The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells

Biochemical and Biophysical Research Communications

Volumn 446, Issue 3, 2014, Pages 681-686

  Khalifa, Shaden A M ^a   De Medina, Philippe ^b,c   Erlandsson, Anna ^f   El Seedi, Hesham R ^g   Silvente Poirot, Sandrine ^c,d,e   Poirot, Marc ^c,d,e  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Affichem   (France)

^c CANCER RESEARCH CENTER OF TOULOUSE   (France)

^d UNIVERSITÉ PAUL SABATIER   (France)

^e INSTITUT CLAUDIUS REGAUD   (France)

^f UPPSALA UNIVERSITY   (Sweden)

^g UPPSALA UNIVERSITY   (Sweden)

Author keywords

Dendrogenin; Neural stem cells; Neurosteroids; Oxysterols

Indexed keywords

ALKALOID DERIVATIVE; BETA TUBULIN; CENTRAL NERVOUS SYSTEM AGENTS; DENDROGENIN A; DENDROGENIN B; OXYSTEROL; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LOSS; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; FEMALE; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NERVE FIBER GROWTH; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; SUBVENTRICULAR ZONE;

DENDROGENIN; NEURAL STEM CELLS; NEUROSTEROIDS; OXYSTEROLS;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHOLESTANOLS; FEMALE; IMIDAZOLES; MICE; MICE, INBRED C57BL; NEURAL STEM CELLS; SPERMIDINE;

EID: 84898783638     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.12.134     Document Type: Article

References (31)

