A thyroxine-containing thyroglobulin peptide induces both lymphocytic and granulomatous forms of experimental autoimmune thyroiditis

Journal of Autoimmunity

Volumn 10, Issue 6, 1997, Pages 531-540

  Braley Mullen, Helen ^a   Sharp, Gordon C ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

Autoimmunity; Granulomatous thyroiditis; Peptide; Thyroglobulin; Thyroxine

Indexed keywords

PEPTIDE; THYROGLOBULIN; THYROXINE;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; EFFECTOR CELL; GRANULOMATOSIS; GRANULOMATOUS INFLAMMATION; HASHIMOTO DISEASE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

EID: 0031438574     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1997.0160     Document Type: Article

References (39)

1. Charreire J. Immune mechanisms in autoimmune thyroiditis. Adv. Immunol. 46:1989;263-334.
2. Weigle W.O. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv. Immunol. 30:1980;159-273.
3. Braley-Mullen H., Johnson M., Sharp G.C., Kyriakos M. Induction of autoimmune thyroiditis in mice with in vitro activated splenic T cells. Cell. Immunol. 93:1985;132-143.
4. Imahori S.C., Vladutiu A.O. Autoimmune granulomatous thyroiditis in inbred mice: resemblance to subacute (deQuervain's) thyroiditis in man. Proc. Soc. Exp. Biol. 173:1983;408-416.
5. Imahori S.C., Vladutiu A.O. Evolution and host-dependent lesions in autoimmune thyroiditis: experimental study in inbred mice. Clin. Immunol. Immunopathol. 33:1984;87-98.
6. Braley-Mullen H., Sharp G.C., Bickel J., Kyriakos M. Induction of severe granulomatous experimental autoimmune thyroiditis in mice by effector cells activated in the presence of anti-interleukin 2 receptor antibody. J. Exp. Med. 173:1991;899-912.
7. Stull S., Sharp G.C., Kyriakos M., Bickel J., Braley-Mullen H. Induction of granulomatous experimental autoimmune thyroiditis in mice with in vitro activated effector T cells and anti-IFNγ antibody. J. Immunol. 149:1992;2219-2226.
8. Sugihara S., Fujiwara H., Shearer G.M. Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. Characterization of thyroiditis-inducing T cell lines and clones. J. Immunol. 150:1993;683-694.
9. Stull S.J., Kyriakos M., Sharp G.C., Braley-Mullen H. Prevention and reversal of experimental autoimmune thyroiditis (EAT) in mice by administration of anti-L3T4 monoclonal antibody at different stages of disease development. Cell. Immunol. 177:1988;188-195.
10. ++. Clin. Exp. Immunol. 77:1989;428-433.
11. Romball C.G., Weigle W.O. Transfer of experimental autoimmune thyroiditis with T cell clones. J. Immunol. 138:1987;1092-1098.
12. Dawe K., Hutchings P., Champion B., Cooke A., Roitt I. Autoantigens in thyroid diseases. Springer Semin. Immunopathol. 14:1993;285-307.
13. Champion, B.R. Rayner, D.C. 1995, Thyroid autoantigens and regulation of thyroiditis. Thyroid Autoimmunity. R. G. Landes Co. London.
14. Champion B.R., Rayner D.C., Byfield P.G.H., Page K.R., Chan C.T., Roitt I. Critical role of iodine for T cell recognition of thyroglobulin in experimental murine thyroid autoimmunity. J. Immunol. 139:1987;3665-3670.
15. Champion B.R., Page K.R., Parish N., Rayner D.C., Biswas-Hughes G., Cooke A., Geysen M., Roitt I.M. Identification of a thyroxine-containing self-epitope of thyroglobulin which triggers thyroid autoreactive T cells. J. Exp. Med. 174:1991;363-370.
16. Hutchings P.R., Cooke A., Dawe K., Champion B.R., Geysen M., Velerio R., Roitt I.M. A thyroxine-containing peptide can induce murine experimental autoimmune thyroiditis. J. Exp. Med. 175:1992;869-872.
17. Dawe K.I., Hutchings P.R., Geysen M., Champion B.R., Cooke A., Roitt I.M. Unique role of thyroxine in T cell recognition of a pathogenic peptide in experimental autoimmune thyroiditis. Eur. J. Immunol. 26:1996;768-772.
