Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 6, 2014, Pages 1628-1637

  Piotto, Stefano ^a   Concilio, Simona ^a   Bianchino, Erminia ^a   Iannelli, Pio ^a   López, David J ^b   Terés, Silvia ^b   Ibarguren, Maitane ^b   Barceló Coblijn, Gwendolyn ^b   Martin, Maria Laura ^b   Guardiola Serrano, Francisca ^b   Alonso Sande, María ^b   Funari, Sérgio S ^c   Busquets, Xavier ^b   Escribá, Pablo V ^b  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^c DESY   (Germany)

Author keywords

2 Hydroxyoleic acid; Anti cancer drug; Membrane lipid therapy; Membrane physical state; Molecular dynamics

Indexed keywords

2 HYDROXYOLEIC ACID; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1; DIHYDROFOLATE REDUCTASE; MEMBRANE LIPID; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; RAS PROTEIN; RICINOLEIC ACID; SPHINGOMYELIN SYNTHASE; SYNTHETASE; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; ENANTIOMER; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; LIPID BILAYER; LIPID COMPOSITION; LIPID MEMBRANE; LIPID RAFT; LUNG ADENOCARCINOMA; MALE; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; X RAY DIFFRACTION;

2-HYDROXYOLEIC ACID; ANTI-CANCER DRUG; MEMBRANE LIPID THERAPY; MEMBRANE PHYSICAL STATE; MOLECULAR DYNAMICS;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL MEMBRANE; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; GLIOMA; HUMANS; LIPID BILAYERS; LUNG NEOPLASMS; MALE; MEMBRANE LIPIDS; MICE; MICE, NUDE; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; OLEIC ACIDS; SIGNAL TRANSDUCTION; STEREOISOMERISM; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS); TUMOR CELLS, CULTURED; X-RAY DIFFRACTION;

EID: 84898995886     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.12.023     Document Type: Article

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