A novel pathogenic peptide of thyroglobulin (2208-2227) induces autoreactive T-cell and B-cell responses in both high and low responder mouse strains

Immunology

Volumn 142, Issue 2, 2014, Pages 300-306

  Kanistras, Ioannis ^a   Hatzioannou, Aikaterini ^a   Lymberi, Peggy ^a  

^a HELLENIC PASTEUR INSTITUTE   (Greece)

Author keywords

Experimental autoimmune thyroiditis; High low responders; Pathogenic thyroglobulin peptides; Resistant susceptible strains; T cell epitopes

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; P2208 PROTEIN; THYROGLOBULIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE RESISTANCE; EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS; HIGH RESPONDER; IMMUNOGENICITY; LOW RESPONDER; LYMPH NODE CELL; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MOUSE STRAIN; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SWISS JAMES LAMBERT MOUSE; T LYMPHOCYTE; TH1 CELL;

EXPERIMENTAL AUTOIMMUNE THYROIDITIS; HIGH/LOW RESPONDERS; PATHOGENIC THYROGLOBULIN PEPTIDES; RESISTANT/SUSCEPTIBLE STRAINS; T-CELL EPITOPES;

ALGORITHMS; ANIMALS; B-LYMPHOCYTES; FEMALE; HUMANS; MICE; MICE, INBRED STRAINS; PEPTIDE FRAGMENTS; T-LYMPHOCYTES; THYROGLOBULIN;

EID: 84899057307     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12254     Document Type: Article

References (38)

