Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse

Journal of Ovarian Research

Volumn 7, Issue 1, 2014, Pages

  Maurya, Vineet Kumar ^a   Sangappa, Chadchan ^a   Kumar, Vijay ^a   Mahfooz, Sahil ^a   Singh, Archana ^a   Rajender, Singh ^a   Jha, Rajesh Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Caveolin1; Dehydroepiandrosterone; Estradiol; Polycystic ovary; Rac1; Vav

Indexed keywords

CAVEOLIN 1; ESTRADIOL; GUANINE NUCLEOTIDE; INHIBIN B; PRAC1 PROTEIN; PRASTERONE; PROTEIN; PVAV PROTEIN; RAC1 PROTEIN; UNCLASSIFIED DRUG; VAV PROTEIN; CAV1 PROTEIN, MOUSE; INHIBIN; RAC1 PROTEIN, HUMAN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DENSITOMETRY; DOWN REGULATION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; ENZYMOLOGY; FEMALE; METABOLISM; OVARY; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; CAVEOLIN 1; DEHYDROEPIANDROSTERONE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ESTRADIOL; FEMALE; INHIBINS; MICE, INBRED C57BL; OVARY; PHOSPHORYLATION; POLYCYSTIC OVARY SYNDROME; PROTO-ONCOGENE PROTEINS C-VAV; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84899072819     PISSN: None     EISSN: 17572215     Source Type: Journal    
DOI: 10.1186/1757-2215-7-32     Document Type: Article

References (56)

