Activation of the EGFR/Akt/NF-κB/cyclinD1 survival signaling pathway in human cholesteatoma epithelium

European Archives of Oto-Rhino-Laryngology

Volumn 271, Issue 2, 2014, Pages 265-273

  Liu, Wei ^a   Yin, Tuanfang ^a   Ren, Jihao ^a   Li, Lihua ^b   Xiao, Zian ^a   Chen, Xing ^c   Xie, Dinghua ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

^c HUNAN CANCER HOSPITAL   (China)

Author keywords

Akt; Cholesteatoma; CyclinD1; EGFR; NF B

Indexed keywords

CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; VASCULOTROPIN;

ADOLESCENT; ADULT; ARTICLE; AUDITORY OSSICLE; BASEMENT MEMBRANE; BONE DESTRUCTION; CANCER SURVIVAL; CELL HYPERPLASIA; CELL PROLIFERATION; CELL SURVIVAL; CHOLESTEATOMA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EXTERNAL AUDITORY CANAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE EAR SURGERY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SEMICIRCULAR CANAL; SIGNAL TRANSDUCTION; SKIN EPITHELIUM;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CELL PROLIFERATION; CELL SURVIVAL; CHOLESTEATOMA, MIDDLE EAR; CYCLIN D1; EAR CANAL; EPITHELIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; YOUNG ADULT;

EID: 84899086697     PISSN: 09374477     EISSN: 14344726     Source Type: Journal    
DOI: 10.1007/s00405-013-2403-6     Document Type: Article

References (33)

