-
2
-
-
0001622033
-
-
Velluz, L.; Valls, J.; Nominé, G. Angew. Chem., Int. Ed. 1965, 41, 181-200
-
(1965)
Angew. Chem., Int. Ed.
, vol.41
, pp. 181-200
-
-
Velluz, L.1
Valls, J.2
Nominé, G.3
-
4
-
-
33947477067
-
-
Corey, E. J.; Ohno, M.; Vatakencherry, P. A.; Mitra, R. B. J. Am. Chem. Soc. 1961, 83, 1251-1253
-
(1961)
J. Am. Chem. Soc.
, vol.83
, pp. 1251-1253
-
-
Corey, E.J.1
Ohno, M.2
Vatakencherry, P.A.3
Mitra, R.B.4
-
5
-
-
0001379170
-
-
Corey, E. J.; Ohno, M.; Mitra, R. B.; Vatakencherry, P. A. J. Am. Chem. Soc. 1964, 86, 478-485
-
(1964)
J. Am. Chem. Soc.
, vol.86
, pp. 478-485
-
-
Corey, E.J.1
Ohno, M.2
Mitra, R.B.3
Vatakencherry, P.A.4
-
8
-
-
84893467790
-
-
Lo, J. C.; Yabe, Y.; Baran, P. S. J. Am. Chem. Soc. 2014, 136, 1304-1307
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 1304-1307
-
-
Lo, J.C.1
Yabe, Y.2
Baran, P.S.3
-
9
-
-
0035907919
-
-
McCarroll, A. J.; Walton, J. C. Angew. Chem., Int. Ed. 2001, 40, 2224-2248
-
(2001)
Angew. Chem., Int. Ed.
, vol.40
, pp. 2224-2248
-
-
McCarroll, A.J.1
Walton, J.C.2
-
10
-
-
6444244303
-
-
Raskin, I.; Ribnicky, D. M.; Komarnytsky, S.; Ilic, N.; Poulev, A.; Borisjuk, N.; Brinker, A.; Moreno, D. A.; Ripoll, C.; Yakoby, N.; O'Neal, J. M.; Cornwell, T.; Pastor, I.; Fridlender, B. Trends in Biotechnol. 2002, 20, 522-531
-
(2002)
Trends in Biotechnol.
, vol.20
, pp. 522-531
-
-
Raskin, I.1
Ribnicky, D.M.2
Komarnytsky, S.3
Ilic, N.4
Poulev, A.5
Borisjuk, N.6
Brinker, A.7
Moreno, D.A.8
Ripoll, C.9
Yakoby, N.10
O'Neal, J.M.11
Cornwell, T.12
Pastor, I.13
Fridlender, B.14
-
14
-
-
84882907547
-
-
Jørgensen, L.; McKerrall, S. J.; Kuttruff, C. A.; Ungeheuer, F.; Felding, J.; Baran, P. S. Science 2013, 341, 878-882
-
(2013)
Science
, vol.341
, pp. 878-882
-
-
Jørgensen, L.1
McKerrall, S.J.2
Kuttruff, C.A.3
Ungeheuer, F.4
Felding, J.5
Baran, P.S.6
-
18
-
-
0003137512
-
-
Zeichmeister, K.; Brandl, F.; Hoppe, W.; Hecker, E.; Opferkuch, H. J.; Adolf, W. Tetrahedron Lett. 1970, 47, 4075-4078
-
(1970)
Tetrahedron Lett.
, vol.47
, pp. 4075-4078
-
-
Zeichmeister, K.1
Brandl, F.2
Hoppe, W.3
Hecker, E.4
Opferkuch, H.J.5
Adolf, W.6
-
19
-
-
0000560130
-
-
For a review of in/out isomerism, see: Alder, R. W.; East, S. P. Chem. Rev. 1996, 96, 2097-2111
-
(1996)
Chem. Rev.
, vol.96
, pp. 2097-2111
-
-
Alder, R.W.1
East, S.P.2
-
20
-
-
12344290175
-
-
Ogbourne, S. M.; Suhrbier, A.; Jones, B.; Cozzi, S.; Boyle, G. M.; Morris, M.; McAlpine, D.; Johns, J.; Scott, T. M.; Sutherland, K. P.; Gardner, J. M.; Le, T. T. T.; Lenarczyk, A.; Aylward, J. H.; Parsons, P. G. Cancer Res. 2004, 64, 2833-2839
-
(2004)
Cancer Res.
