An improved highly sensitive method to determine low oxyresveratrol concentrations in rat plasma and its pharmacokinetic application

Biomedical Chromatography

Volumn 28, Issue 5, 2014, Pages 667-672

  Tian, Fangzhen ^a   Wei, Hongtu ^a   Jia, Tanghong ^b   Tian, Hua ^c  

^a First People's Hospital of Jining   (China)

^b Health Board of Jinan   (China)

^c Xuzhuang Health Center of Jining   (China)

Author keywords

LC MS MS; Oxyresveratrol; Pharmacokinetics; Rat plasma

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; MASS SPECTROMETRY; RATS; RESVERATROL;

CHROMATOGRAPHY COLUMNS; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LC-MS-MS; LC.MS/MS; OXYRESVERATROL; PLASMA SAMPLES; POLYPHENOLICS; RAT PLASMA; SAMPLE VOLUME; SENSITIVE METHOD;

PHARMACOKINETICS;

ACETOACETIC ACID; ACETONITRILE; AMMONIA; HYDROXYL GROUP; OXYRESVERATROL; RESVERATROL; UNCLASSIFIED DRUG; WATER; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; ELECTROSPRAY; ELUTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MEAN RESIDENCE TIME; NONHUMAN; QUALITY CONTROL; RAT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; ANIMAL; BLOOD; EVALUATION STUDY; LIQUID CHROMATOGRAPHY; PROCEDURES; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; CHROMATOGRAPHY, LIQUID; MALE; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; STILBENES;

EID: 84898886719     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3087     Document Type: Article

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