The inhibitory effects of deleted in liver cancer 1 gene on gallbladder cancer growth through induction of cell cycle arrest and apoptosis

Journal of Gastroenterology and Hepatology (Australia)

Volumn 29, Issue 5, 2014, Pages 964-972

  Qin, Yiyu ^a   Chu, Bingfeng ^a   Gong, Wei ^a   Wang, Jiandong ^a   Tang, Zhaohui ^a   Shen, Jun ^a   Quan, Zhiwei ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; Deleted in liver cancer 1; Gallbladder cancer; Gene therapy

Indexed keywords

BAX PROTEIN, HUMAN; CASPASE; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYTOCHROME C; DLC1 PROTEIN, HUMAN; FAS LIGAND; FASLG PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN BAX; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; CELL CYCLE; CELL MOTION; CELL TRANSFORMATION; GALLBLADDER NEOPLASMS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROMES C; FAS LIGAND PROTEIN; GALLBLADDER NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GTPASE-ACTIVATING PROTEINS; HUMANS; IN VITRO TECHNIQUES; MOLECULAR TARGETED THERAPY; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84898903996     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12486     Document Type: Article

References (28)

1. Kiran RP, Pokala N, Dudrick SJ. Incidence pattern and survival for gallbladder cancer over three decades-an analysis of 10301 patients. Ann. Surg. Oncol. 2007; 14: 827-832.
2. Nevin JE, Moran TJ, Kay S, King R. Carcinoma of the gallbladder: staging, treatment, and prognosis. Cancer 1976; 37: 141-148.
3. Misra S, Chaturvedi A, Misra NC, Sharma ID. Carcinoma of the gallbladder. Lancet Oncol. 2003; 4: 167-176.
4. Quan ZW, Wu K, Wang J, Shi W, Zhang Z, Merrell RC. Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gallbladder cancer. J. Am. Coll. Surg. 2001; 193: 380-383.
5. Ma HB, Hu HT, Di ZL etal. Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. World J. Gastroenterol. 2005; 11: 744-747.
6. Xuan YH, Choi YL, Shin YK etal. An immunohistochemical study of the expression of cell-cycle-regulated proteins p53, cyclin D1, RB, p27, Ki67 and MSH2 in gallbladder carcinoma and its precursor lesions. Histol. Histopathol. 2005; 20: 59-66.
7. Liu C, Sun B, An N etal. Inhibitory effect of Survivin promoter-regulated oncolytic adenovirus carrying P53 gene against gallbladder cancer. Mol. Oncol. 2011; 5: 545-554.
8. Qin Y, Zhang S, Gong W, Li J, Jia J, Quan Z. Adenovirus-mediated gene transfer of tissue factor pathway inhibitor-2 inhibits gallbladder carcinoma growth in vitro and in vivo. Cancer Sci. 2012; 103: 723-730.
9. Yuan BZ, Miller MJ, Keck CL, Zimonjic DB, Thorgeirsson SS, Popescu NC. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Cancer Res. 1998; 58: 2196-2199.
10. Yuan BZ, Jefferson AM, Baldwin KT, Thorgeirsson SS, Popescu NC, Reynolds SH. DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. Oncogene 2004; 23: 1405-1411.
11. Yuan BZ, Zhou X, Durkin ME etal. DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity. Oncogene 2003; 22: 445-450.
12. Guan M, Zhou X, Soulitzis N, Spandidos DA, Popescu NC. Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications. Clin. Cancer Res. 2006; 12: 1412-1419.
13. Zhang T, Zheng J, Jiang N etal. Overexpression of DLC-1 induces cell apoptosis and proliferation inhibition in the renal cell carcinoma. Cancer Lett. 2009; 283: 59-67.
14. Yuan BZ, Durkin ME, Popescu NC. Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers. Cancer Genet. Cytogenet. 2003; 140: 113-117.
15. Kim TY, Jong HS, Song SH etal. Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. Oncogene 2003; 22: 3943-3951.
16. García P, Manterola C, Araya JC etal. Promoter methylation profile in preneoplastic and neoplastic gallbladder lesions. Mol. Carcinog. 2009; 48: 79-89.
17. Wong CM, Lee JM, Ching YP, Jin DY, Ng IO. Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma. Cancer Res. 2003; 63: 7646-7651.
18. Zhang Q, Ying J, Zhang K etal. Aberrant methylation of the 8p22 tumor suppressor gene DLC1 in renal cell carcinoma. Cancer Lett. 2007; 249: 220-226.
19. Taylor KH, Pena-Hernandez KE, Davis JW etal. Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia. Cancer Res. 2007; 67: 2617-2625.
20. Goodison S, Yuan J, Sloan D etal. The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. Cancer Res. 2005; 65: 6042-6053.
21. Healy KD, Hodgson L, Kim TY etal. DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol. Carcinog. 2008; 47: 326-337.
22. Ng IO, Liang ZD, Cao L, Lee TK. DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1. Cancer Res. 2000; 60: 6581-6584.
23. Sun W, Fan YZ, Zhang WZ, Ge CY. A pilot histomorphology and hemodynamic of vasculogenic mimicry in gallbladder carcinomas in vivo and in vitro. J. Exp. Clin. Cancer Res. 2011; 30: 46.
24. Jin Y, Tian X, Shang Y, Huang P. Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line. Oncol. Rep. 2008; 19: 669-674.
25. Rosen A, Casciola-Rosen L. Macromolecular substrates for the ICE-like proteases during apoptosis. J. Cell. Biochem. 1997; 64: 50-54.
26. Waldman T, Kinzler KW, Vogelstein B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 1995; 55: 5187-5190.
27. Vogt A, Sun J, Qian Y, Hamilton AD, Sebti SM. The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. J. Biol. Chem. 1997; 272: 27224-27229.
28. Haupt S, Berger M, Goldberg Z, Haupt Y. Apoptosis-the p53 network. J. Cell Sci. 2003; 116: 4077-4085.