Lactoferrin inhibits apoptosis through insulin-like growth factor I in primary rat osteoblasts

Acta Pharmacologica Sinica

Volumn 35, Issue 4, 2014, Pages 523-530

  Hou, Jian Ming ^a,b   Chen, En Yu ^b   Wei, Shi Chao ^a,b   Lin, Fan ^a,b   Lin, Qing Ming ^a,b   Lan, Xu Hua ^a,b   Xue, Ying ^a,b   Wu, Man ^b  

^a FUJIAN PROVINCIAL HOSPITAL   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bone remodeling; IGF I; Lactoferrin; Osteoblast; Osteoporosis; RNA interference

Indexed keywords

ALKALINE PHOSPHATASE; GREEN FLUORESCENT PROTEIN; LACTOFERRIN; SMALL INTERFERING RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; COLLAGEN TYPE 1; INSULIN-LIKE GROWTH FACTOR-1, RAT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BOVINAE; CELL CULTURE; CELL PROTECTION; DOSE RESPONSE; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; METABOLISM; NEWBORN; PATHOLOGY; PRIMARY CELL CULTURE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME; UPREGULATION;

ALKALINE PHOSPHATASE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CATTLE; CELLS, CULTURED; COLLAGEN TYPE I; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; INSULIN-LIKE GROWTH FACTOR I; LACTOFERRIN; OSTEOBLASTS; PRIMARY CELL CULTURE; RATS, SPRAGUE-DAWLEY; RECEPTOR, IGF TYPE 1; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 84898769214     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.173     Document Type: Article

References (24)

1. García-Montoya IA, Cendón TS, Arévalo-Gallegos S, Rascón-Cruz Q. LF a multiple bioactive protein: An overview. Biochim Biophys Acta 2012; 1820: 226-36
2. Baker HM, Baker EN. A structural perspective on LF function. Biochem Cell Biol 2012; 90: 320-8
3. Ward PP, Paz E, Conneely OM. Multifunctional roles of LF: A critical overview. Cell Mol Life Sci 2005; 62: 2540-8
4. Grey A, Zhu Q, Watson M, Callon K, Cornish J. LF potently inhibits osteoblast apoptosis, via an LRP1-independent pathway. Mol Cell Endocrinol 2006; 251: 96-102
5. Amini AA, Nair LS. LF: A biologically active molecule for bone regeneration. Curr Med Chem 2011; 18: 1220-9
6. Cornish J, Naot D. LF as an effector molecule in the skeleton. Biometals 2010; 23: 425-30
7. Hou JM, Xue Y, Lin QM. Bovine LF improves bone mass and microstructure in ovariectomized rats via OPG/RANKL/RANK pathway. Acta Pharmacol Sin 2012; 33: 1277-84
8. Cornish J, Callon KE, Naot D, Palmano KP, Banovic T, Bava U, et al. LF is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 2004; 145: 4366-74
9. Grey A, Banovic T, Zhu Q, Watson M, Callon K, Palmano K, et al. The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for LF in osteoblastic cells. Mol Endocrinol 2004; 18: 2268-78
10. Vincent AM, Feldman EL. Control of cell survival by IGF signaling pathways. Growth Horm IGF Res 2002; 12: 193-7
11. Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest 1999; 104: 1363-74
12. Gohel A, McCarthy MB, Gronowicz G. Estrogen prevents glucocorticoid- induced apoptosis in osteoblasts in vivo and in vitro. Endocrinology 1999; 140: 5339-47
13. Hill PA, Tumber A. Ceramide-induced cell death/survival in murine osteoblasts. J Endocrinol 2010; 206: 225-33
14. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002; 359: 1761-7
15. Garnero P, Delmas PD. Evaluation of risk for osteoporosis fractures. In: Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology. 2nd ed. San Diego, CA: Academic Press; 2002. p 1291-1301
16. Ganji MR. Postmenopausal osteoporosis treatment and risk of urinary calculus development. Iran J Kidney Dis 2013; 7: 171-4
17. Naot D, Grey A, Reid IR, Cornish J. LF-A novel bone growth factor. Clin Med Res 2005; 5: 93-101
18. Cornish J. LF promotes bone growth. Biometals 2004; 17: 331-5
19. Mercer WE, Baserga R. The transformation-related p53 protein: A potential regulator of cell proliferation. Prog Clin Biol Res 1985; 177: 171-91
20. Barres BA, Hart IK, Coles HS, Burne JF, Voyvodic JT, Richardson WD, et al. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 1992; 70: 31-46
21. Hill PA, Tumber A, Meikle MC. Multiple extracellular signals promote osteoblast survival and apoptosis. Endocrinology 1997; 138: 3849-58
22. Kenchappa P, Yadav A, Singh G, Nandana S, Banerjee K. Rescue of TNF-Alpha inhibited neuronal cells by IGF-1 involves Akt and c-Jun N-Terminal kinases. J Neurosci Res 2004; 76: 466-74
23. Tumber A, Meikle MC, Hill PA. Autocrine signals promote osteoblast survival in culture. J Endocrinol 2000; 167: 383-90
24. Cornish J, Naot D. LF as an effector molecule in the skeleton. Biometals 2010; 23: 425-30.