1. Molecular mechanisms underlying the activation of mammalian primordial follicles. Adhikari D, Liu K, Endocr Rev 2009 30 438 464 10.1210/er.2008-0048 19589950
2. Development of follicles in the mammalian ovary. Hirshfield AN, Int Rev Cytol 1991 124 43 101 43-101 2001918
3. Initial and cyclic recruitment of ovarian follicles. McGee EA, Hsueh AJ, Endocr Rev 2000 21 200 214 10782364
4. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R, Nat Rev Endocrinol 2011 7 219 231 10.1038/nrendo.2010.217 21263450
5. Ovarian failure and polycystic ovary syndrome. Petrikova J, Lazurova I, Autoimmun Rev 2012 11 471 A478 10.1016/j.autrev.2011.11.010 22154711
6. Racial and ethnic differences in physiology and clinical symptoms of polycystic ovary syndrome. Wang S, Alvero R, Semin Reprod Med 2013 31 365 369 10.1055/s-0033-1348895 23934697
7. Reproductive endocrinology of adolescent polycystic ovary syndrome. Shayya R, Chang RJ, BJOG 2010 117 150 155 10.1111/j.1471-0528.2009.02421.x 20002395
8. The genetic basis of polycystic ovary syndrome. Franks S, Gharani N, Waterworth D, Batty S, White D, Williamson R, McCarthy M, Hum Reprod 1997 12 2641 2648 10.1093/humrep/12.12.2641 9455828
9. The development of the polycystic ovary syndrome: family history as a risk factor. Kahsar-Miller M, Azziz R, Trends Endocrinol Metab 1998 9 55 58 10.1016/S1043-2760(98)00021-6 18406241
10. Metabolic syndrome in females with polycystic ovary syndrome and International Diabetes Federation criteria. Bhattacharya SM, J Obstet Gynaecol Res 2008 34 62 66 18226131
11. Minireview: physiological and pathological actions of RAS in the ovary. Fan HY, Richards JS, Mol Endocrinol 2010 24 286 298 10.1210/me.2009-0251 19880654
12. Connections between integrins and Rac GTPase pathways control gonad formation and function in C. elegans. Lee M, Shen B, Schwarzbauer JE, Ahn J, Kwon J, Biochim Biophys Acta 2005 1723 248 255 10.1016/j.bbagen.2005.01.003 15716039
13. alpha2beta1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells. Cailleteau L, Estrach S, Thyss R, Boyer L, Doye A, Domange B, Johnsson N, Rubinstein E, Boucheix C, Ebrahimian T, Silvestre JS, Lemichez E, Meneguzzi G, Mettouchi A, J Cell Sci 2010 123 2491 2501 10.1242/jcs.058875 20592186
14. Down-regulation of Rac-1 GTPase by Estrogen. Laufs U, Adam O, Strehlow K, Wassmann S, Konkol C, Laufs K, Schmidt W, Bohm M, Nickenig G, J Biol Chem 2003 278 5956 5962 10.1074/jbc.M209813200 12493759
15. Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Abramovici H, Mojtabaie P, Parks RJ, Zhong XP, Koretzky GA, Topham MK, Gee SH, Mol Biol Cell 2009 20 2049 2059 10.1091/mbc.E07-12-1248 19211846
16. The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. Sauzeau V, Sevilla MA, Montero MJ, Bustelo XR, J Clin Invest 2010 120 315 330 10.1172/JCI38356 20038798
17. Luteinizing hormone receptor-stimulated progesterone production by preovulatory granulosa cells requires protein kinase A-dependent activation/dephosphorylation of the actin dynamizing protein cofilin. Karlsson AB, Maizels ET, Flynn MP, Jones JC, Shelden EA, Bamburg JR, Hunzicker-Dunn M, Mol Endocrinol 2010 24 1765 1781 10.1210/me.2009-0487 20610540
18. The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. Bristow JM, Sellers MH, Majumdar D, Anderson B, Hu L, Webb DJ, J Cell Sci 2009 122 4535 4546 10.1242/jcs.053728 19934221
19. Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. Mettouchi A, Klein S, Guo W, Lopez-Lago M, Lemichez E, Westwick JK, Giancotti FG, Mol Cell 2001 8 115 127 10.1016/S1097-2765(01)00285- 4 11511365
20. VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2. Garrett TA, Van Buul JD, Burridge K, Exp Cell Res 2007 313 3285 3297 10.1016/j.yexcr.2007.05.027 17686471
21. Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Vedham V, Phee H, Coggeshall KM, Mol Cell Biol 2005 25 4211 4220 10.1128/MCB.25.10.4211- 4220.2005 15870290
22. Mechanism of inhibitory effect of atorvastatin on resistin expression induced by tumor necrosis factor-alpha in macrophages. Shyu KG, Chua SK, Wang BW, Kuan P, J Biomed Sci 2009 16 50 50 10.1186/1423-0127-16-50 19473519
23. Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease. Aoukaty A, Tan R, J Immunol 2005 174 4551 4558 15814676
24. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR, Nature 1997 385 169 172 10.1038/385169a0 8990121
25. The mechanisms involved in the action of metformin in regulating ovarian function in hyperandrogenized mice. Elia E, Sander V, Luchetti CG, Solano ME, Di GG, Gonzalez C, Motta AB, Mol Hum Reprod 2006 12 475 481 10.1093/molehr/gal057 16809378
26. Effects of dehydroepiandrosterone on ovarian cystogenesis and immune function. Luchetti CG, Solano ME, Sander V, Arcos ML, Gonzalez C, Di GG, Chiocchio S, Cremaschi G, Motta AB, J Reprod Immunol 2004 64 59 74 10.1016/j.jri.2004.04.002 15596227
27. Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone. Sander V, Luchetti CG, Solano ME, Elia E, Di GG, Gonzalez C, Motta AB, Reproduction 2006 131 591 602 10.1530/rep.1.00941 16514202
28. Demethylation of LHR in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome. Zhu JQ, Zhu L, Liang XW, Xing FQ, Schatten H, Sun QY, Mol Hum Reprod 2010 16 260 266 10.1093/molehr/gap089 19828691
29. Cystogenesis of the ovarian antral follicle of the rat: ultrastructural changes and hormonal profile following the administration of dehydroepiandrosterone. Anderson E, Lee MT, Lee GY, Anat Rec 1992 234 359 382 10.1002/ar.1092340307 1443664
