Pathogenicity of a human thyroglobulin peptide (2340-2359) in mice with high or low genetic susceptibility to thyroiditis

Immunology

Volumn 122, Issue 3, 2007, Pages 343-349

  Hatzioannou, Aikaterini ^a   Liakata, Elisavet ^a   Karras, Evangelos ^a   Thrasyvoulides, Apollon ^a,c   Alevizaki, Maria ^b   Lymberi, Peggy ^a  

^a HELLENIC PASTEUR INSTITUTE   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Experimental autoimmune thyroiditis; Human thyroglobulin; Major histocompatibility complex; Peptide; T cell epitope

Indexed keywords

EPITOPE; FREUND ADJUVANT; THYROGLOBULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE THYROIDITIS; B LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENETIC SUSCEPTIBILITY; IMMUNOGENICITY; LYMPH NODE CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; CELL PROLIFERATION; CYTOKINES; EPITOPES, T-LYMPHOCYTE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOGLOBULIN G; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; SPECIES SPECIFICITY; T-LYMPHOCYTE SUBSETS; THYROGLOBULIN; THYROID GLAND; THYROIDITIS, AUTOIMMUNE;

EID: 35048823329     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2007.02645.x     Document Type: Article

References (26)

1. Rose NR, Twarog FJ, Crowle AJ. Murine thyroiditis: Importance of adjuvant and mouse strain for the induction of thyroid lesions. J Immunol 1971 106 : 698 704.
2. Esquivel PS, Rose NR, Kong YM. Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide. J Exp Med 1977 145 : 1250 62.
3. Carayanniotis G, Kong YM. Pathogenic thyroglobulin peptides as model antigens: Insights on the induction and maintenance of autoimmune thyroiditis. Intern Rev Immunol 2000 19 : 557 72.
4. Vladutiu AO, Rose NR. Autoimmune murine thyroiditis. Relation to histocompatibility (H-2) type. Science 1971 174 : 1137 8.
5. EIRehewy M, Kong YM, Giraldo AA, Rose NR. Syngeneic thyroglobulin is immunogenic in good responder mice. Eur J Immunol 1981 11 : 146 51.
6. Tomazic V, Rose NR. Autoimmune murine thyroiditis. VIII. Role of different thyroid antigens in the induction of experimental autoimmune thyroiditis. Immunology 1976 30 : 63 8.
7. Vladutiu AO, Rose NR. Cellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice. Cell Immunol 1975 17 : 106 13.
8. Kong YM, David CS, Lomo LC, Fuller BE, Motte RW, Giraldo AA. Role of mouse and human class II transgenes in susceptibility to and protection against mouse autoimmune thyroiditis. Immunogenetics 1997 46 : 312 7.
9. Chronopoulou E, Carayanniotis G. Identification of a thyroiditogenic sequence within the thyroglobulin molecule. J Immunol 1992 149 : 1039 44.
10. Carayanniotis G, Chronopoulou E, Rao V. Distinct genetic pattern of mouse susceptibility to thyroiditis induced by a novel thyroglobulin peptide. Immunogenetics 1994 39 : 21 8.
11. Wan Q, Motte RW, McCormick DJ, Fuller BE, Giraldo AA, David CS, Kong YM. Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis. Role of MHC class II. Clin Immunol Immunopathol 1997 85 : 187 94.
12. Verginis P, Carayanniotis G. Experimental autoimmune thyroiditis (EAT) induced by the thyroglobulin peptide (2596-2608): influence of H-2 and non H-2 genes. Autoimmunity 2004 37 : 529 33.
13. Carayanniotis G. The cryptic self in thyroid autoimmunity. The paradigm of thyroglobulin. Autoimmunity 2003 36 : 423 8.
14. k-restricted peptide of human thyroglobulin. Immunology 2003 108 : 556 61.
15. Karras E, Yang H, Lymberi P, Christadoss P. Human thyroglobulin peptide p2340 induces autoimmune thyroiditis in HLA-DR3 transgenic mice. J Autoimmun 2005 24 : 291 6.
16. Kong YM, Flynn JC, Wan Q, David CS. HLA and H2 class II transgenic mouse models to study susceptibility and protection in autoimmune thyroid disease. Autoimmunity 2003 36 : 397 404.
17. Schardt CW, McLachlan SM, Matheson J, Smith BR. An enzyme-linked immunoassay for thyroid microsomal antibodies. J Immunol Methods 1982 55 : 155 68.
18. Van de Graaf SA, Ris-Stalpers C, Pauws E, Mendive FM, Targovnik HM, Vijder JS. Up to date with human thyroglobulin. J Endocrinol 2001 170 : 307 21.
19. Simon LL, Krco CJ, David CS, Kong YM. Characterization of the in vitro murine T-cell proliferative responses to murine and human thyroglobulins in thyroiditis-susceptible and -resistant mice. Cell Immunol 1985 94 : 243 53.
20. Rao VP, Balasa B, Carayanniotis G. Mapping of thyroglobulin epitopes: presentation of 9mer pathogenic peptide by different mouse MHC class II isotypes. Immunogenetics 1994 40 : 352 9.
21. Gentile F, Conte M, Formisano S. Thyroglobulin as an autoantigen: what can we learn about immunopathogenicity from the correlation of antigenic properties with protein structure? Immunology 2004 112 : 13 25.
22. Rao VP, Carayanniotis G. Contrasting immunopathogenic properties of highly homologous peptides from rat and human thyroglobulin. Immunology 1997 90 : 244 9.
23. Verginis P, Stanford MM, Carayannioitis G. Delineation of five thyroglobulin T-cell epitopes with pathogenic potential in experimental autoimmune thyroiditis. J Immunol 2002 169 : 5332 7.
24. Carayanniotis G, Rao VP. Searching for pathogenic epitopes in thyroglobulin: parameters and caveats. Immunol Today 1997 18 : 83 8.
25. Hutchings PR, Cooke A, Dawe K, Champion BR, Geysen M, Valerio R, Roit IM. A thyroxine-containing peptide can induce murine experimental autoimmune thyroiditis. J Exp Med 1992 175 : 869 72.
26. Kong YM, McCormick DJ, Wan Q, Motte RW, Fuller BE, Giraldo AA, David CS. Primary hormogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis. Secondary role of iodination. J Immunol 1995 155 : 5847 54.