Understanding the mechanism of proteasome 20S core particle gating

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 15, 2014, Pages 5532-5537

  Latham, Michael P ^a   Sekhar, Ashok ^a   Kay, Lewis E ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

20S proteasome gating; Energy landscape; Internal friction; Magnetization exchange NMR spectroscopy

Indexed keywords

PROTEASOME; PROTEASOME 20S; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL CELL; CELL FUNCTION; CELL LYSATE; CELL VIABILITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIFFUSION COEFFICIENT; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDRODYNAMICS; IN VITRO STUDY; MACROMOLECULE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; THERMOPLASMA ACIDOPHILUM; VISCOSITY;

20S PROTEASOME GATING; ENERGY LANDSCAPE; INTERNAL FRICTION; MAGNETIZATION EXCHANGE NMR SPECTROSCOPY;

ARCHAEAL PROTEINS; CATALYTIC DOMAIN; ENDOPEPTIDASES; HOMEOSTASIS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; VISCOSITY; WATER;

EID: 84898821640     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322079111     Document Type: Article

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