PGD and heteroplasmic mitochondrial DNA point mutations: A systematic review estimating the chance of healthy offspring

Human Reproduction Update

Volumn 18, Issue 4, 2012, Pages 341-349

  Hellebrekers, D M E I ^a   Wolfe, R ^b   Hendrickx, A T M ^a   de coo, I F M ^c   de die, C E ^a,d   Geraedts, J P M ^a,d   Chinnery, P F ^e   Smeets, H J M ^a,d  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MONASH UNIVERSITY   (Australia)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Heteroplasmy; Mitochondrial DNA mutations; PGD

Indexed keywords

GUANINE; MITOCHONDRIAL DNA; TRANSFER RNA;

GENE FREQUENCY; HETEROZYGOTE; HUMAN; MUTATIONAL ANALYSIS; OOCYTE; PEDIGREE; POINT MUTATION; PRENATAL DIAGNOSIS; PREVALENCE; PRIORITY JOURNAL; PROGENY; REVIEW; SYSTEMATIC REVIEW;

DNA, MITOCHONDRIAL; HETEROZYGOTE; HUMANS; MITOCHONDRIAL DISEASES; MUSCLE, SKELETAL; PEDIGREE; POINT MUTATION; PREIMPLANTATION DIAGNOSIS; RNA, TRANSFER;

EID: 84863448714     PISSN: 13554786     EISSN: 14602369     Source Type: Journal    
DOI: 10.1093/humupd/dms008     Document Type: Review

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