1. L.P. Deleyrolle, and B.A. Reynolds Isolation, expansion, and differentiation of adult mammalian neural stem and progenitor cells using the neurosphere assay Methods Mol. Biol. 549 2009 91 101
2. F. Barnabé-Heider, and J. Frisén Stem cells for spinal cord repair Cell Stem Cell 3 2008 16 24
3. S. Weiss, B.A. Reynolds, A.L. Vescovi, C. Morshead, C.G. Craig, and D. van der Kooy Is there a neural stem cell in the mammalian forebrain? Trends Neurosci. 19 1996 387 393
4. E. Moyse, S. Segura, O. Liard, S. Mahaut, and N. Mechawar Microenvironmental determinants of adult neural stem cell proliferation and lineage commitment in the healthy and injured central nervous system Curr. Stem Cell Res. Ther. 3 2008 163 184
5. R.C. Melcangi, P. Froelichsthal, L. Martini, and A.L. Vescovi Steroid metabolizing enzymes in pluripotential progenitor central nervous system cells: effect of differentiation and maturation Neuroscience 72 1996 467 475
6. P. Taupin Nootropic agents stimulate neurogenesis. Brain Cells Expert Opin. Ther. Pat. 19 2009 727 730
7. J.L. Turgeon, M.C. Carr, P.M. Maki, M.E. Mendelsohn, and P.M. Wise Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: insights from basic science and clinical studies Endocr. Rev. 27 2006 575 605
8. S. Chen, J.M. Wang, R.W. Irwin, J. Yao, L. Liu, and R.D. Brinton Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease PLoS One 6 2011 24293
9. M.R. Paillasse, P. de Medina, G. Amouroux, L. Mhamdi, M. Poirot, and S. Silvente-Poirot Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion J. Lipid Res. 50 2009 2203 2211
10. S. Silvente-Poirot, and M. Poirot Cholesterol metabolism and cancer: the good, the bad and the ugly Curr. Opin. Pharmacol. 12 2012 673 676
11. J.C. Naylor, J.D. Kilts, C.M. Hulette, D.C. Steffens, D.G. Blazer, J.F. Ervin, J.L. Strauss, T.B. Allen, M.W. Massing, and V.M. Payne et al. Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects Biochim. Biophys. Acta 1801 2010 951 959
12. O. Lazarov, M.P. Mattson, D.A. Peterson, S.W. Pimplikar, and H. van Praag When neurogenesis encounters aging and disease Trends Neurosci. 33 2010 569 579
13. Z.X. Yao, R.C. Brown, G. Teper, J. Greeson, and V. Papadopoulos 22R-hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide J. Neurochem. 83 2002 1110 1119
14. W. Mayo, V. Lemaire, J. Malaterre, J.J. Rodriguez, M. Cayre, M.G. Stewart, M. Kharouby, G. Rougon, M. Le Moal, P.V. Piazza, and D.N. Abrous Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus Neurobiol. Aging 26 2005 103 114
15. L. Lecanu, A.I. Hashim, A. McCourty, I. Giscos-Douriez, I. Dinca, W. Yao, S. Vicini, G. Szabo, F. Erdélyi, J. Greeson, and V. Papadopoulos The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo Neuroscience 183 2011 251 264
16. P. de Medina, M.R. Paillasse, B. Payré, S. Silvente-Poirot, and M. Poirot Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases J. Med. Chem. 52 2009 7765 7777
17. M. Poirot, and S. Silvente-Poirot Cholesterol-5,6-epoxides: chemistry, biochemistry, metabolic fate and cancer Biochimie 95 2013 622 631
18. P. de Medina, M.R. Paillasse, G. Segala, M. Poirot, and S. Silvente-Poirot Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands Proc. Natl. Acad. Sci. U S A 107 2010 13520 13525
19. P. de Medina, M.R. Paillasse, G. Segala, M. Voisin, L. Mhamdi, F. Dalenc, M. Lacroix-Triki, T. Filleron, F. Pont, and T.A. Saati et al. Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties Nat. Commun. 4 2013 1840 1850
20. B.Y. Chen, X. Wang, Z.Y. Wang, Y.Z. Wang, L.W. Chen, and Z.J. Luo Brain-derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/β-catenin signaling pathway J. Neurosci. Res. 91 2013 30 41
21. S.B. Rangasamy, K. Soderstrom, R.A. Bakay, and J.H. Kordower Neurotrophic factor therapy for Parkinson's disease Prog. Brain Res. 184 2010 237 264
22. N. Weishaupt, A. Blesch, and K. Fouad BDNF: the career of a multifaceted neurotrophin in spinal cord injury Exp. Neurol. 238 2012 254 264
23. B.A. Reynolds, and R.L. Rietze Neural stem cells and neurospheres: re-evaluating the relationship Nat. Methods 2 2005 333 336
24. J.M. Wang, P.B. Johnston, B.G. Ball, and R.D. Brinton The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression J. Neurosci. 25 2005 4706 4718
25. R.D. Brinton, and J.M. Wang Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease Curr. Alzheimer Res. 3 2006 11 17
26. S.C. Correia, R.X. Santos, S. Cardoso, C. Carvalho, M.S. Santos, C.R. Oliveira, and P.I. Moreira Effects of estrogen in the brain: is it a neuroprotective agent in Alzheimer's disease? Curr. Aging Sci. 3 2010 113 126
27. D. Le Menuet, S. Viengchareun, M. Muffat-Joly, M.C. Zennaro, and M. Lombès Expression and function of the human mineralocorticoid receptor: lessons from transgenic mouse models Mol. Cell Endocrinol. 217 2004 127 136
28. M.A. Arevalo, M. Santos-Galindo, M.J. Bellini, I. Azcoitia, and L.M. Garcia-Segura Actions of estrogens on glial cells: implications for neuroprotection Biochim. Biophys. Acta 1800 2010 1106 1112
29. A.A. Pieper, S. Xie, E. Capota, S.J. Estill, J. Zhong, J.M. Long, G.L. Becker, P. Huntington, S.E. Goldman, and C.H. Shen et al. Discovery of a proneurogenic, neuroprotective chemical Cell 142 2010 39 51
30. F.D. Porter, and G.E. Herman Malformation syndromes caused by disorders of cholesterol synthesis J. Lipid Res. 52 2011 6 34
31. R.D. Brinton The neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one induces cytoarchitectural regression in cultured fetal hippocampal neurons J. Neurosci. 14 1994 2763 2774