Increased amphiregulin expression as a biomarker of cholesteatoma activity

Laryngoscope

Volumn 120, Issue 11, 2010, Pages 2258-2263

  MacIas, Mimi P ^a   Gerkin, Richard D ^b   MacIas, John D ^c  

^a Ear Foundation of Arizona   (United States)

^b BANNER HEALTH   (United States)

^c Macias Otology   (United States)

Author keywords

amphiregulin; biomarker; Cholesteatoma; epidermal growth factor receptor; hyperproliferative; migration; real time reverse transcription polymerase chain reaction

Indexed keywords

AMPHIREGULIN; BIOLOGICAL MARKER; RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE EROSION; CELL GROWTH; CELL PROLIFERATION; CHILD; CHOLESTEATOMA; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM; EXPERIMENTAL STUDY; EXTERNAL AUDITORY CANAL; FEMALE; FISHER EXACT TEST; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUALITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STUDENT T TEST; TUMOR CELL; WESTERN BLOTTING;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CHILD; CHOLESTEATOMA; CHOLESTEATOMA, MIDDLE EAR; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; TEMPORAL BONE; YOUNG ADULT;

EID: 78349243992     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1002/lary.21142     Document Type: Article

References (16)

1. Albino AP, Kimmelman CP, Parisier SC., Cholesteatoma: a molecular and cellular puzzle. Am J Otol 1998; 19: 7-19.
2. Rosenfeld RM, Moura RL, Bluestone CD., Predictors of residual-recurrent cholesteatoma in children. Arch Otolaryngol Head Neck Surg 1992; 118: 384-391.
3. Plowman GD, Green JM, McDonald VL, et al. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol Cell Biol 1990; 10: 1969-1981.
4. Willmarth NE, Ethier SP., Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. J Biol Chem 2006; 281: 37728-37737.
5. Yamane S, Ishida S, Hanamoto Y, et al. Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients. J Inflamm (Lond) 2008; 5: 5.
6. Piepkorn M., Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases. Am J Dermatopathol 1996; 18: 165-171.
7. Cook PW, Piepkorn M, Clegg CH, et al. Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest 1997; 100: 2286-2294.
8. Sakamoto T, Kondo K, Yamasoba T, et al. Overexpression of ErbB-2 protein in human middle ear cholesteatomas. Laryngoscope 2004; 114: 1988-1991.
9. Bujia J, Kim C, Holly A, et al. Epidermal growth factor receptor (EGF-R) in human middle ear cholesteatoma: an analysis of protein production and gene expression. Am J Otol 1996; 17: 203-206.
10. Ergun S, Zheng X, Carlsoo B., Expression of transforming growth factor-alpha and epidermal growth factor receptor in middle ear cholesteatoma. Am J Otol 1996; 17: 393-396.
11. Klingelhofer J, Moller HD, Sumer EU, et al. Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein. FEBS J 2009; 276: 5936-5948.
12. Shoyab M, McDonald VL, Bradley JG, et al. Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci U S A 1988; 85: 6528-6532.
13. Bujia J, Sudhoff H, Holly A, et al. Immunohistochemical detection of proliferating cell nuclear antigen in middle ear cholesteatoma. Eur Arch Otorhinolaryngol 1996; 253: 21-24.
14. Mallet Y, Nouwen J, Lecomte-Houcke M, et al. Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1. Laryngoscope 2003; 113: 328-331.
15. Kim HJ, Tinling SP, Chole RA., Increased proliferation and migration of epithelium in advancing experimental cholesteatomas. Otol Neurotol 2002; 23: 840-844.
16. Robinson R, Bertram JP, Reiter JL, et al. New platform for controlled and sustained delivery of the EGF receptor tyrosine kinase inhibitor AG1478 using poly(lactic-co-glycolic acid) microspheres. J Microencapsul 2010; 27: 263-271.