Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Takamatsu, Akira ^a   Ohkawara, Bisei ^a   Ito, Mikako ^a   Masuda, Akio ^a   Sakai, Tadahiro ^a   Ishiguro, Naoki ^a   Ohno, Kinji ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; BETA CATENIN; CALCIUM CHANNEL BLOCKING AGENT; COLLAGEN TYPE 2; COLLAGEN TYPE 2 ALPHA1; PROTEOGLYCAN; UNCLASSIFIED DRUG; VERAPAMIL; WNT PROTEIN;

ACAN GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AXIN2 GENE; BETA CATENIN SIGNALING; CARTILAGE DEGENERATION; CELL DIFFERENTIATION; CHONDROGENESIS; COL2A1 GENE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EMBRYO; FRZB GENE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MMP3 GENE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SOX9 GENE; TIBIA; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; BIOLOGICAL MARKERS; CALCIUM CHANNEL BLOCKERS; CARTILAGE; CHONDROCYTES; CHONDROGENESIS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; MICE; OSTEOARTHRITIS; PROMOTER REGIONS, GENETIC; PROTEOGLYCANS; RATS; VERAPAMIL; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84899096222     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092699     Document Type: Article

References (42)

1. Hunter DJ, Felson DT (2006) Osteoarthritis. BMJ 332: 639-642.
2. Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, et al. (2008) Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 58: 26-35.
3. Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, et al. (2005) Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 13: 632-641. (Pubitemid 40867863)
4. De Luca F, Barnes KM, Uyeda JA, De-Levi S, Abad V, et al. (2001) Regulation of growth plate chondrogenesis by bone morphogenetic protein-2. Endocrinology 142: 430-436. (Pubitemid 32183705)
5. Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, et al. (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273: 613-622. (Pubitemid 26262108)
6. Stewart AJ, Houston B, Farquharson C (2006) Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes. J Cell Physiol 206: 435-440. (Pubitemid 43062813)
7. Yuasa T, Otani T, Koike T, Iwamoto M, Enomoto-Iwamoto M (2008) Wnt/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration. Lab Invest 88: 264-274. (Pubitemid 351311287)
8. Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, et al. (2011) WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol 193: 551-564.
9. Thomas RS, Clarke AR, Duance VC, Blain EJ (2011) Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Res Ther 13: R203.
10. Zhu M, Tang D, Wu Q, Hao S, Chen M, et al. (2009) Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res 24: 12-21.
11. Hwang SG, Yu SS, Ryu JH, Jeon HB, Yoo YJ, et al. (2005) Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin. J Biol Chem 280: 12758-12765.
12. Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, et al. (2007) Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 56: 4095-4103. (Pubitemid 350262337)
13. Lane NE, Nevitt MC, Lui LY, de Leon P, Corr M, et al. (2007) Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum 56: 3319-3325. (Pubitemid 47585426)
14. Chan BY, Fuller ES, Russell AK, Smith SM, Smith MM, et al. (2011) Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis Cartilage 19: 874-885.
15. Hoang B, Moos M Jr, Vukicevic S, Luyten FP (1996) Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. J Biol Chem 271: 26131-26137. (Pubitemid 26347456)
16. Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, et al. (2004) Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A 101: 9757-9762. (Pubitemid 38869309)
17. Leijten JC, Emons J, Sticht C, van Gool S, Decker E, et al. (2012) Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis. Arthritis Rheum 64: 3302-3312.
18. Abbott A (2002) Neurologists strike gold in drug screen effort. Nature 417: 109.
19. Bian Y, Masuda A, Matsuura T, Ito M, Okushin K, et al. (2009) Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome. Hum Mol Genet 18: 1229-1237.
20. Takigawa M, Tajima K, Pan HO, Enomoto M, Kinoshita A, et al. (1989) Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes. Cancer Res 49: 3996-4002. (Pubitemid 19197434)
21. Mankin HJ, Dorfman H, Lippiello L, Zarins A (1971) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 53: 523-537.
22. Furman BD, Strand J, Hembree WC, Ward BD, Guilak F, et al. (2007) Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis. J Orthop Res 25: 578-592. (Pubitemid 46730511)
23. Beck E, Sieber WJ, Trejo R (2005) Management of cluster headache. Am Fam Physician 71: 717-724. (Pubitemid 40269988)
24. Little CB, Fosang AJ (2010) Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis-insights from studies of aggrecan and collagen proteolysis? Curr Drug Targets 11: 561-575.
25. Jho EH, Zhang T, Domon C, Joo CK, Freund JN, et al. (2002) Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 22: 1172-1183. (Pubitemid 34094853)
26. Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, et al. (2010) Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med 16: 678-686.
27. Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, et al. (2005) TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J Bone Miner Res 20: 1103-1113. (Pubitemid 40863798)
28. Wang Y, Middleton F, Horton JA, Reichel L, Farnum CE, et al. (2004) Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways. Bone 35: 1273-1293. (Pubitemid 40260392)
29. Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, et al. (2004) Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A 101: 17192-17197. (Pubitemid 39627796)
30. Ryu JH, Kim SJ, Kim SH, Oh CD, Hwang SG, et al. (2002) Regulation of the chondrocyte phenotype by beta-catenin. Development 129: 5541-5550.
31. Lefebvre V, Li P, de Crombrugghe B (1998) A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J 17: 5718-5733. (Pubitemid 28445983)
32. Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B (2002) The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16: 2813-2828. (Pubitemid 35253149)
33. Akiyama H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, et al. (2004) Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev 18: 1072-1087. (Pubitemid 38620246)
34. Kumar D, Lassar AB (2009) The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization. Mol Cell Biol 29: 4262-4273.
35. Zhu M, Chen M, Zuscik M, Wu Q, Wang YJ, et al. (2008) Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum 58: 2053-2064. (Pubitemid 351988097)
36. Weng LH, Ko JY, Wang CJ, Sun YC, Wang FS (2012) Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints. Arthritis Rheum 64: 3267-3277.
37. Ouskova G, Spellerberg B, Prehm P (2004) Hyaluronan release from Streptococcus pyogenes: export by an ABC transporter. Glycobiology 14: 931-938. (Pubitemid 39264016)
38. Hamerman D, Sasse J, Klagsbrun M (1986) A cartilage-derived growth factor enhances hyaluronate synthesis and diminishes sulfated glycosaminoglycan synthesis in chondrocytes. J Cell Physiol 127: 317-322. (Pubitemid 16074741)
39. Prehm P, Schumacher U (2004) Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters. Biochem Pharmacol 68: 1401-1410. (Pubitemid 39179398)
40. Prehm P (2005) Inhibitors of hyaluronan export prevent proteoglycan loss from osteoarthritic cartilage. J Rheumatol 32: 690-696.
41. Strazielle N, Ghersi-Egea JF (2013) Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules. Molecular pharmaceutics 10: 1473-1491.
42. Correa S, Binato R, Du Rocher B, Castelo-Branco MT, Pizzatti L, et al. (2012) Wnt/beta-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia. BMC cancer 12: 303.