W (2012) Association of bone turnover markers with mortality in men referred to coronary angiography. Osteoporos Int 24:1321-1332
5. Reyes-Garcia R, Rozas-Moreno P, Jimenez-Moleon JJ, Villoslada MJ, Garcia-Salcedo JA, Santana-Morales S, Muñoz-Torres M (2012) Relationship between serum levels of osteocalcin and atherosclerotic disease in type 2 diabetes. Diabetes Metab 38:76-81
6. Vogt MT, San Valentin R, Forrest KY, Nevitt MC, Cauley JA (1997) Bone mineral density and aortic calcification: the Study of Osteoporotic Fractures. J Am Geriatr Soc 45:140-145 (Pubitemid 27066521)
7. Watson KE, Boström K, Ravindranath R, Lam T, Norton B, Demer LL (1994) TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest 93:2106-2113
8. Zitzmann M (2009) Testosterone deficiency, insulin reistance and the metabolic syndrome. Nat Rev Endocrinol 5:673- 681
9. Schwetz V, Pieber T, Obermayer-Pietsch B (2012) The endocrine role of the skeleton: background and clinical evidence. Eur J Endocrinol 166:959-967
10. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130:456-469 (Pubitemid 47208519)
11. Ferron M, Hinoi E, Karsenty G, Ducy P (2008) Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A 105:5266-5270 (Pubitemid 351738545)
12. Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S, Sugimoto T (2011) Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int 22:187-194
13. Shea MK, Gundberg CM, Meigs JB, Dallal GE, Saltzman E, Yoshida M, Jacques PF, Booth SL (2009) Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. Am J Clin Nutr 90:1230-1235
14. Winkelmann BR, März W, Boehm BO, Zotz R, Hager J, Hellstern P, Senges J, LURIC Study Group (LUdwigshafen RIsk and Cardiovascular Health) (2001) Rationale and design of the LURIC study-a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics 2(S1):73
15. Szulc P, Garnero P, Claustrat B, Marchand F, Duboeuf F, Delmas PD (2002) Increased bone resorption in moderate smokers with low body weight: the Minos study. J Clin Endocrinol Metab 87:666-674 (Pubitemid 34158235)
16. Mussolino MEMJ, Gillum RF (2003) Bone mineral density and mortality in women and men: the NHANES I epidemiologic follow-up study. Ann Epidemiol 13:692-697
17. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266-281
18. Pilz SKK, Tomaschitz A, Lerchbaum E, Meinitzer A, März W, Zittermann A, Dekker JM (2012) Vitamin D and cardiovascular disease: update and outlook. Scand J Clin Lab Invest Suppl 243:83-91
19. Pludowski PHM, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, Soni M (2013) Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. doi:10.1016/j.autrev.2013.02.004
20. Pilz SMW, Wellnitz B, Seelhorst U, Fahrleitner-Pammer A, Dimai HP, Boehm BO, Dobnig H (2008) Association of vitamin D deficiency with heart failure and sudden cardiac death in a large crosssectional study of patients referred for coronary angiography. J Clin Endocrinol Metab 93:3927-3935
21. Dobnig HPS, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, Kinkeldei J, Boehm BO, Weihrauch G, Maerz W (2008) Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med 168:1340-1349 (Pubitemid 351930842)
22. Lerchbaum E, Pilz S, Grammer TB, Boehm BO, März W, Obermayer-Pietsch B (2011) High estradiol levels are associated with increased mortality in older men referred to coronary angiography. Exp Clin Endocrinol Diabetes 119:490-496
23. Lerchbaum E (2012) Androgens and cardiovascular risk. J Lab Med 36:217-225
24. Wehr E, Pilz S, Boehm BO, März W, Grammer T, Obermayer-Pietsch B (2011) Low free testosterone is associated with heart failure mortality in older men referred for coronary angiography. Eur J Heart Fail 13:482-488
25. Wehr E, Pilz S, Boehm BO, März W, Grammer TB, Obermayer-Pietsch B (2010) Sex steroids and mortality in men referred for coronary angiography. Clin Endocrinol (Oxf) 73:613 -621
26. Wehr E, Pilz S, Boehm BO, Grammer TB, März W, Obermayer-Pietsch B (2011) Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women. Diabetes Care 34:1771-1777
27. Hagström E, Hellman P, Larsson TE, Ingelsson E, Berglund L, Sundström J, Melhus H, Held C, Lind L, Michaëlsson K, Arnlöv J (2009) Plasma parathyroid hormone and the risk of cardiovascular mortality in the community. Circulation 119:2765-2771
28. Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Hankey GJ, Beilby JP, Norman PE (2012) Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study. Osteoporos Int 23:599-606
29. Hamann C, Kirschner S, Günther KP, Hofbauer LC (2012) Bone, sweet bone-osteoporotic fractures in diabetes mellitus. Nat Rev Endocrinol 8:297-305
30. Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes B (2009) Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Metab 94:827- 832