1. Charreire J. Immune mechanisms in autoimmune thyroiditis. Adv Immunol 1989; 46:263-334.
2. Rose NR, Twarog FJ, Crowle AJ. Murine thyroiditis: importance of adjuvant and mouse strain for the induction of thyroid lesions. J Immunol 1971; 106:698-704.
3. Esquivel PS, Rose NR, Kong YC. Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide. J Exp Med 1977; 145:1250-63.
4. Vladutiu AO, Rose NR. Cellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice. Cell Immunol 1975; 17:106-13.
5. Vladutiu AO, Rose NR. Autoimmune murine thyroiditis relation to histocompatibility (H-2) type. Science 1971; 174:1137-9.
6. Texier B, Bedin C, Tang H, Camoin L, Laurent-Winter C, Charreire J. Characterization and sequencing of a 40-amino-acid peptide from human thyroglobulin inducing experimental autoimmune thyroiditis. J Immunol 1992; 148:3405-11.
7. Rao VP, Balasa B, Carayanniotis G. Mapping of thyroglobulin epitopes: presentation of a 9mer pathogenic peptide by different mouse MHC class II isotypes. Immunogenetics 1994; 40:352-9.
8. Carayanniotis G, Chronopoulou E, Rao VP. Distinct genetic pattern of mouse susceptibility to thyroiditis induced by a novel thyroglobulin peptide. Immunogenetics 1994; 39:21-8.
9. Kong YC, McCormick DJ, Wan Q et al. Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis. Secondary role of iodination. J Immunol 1995; 155:5847-54.
10. Wan Q, Motte RW, McCormick DJ et al. Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis: role of MHC class II. Clin Immunol Immunopathol 1997; 85:187-94.
11. Braley-Mullen H, Sharp GC. A thyroxine-containing thyroglobulin peptide induces both lymphocytic and granulomatous forms of experimental autoimmune thyroiditis. J Autoimmun 1997; 10:531-40.
12. Rao VP, Carayanniotis G. Contrasting immunopathogenic properties of highly homologous peptides from rat and human thyroglobulin. Immunology 1997; 90:244-9.
13. Verginis P, Stanford MM, Carayanniotis G. Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis. J Immunol 2002; 169:5332-7.
14. Flynn JC, McCormick DJ, Brusic V et al. Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. Cell Immunol 2004; 229:79-85.
15. Verginis P, Carayanniotis G. Experimental autoimmune thyroiditis (EAT) induced by the thyroglobulin peptide (2596-2608): influence of H-2 and non H-2 genes. Autoimmunity 2004; 37:529-33.
16. Li HS, Carayanniotis G. Iodination of tyrosyls in thyroglobulin generates neoantigenic determinants that cause thyroiditis. J Immunol 2006; 176:4479-83.
17. Li HS, Jiang HY, Carayanniotis G. Modifying effects of iodine on the immunogenicity of thyroglobulin peptides. J Autoimmun 2007; 28:171-6.
18. Hatzioannou A, Liakata E, Karras E, Thrasyvoulides A, Alevizaki M, Lymberi P. Pathogenicity of a human thyroglobulin peptide (2340-2359) in mice with high or low genetic susceptibility to thyroiditis. Immunology 2007; 122:343-9.
19. Thrasyvoulides A, Sakarellos-Daitsiotis M, Philippou G, Souvatzoglou A, Sakarellos C, Lymberi P. B-cell autoepitopes on the acetylcholinesterase-homologous region of human thyroglobulin: association with Graves' disease and thyroid eye disease. Eur J Endocrinol 2001; 145:119-27.
20. Thrasyvoulides A, Lymberi P. Evidence for intramolecular B-cell epitope spreading during experimental immunization with an immunogenic thyroglobulin peptide. Clin Exp Immunol 2003; 132:401-7.
21. k-restricted peptide of human thyroglobulin. Immunology 2003; 108:556-61.
22. Karras E, Yang H, Lymberi P, Christadoss P. Human thyroglobulin peptide p2340 induces autoimmune thyroiditis in HLA-DR3 transgenic mice. J Autoimmun 2005; 24:291-6.
23. Hatzioannou A, Alevizaki M, Carayanniotis G, Lymberi P. Fine epitope mapping within the pathogenic thyroglobulin peptide 2340-2359: minimal epitopes retaining antigenicity across various MHC haplotypes are not necessarily immunogenic. Immunology 2012; 135:245-53.
24. van de Graaf SA, Ris-Stalpers C, Pauws E, Mendive FM, Targovnik HM, de Vijlder JJ. Up to date with human thyroglobulin. J Endocrinol 2001; 170:307-21.
25. Schardt CW, McLachlan SM, Matheson J, Smith BR. An enzyme-linked immunoassay for thyroid microsomal antibodies. J Immunol Methods 1982; 55:155-68.
26. Altuvia Y, Berzofsky JA, Rosenfeld R, Margalit H. Sequence features that correlate with MHC restriction. Mol Immunol 1994; 31:1-19.
27. Reche PA, Reinherz EL. Prediction of peptide-MHC binding using profiles. Methods Mol Biol 2007; 409:185-200.
28. Guilbert B, Dighiero G, Avrameas S. Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization. J Immunol 1982; 128:2779-87.
29. Ternynck T, Avrameas S. Polyacrylamide-protein immunoadsorbents prepared with glutaraldehyde. FEBS Lett 1972; 23:24-8.
30. Ternynck T, Weston P, Guilbert B, Avrameas S. A new process for the preparation of insoluble proteins and of proteins coupled with peroxidase. Ann Inst Pasteur (Paris) 1972; 123:146-7.
31. Simon LL, Krco CJ, David CS, Kong YM. Characterization of the in vitro murine T-cell proliferative responses to murine and human thyroglobulins in thyroiditis-susceptible and -resistant mice. Cell Immunol 1985; 94:243-53.
32. + transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes. Cell Immunol 2008; 251:1-7.
33. Chronopoulou E, Carayanniotis G. Identification of a thyroiditogenic sequence within the thyroglobulin molecule. J Immunol 1992; 149:1039-44.
34. Jiang HY, Li HS, Carayanniotis K, Carayanniotis G. Variable influences of iodine on the T-cell recognition of a single thyroglobulin epitope. Immunology 2007; 121:370-6.
35. Hoshioka A, Kohno Y, Katsuki T et al. A common T-cell epitope between human thyroglobulin and human thyroid peroxidase is related to murine experimental autoimmune thyroiditis. Immunol Lett 1993; 37:235-9.
36. Kolypetri P, Jiang H, Carayanniotis G. Identification of pathogenic T cell epitopes near cathepsin cleavage sites in thyroglobulin. J Immunol 2013; 190:1466-71.
37. El Hassani RA, Estienne V, Blanchin S et al. Antigenicity and immunogenicity of the C-terminal peptide of human thyroglobulin. Peptides 2004; 25:1021-9.
38. k expression influences thyroiditis induction by the thyroglobulin peptide (2495-2511). Immunogenetics 1993; 38:150-3.