18. Kong Y., McCormick D.J., Wan Q., Motte R.W., Fuller B.E., Giraldo A.A., David C.S. Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis. J. Immunol. 155:1995;5847-5854.
19. Kuppers R.C., Hu Q., Rose N.R. Mouse thyroglobulin: conservation of sequence homology in C-terminal immunogenic regions of thyroglobulin. Autoimmunity. 23:1996;175-180.
20. +. Cell. Immunol. 153:1994;492-504.
21. McMurray R.W., Sharp G.C., Braley-Mullen H. Intrathyroidal cell phenotype in murine lymphocytic and granulomatous experimental autoimmune thyroiditis. Autoimmunity. 18:1994;93-102.
22. McMurray R.W., Tang H., Braley-Mullen H. The role of α4 integrin and intercellular adhesion molecule-1 (ICAM-1) in murine experimental autoimmune thyroiditis. Autoimmunity. 23:1996;9-23.
23. β. Cell. Immunol. 172:1996;1-9.
24. Braley-Mullen H., Sharp G., Kyriakos M. Differential requirement for autoantibody producing B cells for induction of lymphocytic versus granulomatous experimental autoimmune thyroiditis. J. Immunol. 152:1994;307-314.
25. Sakaguchi S., Toda M., Asano M., Itoh M., Morse S.S., Sakaguchi N. T-cell mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases. J. Autoimmun. 9:1996;211-220.
26. Taguchi O., Takahashi T. Administration of anti-interleukin-2 receptor α antibody in vivo induces localized autoimmune disease. Eur. J. Immunol. 26:1996;1608-1612.
27. Pfeiffer C., Stein J., Southwood S., Ketelaar H., Sette A., Bottomly K. Altered peptide ligands can control CD4 lymphocyte differentiation in vivo. J. Exp. Med. 181:1995;1569-1574.
28. +. Int. Immunol. 6:1995;785-791.
29. Hernandez H.J., Trzyna W., Brodeur P.H., Stadecker M.J. Differential antigen recognition by T cell populations from strains of mice developing polar forms of granulomatous inflammation in response to eggs of Schistosoma mansoni. Europ. J. Immunol. 27:1997;666-670.
30. Sercarz E.E., Leymann P.V., Ametani A., Benichou G., Miller A., Moudgil K. Dominance and crypticity of T cell antigenic determinants. Ann. Rev. Immunol. 11:1993;729-766.
31. Chronopoulou E., Carayanniotis G. Identification of a thyroiditogenic sequence within the thyroglobulin molecule. J. Immunol. 149:1992;1039-1044.
32. Balasa B., Carayanniotis G. Induction of EAT in rats with the synthetic peptide (2495-2511) of thyroglobulin molecule. Cell. Immunol. 148:1993;259-268.
33. Hoshioka A., Kohno Y., Katsui T., Shimojo N., Maruyama N., Inagaki Y., Yokochi T., Tarutani O., Hosoya T., Niimi H. A common T-cell epitope between human thyroglobulin and human thyroid peroxidase is related to murine experimental autoimmune thyroiditis. Immunol. Letters. 37:1993;235-239.
34. Carayanniotis G., Chronopoulou E., Rao V.P. Distinct genetic pattern of mouse susceptibility to thyroiditis induced by a novel thyroglobulin peptide. Immunogenetics. 39:1994;21-28.
35. Texier B., Bedin C., Tang H., Camoin L., Laurent-Winter C., Charriere J. Characterization and sequencing of a 40 amino-acid peptide from human thyroglobulin inducing experimental autoimmune thyroiditis. J. Immunol. 148:1992;3405-3411.
36. Rao R.P., Balasa B., Carayanniotis G. Mapping of thyroglobulin epitopes: nonisotypic MHC class II present a 9 mer pathogenic peptide in mice of different H-2 haplotypes. Immunogenetics. 40:1994;352-359.
37. Rayner D.C., Champion B.R., Cooke A. Thyroglobulin as autoantigen and tolerogen. Immunol. Ser. 59:1993;359-376.
38. Herman A., Kappler J.W., Marrack P., Pullen A.M. Superantigens: mechanism of T cell stimulation and role in immune responses. Ann. Rev. Immunol. 9:1991;745-772.
39. Sundick R.S., Herdegen D.M., Brown T.R., Bagchi N. The incorporation of dietary iodine into thyroglobulin increased its immunogenicity. Endocrinology. 120:1987;2078-2084.