Mesenchymal stromal cells integrate and form longitudinally-aligned layers when delivered to injured spinal cord via a novel fibrin scaffold

Neuroscience Letters

Volumn 569, Issue , 2014, Pages 12-17

  Hyatt, Alex J T ^a   Wang, Difei ^a   van Oterendorp, Christian ^a,b   Fawcett, James W ^a   Martin, Keith R ^a,c,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF FREIBURG   (Germany)

^c NIHR Cambridge Biomedical Research Centre   (United Kingdom)

^d University of Cambridge   (United Kingdom)

Author keywords

Cell scaffold; Fibrin; Mesenchymal stromal cells; Spinal cord injury

Indexed keywords

FIBRIN; TISSUE SCAFFOLD;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL THERAPY; CONTROLLED STUDY; MESENCHYMAL STROMA CELL; NEURITE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; SPINAL CORD LESION; ANIMAL; CYTOLOGY; FEMALE; INTRASPINAL DRUG ADMINISTRATION; MESENCHYMAL STEM CELL TRANSPLANTATION; PATHOLOGY; PROCEDURES; SPINAL CORD; SPINAL CORD INJURIES; SPRAGUE DAWLEY RAT; TISSUE SCAFFOLD;

ANIMALS; FEMALE; FIBRIN; INJECTIONS, SPINAL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL CORD INJURIES; TISSUE SCAFFOLDS;

EID: 84898868298     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.03.023     Document Type: Article

References (28)

1. Kadoya K., Tsukada S., Lu P., Coppola G., Geschwind D., Filbin M.T., Blesch A., Tuszynski M.H. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron 2009, 64(2):165-172.
2. Mahmood A., Lu D., Chopp M. Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury. J. Neurotrauma 2004, 21(1):33-39.
3. Chopp M., Li Y. Treatment of neural injury with marrow stromal cells. Lancet Neurol. 2002, 1(2):92-100.
4. Chopp M., Zhang X.H., Li Y., Wang L., Chen J., Lu D., Lu M., Rosenblum M. Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport 2000, 11(13):3001-3005.
5. Wu S., Suzuki Y., Ejiri Y., Noda T., Bai H., Kitada M., Kataoka K., Ohta M., Chou H., Ide C. Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord. J. Neurosci. Res. 2003, 72(3):343-351.
6. Zurita M., Vaquero J. Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation. Neuroreport 2004, 15(7):1105-1108.
7. Hofstetter C.P., Schwarz E.J., Hess D., Widenfalk J., El Manira A., Prockop D.J., Olson L. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc. Natl. Acad. Sci. U.S.A. 2002, 99(4):2199-2204.
8. Cízková D., Rosocha J., Vanický I., Jergová S., Cízek M. Transplants of human mesenchymal stem cells improve functional recovery after spinal cord injury in the rat. Cell. Mol. Neurobiol. 2006, 26(7-8):1167-1180.
9. Koda M., Okada S., Nakayama T., Koshizuka S., Kamada T., Nishio Y., Someya Y., Yoshinaga K., Okawa A., Moriya H., Yamazaki M. Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice. Neuroreport 2005, 16(16):1763-1767.
10. Gu W., Zhang F., Xue Q., Ma Z., Lu P., Yu B. Transplantation of bone marrow mesenchymal stem cells reduces lesion volume and induces axonal regrowth of injured spinal cord. Neuropathology 2010, 30(3):205-217.
11. Parr A.M., Tator C.H., Keating A. Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplant. 2007, 40(7):609-619.
12. Shen L.H., Li Y., Chen J., Zhang J., Vanguri P., Borneman J., Chopp M. Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke. Neuroscience 2006, 137(2):393-399.
13. Bai L., Lennon D.P., Eaton V., Maier K., Caplan A.I., Miller S.D., Miller R.H. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia 2009, 57(11):1192-1203.
14. Ohtaki H., Ylostalo J.H., Foraker J.E., Robinson A.P., Reger R.L., Shioda S., Prockop D.J. Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proc. Natl. Acad. Sci. U.S.A. 2008, 105(38):14638-14643.
15. Vaquero J., Zurita M., Oya S., Santos M. Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration?. Neurosci. Lett. 2006, 398(1-2):129-134.
16. Guest J., Benavides F., Padgett K., Mendez E., Tovar D. Technical aspects of spinal cord injections for cell transplantation. Clinical and translational considerations. Brain Res. Bull. 2011, 84(4-5):267-279.
17. Lavik E.B., Klassen H., Warfvinge K., Langer R., Young M.J. Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors. Biomaterials 2005, 26(16):3187-3196.
18. Zurita M., Otero L., Aguayo C., Bonilla C., Ferreira E., Parajón A., Vaquero J. Cell therapy for spinal cord repair: optimization of biologic scaffolds for survival and neural differentiation of human bone marrow stromal cells. Cytotherapy 2010, 12(4):522-537.
19. Johnson T.V., Bull N.D., Hunt D.P., Marina N., Tomarev S.I., Martin K.R. Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 2010, 51(4):2051-2059.
20. García-Alías G., Barkhuysen S., Buckle M., Fawcett J.W. Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation. Nat. Neurosci. 2009, 12(9):1145-1151.
21. Bradbury E.J., Khemani S., Von R., King, Priestley J.V., McMahon S.B. NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord. Eur. J. Neurosci. 1999, 11(11):3873-3883.
22. Griffith M., Osborne R., Munger R., Xiong X., Doillon C.J., Laycock N.L., Hakim M., Song Y., Watsky M.A. Functional human corneal equivalents constructed from cell lines. Science 1999, 286(5447):2169-2172.
23. Hardin-Young J., Carr R.M., Downing G.J., Condon K.D., Termin P.L. Modification of native collagen reduces antigenicity but preserves cell compatibility. Biotechnol. Bioeng. 1996, 49(6):675-682.
24. Lammers G., Tjabringa G.S., Schalkwijk J., Daamen W.F., van Kuppevelt T.H. A molecularly defined array based on native fibrillar collagen for the assessment of skin tissue engineering biomaterials. Biomaterials 2009, 30(31):6213-6220.
25. Fagerholm P., Lagali N.S., Merrett K., Jackson W.B., Munger R., Liu Y., Polarek J.W., Söderqvist M., Griffith M. A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study. Sci. Transl. Med. 2010, 2(46):46ra61.
26. Paíno C.L., Fernandez-Valle C., Bates M.L., Bunge M.B. Regrowth of axons in lesioned adult rat spinal cord: promotion by implants of cultured Schwann cells. J. Neurocytol. 1994, 23(7):433-452.
27. Gámez Sazo R.E., Maenaka K. Fabrication of growth factor- and extracellular matrix-loaded: gelatin-based scaffolds and their biocompatibility with Schwann cells and dorsal root ganglia. Biomaterials 2012, 33(33):8529-8539.
28. Parr A.M., Kulbatski I., Zahir T., Wang X., Yue C., Keating A., Tator C.H. Transplanted adult spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. Neuroscience 2008, 155(3):760-770.