Pulmonary vasodilation by acetazolamide during hypoxia: Impact of methyl-group substitutions and administration route in conscious, spontaneously breathing dogs

Journal of Applied Physiology

Volumn 116, Issue 7, 2014, Pages 715-723

  Pickerodt, Philipp A ^a   Francis, Roland C ^a   Höhne, Claudia ^b   Neubert, Friederike ^a   Telalbasic, Stella ^a   Boemke, Willehad ^a   Swenson, Erik R ^c,d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c UNIVERSITY OF WASHINGTON   (United States)

^d VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

Acetazolamide; Hypoxic pulmonary vasoconstriction; N methyl Acet Azolamide; Pulmonary arterial pressure; Pulmonary vascular resistance

Indexed keywords

ACETAZOLAMIDE; CARBONATE DEHYDRATASE INHIBITOR; VASODILATOR AGENT;

ANIMAL; ANOXIA; ARTERIAL PRESSURE; BREATHING; CHEMISTRY; COMPARATIVE STUDY; DISEASE MODEL; DOG; DRUG EFFECTS; ENZYMOLOGY; FEMALE; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; METHYLATION; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PULMONARY ARTERY; STRUCTURE ACTIVITY RELATION; TIME; VASCULAR RESISTANCE; VASODILATATION;

ACETAZOLAMIDE; ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMALS; ANOXIA; ARTERIAL PRESSURE; CARBONIC ANHYDRASE INHIBITORS; DISEASE MODELS, ANIMAL; DOGS; FEMALE; INFUSIONS, INTRAVENOUS; METHYLATION; PULMONARY ARTERY; RESPIRATION; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; VASCULAR RESISTANCE; VASODILATION; VASODILATOR AGENTS;

EID: 84899077633     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01235.2013     Document Type: Article

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