Combined effects of connective tissue growth factor-modified bone marrow-derived mesenchymal stem cells and NaOH-treated PLGA scaffolds on the repair of articular cartilage defect in rabbits

Cell Transplantation

Volumn 23, Issue 6, 2014, Pages 715-727

  Zhu, Songsong ^a   Zhang, Bi ^a   Man, Cheng ^a   Ma, Yongqing ^a   Liu, Xianwen ^a   Hu, Jing ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Articular cartilage; Connective tissue growth factor (CTGF); Defect and repair; Mesenchymal stem cells; Poly(lactic co glycolic) acid (PLGA)

Indexed keywords

BETA GALACTOSIDASE; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; POLYGLACTIN; SODIUM HYDROXIDE; TISSUE SCAFFOLD; BIOMATERIAL; DNA; GLYCOSAMINOGLYCAN; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BONE MARROW CELL; CARTILAGE CELL; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CELL VIABILITY; CHONDROGENESIS; CHONDROPATHY; CONTROLLED STUDY; DNA CONTENT; GENE TRANSFER; HISTOPATHOLOGY; HYALINE CARTILAGE; IN VITRO STUDY; IN VIVO STUDY; KNEE; MALE; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; STEM CELL GENE THERAPY; TISSUE ENGINEERING; TISSUE REGENERATION; TISSUE REPAIR; ANIMAL; CARTILAGE DISEASES; CELL CULTURE; CHEMISTRY; CYTOLOGY; GENETICS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; TISSUE SCAFFOLD; YOUNG MODULUS;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE MARROW CELLS; CARTILAGE DISEASES; CELLS, CULTURED; CHONDROGENESIS; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; DNA; ELASTIC MODULUS; GLYCOSAMINOGLYCANS; KNEE JOINT; LACTIC ACID; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; POLYGLYCOLIC ACID; RABBITS; SODIUM HYDROXIDE; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84898905199     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368913X669770     Document Type: Article

References (31)