1. Olszewska E, Wagner M, Bernal-Sprekelsen M, Ebmeyer J, Dazert S, Hildmann H, Sudhoff H (2004) Etiopathogenesis of cholesteatoma. Eur Arch Otorhinolaryngol 261:6-24 (Pubitemid 38173028)
2. Louw L (2010) Acquired cholesteatoma pathogenesis: stepwise explanations. J Laryngol Otol 124:587-593
3. Juhn SK, Jung MK, Hoffman MD, Drew BR, Preciado DA, Sausen NJ, Jung TT, Kim BH, Park SY, Lin J, Ondrey FG, Mains DR, Huang T (2008) The role of inflammatory mediators in the pathogenesis of otitis media and sequelae. Clin Exp Otorhinolaryngol 1:117-138
4. McGrath MH (1990) Peptide growth factors and wound healing. Clin Plast Surg 17:421-432
5. Kojima H, Shiwa M, Kamide Y, Moriyama H (1994) Expression and localization of mRNA for epidermal growth factor and epidermal growth factor receptor in human cholesteatoma. Acta Otolaryngol 114:423-429 (Pubitemid 24262811)
6. Yetiser S, Satar B, Aydin N (2002) Expression of epidermal growth factor, tumor necrosis factor-alpha, and interleukin-1alpha in chronic otitis media with or without cholesteatoma. Otol Neurotol 23:647-652
7. Goto Y (1990) Epidermal growth factor in cholesteatoma - the second report: the localization in the horny layer. Nihon Jibiinkoka Gakkai Kaiho 93:1192-1199
8. Bazley LA, Gullick WJ (2005) The epidermal growth factor receptor family. Endocr Relat Cancer 12(Suppl 1):S17-S27 (Pubitemid 41395411)
9. Xu N, Lao Y, Zhang Y, Gillespie DA (2012) Akt: a double-edged sword in cell proliferation and genome stability. J Oncol. doi:10.1155/2012/951724
10. Song G, Ouyang G, Bao S (2005) The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9:59-71
11. Alves AL, Pereira CS, Carvalho Mde F, Fregnani JH, Ribeiro FQ (2012) EGFR expression in acquired middle ear cholesteatoma in children and adults. Eur J Pediatr 171:307-310
12. Jin BJ, Min HJ, Jeong JH, Park CW, Lee SH (2011) Expression of EGFR and microvessel density in middle ear cholesteatoma. Clin Exp Otorhinolaryngol 4:67-71
13. Barbara M, Raffa S, Murè C, Manni V, Ronchetti F, Monini S, Torrisi MR (2008) Keratinocyte growth factor receptor (KGF-R) in cholesteatoma tissue. Acta Otolaryngol 128:360-364 (Pubitemid 351450940)
14. Bujía J, Holly A, Schilling V, Negri B, Pitzke P, Schulz P (1993) Aberrant expression of epidermal growth factor receptor in aural cholesteatoma. Laryngoscope 103:326-329 (Pubitemid 23073333)
15. Ergün S, Zheng X, Carlsöö B (1996) Expression of transforming growth factor- alpha and epidermal growth factor receptor in middle ear cholesteatoma. Am J Otol 17:393-396
16. Bujía J, Kim C, Holly A, Sudhoff H, Ostos P, Kastenbauer E (1996) Epidermal growth factor receptor (EGF-R) in human middle ear cholesteatoma: an analysis of protein production and gene expression. Am J Otol 17:203-206 (Pubitemid 26171759)
17. Hussein MR, Sayed RH, Abu-Dief EE (2010) Immune cell profile in invasive cholesteatomas: preliminary findings. Exp Mol Pathol 88:316-323
18. Sikka K, Sharma SC, Thakar A, Dattagupta S (2012) Evaluation of epithelial proliferation in paediatric and adult cholesteatomas using the Ki-67 proliferation marker. J Laryngol Otol 126:460-463
19. Jung MH, Lee JH, Cho JG, Jung HH, Hwang SJ, Chae SW (2008) Expressions of caspase-14 in human middle ear cholesteatoma. Laryngoscope 118:1047-1050 (Pubitemid 351787276)
20. Lee NH, Chang JW, Choi J, Jung HH, Im GJ (2012) Expression of Ras-related C3 botulinum toxin substrate 1 (RAC1) in human cholesteatoma. Eur Arch Otorhinolaryngol. doi:10.1007/s00405-012-1966-y
21. Hiraishi Y, Wada T, Nakatani K, Negoro K, Fujita S (2006) Immunohistochemical expression of EGFR and p-EGFR in oral squamous cell carcinomas. Pathol Oncol Res 12:87-91 (Pubitemid 44197175)
22. Macias MP, Gerkin RD, Macias JD (2010) Increased amphiregulin expression as a biomarker of cholesteatoma activity. Laryngoscope 120:2258-2263
23. Huisman MA, De Heer E, Grote JJ (2007) Survival signaling and terminal differentiation in cholesteatoma epithelium. Acta Otolaryngol 127:424-429 (Pubitemid 46572874)
24. Byun JY, Yune TY, Lee JY, Yeo SG, Park MS (2010) Expression of CYLD and NF-kappaB in human cholesteatoma epithelium. Mediators Inflamm. doi:10.1155/2010/796315
25. Bussink J, van der Kogel AJ, Kaanders JH (2008) Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol 9:288-296 (Pubitemid 351722948)
26. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655-1657
27. Baeuerle PA, Baltimore D (1996) NF-kappa B: ten years after. Cell 87:13-20
28. Ouyang W, Li J, Ma Q, Huang C (2006) Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclinD1 induction by arsenite in JB6 Cl41 cells. Carcinogenesis 27:864-873
29. Zhang QA, Hamajima Y, Zhang Q, Lin J (2008) Identification of Id1 in acquired middle ear cholesteatoma. Arch Otolaryngol Head Neck Surg 134:306-310 (Pubitemid 351439260)
30. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G (1993) CyclinD1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 7:812-821 (Pubitemid 23163585)
31. Klein EA, Assoian RK (2008) Transcriptional regulation of the cyclinD1 gene at a glance. J Cell Sci 121:3853-3857
32. He YY, Council SE, Feng L, Chignell CF (2008) UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/CyclinD1 pathways in keratinocytes. Cancer Res 68:3752-3758
33. Vokes EE, Chu E (2006) Anti-EGFR therapies: clinical experience in colorectal, lung, and head and neck cancers. Oncology (Williston Park) 20:15-25