Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patients

Journal of Neuroimmunology

Volumn 270, Issue 1-2, 2014, Pages 51-55

  Mameli, Giuseppe ^a   Cossu, Davide ^a   Cocco, Eleonora ^b   Masala, Speranza ^a   Frau, Jessica ^b   Marrosu, Maria Giovanna ^b   Sechi, Leonardo A ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Epstein Barr virus; Molecular mimicry; Multiple sclerosis; Mycobacterium avium subsp. paratuberculosis; Myelin basic protein

Indexed keywords

EPSTEIN-BARR VIRUS; MOLECULAR MIMICRY; MULTIPLE SCLEROSIS; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; MYELIN BASIC PROTEIN;

ADULT; ANTIGENS, VIRAL; AUTOANTIBODIES; AUTOANTIGENS; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; MALE; MULTIPLE SCLEROSIS; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; MYELIN BASIC PROTEIN;

EID: 84898835438     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2014.02.013     Document Type: Article

References (22)

1. Ascherio A., Munger K.L. Environmental risk factors for multiple sclerosis. Part I: the role of the infection. Ann. Neurol. 2007, 61:288-299.
2. Cossu D., Cocco E., Paccagnini D., Masala S., Ahmed N., Frau J., Marrosu M.G., Sechi L.A. Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients. PLoS One 2011, 6:e18482.
3. Cossu D., Masala S., Cocco E., Paccagnini D., Frau J., Marrosu M.G., Sechi L.A. Are Mycobacterium avium subsp. paratuberculosis and Epstein-Barr virus triggers of multiple sclerosis in Sardinia?. Mult. Scler. 2012, 18:1181-1184.
4. Cossu D., Masala S., Sechi L.A. A Sardinian map for multiple sclerosis. Future Microbiol 2013, 8:223-232.
5. Cossu D., Masala S., Frau J., Cocco E., Marrosu M.G., Sechi L.A. Anti Mycobacterium avium subsp. paratuberculosis heat shock protein 70 antibodies in the sera of Sardinian patients with multiple sclerosis. J. Neurol. Sci. 2013, 335:131-133.
6. Cossu D., Masala S., Frau J., Mameli G., Marrosu M.G., Cocco E., Sechi L.A. Antigenic epitopes of MAP2694 homologous to T-cell receptor gamma-chain are highly recognized in multiple sclerosis Sardinia patients. Mol. Immunol. 2014, 57:138-140.
7. Csuka D., Simon D., Hóbor R., Uray K., Prohászka Z., Bánlaki Z., Jani P.K., Szilágyi Á., Hudecz F., Rajczy K., Beke G., Boros, Major A., Tordai A., Illés Z., Berki T., Czirják L., Füst G. Serum concentration of immunoglobulin G-type antibodies against the whole Epstein-Barr nuclear antigen 1 and its aa35-58 or aa398-404 fragments in the sera of patients with systemic lupus erythematosus and multiple sclerosis. Clin. Exp. Immunol. 2013, 171:255-262.
8. Farrell R.A., Antony D., Wall G.R., Clark D.A., Fisniku L., Swanton J., Khaleeli Z., Schmierer K., Miller D.H., Giovannoni G. Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology 2009, 73:32-38.
9. Giovannoni G., Ebers G. Multiple sclerosis: the environment and causation. Curr. Opin. Neurol. 2007, 20:261-268.
10. Kakalacheva K., Münz C., Lünemann J.D. Viral triggers of multiple sclerosis. Biochim. Biophys. Acta 2011, 1812:132-140.
11. Kumar A., Cocco E., Atzori L., Marrosu M.G., Pieroni E. Structural and dynamical insights on HLA-DR2 complexes that confer susceptibility to multiple sclerosis in Sardinia: a molecular dynamics simulation study. PLoS One 2013, 8:e59711.
12. Mameli G., Cossu D., Cocco E., Masala S., Frau J., Marrosu M.G., Sechi L.A. EBNA-1 IgG titers in Sardinian multiple sclerosis patients and controls. J. Neuroimmunol. 2013, 264:120-122.
13. Masala S., Zedda M.A., Cossu D., Ripoli C., Palermo M., Sechi L.A. Zinc transporter 8 and MAP3865c homologous epitopes are recognized at T1D onset in Sardinian children. PLoS One 2013, 8:e63371.
14. McQualter J.L., Bernard C.C. Multiple sclerosis: a battle between destruction and repair. J. Neurochem. 2007, 100:295-306.
15. Mechelli R., Anderson J., Vittori D., Coarelli G., Annibali V., Cannoni S., Aloisi F., Salvetti M., James J.A., Ristori G. Epstein-Barr virus nuclear antigen-1 B-cell epitopes in multiple sclerosis twins. Mult. Scler. 2011, 17:1290-1294.
16. Munger K.L., Levin L.I., O'Reilly E.J., Falk K.I., Ascherio A. Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel. Mult. Scler. 2011, 17:1185-1193.
17. Pakpoor J., Giovannoni G., Ramagopalan S.V. Epstein-Barr virus and multiple sclerosis: association or causation?. Expert. Rev. Neurother. 2013, 13:287-297.
18. Polman C.H., Reingold S.C., Banwell B., Clanet M., Cohen J.A., Filippi M., Fujihara K., Havrdova E., Hutchinson M., Kappos L., Lublin F.D., Montalban X., O'Connor P., Sandberg-Wollheim M., Thompson A.J., Waubant E., Weinshenker B., Wolinsky J.S. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 2010, 69:292-302.
19. Strautins K., Tschochner M., James I., Choo L., Dunn D., Pedrini M., Kermode A., Carroll W., Nolan D. Combining HLA-DR risk alleles and anti-Epstein-Barr virus antibody profiles to stratify multiple sclerosis risk. Mult. Scler. 2014, 20:286-294.
20. Virtanen J.O., Jacobson S. Viruses and multiple sclerosis. CNS Neurol. Disord. Drug. Targets 2012, 11:528-544.
21. Vojdani A., Vojdani E., Cooper E. Antibodies to myelin basic protein, myelin oligodendrocyte peptides, α-β-crystallin, lymphocyte activation and cytokine production in patients with multiple sclerosis. J. Intern. Med. 2003, 254:363-374.
22. Wucherpfennig K.W., Strominger J.L. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995, 80:695-705.