1. Eve, D. J.; Fillmore, R. W.; Borlongan, C. V.; Sanberg, P. R. Stem cell research in cell transplantation: Sources, geopolitical influence, and transplantation. Cell Transplant. 19:1493-1509; 2010.
2. Farndale, R. W.; Buttle, D. J.; Barrett, A. J. Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylene blue. Biochem. Biophys. Acta 883:173-177; 1986.
3. Fujisawa, T.; Hattori, T.; Ono, M.; Uehara, J.; Kubota, S.; Kuboki, T.; Takigawa, M. CCN family 2/connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes. Osteoarthritis Cartilage 16:787-795; 2008.
4. Fukuda, A.; Kato, K.; Hasegawa, M.; Hirata, H.; Sudo, A.; Okazaki, K.; Tsutab, K.; Shikinamib, Y.; Uchida, A. Enhanced repair of large osteochondral defects using a combination of artificial cartilage and basic fibroblast growth factor. Biomaterials 26:4301-4308; 2005.
5. Ge, Z.; Goh, J. C.; Lee, E. H. The effects of bone marrowderived mesenchymal stem cells and fascia wrap application to anterior cruciate ligament tissue engineering. Cell Transplant. 14:763-773; 2005.
6. Gilbert, J. E. Current treatment options for the restoration of articular cartilage. Am. J. Knee Surg. 11:42-46; 1998.
7. Han, S. H.; Kim, Y. H.; Park, M. S.; Kim, I. A.; Shin, J. W.; Yang, W. I.; Jee, K. S.; Park, K. D.; Ryu, G. H.; Lee, J. W. Histological and biomechanical properties of regenerated articular cartilage using chondrogenic bone marrow stromal cells with a PLGA scaffold in vivo. J. Biomed. Mater. Res. A 87:850-861; 2008.
8. Mockros, L. F. A. Mathematical analysis for indentation tests of articular cartilage. J. Biomech. 5:541-551; 1972.
9. Hunziker, E. B.; Driesang, I. M.; Morris, E. A. Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily. Clin. Orthop. 391S:171-181; 2001.
10. Jung, M.; Kaszap, B.; Redöhl, A.; Steck, E.; Breusch, S.; Richter, W.; Gotterbarm, T. Enhanced early tissue regeneration after matrix-assisted autologous mesenchymal stem cell transplantation in full thickness chondral defects in a minipig model. Cell Transplant. 18:923-932; 2009.
11. Kay, S.; Thapa, A.; Haberstroh, K. M.; Webster, T. J. Nanostructured polymer: Nanophase ceramic composites enhance osteoblast and chondrocyte adhesion. Tissue Eng. 8:753-761; 2002.
12. Kumai, T.; Takakura, Y.; Higashiyama, I.; Tamai, S. Arthroscopic drilling for the treatment of osteochondral lesions of the tarus. J. Bone Joint Surg. Am. 81:1229-1235; 1999.
13. Markway, B. D.; Tan, G. K.; Brooke, G.; Hudson, J. E.; Cooper-White, J. J.; Doran, M. R. Enhanced chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in low oxygen environment micropellet cultures. Cell Transplant. 19:29-42; 2010.
14. Martin, I.; Miot, S.; Barbero, A.; Jakob, M.; Wendt, D. Osteochondral tissue engineering. J. Biomech. 40:750-765; 2007.
15. Miller, D. C.; Thapa, A.; Haberstroh, K. M.; Webster, T. J. Endothelial and vascular smooth muscle cell function on poly (lactic-co-glycolic acid) with nano-structured surface features. Biomaterials 25:53-61; 2004.
16. Nakanishi, T.; Nishida, T.; Shimo, T.; Kobayashi, K.; Kubo, T.; Tamatani, T.; Tezuka, K.; Takigawa, M. Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture. Endocrinology 141:264-273; 2000.
17. Neuss, S.; Stainforth, R.; Salber, J.; Schenck, P.; Bovi, M.; Knüchel, R.; Perez-Bouza, A. Long-term survival and bipotent terminal differentiation of human mesenchymal stem cells (hMSC) in combination with a commercially available three-dimensional collagen scaffold. Cell Transplant. 17:977-986; 2008.
18. Nishida, T.; Kubota, S.; Kojima, S.; Kuboki, T.; Nakao, K.; Kushibiki, T.; Tabata, Y.; Takigawa, M. Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). J. Bone Miner. Res. 19:1308-1319; 2004.
19. Nishida, T.; Kubota, S.; Nakanishi, T.; Kuboki, T.; Yosimichi, G.; Kondo, S.; Takigawa, M. CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes. J. Cell. Physiol. 192:55-63; 2002.
20. Park, G. E.; Pattison, M. A.; Park, K.; Webster, T. J. Accelerated chondrocyte functions on NaOH-treated PLGA scaffolds. Biomaterials 26:3075-3082; 2005.
21. Park, K.; Cho, K. J.; Kim, J. J.; Kim, I. H.; Han, D. K. Functional PLGA scaffolds for chondrogenesis of bonemarrow-derived mesenchymal stem cells. Macromol. Biosci. 9:221-229; 2009.
22. Reinold, M. M.; Wilk, K. E.; Macrina, L. C.; Dugas, J. R.; Cain, E. L. Current concepts in the rehabilitation following articular cartilage repair procedures in the knee. J. Orthop. Sports Phys. Ther. 36:774-794; 2006.
23. Savaiano, J. K.; Webster, T. J. Altered responses of chondrocytes to nanophase PLGA/nanophase titania composites. Biomaterials 25:1205-1213; 2004.
24. Sellers, R. S.; Peluso, D.; Morris, E. A. The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage. J. Bone Joint Surg. Am. 79:1452-1463; 1997.
25. Shao, X.; Goh, J. C.; Hutmacher, D. W.; Lee, E. H.; Zigang, G. Repair of large articular osteochondral defects using hybrid scaffolds and bone marrow-derived mesenchymal stem cells in a rabbit model. Tissue Eng. 12:1539-1551; 2006.
26. Steinert, A. F.; Ghivizzani, S. C.; Rethwilm, A.; Tuan, R. S.; Evans, C. H.; Nöth, U. Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res. Ther. 9:213-221; 2007.
27. Takigawa, M.; Nakanishi, T.; Kubota, S.; Nishida, T. Role of CTGF/HCS24/ecogenin in skeletal growth control. J. Cell. Physiol. 194:256-266; 2003.
28. Uematsu, K.; Hattori, K.; Ishimoto, Y.; Yamauchi, J.; Habata, T.; Takakura, Y.; Ohgushi, H.; Fukuchi, T.; Sato, M. Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold. Biomaterials 26:4273-4279; 2005.
29. Wakitani, S.; Goto, T.; Pineda, S. J.; Young, R. G.; Mansour, J. M.; Caplan, A. I.; Goldberg, V. M. Mesenchymal cellbased repair of large, full-thickness defects of articular cartilage. J. Bone Joint Surg. Am. 76:579-592; 1994.
30. Webster, T. J.; Smith, T. A. Increased osteoblast function on PLGA composites containing nanophase titania. J. Biomed. Mater. Res. A 74:677-686; 2005.
31. Zhu, S. S.; Zhang, B.; Man, C.; Ma, Y. Q.; Hu, J. NELlike molecule-1-modified bone marrow mesenchymal stem cells/poly lactic-co-glycolic acid composite improves repair of large osteochondral defects in mandibular condyle. Osteoarthritis Cartilage. 19:743-750; 2011.