Let-7g improves multiple endothelial functions through targeting transforming growth factor-beta and sirt-1 signaling

Journal of the American College of Cardiology

Volumn 63, Issue 16, 2014, Pages 1685-1694

  Liao, Yi Chu ^a,b   Wang, Yung Song ^c   Guo, Yuh Cherng ^d,e   Lin, Wen Lien ^c   Chang, Ming Hung ^a,b   Juo, Suh Hang Hank ^c,f  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

endothelial function; Let 7g; PAI 1; SIRT 1; TGF pathway

Indexed keywords

ENDOTHELIAL FUNCTION; LET-7G; PAI-1; SIRT-1; TGF-Β PATHWAY;

ANIMALS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, KNOCKOUT; MICRORNAS; POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSFORMING GROWTH FACTOR BETA; VASODILATION;

INTERLEUKIN 6; MICRORNA; MICRORNA LET7G; MONOCYTE CHEMOTACTIC PROTEIN 1; N(G),N(G) DIMETHYLARGININE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SIRTUIN 1; SMAD2 PROTEIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BLOOD VESSEL FUNCTION; CELL ADHESION; CELL AGING; CELL INFILTRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MACROPHAGE; MAJOR CLINICAL STUDY; MONOCYTE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMAD2 GENE; THROMBOSPONDIN 1 GENE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1 GENE; UPREGULATION; VASCULAR ENDOTHELIUM;

EID: 84898990576     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.09.069     Document Type: Article

References (28)

1. K. Ono, Y. Kuwabara, and J. Han MicroRNAs and cardiovascular diseases FEBS J 278 2011 1619 1633
2. K.C. Chen, I.C. Hsieh, and E. Hsi et al. Negative feedback regulation between microRNA Let-7g and the oxLDL receptor LOX-1 J Cell Sci 124 2011 4115 4124
3. M. Satoh, T. Tabuchi, Y. Minami, Y. Takahashi, T. Itoh, and M. Nakamura Expression of Let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: effect of statins on Let-7i and Toll-like receptor 4 signal Immunobiology 217 2012 533 539
4. G.H. Gibbons Endothelial function as a determinant of vascular function and structure: a new therapeutic target Am J Cardiol 79 1997 3 8
5. P.O. Bonetti, L.O. Lerman, and A. Lerman Endothelial dysfunction: a marker of atherosclerotic risk Arterioscler Thromb Vasc Biol 23 2003 168 175
6. P.M. Vanhoutte Endothelial dysfunction: the first step toward coronary arteriosclerosis Circ J 73 2009 595 601
7. A. Hassan, B.J. Hunt, and M. O'Sullivan et al. Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis Brain 126 2003 424 432
8. I.L. Knottnerus, H. Ten Cate, J. Lodder, F. Kessels, and R.J. van Oostenbrugge Endothelial dysfunction in lacunar stroke: a systematic review Cerebrovasc Dis 27 2009 519 526
9. A. Bobik Transforming growth factor-betas and vascular disorders Arterioscler Thromb Vasc Biol 26 2006 1712 1720
10. M.J. Goumans, Z. Liu, and P. ten Dijke TGF-beta signaling in vascular biology and dysfunction Cell Res 19 2009 116 127
11. B.P. Lewis, C.B. Burge, and D.P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 2005 15 20
12. J. Constans, and C. Conri Circulating markers of endothelial function in cardiovascular disease Clin Chim Acta 368 2006 33 47
13. L. Badimon, J.C. Romero, J. Cubedo, and M. Borrell-Pages Circulating biomarkers Thromb Res 130 Suppl 1 2012 S12 S15
14. A. Tjarnlund-Wolf, H. Brogren, E.H. Lo, and X. Wang Plasminogen activator inhibitor-1 and thrombotic cerebrovascular diseases Stroke 43 2012 2833 2839
15. B. Schmierer, and C.S. Hill TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility Nat Rev Mol Cell Biol 8 2007 970 982
16. I. Mattagajasingh, C.S. Kim, and A. Naqvi et al. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase Proc Natl Acad Sci U S A 104 2007 14855 14860
17. B. Boyerinas, S.M. Park, A. Hau, A.E. Murmann, and M.E. Peter The role of Let-7 in cell differentiation and cancer Endocr Relat Cancer 17 2010 F19 F36
18. J.E. Murphy-Ullrich, and M. Poczatek Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology Cytokine Growth Factor Rev 11 2000 59 69
19. N.V. Narizhneva, O.V. Razorenova, and E.A. Podrez et al. Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium FASEB J 19 2005 1158 1160
20. J. Lawler Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth J Cell Mol Med 6 2002 1 12
21. G. Otsuka, R. Agah, A.D. Frutkin, T.N. Wight, and D.A. Dichek Transforming growth factor beta 1 induces neointima formation through plasminogen activator inhibitor-1-dependent pathways Arterioscler Thromb Vasc Biol 26 2006 737 743
22. L. Vecerova, Z. Strasky, and J. Rathouska et al. Activation of TGF-beta receptors and Smad proteins by atorvastatin is related to reduced atherogenesis in ApoE/LDLR double knockout mice J Atheroscler Thromb 19 2012 115 126
23. S. Roush, and F.J. Slack The Let-7 family of microRNAs Trends Cell Biol 18 2008 505 516
24. C.M. Fisher Lacunar strokes and infarcts: a review Neurology 32 1982 871 876
25. S. Stein, and C.M. Matter Protective roles of SIRT1 in atherosclerosis Cell Cycle 10 2011 640 647
26. W. Yu, Y.C. Fu, C.J. Chen, X. Wang, and W. Wang SIRT1: a novel target to prevent atherosclerosis J Cell Biochem 108 2009 10 13
27. M. Benhamed, U. Herbig, T. Ye, A. Dejean, and O. Bischof Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells Nat Cell Biol 14 2012 266 275
28. S. Nemoto, M.M. Fergusson, and T. Finkel Nutrient availability regulates SIRT1 through a forkhead-dependent pathway Science 306 2004 2105 2108