Prospect of preimplantation genetic diagnosis for heritable mitochondrial DNA diseases

Molecular Human Reproduction

Volumn 9, Issue 10, 2003, Pages 631-638

  Dean, Nicola L ^a,b   Battersby, Brendan J ^b,c   Ao, Asangla ^a,b   Gosden, Roger G ^d   LinTan, Seang ^a,b   Shoubridge, Eric A ^b,c  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

Heteroplasmy; Mitochondrial DNA; Mouse model; mtDNA diseases; Preimplantation genetic diagnosis

Indexed keywords

MITOCHONDRIAL DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLASTOMERE; CELL DIVISION; CONTROLLED STUDY; CYTOPLASM; DIAGNOSTIC ACCURACY; DISEASE TRANSMISSION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; FEASIBILITY STUDY; FEMALE; GAMETE; GENETIC DISORDER; GENETIC VARIABILITY; GENOTYPE; HETEROPLASMY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; OOCYTE MATURATION; PATHOGENICITY; PRENATAL DIAGNOSIS; PRIORITY JOURNAL;

ANIMALS; DNA, MITOCHONDRIAL; EMBRYO; FEMALE; GENOTYPE; MICE; MITOCHONDRIAL DISEASES; OOCYTES; POLYMERASE CHAIN REACTION; PREGNANCY; PREIMPLANTATION DIAGNOSIS;

ANIMALIA;

EID: 0141504960     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/gag077     Document Type: Article

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