, vol.64
, pp. 2833-2839
-
-
Ogbourne, S.M.1
Suhrbier, A.2
Jones, B.3
Cozzi, S.4
Boyle, G.M.5
Morris, M.6
McAlpine, D.7
Johns, J.8
Scott, T.M.9
Sutherland, K.P.10
Gardner, J.M.11
Le, T.T.T.12
Lenarczyk, A.13
Aylward, J.H.14
Parsons, P.G.15
-
21
-
-
0030044459
-
-
Fujiwara, M.; Fujiwara, M.; Ijichi, K.; Tokuhisa, K.; Katsuura, K.; Shigeta, S.; Konno, K.; Wang, G. Y.; Uemura, D.; T Yokota, T.; Baba, M. Antimicrob. Agents Chemother. 1996, 40, 271-273
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 271-273
-
-
Fujiwara, M.1
Fujiwara, M.2
Ijichi, K.3
Tokuhisa, K.4
Katsuura, K.5
Shigeta, S.6
Konno, K.7
Wang, G.Y.8
Uemura, D.9
Yokota T, T.10
Baba, M.11
-
22
-
-
84899026929
-
-
U.S. Food and Drug Administration, 2012 Novel New Drugs Summary (FDA, Washington, DC, 2013).
-
U.S. Food and Drug Administration, 2012 Novel New Drugs Summary (FDA, Washington, DC, 2013); www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/ DrugInnovation/UCM337830.pdf.
-
-
-
-
23
-
-
84866253543
-
-
For a review of the development of ingenol mebutate (3), see: Vasas, A.; Rédei, D.; Csupor, D.; Molnár, J.; Hohmann, J. Eur. J. Org. Chem. 2012, 5115-5130
-
(2012)
Eur. J. Org. Chem.
, pp. 5115-5130
-
-
Vasas, A.1
Rédei, D.2
Csupor, D.3
Molnár, J.4
Hohmann, J.5
-
24
-
-
77951989505
-
-
Siller, G.; Rosen, R.; Freeman, M.; Welburn, P.; Katsamas, J.; Ogbourne, S. M. Aust. J. Dermatol. 2010, 51, 99-105
-
(2010)
Aust. J. Dermatol.
, vol.51
, pp. 99-105
-
-
Siller, G.1
Rosen, R.2
Freeman, M.3
Welburn, P.4
Katsamas, J.5
Ogbourne, S.M.6
-
25
-
-
84898930766
-
-
ClinicalTrials.gov, NCT00329121.
-
ClinicalTrials.gov, NCT00329121, http://clinicaltrials.gov/show/ NCT00329121.
-
-
-
-
26
-
-
84857448930
-
-
Rosen, R. H.; Gupta, A. K.; Tyring, S. K. J. Am. Acad. Dermatol. 2012, 66, 486-493
-
(2012)
J. Am. Acad. Dermatol.
, vol.66
, pp. 486-493
-
-
Rosen, R.H.1
Gupta, A.K.2
Tyring, S.K.3
-
27
-
-
77958049128
-
-
Ersvaer, E.; Kittang, A. O.; Hampson, P.; Sand, K.; Gjertsen, B. T.; Lord, J. M.; Bruserud, Ø Toxins 2010, 2, 174-194
-
(2010)
Toxins
, vol.2
, pp. 174-194
-
-
Ersvaer, E.1
Kittang, A.O.2
Hampson, P.3
Sand, K.4
Gjertsen, B.T.5
Lord, J.M.6
Bruserud Ø7
-
28
-
-
42249097899
-
-
Serova, M.; Ghoul, A.; Benhadji, K. A.; Faivre, S.; Le Tourneau, C.; Cvitkovic, E.; Lokiec, F.; Lord, J.; Ogbourne, S. M.; Calvo, F.; Raymond, E. Mol. Cancer Ther. 2008, 7, 915-922
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 915-922
-
-
Serova, M.1
Ghoul, A.2
Benhadji, K.A.3
Faivre, S.4
Le Tourneau, C.5
Cvitkovic, E.6
Lokiec, F.7
Lord, J.8
Ogbourne, S.M.9
Calvo, F.10
Raymond, E.11
-
29
-
-
0034053910
-
-
Hohmann, J.; Evanics, F.; Berta, L.; Bartók, T. Planta Med. 2000, 66, 291-294
-
(2000)
Planta Med.
