Chronic effects of mild hyperglycaemia on left ventricle transcriptional profile and structural remodelling in the spontaneously type 2 diabetic Goto-Kakizaki rat

Heart Failure Reviews

Volumn 19, Issue 1, 2014, Pages 65-74

  D'Souza, Alicia ^a   Howarth, Frank C ^b   Yanni, Joseph ^a   Dobrzynski, Halina ^a   Boyett, Mark R ^a   Adeghate, Ernest ^b   Bidasee, Keshore R ^c   Singh, Jaipaul ^d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

Extracellular matrix; Goto Kakizaki rat; Transcriptional profile; Type 2 diabetes mellitus; Ventricular remodelling

Indexed keywords

ALPHA5 INTEGRIN; CALCIUM CHANNEL L TYPE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNEXIN 43; FIBRONECTIN; GELATINASE A; GELATINASE B; MESSENGER RNA; NATRIURETIC FACTOR; PROTEIN KINASE B; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 4; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME KINETICS; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HEART LEFT VENTRICLE; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; HYPERGLYCEMIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR DYNAMICS; MORPHOLOGICAL ADAPTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; CHRONIC DISEASE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; EXTRACELLULAR MATRIX; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION; HEART VENTRICLES; HUMANS; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFORMING GROWTH FACTOR BETA1; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84899053850     PISSN: 13824147     EISSN: 15737322     Source Type: Journal    
DOI: 10.1007/s10741-013-9376-9     Document Type: Article

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