P21 overexpression sensitizes osteosarcoma U2OS cells to cisplatin via evoking caspase-3 and Bax/Bcl-2 cascade

Tumor Biology

Volumn 35, Issue 4, 2014, Pages 3119-3123

  Ding, Yong ^a   Wang, Yucai ^a   Chen, Jun ^a   Hu, Yunsheng ^a   Cao, Zhuo ^a   Ren, Pengcheng ^a   Zhang, Yong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cisplatin; Osteosarcoma U2OS; Tumor suppressor gene p21

Indexed keywords

CASPASE 3; CISPLATIN; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL GROWTH; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BONE NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; OSTEOSARCOMA; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84898799685     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-1404-9     Document Type: Article

References (32)

1. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993;75:805-16.
2. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, et al. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 1994;76:1013-23.
3. Ando T, Kawabe T, Ohara H, Ducommun B, Itoh M, Okamoto T. Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage. J Biol Chem. 2001;276:42971-7.
4. Dash BC, El-Deiry WS. Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity. Mol Cell Biol. 2005;25:3364-87.
5. Matsumoto T, Sowa Y, Ohtani-Fujita N, Tamaki T, Takenaka T, Kuribayashi K, et al. p53-independent induction of WAF1/Cip1 is correlated with osteoblastic differentiation by vitamin D3. Cancer Lett. 1998;129:61-8.
6. Gartel AL, Serfas MS, Tyner AL. p21-negative regulator of the cell cycle. Proc Soc Exp Biol Med. 1996;213:138-49.
7. Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer. 2009;9:400-14.
8. Martin-Caballero J, Flores JM, Garcia-Palencia P, Serrano M. Tumor susceptibility of p21(Waf1/Cip1)-deficient mice. Cancer Res. 2001;61:6234-8.
9. Young NP, Crowley D, Jacks T. Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis. Cancer Res. 2011;71:4040-7.
10. Zhang Y, Sturgis EM, Zafereo ME, Wei Q, Li G. p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck. Cancer. 2011;117:1227-35.
11. Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer. 2009;115:1531-43.
12. Marina N, Gebhardt M, Teot L, Gorlick R. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist. 2004;9:422-41.
13. Hirata M, Kusuzaki K, Takeshita H, Hashiguchi S, Hirasawa Y, Ashihara T. Drug resistance modification using pulsing electromagnetic field stimulation for multidrug resistant mouse osteosarcoma cell line. Anticancer Res. 2001;21:317-20.
14. Takeshita H, Gebhardt MC, Springfield DS, Kusuzaki K, Mankin HJ. Experimental models for the study of drug resistance in osteosarcoma: p-glycoprotein-positive, murine osteosarcoma cell lines. J Bone Joint Surg. 1996;78A:366-75.
15. Kuijjer ML, Rydbeck H, Kresse SH, Buddingh EP, Lid AB, Roelofs H, et al. Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data. Genes Chromosomes Cancer. 2012;51:696-706.
16. Zhong GX, Liu AL, Lin JH. Detection of femtomolar level osteosarcoma-related gene via a chronocoulometric DNA biosensor based on nanostructure gold electrode. Int J Nanomedicine. 2012;7:527-36.
17. Matsui TA, Sowa Y, Murata H, Takagi K, Nakanishi R, Aoki S, et al. The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. Int J Oncol. 2007;31:915-22.
18. Izawa H, Yamamoto H, Damdinsuren B, Ikeda K, Tsujie M, Suzuki R, et al. Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells. Int J Oncol. 2005;27:69-76.
19. Wang WZ, Zhang BY, Mei WJ, Mao JW, Li M. Effect of p21-targeted shRNA on curcumin-induced apoptosis of human hepatoma Huh7 cells. Yao Xue Xue Bao. 2009;44:1102-6.
20. Li Z, Yang L, Wang J, Shi W, Pawar RA, Liu Y, et al. beta-Actin is a useful internal control for tissue-specific gene expression studies using quantitative real-time PCR in the half-smooth tongue sole Cynoglossus semilaevis challenged with LPS or Vibrio anguillarum. Fish Shellfish Immunol. 2010;29:89-93.
21. Liao WM, Zhang CL, Li FB, Zeng BF, Zeng YX. p21WAF1/CIP1 gene DNA sequencing and its expression in human osteosarcoma. Chin Med J (Engl). 2004;117:936-40.
22. Zhang CL, Liao WM, Li FB, Zeng BF, Zeng YX. Prognostic significance of p21 (WAF1) expression in osteosarcoma. Zhonghua Bing Li Xue Za Zhi. 2005;34:524-7.
23. Huschtscha L, Bartier W, Malmstrom A, Tattersall M. Cell death by apoptosis following anticancer drug treatment in vitro. Int J Oncol. 1995;6:585-93.
24. Vinatier D, Dufour P, Subtil D. Apoptosis: a programmed cell death involved in ovarian and uterine physiology. Eur J Obstet Gynecol Reprod Biol. 1996;67:85-102.
25. Wang C, Youle RJ. The role of mitochondria in apoptosis. Annu Rev Genet. 2009;43:95-118.
26. Roos WP, Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol Med. 2006;12:440-50.
27. Vinatier D, Dufour P, Subtil D. Caspases: pharmacological manipulation of cell death. Eur J Obstet Gynecol Reprod Biol. 1996;67:85-102.
28. Norbury CJ, Zhivotovsky B. DNA damage-induced apoptosis. Oncogene. 2004;23:2797-808.
29. Soldani C, Scovassi AI. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis. 2002;7:321-8.
30. Orrenius S. Mitochondrial regulation of apoptotic cell death. Toxicol Lett. 2004;149:19-23.
31. Scorrano L, Korsmeyer SJ. Mechanisms of cytochrome c release by proapoptotic Bcl-2 family members. Biochem Biophys Res Commun. 2003;304:437-44.
32. Meeran SM, Katiyar SK. Grape seed proanthocyanidins promote apoptosis in human epidermoid carcinoma A431 cells through alterations in Cdki-Cdk-cyclin cascade, and caspase-3 activation via loss of mitochondrial membrane potential. Exp Dermatol. 2007;16:405-15.