, vol.66
, pp. 291-294
-
-
Hohmann, J.1
Evanics, F.2
Berta, L.3
Bartók, T.4
-
30
-
-
84867488429
-
-
Liang, X.; Grue-Sørensen, G.; Petersen, A. K.; Högberg, T. Synlett 2012, 23, 2647-2652
-
(2012)
Synlett
, vol.23
, pp. 2647-2652
-
-
Liang, X.1
Grue-Sørensen, G.2
Petersen, A.K.3
Högberg, T.4
-
31
-
-
0032912055
-
-
Appendino, G.; Tron, G. C.; Cravatto, G.; Palmisano, G.; Jakupovic, J. Nat. Prod. Rep. 1999, 62, 76-79
-
(1999)
Nat. Prod. Rep.
, vol.62
, pp. 76-79
-
-
Appendino, G.1
Tron, G.C.2
Cravatto, G.3
Palmisano, G.4
Jakupovic, J.5
-
32
-
-
0037151671
-
-
Winkler, J. D.; Rouse, M. B.; Greaney, M. F.; Harrison, S. J.; Jeon, Y. T. J. Am. Chem. Soc. 2002, 124, 9726-9728
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 9726-9728
-
-
Winkler, J.D.1
Rouse, M.B.2
Greaney, M.F.3
Harrison, S.J.4
Jeon, Y.T.5
-
33
-
-
0037433234
-
-
Tanino, K.; Onuki, K.; Asano, K.; Miyashita, M.; Nakamura, T.; Takahashi, Y.; Kuwajima, I. J. Am. Chem. Soc. 2003, 125, 1498-1500
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 1498-1500
-
-
Tanino, K.1
Onuki, K.2
Asano, K.3
Miyashita, M.4
Nakamura, T.5
Takahashi, Y.6
Kuwajima, I.7
-
34
-
-
11444258937
-
-
Nickel, A.; Maruyama, T.; Tang, H.; Murphy, P. D.; Greene, B.; Yusuff, N.; Wood, J. L. J. Am. Chem. Soc. 2004, 126, 16300-16301
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 16300-16301
-
-
Nickel, A.1
Maruyama, T.2
Tang, H.3
Murphy, P.D.4
Greene, B.5
Yusuff, N.6
Wood, J.L.7
-
35
-
-
84860872974
-
-
Ohyoshi, T.; Ohyoshi, T.; Funakubo, S.; Miyazawa, Y.; Niida, K.; Hayakawa, I.; Kigoshi, H. Angew. Chem., Int. Ed. 2012, 51, 4972-4975
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 4972-4975
-
-
Ohyoshi, T.1
Ohyoshi, T.2
Funakubo, S.3
Miyazawa, Y.4
Niida, K.5
Hayakawa, I.6
Kigoshi, H.7
-
39
-
-
84896129354
-
-
Kuttruff, C. A.; Eastgate, M. D.; Baran, P. S. Nat. Prod. Rep. 2014, 31, 419-432
-
(2014)
Nat. Prod. Rep.
, vol.31
, pp. 419-432
-
-
Kuttruff, C.A.1
Eastgate, M.D.2
Baran, P.S.3
-
40
-
-
78650111987
-
-
Szpilman, A. M.; Carreira, E. M. Angew. Chem., Int. Ed. 2010, 49, 9592-9628
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 9592-9628
-
-
Szpilman, A.M.1
Carreira, E.M.2
-
41
-
-
70350500463
-
-
Newhouse, T.; Baran, P. S.; Hoffmann, R. W. Chem. Soc. Rev. 2009, 38, 3010-3021
-
(2009)
Chem. Soc. Rev.
, vol.38
, pp. 3010-3021
-
-
Newhouse, T.1
Baran, P.S.2
Hoffmann, R.W.3
-
42
-
-
38949138457
-
-
Wender, P. A.; Verma, V. A.; Paxton, T. J.; Pillow, T. H. Acc. Chem. Res. 2008, 41, 40-49
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 40-49
-
-
Wender, P.A.1
Verma, V.A.2
Paxton, T.J.3
Pillow, T.H.4
-
45
-
-
77955430862
-
-
Kirby, J.; Nishimoto, M.; Park, J. G.; Withers, S. T.; Nowroozi, F.; Behrendt, D.; Garcia Rutledge, E. J.; Fortman, J. L.; Johnson, H. E.; Anderson, J. V.; Keasling, J. D. Phytochemistry 2010, 71, 1466-1473
-
(2010)
Phytochemistry
, vol.71
, pp. 1466-1473
-
-
Kirby, J.1
Nishimoto, M.2
Park, J.G.3
Withers, S.T.4
Nowroozi, F.5
Behrendt, D.6
Garcia Rutledge, E.J.7
Fortman, J.L.8
Johnson, H.E.9
Anderson, J.V.10
Keasling, J.D.11
-
46
-
-
0032709108
-
-
Appendino, G.; Tron, G. C.; Cravotto, G.; Palmisano, G.; Annunziata, R.; Baj, G.; Surico, N. Eur. J. Org. Chem. 1999, 3413-3420
-
(1999)
Eur. J. Org. Chem.
