Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons

Human Molecular Genetics

Volumn 23, Issue 10, 2014, Pages 2527-2541

  Havlicek, Steven ^a,b   Kohl, Zacharias ^a   Mishra, Himanshu K ^a   Prots, Iryna ^a   Eberhardt, Esther ^a   Denguir, Naime ^a   Wend, Holger ^a   Plötz, Sonja ^a   Boyer, Leah ^b   Marchetto, Maria C N ^b   Aigner, Stefan ^b,d   Sticht, Heinrich ^a   Groemer, Teja W ^a   Hehr, Ute ^c   Lampert, Angelika ^a,e   Schlötzer schrehardt, Ursula ^a   Winkler, Jürgen ^a   Gage, Fred H ^b   Winner, Beate ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

^e UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P60; SMOOTH MUSCLE ACTIN; SPASTIC GAIT 4 PROTEIN; SPASTIN; SYNAPTOPHYSIN; TAU PROTEIN; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR SOX2; TUBULIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; ISOPROTEIN; SPAST PROTEIN, HUMAN;

ARTICLE; ASTROCYTE; CELL COUNT; CONTROLLED STUDY; FEMALE; FIBROBLAST; GENE DOSAGE; GENE MUTATION; GLIA CELL; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; HUMAN CELL; MALE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE FIBER TRANSPORT; NEURITE; NONSENSE MUTATION; ONCOGENE C MYC; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ADULT; CELL CULTURE; CELL SHAPE; GENE EXPRESSION; GENE THERAPY; GENETICS; METABOLISM; MICROTUBULE; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SPASTIC PARAPLEGIA, HEREDITARY;

ADENOSINE TRIPHOSPHATASES; ADULT; AXONAL TRANSPORT; CELL SHAPE; CELLS, CULTURED; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENETIC THERAPY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MICROTUBULES; MIDDLE AGED; NEURITES; PROTEIN ISOFORMS; SPASTIC PARAPLEGIA, HEREDITARY;

EID: 84898828349     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt644     Document Type: Article

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