Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines

European Journal of Medicinal Chemistry

Volumn 79, Issue , 2014, Pages 266-272

  Monteiro, Ângelo ^a   Gonçalves, Lídia M ^a   Santos, Maria M M ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Anticancer agents; Cytotoxicity; Pyrazoline; Spirooxindole; Structure activity relationship

Indexed keywords

CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; OXINDOLE; SPIROPYRAZOLINE OXINDOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CYTOTOXIN; INDOLE DERIVATIVE; PYRAZOLE DERIVATIVE; SPIRO COMPOUND;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FEMALE; HEK293 CELL LINE; MCF 7 CELL LINE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYTOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEK293 CELLS; HUMANS; INDOLES; MCF-7 CELLS; MOLECULAR STRUCTURE; PYRAZOLES; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898838853     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.023     Document Type: Article

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