The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: The Atlantic Diabetes in Pregnancy cohort

Diabetes Care

Volumn 37, Issue 5, 2014, Pages 1230-1236

  Chakera, Ali J ^a,b   Spyer, Gill ^c   Vincent, Nicola ^a   Ellard, Sian ^a,b   Hattersley, Andrew T ^a,b   Dunne, Fidelma P ^d  

^a UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^b ROYAL DEVON AND EXETER NHS FOUNDATION TRUST   (United Kingdom)

^c TORBAY AND SOUTH DEVON NHS FOUNDATION TRUST   (United Kingdom)

^d NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; GLUCOSE; GLUCOSE BLOOD LEVEL;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DIAGNOSTIC ERROR; DIAGNOSTIC TEST ACCURACY STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; FEMALE; GENE; GENE MUTATION; GLUCOKINASE MONOGENIC DIABETES; GSCK GENE; HUMAN; MAJOR CLINICAL STUDY; MONOGENIC DISORDER; OUTCOME ASSESSMENT; PREGNANCY; PREGNANCY DIABETES MELLITUS; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS; BLOOD; CASE CONTROL STUDY; DIABETES MELLITUS, TYPE 2; DIABETES, GESTATIONAL; DIFFERENTIAL DIAGNOSIS; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED; MUTATION; PREGNANCY COMPLICATIONS; PREGNANCY IN DIABETICS; RISK FACTOR; YOUNG ADULT;

ADOLESCENT; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; CASE-CONTROL STUDIES; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DIABETES, GESTATIONAL; DIAGNOSIS, DIFFERENTIAL; FASTING; FEMALE; GLUCOKINASE; HUMANS; MIDDLE AGED; MUTATION; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY IN DIABETICS; PREVALENCE; RISK FACTORS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84899074567     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc13-2248     Document Type: Article

References (20)

1. Stride A, Vaxillaire M, Tuomi T, et al. The genetic abnormality in the beta cell determines the response to an oral glucose load. Diabetologia 2002;45:427-435 (Pubitemid 34267366)
2. Hattersley AT, Beards F, Ballantyne E, Appleton M, Harvey R, Ellard S. Mutations in the glucokinase gene of the fetus result in reduced birth weight. Nat Genet 1998;19:268-270 (Pubitemid 28309340)
3. Spyer G, Macleod KM, Shepherd M, Ellard S, Hattersley AT. Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutation. Diabet Med 2009;26:14-18
4. Colom C, Corcoy R. Maturity onset diabetes of the young and pregnancy. Best Pract Res Clin Endocrinol Metab 2010;24:605-615
5. Spyer G, Hattersley AT, Sykes JE, Sturley RH, MacLeod KM. Influence of maternal and fetal glucokinase mutations in gestational diabetes. Am J Obstet Gynecol 2001;185:240-241 (Pubitemid 32681826)
6. Metzger BE, Gabbe SG, Persson B, et al.; International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010;33:676-682
7. World Health Organization. Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy. Geneva, World Health Org., 2013
8. Zouali H, Vaxillaire M, Lesage S, et al. Linkage analysis and molecular scanning of glucokinase gene in NIDDM families. Diabetes 1993;42:1238-1245 (Pubitemid 23259842)
9. Stoffel M, Bell KL, Blackburn CL, et al. Identification of glucokinase mutations in subjects with gestational diabetes mellitus. Diabetes 1993;42:937-940 (Pubitemid 23151590)
10. Chiu KC, Go RC, Aoki M, et al. Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning. Diabetologia 1994;37:104-110 (Pubitemid 24044715)
11. Saker PJ, Hattersley AT, BarrowB, et al. High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population. Diabetologia 1996;39:1325-1328 (Pubitemid 26356061)
12. Allan CJ, Argyropoulos G, Bowker M, et al. Gestational diabetes mellitus and gene mutations which affect insulin secretion. Diabetes Res Clin Pract 1997;36:135-141 (Pubitemid 27306816)
13. Ellard S, Beards F, Allen LI, et al. A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria. Diabetologia 2000;43:250-253 (Pubitemid 30126833)
14. Kousta E, Ellard S, Allen LI, et al. Glucokinase mutations in a phenotypically selected multiethnic group of women with a history of gestational diabetes. Diabet Med 2001;18:683-684 (Pubitemid 32823070)
15. Weng J, Ekelund M, Lehto M, et al. Screening for MODY mutations, GAD antibodies, and type 1 diabetes-associated HLA genotypes in women with gestational diabetes mellitus. Diabetes Care 2002;25:68-71 (Pubitemid 41070785)
16. Zurawek M, Wender-Ozegowska E, Januszkiewicz-Lewandowska D, Zawiejska A, Nowak J. GCK and HNF1alpha mutations and polymorphisms in Polish women with gestational diabetes. Diabetes Res Clin Pract 2007;76:157-158 (Pubitemid 46240363)
17. O'Sullivan EP, Avalos G, O'Reilly M, Dennedy MC, Gaffney G, Dunne F; Atlantic DIP collaborators. Atlantic Diabetes in Pregnancy (DIP): the prevalence and outcomes of gestational diabetes mellitus using new diagnostic criteria. Diabetologia 2011;54:1670-1675
18. Ellard S, Bellanné-Chantelot C, Hattersley AT; European Molecular Genetics Quality Network (EMQN) MODY group. Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young. Diabetologia 2008;51:546-553
19. Gloyn AL. Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy. Hum Mutat 2003;22:353-362 (Pubitemid 37346107)
20. Shields BM, Hicks S, Shepherd MH, Colclough K, Hattersley AT, Ellard S. Maturity-onset diabetes of the young (MODY): how many cases are we missing? Diabetologia 2010;53:2504-2508