Associations between urine excretion of isoflavonoids and cognition in postmenopausal women in the Women'S Isoflavone Soy Health clinical trial

Journal of the American Geriatrics Society

Volumn 62, Issue 4, 2014, Pages 629-635

  John, Jan A St ^a,b   Henderson, Victor W ^c   Hodis, Howard N ^a,b   Kono, Naoko ^a,b   McCleary, Carol A ^b   Franke, Adrian A ^d   Mack, Wendy J ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

cognition; isoflavones; menopause; soy; women's health

Indexed keywords

ISOFLAVONE; ISOFLAVONE RICH SOY PROTEIN; ISOFLAVONOID; SOYBEAN PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; COGNITION; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; EPISODIC MEMORY; FEMALE; HORMONE SUBSTITUTION; HUMAN; INTELLIGENCE; NORMAL HUMAN; POST HOC ANALYSIS; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; URINARY EXCRETION;

COGNITION; ISOFLAVONES; MENOPAUSE; SOY; WOMEN'S HEALTH;

AGED; AGED, 80 AND OVER; ATHEROSCLEROSIS; COGNITION; COGNITION DISORDERS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; ISOFLAVONES; MEMORY; MIDDLE AGED; POSTMENOPAUSE; PROGNOSIS; REFERENCE VALUES; SOYBEAN PROTEINS; TIME FACTORS; URINALYSIS; VEGETABLE PROTEINS; WOMEN'S HEALTH;

EID: 84898786847     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.12752     Document Type: Article

References (27)

1. Kreijkamp-Kaspers S, Kok L, Grobbee DE, et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: A randomized controlled trial. JAMA 2004; 292: 65-74.
2. Henderson VW, St John JA, Hodis HN, et al. Long-term soy isoflavone supplementation and cognition in women. A randomized, controlled trial. Neurology 2012; 78: 1841-1848.
3. Kritz-Silverstein D, Von Muehlen D, Barrett-Connor E, et al. Isoflavones and cognitive function in older women: The SOy and Postmenopausal Health in Aging (SOPHIA) Study. Menopause 2003; 10: 196-202.
4. Duffy R, Wiseman H, File SE,. Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones. Pharmacol Biochem Behav 2003; 75: 721-729.
5. File SE, Hartley DE, Elsabagh S, et al. Cognitive improvement after 6 weeks of soy supplements in postmenopausal women is limited to frontal lobe function. Menopause 2005; 12: 193-201.
6. Gleason CE, Carlsson CM, Barnet JH, et al. A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women. Age Ageing 2009; 38 (1): 86-93.
7. Greendale GA, Huang MH, Leung K, et al. Dietary phytoestrogen intakes and cognitive function during the menopausal transition: Results from the Study of Women's Health Across the Nation Phytoestrogen Study. Menopause 2012; 19: 894-903.
8. Fournier LR, Ryan Borchers TA, Robison LM, et al. The effects of soy milk and isoflavone supplements on cognitive performance in healthy, postmenopausal women. J Nutr Health Aging 2007; 11: 155-164.
9. White LR, Petrovitch H, Ross GW, et al. Brain aging and midlife tofu consumption. J Am Coll Nutr 2000; 19: 242-255.
10. Hogervorst E, Sadjimim T, Yesufu A, et al. High tofu intake is associated with worse memory in elderly Indonesian men and women. Dement Geriatr Cogn Disord 2008; 26: 50-57.
11. Hodis HN, Mack WJ, Kono N, et al. Isoflavone soy protein supplementation and progression of subclinical atherosclerosis in healthy postmenopausal women: A randomized controlled trial. Stroke 2011; 42: 3168-3175.
12. WTAR: Wechsler Test of Adult Reading Manual. San Antonio, TX: Harcourt Assessment, 2001.
13. Radloff LS,. The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas 1977; 1: 385-401.
14. Guidance for Industry: Estrogen and Estrogen/Progestin Drug Products to Treat Vasomotor Symptoms and Vulva and Vaginal Atrophy Symptoms: Recommendations for Clinical Evaluation. Rockville, MD: Food and Drug Administration, Center for Drug Evaluation and Research, 2003.
15. Franke AA, Hebshi SM, Pagano I, et al. Urine accurately reflects circulating isoflavonoids and ascertains compliance during soy intervention. Cancer Epidemiol Biomarkers Prev 2010; 19: 1775-1783.
16. Shiang K-D,. The SAS Calculations of Areas Under the Curve (AUC) for Multiple Metabolic Readings [on-line]. Available at www.lexjansen.com/wuss/2004/ posters/cpost-the-sas-calculations-.pdf Accessed June 6, 2013.
17. Messina M, Nagata C, Wu AH,. Estimated Asian adult soy protein and isoflavone intakes. Nutr Cancer 2006; 55: 1-12.
18. Eichenbaum H, Sauvage M, Fortin N, et al. Towards a functional organization of episodic memory in the medial temporal lobe. Neurosci Biobehav R 2011; 36: 1597-1608.
19. Barbey AK, Colom R, Solomon J, et al. An integrative architecture for general intelligence and executive function revealed by lesion mapping. Brain 2012; 135: 1154-1164.
20. Frankenfeld CL,. O-Desmethylangolensin: The importance of equol's lesser known cousin to human health. Adv Nutr 2011; 2: 317-324.
21. Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor ß. Endocrinology 1998; 139: 4252-4263.
22. The role of soy isoflavones in menopausal health: Report of the North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010). Menopause 2011; 18: 732-753.
23. Schreihofer DA,. Transcriptional regulation by phytoestrogens in neuronal cell lines. Mol Cell Endocrinol 2005; 231: 13-22.
24. González M, Cabrera-Socorro A, Pérez-García CG, et al. Distribution patterns of estrogen receptor alpha and beta in the human cortex and hippocampus during development and adulthood. J Comp Neurol 2007; 503: 790-802.
25. Setchell KDR,. Soy isoflavones-benefits and risks from nature's selective estrogen receptor modulators (SERMs). J Am Coll of Nutr 2001; 20: 354S-363S.
26. Cyr M, Ghribi O, Thibault C, et al. Ovarian steroids and selective estrogen receptor modulators activity on rat brain NMDA and AMPA receptors. Brain Res Brain Res Rev 2001; 37: 153-161.
27. Lee YB, Lee HJ, Sohn HS,. Soy isoflavones and cognitive function. J Nutr Biochem 2005; 16: 641-649.