Selectins mediate small cell lung cancer systemic metastasis

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Heidemann, Franziska ^a   Schildt, Anna ^a   Schmid, Katharina ^b   Bruns, Oliver T ^c,d   Riecken, Kristoffer ^a   Jung, Caroline ^a   Ittrich, Harald ^a   Wicklein, Daniel ^a   Reimer, Rudolph ^c   Fehse, Boris ^a   Heeren, Joerg ^a   Lüers, Georg ^a   Schumacher, Udo ^a   Heine, Markus ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF HAMBURG   (Germany)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE DERIVATIVE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; PADGEM PROTEIN; 5-ACETYLNEURAMINYL-2-3-GALACTOSYL-1-3-(FUCOPYRANOSYL-1-4)-N-ACETYLGLUCOSAMINE; OLIGOSACCHARIDE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL ADHESION; CELL FUNCTION; CELL GROWTH; CELL STRAIN; CELL STRAIN CD44; CELL STRAIN CEA; CELL STRAIN OH 1; CELL STRAIN PSGL 1; CONTROLLED STUDY; DISTANT METASTASIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; LIGAND BINDING; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN MOTIF; SYSTEMIC DISEASE; TUMOR XENOGRAFT; ANIMAL; CANCER STAGING; ENZYME IMMUNOASSAY; FLOW CYTOMETRY; KNOCKOUT MOUSE; LUNG TUMOR; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; SCID MOUSE; SECONDARY; SMALL CELL LUNG CANCER; SURVIVAL RATE; TISSUE MICROARRAY; TUMOR CELL CULTURE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; E-SELECTIN; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; MALE; MICE; MICE, KNOCKOUT; MICE, SCID; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; OLIGOSACCHARIDES; P-SELECTIN; PROGNOSIS; SMALL CELL LUNG CARCINOMA; SURVIVAL RATE; TISSUE ARRAY ANALYSIS; TUMOR CELLS, CULTURED;

EID: 84899104734     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092327     Document Type: Article

References (43)

