Immunolocalization of vimentin, keratin 17, Ki-67, involucrin, β-catenin and E-cadherin in cutaneous squamous cell carcinoma

Pathology and Oncology Research

Volumn 20, Issue 2, 2014, Pages 263-266

  Lan, Yan Ju ^a   Chen, Huan ^a   Chen, Jia Qi ^b   Lei, Qiu Hua ^b   Zheng, Min ^b   Shao, Zhe Ren ^b  

^a LISHUI CENTRAL HOSPITAL   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Epithelial mesenchymal transition; Immunolocalization; Squamous cell carcinoma

Indexed keywords

BETA CATENIN; CYTOKERATIN 17; INVOLUCRIN; KI 67 ANTIGEN; UVOMORULIN; VIMENTIN; CADHERIN; PROTEIN PRECURSOR; TUMOR MARKER;

AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOLOCALIZATION; MALE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SKIN CARCINOMA; CASE CONTROL STUDY; METABOLISM; MIDDLE AGED; PHYSIOLOGY; SKIN TUMOR; SQUAMOUS CELL CARCINOMA;

AGED; BETA CATENIN; CADHERINS; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; KERATIN-17; KI-67 ANTIGEN; MALE; MIDDLE AGED; PROTEIN PRECURSORS; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; VIMENTIN;

EID: 84898777098     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-013-9690-5     Document Type: Article

References (22)

1. Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7(2):131-142. doi: 10.1038/nrm1835
2. Said NA, Williams ED (2011) Growth factors in induction of epithelial-mesenchymal transition and metastasis. Cells Tissues Organs 193(1-2):85-97. doi: 10.1159/000320360
3. Kalluri R, Neilson EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112(12):1776-1784. doi: 10.1172/JCI20530
4. Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED, Thompson EW (2007) Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cel Physiol 213(2):374-383. doi: 10.1002/jcp.21223
5. Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119(6):1420-1428. doi: 10.1172/JCI39104
6. Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119(6):1438-1449. doi: 10.1172/JCI38019
7. Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119(6):1429-1437. doi: 10.1172/JCI36183
8. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133(4):704-715. doi: 10.1016/j.cell.2008.03.027
9. Man XY, Finnson KW, Baron M, Philip A (2012) CD109, a TGF-beta co-receptor, attenuates extracellular matrix production in scleroderma skin fibroblasts. Arthritis Res Ther 14(3):R144. doi: 10.1186/ar3877
10. Marks R (1996) Squamous cell carcinoma. Lancet 347(9003):735-738
11. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133(4):1710-1715
12. Scholzen T, Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J Cel Physiol 182(3):311-322. doi: 10.1002/(SICI)1097-4652(200003)182: 3<311::AID-JCP1>3.0.CO;2-9
13. Pich A, Chiusa L, Navone R (2004) Prognostic relevance of cell proliferation in head and neck tumors. Ann Oncol: official journal of the European Society for Medical Oncology/ESMO 15(9):1319-1329. doi: 10.1093/annonc/mdh299
14. Iyer PV, Leong AS (1992) Poorly differentiated squamous cell carcinomas of the skin can express vimentin. J Cutan Pathol 19(1):34-39
15. Chang HW, Lee YS, Nam HY, Han MW, Kim HJ, Moon SY, Jeon H, Park JJ, Carey TE, Chang SE, Kim SW, Kim SY (2012) Knockdown of beta-catenin controls both apoptotic and autophagic cell death through LKB1/AMPK signaling in head and neck squamous cell carcinoma cell lines. Cell Signal. doi: 10.1016/j.cellsig.2012. 12.020
16. Depianto D, Kerns ML, Dlugosz AA, Coulombe PA (2010) Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet 42(10):910-914. doi: 10.1038/ng.665
17. Proby CM, Churchill L, Purkis PE, Glover MT, Sexton CJ, Leigh IM (1993) Keratin 17 expression as a marker for epithelial transformation in viral warts. Am J Pathol 143(6):1667-1678
18. Wei KJ, Zhang L, Yang X, Zhong LP, Zhou XJ, Pan HY, Li J, Chen WT, Zhang ZY (2009) Overexpression of cytokeratin 17 protein in oral squamous cell carcinoma in vitro and in vivo. Oral Dis 15(1):111-117. doi: 10.1111/j.1601-0825.2008.01501.x
19. Toyoshima T, Koch F, Kaemmerer P, Vairaktaris E, Al-Nawas B, Wagner W (2009) Expression of cytokeratin 17 mRNA in oral squamous cell carcinoma cells obtained by brush biopsy: preliminary results. J Oral Pathol Med: official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 38(6):530-534. doi: 10.1111/j.1600-0714.2009. 00748.x
20. Kitamura R, Toyoshima T, Tanaka H, Kawano S, Kiyosue T, Matsubara R, Goto Y, Hirano M, Oobu K, Nakamura S (2012) Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma. J Cancer Res Clin Oncol 138(8):1299-1310. doi: 10.1007/s00432-012-1202-6
21. Rice RH, Green H (1977) The cornified envelope of terminally differentiated human epidermal keratinocytes consists of cross-linked protein. Cell 11(2):417-422
22. Bhargava G, Rifas L, Makman MH (1979) Presence of epidermal growth factor receptors and influence of epidermal growth factor on proliferation and aging in cultured smooth muscle cells. J Cell Physiol 100(2):365-374. doi: 10.1002/jcp.1041000217