, pp. 3413-3420
-
-
Appendino, G.1
Tron, G.C.2
Cravotto, G.3
Palmisano, G.4
Annunziata, R.5
Baj, G.6
Surico, N.7
-
47
-
-
11244300691
-
-
Epstein, O. L.; Cha, J. K. Angew. Chem., Int. Ed. 2005, 44, 121-123
-
(2005)
Angew. Chem., Int. Ed.
, vol.44
, pp. 121-123
-
-
Epstein, O.L.1
Cha, J.K.2
-
48
-
-
0034005284
-
-
Paquette, L. A.; Zhao, Z.; Gallou, F.; Liu, J. J. Am. Chem. Soc. 2000, 122, 1540-1541
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 1540-1541
-
-
Paquette, L.A.1
Zhao, Z.2
Gallou, F.3
Liu, J.4
-
49
-
-
0034638376
-
-
Paquette, L. A.; Gallou, F.; Zhao, Z.; Young, D. G.; Liu, J.; Yang, J.; Friedrich, D. J. Am. Chem. Soc. 2000, 122, 9610-9620
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 9610-9620
-
-
Paquette, L.A.1
Gallou, F.2
Zhao, Z.3
Young, D.G.4
Liu, J.5
Yang, J.6
Friedrich, D.7
-
52
-
-
83655183058
-
-
Mendoza, A.; Ishihara, Y.; Baran, P. S. Nat. Chem. 2012, 4, 21-25
-
(2012)
Nat. Chem.
, vol.4
, pp. 21-25
-
-
Mendoza, A.1
Ishihara, Y.2
Baran, P.S.3
-
53
-
-
84882279077
-
-
Cherney, E. C.; Green, J. C.; Baran, P. S. Angew. Chem., Int. Ed. 2013, 52, 9019-9022
-
(2013)
Angew. Chem., Int. Ed.
, vol.52
, pp. 9019-9022
-
-
Cherney, E.C.1
Green, J.C.2
Baran, P.S.3
-
54
-
-
1642284120
-
-
Blanco-Urgoiti, J.; Añorbe, L.; Pérez-Serrano, L.; Domínguez, G.; Pérez-Castells, J. Chem. Soc. Rev. 2004, 33, 32-42
-
(2004)
Chem. Soc. Rev.
, vol.33
, pp. 32-42
-
-
Blanco-Urgoiti, J.1
Añorbe, L.2
Pérez-Serrano, L.3
Domínguez, G.4
Pérez-Castells, J.5
-
56
-
-
80052314928
-
-
Su, S.; Rodriguez, R. A.; Baran, P. S. J. Am. Chem. Soc. 2011, 133, 13922-13925
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 13922-13925
-
-
Su, S.1
Rodriguez, R.A.2
Baran, P.S.3
-
58
-
-
0000455153
-
-
Paquette, L. A.; Ross, R. J.; Shi, Y. J. Org. Chem. 1990, 55, 1589-1598
-
(1990)
J. Org. Chem.
, vol.55
, pp. 1589-1598
-
-
Paquette, L.A.1
Ross, R.J.2
Shi, Y.3
-
59
-
-
0001294824
-
-
Lovely, C. J.; Seshadri, H.; Wayland, B. R.; Cordes, A. W. Org. Lett. 2001, 3, 2607-2610
-
(2001)
Org. Lett.
, vol.3
, pp. 2607-2610
-
-
Lovely, C.J.1
Seshadri, H.2
Wayland, B.R.3
Cordes, A.W.4
-
60
-
-
0001066504
-
-
Mukai, C.; Nomura, I.; Yamanishi, K.; Hanaoka, M. Org. Lett. 2002, 4, 1755-1758
-
(2002)
Org. Lett.