1. Govindan R, Page N, Morgensztern D, Read W, Tierney R, et al. (2006) Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 24: 4539-4544. (Pubitemid 46630948)
2. Merrill RM, Henson DE, Barnes M (1999) Conditional survival among patients with carcinoma of the lung. Chest 116: 697-703. (Pubitemid 29428487)
3. Gustafsson BI, Kidd M, Chan A, Malfertheiner MV, Modlin IM (2008) Bronchopulmonary neuroendocrine tumors. Cancer 113: 5-21. (Pubitemid 351976381)
4. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70. (Pubitemid 30046295)
5. Gupta GP, Massague J (2006) Cancer metastasis: building a framework. Cell 127: 679-695. (Pubitemid 44781029)
6. Orr FW, Wang HH, Lafrenie RM, Scherbarth S, Nance DM (2000) Interactions between cancer cells and the endothelium in metastasis. J Pathol 190: 310-329. (Pubitemid 30141377)
7. Strell C, Entschladen F (2008) Extravasation of leukocytes in comparison to tumor cells. Cell Commun Signal 6: 10.
8. Ley K, Laudanna C, Cybulsky MI, Nourshargh S (2007) Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 7: 678-689. (Pubitemid 47327397)
9. Varki A (1994) Selectin ligands. Proceedings of the National Academy of Sciences of the United States of America 91: 7390-7397.
10. Hidalgo A, Peired AJ, Wild MK, Vestweber D, Frenette PS (2007) Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44. Immunity 26: 477-489. (Pubitemid 46603003)
11. McEver RP, Zhu C (2009) Rolling cell adhesion. Annu Rev Cell Dev Biol 26: 363-396.
12. Thomas SN, Tong Z, Stebe KJ, Konstantopoulos K (2009) Identification, characterization and utilization of tumor cell selectin ligands in the design of colon cancer diagnostics. Biorheology 46: 207-225.
13. Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (2008) Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow. J Biol Chem 283: 15647-15655.
14. Barthel SR, Wiese GK, Cho J, Opperman MJ, Hays DL, et al. (2009) Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proc Natl Acad Sci U S A 106: 19491-19496.
15. Kannagi R (1997) Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer. Glycoconj J 14: 577-584.
16. Köhler S, Ullrich S, Richter U, Schumacher U (2009) E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung. Br J Cancer 102: 602-609.
17. Stübke K, Wicklein D, Herich L, Schumacher U, Nehmann N (2012) Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer. Cancer Lett 321: 89-99.
18. Gebauer F, Wicklein D, Stubke K, Nehmann N, Schmidt A, et al. (2012) Selectin binding is essential for peritoneal carcinomatosis in a xenograft model of human pancreatic adenocarcinoma in pfp-/rag2- mice. Gut.
19. Carney DN, Gazdar AF, Bepler G, Guccion JG, Marangos PJ, et al. (1985) Establishment and identification of small cell lung cancer cell lines having classic and variant features. Cancer Res 45: 2913-2923. (Pubitemid 15232769)
20. Richter U, Schroder C, Wicklein D, Lange T, Geleff S, et al. (2011) Adhesion of small cell lung cancer cells to E- and P-selectin under physiological flow conditions: implications for metastasis formation. Histochem Cell Biol 135: 499-512.
21. Weber K, Mock U, Petrowitz B, Bartsch U, Fehse B (2010) Lentiviral gene ontology (LeGO) vectors equipped with novel drug-selectable fluorescent proteins: new building blocks for cell marking and multi-gene analysis. Gene therapy 17: 511-520.
22. Weber K, Bartsch U, Stocking C, Fehse B (2008) A multicolor panel of novel lentiviral "gene ontology" (LeGO) vectors for functional gene analysis. Molecular therapy : the journal of the American Society of Gene Therapy 16: 698-706.
23. Jojovic M, Schumacher U (2000) Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice. Cancer Lett 152: 151-156. (Pubitemid 30201496)
24. Sodeur S, Ullrich S, Gustke H, Zangemeister-Wittke U, Schumacher U (2009) Increased numbers of spontaneous SCLC metastasis in absence of NK cells after subcutaneous inoculation of different SCLC cell lines into pfp/rag2 double knock out mice. Cancer Lett 282: 146-151.
25. Trillet V, Revel D, Combaret V, Favrot M, Loire R, et al. (1989) Bone marrow metastases in small cell lung cancer: detection with magnetic resonance imaging and monoclonal antibodies. British journal of cancer 60: 83-88. (Pubitemid 19187752)
26. Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, et al. (1998) Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium. Microcirculation 5: 153-171. (Pubitemid 128647891)
27. Sundd P, Pospieszalska MK, Cheung LS, Konstantopoulos K, Ley K (2011) Biomechanics of leukocyte rolling. Biorheology 48: 1-35.
28. Wan MX, Riaz AA, Schramm R, Wang Y, Vestweber D, et al. (2002) Leukocyte rolling is exclusively mediated by P-selectinin colonic venules. Br J Pharmacol 135: 1749-1756. (Pubitemid 38075540)
29. Zarbock A, Ley K, McEver RP, Hidalgo A (2011) Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Blood 118: 6743-6751.
30. Pantel K, Brakenhoff RH, Brandt B (2008) Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nature reviews Cancer 8: 329-340. (Pubitemid 351596394)
31. Ochiai S, Nakanishi Y, Mizuno K, Hashimoto S, Inutsuka S, et al. (1997) [Expression of CD44 standard and CD44 variant 6 in human lung cancer]. Nihon Kyobu Shikkan Gakkai Zasshi 35: 1179-1185.
32. Afify AM, Tate S, Durbin-Johnson B, Rocke DM, Konia T (2011) Expression of CD44s and CD44v6 in lung cancer and their correlation with prognostic factors. Int J Biol Markers 26: 50-57.
33. Zhao H, Fang J, Du G (1998) [Expression of standard and variant CD44 in human lung cancer]. Zhonghua Jie He He Hu Xi Za Zhi 21: 541-543.
34. Wang FL, Wei LX (2001) Expression of CD44 variant exon 6 in lung cancers. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23: 401-402.
35. Ariza A, Mate JL, Isamat M, Lopez D, Von Uexkull-Guldeband C, et al. (1995) Standard and variant CD44 isoforms are commonly expressed in lung cancer of the non-small cell type but not of the small cell type. J Pathol 177: 363-368.
36. Nguyen VN, Mirejovsky T, Melinova L, Mandys V (2000) CD44 and its v6 spliced variant in lung carcinomas: relation to NCAM, CEA, EMA and UP1 and prognostic significance. Neoplasma 47: 400-408.
37. Nitadori J, Ishii G, Tsuta K, Yokose T, Murata Y, et al. (2006) Immunohistochemical differential diagnosis between large cell neuroendocrine carcinoma and small cell carcinoma by tissue microarray analysis with a large antibody panel. Am J Clin Pathol 125: 682-692.
38. Kondo K, Miyoshi T, Hino N, Shimizu E, Masuda N, et al. (1998) High frequency expressions of CD44 standard and variant forms in non-small cell lung cancers, but not in small cell lung cancers. J Surg Oncol 69: 128-136. (Pubitemid 28549887)
39. Oikawa S, Inuzuka C, Kuroki M, Matsuoka Y, Kosaki G, et al. (1989) Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. Biochem Biophys Res Commun 164: 39-45. (Pubitemid 19269692)
40. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, et al. (1989) Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57: 327-334. (Pubitemid 19112371)
41. Stern N, Markel G, Arnon TI, Gruda R, Wong H, et al. (2005) Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol 174: 6692-6701. (Pubitemid 40705631)
42. Barthel SR, Gavino JD, Descheny L, Dimitroff CJ (2007) Targeting selectins and selectin ligands in inflammation and cancer. Expert Opin Ther Targets 11: 1473-1491. (Pubitemid 350200482)
43. McDermott KM, Crocker PR, Harris A, Burdick MD, Hinoda Y, et al. (2001) Overexpression of MUC1 reconfigures the binding properties of tumor cells. International journal of cancer Journal international du cancer 94: 783-791.