30. Lysyl oxidase and MMP-2 expression in dehydroepiandrosterone-induced polycystic ovary in rats. Henmi H, Endo T, Nagasawa K, Hayashi T, Chida M, Akutagawa N, Iwasaki M, Kitajima Y, Kiya T, Nishikawa A, Manase K, Kudo R, Biol Reprod 2001 64 157 162 10.1095/biolreprod64.1.157 11133670
31. Multidrug resistance gene expression correlates with progesterone production in dehydroepiandrosterone-induced polycystic and equine chorionic gonadotropin-stimulated ovaries of prepubertal rats. Lee GY, Croop JM, Anderson E, Biol Reprod 1998 58 330 337 10.1095/biolreprod58.2.330 9475386
32. Transforming growth factor-beta 1 (TGF-B1) liberation from its latent complex during embryo implantation and its regulation by estradiol in mouse. Maurya VK, Jha RK, Kumar V, Joshi A, Chadchan S, Mohan JJ, Laloraya M, Biol Reprod 2013 89 84 10.1095/biolreprod.112.106542 23926286
33. Loss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activity. Hayashida T, Jones JC, Lee CK, Schnaper HW, J Biol Chem 2010 285 30741 30751 10.1074/jbc.M110.105700 20650890
34. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Laemmli UK, Nature 1970 227 680 685 10.1038/227680a0 5432063
35. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. 1979. Towbin H, Staehelin T, Gordon J, Biotechnology 1992 24 145 149 145-9 1422008
36. Relationship between serum inhibin A and B and ovarian follicle development after a daily fixed dose administration of recombinant follicle-stimulating hormone. Eldar-Geva T, Robertson DM, Cahir N, Groome N, Gabbe MP, Maclachlan V, Healy DL, J Clin Endocrinol Metab 2000 85 607 613 10690863
37. Inhibin A and inhibin B in women with polycystic ovarian syndrome during treatment with FSH to induce mono-ovulation. Anderson RA, Groome NP, Baird DT, Clin Endocrinol (Oxf) 1998 48 577 584 10.1046/j.1365-2265.1998.00442.x 9666869
38. Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone. Dafopoulos K, Venetis C, Messini CI, Pournaras S, Anifandis G, Garas A, Messinis IE, Reprod Biol Endocrinol 2011 9 59 doi: 10.1186/1477-7827-9-59.: 59 10.1186/1477-7827-9-59 21529351
39. Mid-follicular phase pulses of inhibin B are absent in polycystic ovarian syndrome and are initiated by successful laparoscopic ovarian diathermy: a possible mechanism regulating emergence of the dominant follicle. Lockwood GM, Muttukrishna S, Groome NP, Matthews DR, Ledger WL, J Clin Endocrinol Metab 1998 83 1730 1735 10.1210/jcem.83.5.4756 9589683
40. c-Abl tyrosine kinase plays a critical role in beta2 integrin-dependent neutrophil migration by regulating Vav1 activity. Tong H, Zhao B, Shi H, Ba X, Wang X, Jiang Y, Zeng X, J Leukoc Biol 2013 93 611 622 10.1189/jlb.1012487 23325923
41. Caveolin regulation of endothelial function. Minshall RD, Sessa WC, Stan RV, Anderson RG, Malik AB, Am J Physiol Lung Cell Mol Physiol 2003 285 1179 L1183 14604847
42. Fate of the initial follicle pool: empirical and mathematical evidence supporting its sufficiency for adult fertility. Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Mayo KE, Shea LD, Woodruff TK, Dev Biol 2006 298 149 154 10.1016/j.ydbio.2006.06.023 16925987
43. The kinetics of pre-antral follicle development in ovaries of CBA/Ca mice during the first 14 weeks of life. Faddy MJ, Telfer E, Gosden RG, Cell Tissue Kinet 1987 20 551 560 3502925
44. Consequences of RAS and MAPK activation in the ovary: the good, the bad and the ugly. Fan HY, Liu Z, Mullany LK, Richards JS, Mol Cell Endocrinol 2012 356 74 79 10.1016/j.mce.2011.12.005 22197887
45. Ras signaling modulates activity of the ecdysone receptor EcR during cell migration in the Drosophila ovary. Hackney JF, Pucci C, Naes E, Dobens L, Dev Dyn 2007 236 1213 1226 10.1002/dvdy.21140 17436275
46. Multiple Ras signals pattern the Drosophila ovarian follicle cells. Lee T, Montell DJ, Dev Biol 1997 185 25 33 10.1006/dbio.1997.8537 9169047
47. RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly. Yodoi R, Tamba S, Morimoto K, Segi-Nishida E, Nishihara M, Ichikawa A, Narumiya S, Sugimoto Y, Endocrinology 2009 150 3345 3352 10.1210/en.2008-1449 19342461
48. Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis. Vlachos S, Harden N, Genetics 2011 187 501 512 10.1534/genetics.110. 120998 21098722
49. Current concepts in the polycystic ovary syndrome. Dunaif A, Thomas A, Annu Rev Med 2001 52 401 419 401-19 10.1146/annurev.med.52.1.401 11160786
50. Polycystic ovary syndrome. Ehrmann DA, N Engl J Med 2005 352 1223 1236 10.1056/NEJMra041536 15788499
51. Polycystic ovary syndrome. Norman RJ, Dewailly D, Legro RS, Hickey TE, Lancet 2007 370 685 697 10.1016/S0140-6736(07)61345-2 17720020
52. Dehydroepiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats. Aragno M, Brignardello E, Tamagno E, Gatto V, Danni O, Boccuzzi G, J Endocrinol 1997 155 233 240 10.1677/joe.0. 1550233 9415057
53. Criteria for polycystic ovarian morphology in polycystic ovary syndrome as a function of age. Alsamarai S, Adams JM, Murphy MK, Post MD, Hayden DL, Hall JE, Welt CK, J Clin Endocrinol Metab 2009 94 4961 4970 10.1210/jc.2009-0839 19846740
54. The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. Citterio C, Menacho-Marquez M, Garcia-Escudero R, Larive RM, Barreiro O, Sanchez-Madrid F, Paramio JM, Bustelo XR, Sci Signal 2012 5 a71 23033540
55. The role of ubiquitylation and degradation in RhoGTPase signalling. Nethe M, Hordijk PL, J Cell Sci 2010 123 4011 4018 10.1242/jcs.078360 21084561
56. The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanism. Cerezo A, Guadamillas MC, Goetz JG, Sanchez-Perales S, Klein E, Assoian RK, del Pozo MA, Mol Cell Biol 2009 29 5046 5059 10.1128/MCB.00315-09 19620284