, vol.4
, pp. 1755-1758
-
-
Mukai, C.1
Nomura, I.2
Yamanishi, K.3
Hanaoka, M.4
-
61
-
-
0037198748
-
-
Brummond, K. M.; Chen, H.; Fisher, K. D.; Kerekes, A. D.; Rickards, B.; Sill, P. C.; Geib, S. J. Org. Lett. 2002, 4, 1931-1934
-
(2002)
Org. Lett.
, vol.4
, pp. 1931-1934
-
-
Brummond, K.M.1
Chen, H.2
Fisher, K.D.3
Kerekes, A.D.4
Rickards, B.5
Sill, P.C.6
Geib, S.J.7
-
62
-
-
0037458984
-
-
Mukai, C.; Nomura, I.; Kitagaki, S. J. Org. Chem. 2003, 68, 1376-1385
-
(2003)
J. Org. Chem.
, vol.68
, pp. 1376-1385
-
-
Mukai, C.1
Nomura, I.2
Kitagaki, S.3
-
63
-
-
46849109760
-
-
Brummond, K. M.; Chen, D.; Davis, M. M. J. Org. Chem. 2008, 73, 5064-5068
-
(2008)
J. Org. Chem.
, vol.73
, pp. 5064-5068
-
-
Brummond, K.M.1
Chen, D.2
Davis, M.M.3
-
64
-
-
0001397602
-
-
4-catalyzed dihydroxylations, see: Lohray, B. B.; Bhushan, V.; Kumar, R. K. J. Org. Chem. 1994, 59, 1375-1380
-
(1994)
J. Org. Chem.
, vol.59
, pp. 1375-1380
-
-
Lohray, B.B.1
Bhushan, V.2
Kumar, R.K.3
-
65
-
-
85069329278
-
-
John Wiley & Sons, Ltd. New York, (DOI: 10.1002/047084289X.rs008. pub2).
-
Hoekstra, W. J.; Fairlamb, I. J. S.; Giroux, S.. Selenium(IV) Oxide. e-EROS Encyclopedia of Reagents for Organic Synthesis; John Wiley & Sons, Ltd.: New York, 2007, (DOI: 10.1002/047084289X.rs008.pub2).
-
(2007)
Selenium(IV) Oxide. E-EROS Encyclopedia of Reagents for Organic Synthesis
-
-
Hoekstra, W.J.1
Fairlamb, I.J.S.2
Giroux, S.3
-
70
-
-
77952819729
-
-
Gaussian 09 was utilized for all calculations: Revision D.01; Gaussian, Inc. Pittsburgh, PA, (full reference in the Supporting Information).
-
Gaussian 09 was utilized for all calculations: Frisch, M. J.; Gaussian09, Revision D.01; Gaussian, Inc.: Pittsburgh, PA, 2009, (full reference in the Supporting Information).
-
(2009)
Gaussian09
-
-
Frisch, M.J.1
-
71
-
-
77249114675
-
-
Structures were visualized with CYLView: 1.0b; Université de Sherbrooke: Quebec, Canada.
-
Structures were visualized with CYLView: Legault, C. Y. CYLview, 1.0b; Université de Sherbrooke: Quebec, Canada, 2009; http://www.cylview.org.
-
(2009)
CYLview
-
-
Legault, C.Y.1
-
72
-
-
0022026522
-
-
Wierschke, S. G.; Chandrasekhar, J.; Jorgensen, W. L. J. Am. Chem. Soc. 1985, 107, 1496-1500
-
(1985)
J. Am. Chem. Soc.
, vol.107
, pp. 1496-1500
-
-
Wierschke, S.G.1
Chandrasekhar, J.2
Jorgensen, W.L.3
-
73
-
-
0032253961
-
-
For a review on the use of theozymes (theoretical enzyme mimics made up of model functional groups) in computational chemistry, see: Tantillo, D. J.; Chen, J.; Houk, K. N. Curr. Opin. Chem. Biol. 1998, 2, 743-750
-
(1998)
Curr. Opin. Chem. Biol.
, vol.2
, pp. 743-750
-
-
Tantillo, D.J.1
Chen, J.2
Houk, K.N.3
-
74
-
-
70349769724
-
-
Burns, N. Z.; Baran, P. S.; Hoffmann, R. W. Angew. Chem., Int. Ed. 2009, 48, 2854-2867
-
(2009)
Angew. Chem., Int. Ed.
, vol.48
, pp. 2854-2867
-
-
Burns, N.Z.1
Baran, P.S.2
Hoffmann, R.W.3
|