Hepatitis C virus replication compartment formation: Mechanism and drug target

Gastroenterology

Volumn 146, Issue 5, 2014, Pages 1164-1167

  Chukkapalli, Vineela ^a   Randall, Glenn ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALISPORIVIR; ANTIVIRUS AGENT; BINDING PROTEIN; BMS 553; BOCEPREVIR; CHOLESTEROL; CYCLOPHILIN A; ENVIROXIME; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4B; NONSTRUCTURAL PROTEIN 5A; OXYSTEROL BINDING PROTEIN; PEGINTERFERON; PHOSPHATIDYLINOSITOL 4 KINASE ALPHA; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHOTRANSFERASE; RIBAVIRIN; SOFOSBUVIR; TELAPREVIR; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL RESISTANCE; BIOACCUMULATION; CLINICAL TRIAL (TOPIC); COMPLEX FORMATION; ENDOPLASMIC RETICULUM; HEPATITIS C VIRUS; MEMBRANE VESICLE; MEMBRANOUS WEB; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; VIRUS MORPHOLOGY; VIRUS REPLICATION;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANTIVIRAL AGENTS; CELL MEMBRANE; CHOLESTEROL; CYCLOPHILIN A; CYCLOSPORINS; HEPACIVIRUS; HUMANS; RECEPTORS, STEROID; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84898950330     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.03.017     Document Type: Editorial

References (31)

1. J.A. den Boon, and P. Ahlquist Organelle-like membrane compartmentalization of positive-strand RNA virus replication factories Annu Rev Microbiol 64 2010 241 256
2. D. Egger, B. Wolk, and R. Gosert et al. Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex J Virol 76 2002 5974 5984
3. I. Romero-Brey, A. Merz, and A. Chiramel et al. Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication PLoS Pathog 8 2012 e1003056
4. S. Reiss, I. Rebhan, and P. Backes et al. Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment Cell Host Microbe 9 2011 32 45
5. K.L. Berger, S.M. Kelly, and T.X. Jordan et al. Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication J Virol 85 2011 8870 8883
6. A.W. Tai, and S. Salloum The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement PLoS One 6 2011 e26300
7. H. Wang, J.W. Perry, and A.S. Lauring et al. Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking Gastroenterology 146 2014 1373 1385
8. V. Madan, D. Paul, and V. Lohmann et al. Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation Gastroenterology 146 2014 1361 1372
9. M.P. Manns, and T. von Hahn Novel therapies for hepatitis C - one pill fits all? Nat Rev Drug Discov 12 2013 595 610
10. P.A. Gallay, and K. Lin Profile of alisporivir and its potential in the treatment of hepatitis C Drug Des Dev Ther 7 2013 105 115
11. U. Chatterji, M. Bobardt, and S. Selvarajah et al. The isomerase active site of cyclophilin A is critical for hepatitis C virus replication J Biol Chem 284 2009 16998 17005
12. A. Kaul, S. Stauffer, and C. Berger et al. Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics PLoS Pathog 5 2009 e1000546
13. Z. Liu, F. Yang, and J.M. Robotham et al. Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex J Virol 83 2009 6554 6565
14. L. Coelmont, X. Hanoulle, and U. Chatterji et al. DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A PLoS One 5 2010 e13687
15. T.L. Foster, P. Gallay, and N.J. Stonehouse et al. Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner J Virol 85 2011 7460 7464
16. S. Ciesek, E. Steinmann, and H. Wedemeyer et al. Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A Hepatology 50 2009 1638 1645
17. A. Bianco, V. Reghellin, and L. Donnici et al. Metabolism of phosphatidylinositol 4-kinase IIIalpha-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity PLoS Pathog 8 2012 e1002576
18. N.Y. Hsu, O. Ilnytska, and G. Belov et al. Viral reorganization of the secretory pathway generates distinct organelles for RNA replication Cell 141 2010 799 811
19. S. Reiss, C. Harak, and I. Romero-Brey et al. The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A PLoS Pathog 9 2013 e1003359
20. K.L. Berger, and G. Randall Potential roles for cellular cofactors in hepatitis C virus replication complex formation Commun Integr Biol 2 2009 471 473
21. B. Bishe, G. Syed, and A. Siddiqui Phosphoinositides in the hepatitis C virus life cycle Viruses 4 2012 2340 2358
22. Y. Amako, A. Sarkeshik, and H. Hotta et al. Role of oxysterol binding protein in hepatitis C virus infection J Virol 83 2009 9237 9246
23. Y. Amako, G.H. Syed, and A. Siddiqui Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein J Biol Chem 286 2011 11265 11274
24. S. Lev Non-vesicular lipid transport by lipid-transfer proteins and beyond Nat Rev Mol Cell Biol 11 2010 739 750
25. M. Arita Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure Microbiol Immunol 2014 Feb 15 [Epub ahead of print]
26. M. Arita, H. Kojima, and T. Nagano et al. Oxysterol-binding protein family I is the target of minor enviroxime-like compounds J Virol 87 2013 4252 4260
27. O. Ilnytska, M. Santiana, and N.Y. Hsu et al. Enteroviruses harness the cellular endocytic machinery to remodel the host cell cholesterol landscape for effective viral replication Cell Host Microbe 14 2013 281 293
28. K.L. Berger, J.D. Cooper, and N.S. Heaton et al. Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication Proc Natl Acad Sci U S A 106 2009 7577 7582
29. H.M. van der Schaar, L. van der Linden, and K.H. Lanke et al. Coxsackievirus mutants that can bypass host factor PI4KIIIbeta and the need for high levels of PI4P lipids for replication Cell Res 22 2012 1576 1592
30. M. Arita, H. Kojima, and T. Nagano et al. Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity J Virol 85 2011 2364 2372
31. J. Guedj, H. Dahari, and L. Rong et al. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life Proc Natl Acad Sci U S A 110 2013 3991 3996